7WEL
Human Nav1.8 with A-803467, class II
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0002027 | biological_process | regulation of heart rate |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0007600 | biological_process | sensory perception |
| A | 0016020 | cellular_component | membrane |
| A | 0030424 | cellular_component | axon |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0034765 | biological_process | regulation of monoatomic ion transmembrane transport |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042475 | biological_process | odontogenesis of dentin-containing tooth |
| A | 0042734 | cellular_component | presynaptic membrane |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0055117 | biological_process | regulation of cardiac muscle contraction |
| A | 0060371 | biological_process | regulation of atrial cardiac muscle cell membrane depolarization |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071439 | cellular_component | clathrin complex |
| A | 0086002 | biological_process | cardiac muscle cell action potential involved in contraction |
| A | 0086010 | biological_process | membrane depolarization during action potential |
| A | 0086016 | biological_process | AV node cell action potential |
| A | 0086043 | biological_process | bundle of His cell action potential |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099505 | biological_process | regulation of presynaptic membrane potential |
| A | 0099508 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 193 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 131 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 87 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat III","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat IV","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 309 |
| Details | Repeat: {"description":"III","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"Q14524","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 7 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
