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7WI4

Cryo-EM structure of E.Coli FtsH protease cytosolic domains

Functional Information from GO Data
ChainGOidnamespacecontents
A0004176molecular_functionATP-dependent peptidase activity
A0004222molecular_functionmetalloendopeptidase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0030163biological_processprotein catabolic process
A0046872molecular_functionmetal ion binding
A0098796cellular_componentmembrane protein complex
A0098797cellular_componentplasma membrane protein complex
B0004176molecular_functionATP-dependent peptidase activity
B0004222molecular_functionmetalloendopeptidase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0030163biological_processprotein catabolic process
B0046872molecular_functionmetal ion binding
B0098796cellular_componentmembrane protein complex
B0098797cellular_componentplasma membrane protein complex
C0004176molecular_functionATP-dependent peptidase activity
C0004222molecular_functionmetalloendopeptidase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0008233molecular_functionpeptidase activity
C0008237molecular_functionmetallopeptidase activity
C0008270molecular_functionzinc ion binding
C0016020cellular_componentmembrane
C0016887molecular_functionATP hydrolysis activity
C0030163biological_processprotein catabolic process
C0046872molecular_functionmetal ion binding
C0098796cellular_componentmembrane protein complex
C0098797cellular_componentplasma membrane protein complex
D0004176molecular_functionATP-dependent peptidase activity
D0004222molecular_functionmetalloendopeptidase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0006508biological_processproteolysis
D0008233molecular_functionpeptidase activity
D0008237molecular_functionmetallopeptidase activity
D0008270molecular_functionzinc ion binding
D0016020cellular_componentmembrane
D0016887molecular_functionATP hydrolysis activity
D0030163biological_processprotein catabolic process
D0046872molecular_functionmetal ion binding
D0098796cellular_componentmembrane protein complex
D0098797cellular_componentplasma membrane protein complex
E0004176molecular_functionATP-dependent peptidase activity
E0004222molecular_functionmetalloendopeptidase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005886cellular_componentplasma membrane
E0006508biological_processproteolysis
E0008233molecular_functionpeptidase activity
E0008237molecular_functionmetallopeptidase activity
E0008270molecular_functionzinc ion binding
E0016020cellular_componentmembrane
E0016887molecular_functionATP hydrolysis activity
E0030163biological_processprotein catabolic process
E0046872molecular_functionmetal ion binding
E0098796cellular_componentmembrane protein complex
E0098797cellular_componentplasma membrane protein complex
F0004176molecular_functionATP-dependent peptidase activity
F0004222molecular_functionmetalloendopeptidase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005886cellular_componentplasma membrane
F0006508biological_processproteolysis
F0008233molecular_functionpeptidase activity
F0008237molecular_functionmetallopeptidase activity
F0008270molecular_functionzinc ion binding
F0016020cellular_componentmembrane
F0016887molecular_functionATP hydrolysis activity
F0030163biological_processprotein catabolic process
F0046872molecular_functionmetal ion binding
F0098796cellular_componentmembrane protein complex
F0098797cellular_componentplasma membrane protein complex
Functional Information from PROSITE/UniProt
site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. IiVIaATNrpdvLDpALl.R
ChainResidueDetails
AILE291-ARG309

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:8444797
ChainResidueDetails
AMET1-ASN4
DMET1-ASN4
EMET1-ASN4
FMET1-ASN4
BMET1-ASN4
CMET1-ASN4

site_idSWS_FT_FI2
Number of Residues240
DetailsTRANSMEM: Helical => ECO:0000305
ChainResidueDetails
ALEU5-SER25
BLEU99-PHE119
CLEU5-SER25
CLEU99-PHE119
ALEU99-PHE119
DLEU5-SER25
DLEU99-PHE119
ELEU5-SER25
ELEU99-PHE119
FLEU5-SER25
FLEU99-PHE119
BLEU5-SER25

site_idSWS_FT_FI3
Number of Residues432
DetailsTOPO_DOM: Periplasmic => ECO:0000305|PubMed:8444797
ChainResidueDetails
AGLU26-LEU98
DGLU26-LEU98
EGLU26-LEU98
FGLU26-LEU98
BGLU26-LEU98
CGLU26-LEU98

site_idSWS_FT_FI4
Number of Residues3144
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15919996, ECO:0000305|PubMed:8444797
ChainResidueDetails
AMET120-LYS644
DMET120-LYS644
EMET120-LYS644
FMET120-LYS644
BMET120-LYS644
CMET120-LYS644

site_idSWS_FT_FI5
Number of Residues6
DetailsACT_SITE: ACT_SITE => ECO:0000305
ChainResidueDetails
AGLN415
DGLN415
EGLN415
FGLN415
BGLN415
CGLN415

site_idSWS_FT_FI6
Number of Residues12
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01458
ChainResidueDetails
AGLY192
BASP492
CGLY192
CASP492
AASP492
DGLY192
DASP492
EGLY192
EASP492
FGLY192
FASP492
BGLY192

site_idSWS_FT_FI7
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
AHIS414
BHIS418
CHIS414
CHIS418
AHIS418
DHIS414
DHIS418
EHIS414
EHIS418
FHIS414
FHIS418
BHIS414

site_idSWS_FT_FI8
Number of Residues6
DetailsSITE: Substrate binding => ECO:0000305
ChainResidueDetails
APHE225
DPHE225
EPHE225
FPHE225
BPHE225
CPHE225

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PDB entries from 2024-07-17

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