7WI6
Cryo-EM structure of LY341495/NAM-bound mGlu3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001641 | molecular_function | group II metabotropic glutamate receptor activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0005246 | molecular_function | calcium channel regulator activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007194 | biological_process | negative regulation of adenylate cyclase activity |
| A | 0007196 | biological_process | adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway |
| A | 0007216 | biological_process | G protein-coupled glutamate receptor signaling pathway |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0008066 | molecular_function | glutamate receptor activity |
| A | 0010467 | biological_process | gene expression |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0016020 | cellular_component | membrane |
| A | 0030424 | cellular_component | axon |
| A | 0042734 | cellular_component | presynaptic membrane |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043197 | cellular_component | dendritic spine |
| A | 0045211 | cellular_component | postsynaptic membrane |
| A | 0051966 | biological_process | regulation of synaptic transmission, glutamatergic |
| A | 0097110 | molecular_function | scaffold protein binding |
| A | 0097449 | cellular_component | astrocyte projection |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099170 | biological_process | postsynaptic modulation of chemical synaptic transmission |
| B | 0001641 | molecular_function | group II metabotropic glutamate receptor activity |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0005246 | molecular_function | calcium channel regulator activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007194 | biological_process | negative regulation of adenylate cyclase activity |
| B | 0007196 | biological_process | adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway |
| B | 0007216 | biological_process | G protein-coupled glutamate receptor signaling pathway |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0008066 | molecular_function | glutamate receptor activity |
| B | 0010467 | biological_process | gene expression |
| B | 0014069 | cellular_component | postsynaptic density |
| B | 0016020 | cellular_component | membrane |
| B | 0030424 | cellular_component | axon |
| B | 0042734 | cellular_component | presynaptic membrane |
| B | 0043005 | cellular_component | neuron projection |
| B | 0043197 | cellular_component | dendritic spine |
| B | 0045211 | cellular_component | postsynaptic membrane |
| B | 0051966 | biological_process | regulation of synaptic transmission, glutamatergic |
| B | 0097110 | molecular_function | scaffold protein binding |
| B | 0097449 | cellular_component | astrocyte projection |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0099170 | biological_process | postsynaptic modulation of chemical synaptic transmission |
Functional Information from PROSITE/UniProt
| site_id | PS00979 |
| Number of Residues | 19 |
| Details | G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLrLFqIPQISyASTS |
| Chain | Residue | Details |
| A | VAL157-SER175 |
| site_id | PS00980 |
| Number of Residues | 23 |
| Details | G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWiCipCepyeYla...DefTCmdC |
| Chain | Residue | Details |
| A | CYS527-CYS549 |
| site_id | PS00981 |
| Number of Residues | 11 |
| Details | G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfIGFTM |
| Chain | Residue | Details |
| A | PHE765-MET775 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1192 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU23-TRP576 | |
| A | LYS635-ARG645 | |
| A | GLU710-ASP734 | |
| A | SER793-THR802 | |
| B | LEU23-TRP576 | |
| B | LYS635-ARG645 | |
| B | GLU710-ASP734 | |
| B | SER793-THR802 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA577-ILE599 | |
| B | ALA577-ILE599 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 196 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS600-GLU613 | |
| A | CYS665-GLN688 | |
| A | LYS757-LYS769 | |
| A | GLN829-LEU879 | |
| B | LYS600-GLU613 | |
| B | CYS665-GLN688 | |
| B | LYS757-LYS769 | |
| B | GLN829-LEU879 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU614-ALA634 | |
| B | LEU614-ALA634 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU646-ASN664 | |
| B | LEU646-ASN664 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL689-LEU709 | |
| B | VAL689-LEU709 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | SER735-PHE756 | |
| B | SER735-PHE756 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE770-THR792 | |
| B | PHE770-THR792 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET803-PHE828 | |
| B | MET803-PHE828 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | SER151 | |
| B | ASP301 | |
| B | LYS389 | |
| A | ALA172 | |
| A | TYR222 | |
| A | ASP301 | |
| A | LYS389 | |
| B | SER151 | |
| B | ALA172 | |
| B | TYR222 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN209 | |
| A | ASN292 | |
| A | ASN414 | |
| A | ASN439 | |
| B | ASN209 | |
| B | ASN292 | |
| B | ASN414 | |
| B | ASN439 |
