7WDC
Crystal Structure of Cyanobacterial Circadian Clock Protein KaiC
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0009649 | biological_process | entrainment of circadian clock |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0042752 | biological_process | regulation of circadian rhythm |
| A | 0042754 | biological_process | negative regulation of circadian rhythm |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048511 | biological_process | rhythmic process |
| A | 0070297 | biological_process | regulation of phosphorelay signal transduction system |
| A | 0106310 | molecular_function | protein serine kinase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0007623 | biological_process | circadian rhythm |
| B | 0009649 | biological_process | entrainment of circadian clock |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0042752 | biological_process | regulation of circadian rhythm |
| B | 0042754 | biological_process | negative regulation of circadian rhythm |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048511 | biological_process | rhythmic process |
| B | 0070297 | biological_process | regulation of phosphorelay signal transduction system |
| B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor in CI (KaiC 1) => ECO:0000305|PubMed:22304631 |
| Chain | Residue | Details |
| A | GLU77 | |
| B | GLU77 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor in CII (KaiC 2) => ECO:0000305|PubMed:22304631 |
| Chain | Residue | Details |
| A | GLU318 | |
| B | GLU318 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15304218, ECO:0000269|PubMed:16628225, ECO:0000269|PubMed:22304631, ECO:0007744|PDB:1TF7, ECO:0007744|PDB:2GBL, ECO:0007744|PDB:4DUG |
| Chain | Residue | Details |
| A | GLY49 | |
| A | THR50 | |
| A | GLY51 | |
| A | LYS52 | |
| A | LEU54 | |
| A | SER89 | |
| A | LYS224 | |
| A | ARG226 | |
| A | THR228 | |
| A | HIS230 | |
| A | THR240 | |
| A | ASP241 | |
| A | THR290 | |
| A | GLY291 | |
| A | THR292 | |
| A | GLY293 | |
| A | LYS294 | |
| A | LEU296 | |
| A | TRP331 | |
| A | ARG451 | |
| A | LYS457 | |
| A | ARG459 | |
| A | SER461 | |
| A | HIS463 | |
| A | LYS465 | |
| B | GLY49 | |
| B | THR50 | |
| B | GLY51 | |
| B | LYS52 | |
| B | LEU54 | |
| B | SER89 | |
| B | LYS224 | |
| B | ARG226 | |
| B | THR228 | |
| B | HIS230 | |
| B | THR240 | |
| B | ASP241 | |
| B | THR290 | |
| B | GLY291 | |
| B | THR292 | |
| B | GLY293 | |
| B | LYS294 | |
| B | LEU296 | |
| B | TRP331 | |
| B | ARG451 | |
| B | LYS457 | |
| B | ARG459 | |
| B | SER461 | |
| B | HIS463 | |
| B | LYS465 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0007744|PDB:4DUG, ECO:0007744|PDB:4TL6, ECO:0007744|PDB:7DXQ |
| Chain | Residue | Details |
| A | THR53 | |
| B | THR53 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15304218, ECO:0000269|PubMed:16628225, ECO:0007744|PDB:1TF7, ECO:0007744|PDB:2GBL |
| Chain | Residue | Details |
| A | LEU225 | |
| A | MET458 | |
| B | LEU225 | |
| B | MET458 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15304218, ECO:0000269|PubMed:16628225, ECO:0007744|PDB:1U9I, ECO:0007744|PDB:2GBL, ECO:0007744|PDB:4DUG, ECO:0007744|PDB:7DXQ |
| Chain | Residue | Details |
| A | THR295 | |
| B | THR295 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15304218, ECO:0000269|PubMed:16628225 |
| Chain | Residue | Details |
| A | GLU318 | |
| B | GLU318 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15347809, ECO:0000269|PubMed:15347812, ECO:0000269|PubMed:17717528, ECO:0000269|PubMed:17916691, ECO:0007744|PDB:1U9I, ECO:0007744|PDB:2GBL |
| Chain | Residue | Details |
| A | SER431 | |
| B | SER431 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000255|HAMAP-Rule:MF_01836, ECO:0000269|PubMed:15304218, ECO:0000269|PubMed:15347809, ECO:0000269|PubMed:15347812, ECO:0000269|PubMed:17717528, ECO:0000269|PubMed:17916691, ECO:0007744|PDB:1U9I, ECO:0007744|PDB:2GBL |
| Chain | Residue | Details |
| A | THR432 | |
| B | THR432 |
