7WCD

Cryo EM structure of SARS-CoV-2 spike in complex with TAU-2212 mAbs in conformation 4

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0016020	cellular_component	membrane
C	0019031	cellular_component	viral envelope
C	0019064	biological_process	fusion of virus membrane with host plasma membrane
C	0039654	biological_process	fusion of virus membrane with host endosome membrane
C	0046813	biological_process	receptor-mediated virion attachment to host cell
C	0055036	cellular_component	virion membrane
C	0075509	biological_process	endocytosis involved in viral entry into host cell
H	0016020	cellular_component	membrane
H	0019031	cellular_component	viral envelope
H	0019064	biological_process	fusion of virus membrane with host plasma membrane
H	0039654	biological_process	fusion of virus membrane with host endosome membrane
H	0046813	biological_process	receptor-mediated virion attachment to host cell
H	0055036	cellular_component	virion membrane
H	0075509	biological_process	endocytosis involved in viral entry into host cell
J	0016020	cellular_component	membrane
J	0019031	cellular_component	viral envelope
J	0019064	biological_process	fusion of virus membrane with host plasma membrane
J	0039654	biological_process	fusion of virus membrane with host endosome membrane
J	0046813	biological_process	receptor-mediated virion attachment to host cell
J	0055036	cellular_component	virion membrane
J	0075509	biological_process	endocytosis involved in viral entry into host cell

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
E	TYR207-HIS213
F	TYR197-HIS203

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
H	SER685
J	SER685
C	SER685

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site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
H	ARG815
J	ARG815
C	ARG815

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site_id	SWS_FT_FI3
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
H	ASN17
H	ASN1158
H	ASN1173
J	ASN17
J	ASN1158
J	ASN1173
C	ASN17
C	ASN1158
C	ASN1173

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site_id	SWS_FT_FI4
Number of Residues	15
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
H	ASN61
J	ASN1074
C	ASN61
C	ASN122
C	ASN717
C	ASN801
C	ASN1074
H	ASN122
H	ASN717
H	ASN801
H	ASN1074
J	ASN61
J	ASN122
J	ASN717
J	ASN801

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site_id	SWS_FT_FI5
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
H	ASN74
H	ASN149
H	ASN1194
J	ASN74
J	ASN149
J	ASN1194
C	ASN74
C	ASN149
C	ASN1194

---

site_id	SWS_FT_FI6
Number of Residues	21
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
H	ASN165
J	ASN331
J	ASN343
J	ASN616
J	ASN657
J	ASN1098
C	ASN165
C	ASN282
C	ASN331
C	ASN343
C	ASN616
H	ASN282
C	ASN657
C	ASN1098
H	ASN331
H	ASN343
H	ASN616
H	ASN657
H	ASN1098
J	ASN165
J	ASN282

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
H	ASN234
H	ASN709
J	ASN234
J	ASN709
C	ASN234
C	ASN709

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site_id	SWS_FT_FI8
Number of Residues	3
Details	CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
H	THR323
J	THR323
C	THR323

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site_id	SWS_FT_FI9
Number of Residues	3
Details	CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
H	SER325
J	SER325
C	SER325

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site_id	SWS_FT_FI10
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
H	ASN603
J	ASN603
C	ASN603

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site_id	SWS_FT_FI11
Number of Residues	6
Details	CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583

Chain	Residue	Details
H	THR676
H	THR678
J	THR676
J	THR678
C	THR676
C	THR678

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site_id	SWS_FT_FI12
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
H	ASN1134
J	ASN1134
C	ASN1134

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