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7W8G

Cryo-EM structure of MCM double hexamer

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
20000727biological_processdouble-strand break repair via break-induced replication
20003677molecular_functionDNA binding
20003682molecular_functionchromatin binding
20003688molecular_functionDNA replication origin binding
20003697molecular_functionsingle-stranded DNA binding
20004386molecular_functionhelicase activity
20005515molecular_functionprotein binding
20005524molecular_functionATP binding
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005656cellular_componentnuclear pre-replicative complex
20005737cellular_componentcytoplasm
20006260biological_processDNA replication
20006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
20006268biological_processDNA unwinding involved in DNA replication
20006270biological_processDNA replication initiation
20006271biological_processDNA strand elongation involved in DNA replication
20006279biological_processpremeiotic DNA replication
20006974biological_processDNA damage response
20008270molecular_functionzinc ion binding
20016787molecular_functionhydrolase activity
20016887molecular_functionATP hydrolysis activity
20017116molecular_functionsingle-stranded DNA helicase activity
20031261cellular_componentDNA replication preinitiation complex
20031298cellular_componentreplication fork protection complex
20032508biological_processDNA duplex unwinding
20042555cellular_componentMCM complex
20043138molecular_function3'-5' DNA helicase activity
20043596cellular_componentnuclear replication fork
20046872molecular_functionmetal ion binding
20071162cellular_componentCMG complex
21902975biological_processmitotic DNA replication initiation
21905775biological_processnegative regulation of DNA helicase activity
30000727biological_processdouble-strand break repair via break-induced replication
30000781cellular_componentchromosome, telomeric region
30003677molecular_functionDNA binding
30003682molecular_functionchromatin binding
30003688molecular_functionDNA replication origin binding
30003697molecular_functionsingle-stranded DNA binding
30004386molecular_functionhelicase activity
30005515molecular_functionprotein binding
30005524molecular_functionATP binding
30005634cellular_componentnucleus
30005654cellular_componentnucleoplasm
30005656cellular_componentnuclear pre-replicative complex
30005737cellular_componentcytoplasm
30006260biological_processDNA replication
30006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
30006268biological_processDNA unwinding involved in DNA replication
30006270biological_processDNA replication initiation
30006271biological_processDNA strand elongation involved in DNA replication
30006279biological_processpremeiotic DNA replication
30016787molecular_functionhydrolase activity
30016887molecular_functionATP hydrolysis activity
30017116molecular_functionsingle-stranded DNA helicase activity
30030466biological_processsilent mating-type cassette heterochromatin formation
30031261cellular_componentDNA replication preinitiation complex
30031298cellular_componentreplication fork protection complex
30031509biological_processsubtelomeric heterochromatin formation
30032508biological_processDNA duplex unwinding
30042555cellular_componentMCM complex
30043596cellular_componentnuclear replication fork
30071162cellular_componentCMG complex
31902975biological_processmitotic DNA replication initiation
31904931molecular_functionMCM complex binding
40000727biological_processdouble-strand break repair via break-induced replication
40003677molecular_functionDNA binding
40003678molecular_functionDNA helicase activity
40003688molecular_functionDNA replication origin binding
40003697molecular_functionsingle-stranded DNA binding
40004386molecular_functionhelicase activity
40005515molecular_functionprotein binding
40005524molecular_functionATP binding
40005634cellular_componentnucleus
40005654cellular_componentnucleoplasm
40005656cellular_componentnuclear pre-replicative complex
40005737cellular_componentcytoplasm
40006260biological_processDNA replication
40006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
40006268biological_processDNA unwinding involved in DNA replication
40006270biological_processDNA replication initiation
40006271biological_processDNA strand elongation involved in DNA replication
40006279biological_processpremeiotic DNA replication
40008270molecular_functionzinc ion binding
40009378molecular_functionfour-way junction helicase activity
40016787molecular_functionhydrolase activity
40016887molecular_functionATP hydrolysis activity
40017116molecular_functionsingle-stranded DNA helicase activity
40031261cellular_componentDNA replication preinitiation complex
40031298cellular_componentreplication fork protection complex
40032508biological_processDNA duplex unwinding
40033260biological_processnuclear DNA replication
40042555cellular_componentMCM complex
40043138molecular_function3'-5' DNA helicase activity
40043596cellular_componentnuclear replication fork
40071162cellular_componentCMG complex
40097373cellular_componentMCM core complex
41902975biological_processmitotic DNA replication initiation
50000727biological_processdouble-strand break repair via break-induced replication
50000781cellular_componentchromosome, telomeric region
50003677molecular_functionDNA binding
50003682molecular_functionchromatin binding
50003688molecular_functionDNA replication origin binding
50003697molecular_functionsingle-stranded DNA binding
50004386molecular_functionhelicase activity
50005515molecular_functionprotein binding
50005524molecular_functionATP binding
50005634cellular_componentnucleus
50005654cellular_componentnucleoplasm
50005656cellular_componentnuclear pre-replicative complex
50005737cellular_componentcytoplasm
50006260biological_processDNA replication
50006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
50006268biological_processDNA unwinding involved in DNA replication
50006270biological_processDNA replication initiation
50006279biological_processpremeiotic DNA replication
50006368biological_processtranscription elongation by RNA polymerase II
50008270molecular_functionzinc ion binding
50016787molecular_functionhydrolase activity
50016887molecular_functionATP hydrolysis activity
50017116molecular_functionsingle-stranded DNA helicase activity
50030174biological_processregulation of DNA-templated DNA replication initiation
50031261cellular_componentDNA replication preinitiation complex
50031298cellular_componentreplication fork protection complex
50031507biological_processheterochromatin formation
50031509biological_processsubtelomeric heterochromatin formation
50032508biological_processDNA duplex unwinding
50033260biological_processnuclear DNA replication
50042555cellular_componentMCM complex
50043138molecular_function3'-5' DNA helicase activity
50043596cellular_componentnuclear replication fork
50071162cellular_componentCMG complex
60000727biological_processdouble-strand break repair via break-induced replication
60003677molecular_functionDNA binding
60003678molecular_functionDNA helicase activity
60003688molecular_functionDNA replication origin binding
60003697molecular_functionsingle-stranded DNA binding
60004386molecular_functionhelicase activity
60005515molecular_functionprotein binding
60005524molecular_functionATP binding
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60005656cellular_componentnuclear pre-replicative complex
60005737cellular_componentcytoplasm
60006260biological_processDNA replication
60006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
60006268biological_processDNA unwinding involved in DNA replication
60006270biological_processDNA replication initiation
60006271biological_processDNA strand elongation involved in DNA replication
60006279biological_processpremeiotic DNA replication
60008270molecular_functionzinc ion binding
60009378molecular_functionfour-way junction helicase activity
60016787molecular_functionhydrolase activity
60016887molecular_functionATP hydrolysis activity
60017116molecular_functionsingle-stranded DNA helicase activity
60031261cellular_componentDNA replication preinitiation complex
60031298cellular_componentreplication fork protection complex
60032508biological_processDNA duplex unwinding
60042555cellular_componentMCM complex
60043138molecular_function3'-5' DNA helicase activity
60043596cellular_componentnuclear replication fork
60071162cellular_componentCMG complex
60097373cellular_componentMCM core complex
61902969biological_processmitotic DNA replication
61990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
70000727biological_processdouble-strand break repair via break-induced replication
70000781cellular_componentchromosome, telomeric region
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003682molecular_functionchromatin binding
70003688molecular_functionDNA replication origin binding
70003697molecular_functionsingle-stranded DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005656cellular_componentnuclear pre-replicative complex
70005737cellular_componentcytoplasm
70006260biological_processDNA replication
70006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
70006268biological_processDNA unwinding involved in DNA replication
70006270biological_processDNA replication initiation
70006271biological_processDNA strand elongation involved in DNA replication
70006279biological_processpremeiotic DNA replication
70008270molecular_functionzinc ion binding
70009378molecular_functionfour-way junction helicase activity
70016787molecular_functionhydrolase activity
70016887molecular_functionATP hydrolysis activity
70017116molecular_functionsingle-stranded DNA helicase activity
70030466biological_processsilent mating-type cassette heterochromatin formation
70031261cellular_componentDNA replication preinitiation complex
70031298cellular_componentreplication fork protection complex
70031509biological_processsubtelomeric heterochromatin formation
70032508biological_processDNA duplex unwinding
70033260biological_processnuclear DNA replication
70042555cellular_componentMCM complex
70043138molecular_function3'-5' DNA helicase activity
70043596cellular_componentnuclear replication fork
70071162cellular_componentCMG complex
70097373cellular_componentMCM core complex
71904931molecular_functionMCM complex binding
B0000727biological_processdouble-strand break repair via break-induced replication
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003688molecular_functionDNA replication origin binding
B0003697molecular_functionsingle-stranded DNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005656cellular_componentnuclear pre-replicative complex
B0005737cellular_componentcytoplasm
B0006260biological_processDNA replication
B0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
B0006268biological_processDNA unwinding involved in DNA replication
B0006270biological_processDNA replication initiation
B0006271biological_processDNA strand elongation involved in DNA replication
B0006279biological_processpremeiotic DNA replication
B0006974biological_processDNA damage response
B0008270molecular_functionzinc ion binding
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017116molecular_functionsingle-stranded DNA helicase activity
B0031261cellular_componentDNA replication preinitiation complex
B0031298cellular_componentreplication fork protection complex
B0032508biological_processDNA duplex unwinding
B0042555cellular_componentMCM complex
B0043138molecular_function3'-5' DNA helicase activity
B0043596cellular_componentnuclear replication fork
B0046872molecular_functionmetal ion binding
B0071162cellular_componentCMG complex
B1902975biological_processmitotic DNA replication initiation
B1905775biological_processnegative regulation of DNA helicase activity
C0000727biological_processdouble-strand break repair via break-induced replication
C0000781cellular_componentchromosome, telomeric region
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003688molecular_functionDNA replication origin binding
C0003697molecular_functionsingle-stranded DNA binding
C0004386molecular_functionhelicase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005656cellular_componentnuclear pre-replicative complex
C0005737cellular_componentcytoplasm
C0006260biological_processDNA replication
C0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
C0006268biological_processDNA unwinding involved in DNA replication
C0006270biological_processDNA replication initiation
C0006271biological_processDNA strand elongation involved in DNA replication
C0006279biological_processpremeiotic DNA replication
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0017116molecular_functionsingle-stranded DNA helicase activity
C0030466biological_processsilent mating-type cassette heterochromatin formation
C0031261cellular_componentDNA replication preinitiation complex
C0031298cellular_componentreplication fork protection complex
C0031509biological_processsubtelomeric heterochromatin formation
C0032508biological_processDNA duplex unwinding
C0042555cellular_componentMCM complex
C0043596cellular_componentnuclear replication fork
C0071162cellular_componentCMG complex
C1902975biological_processmitotic DNA replication initiation
C1904931molecular_functionMCM complex binding
D0000727biological_processdouble-strand break repair via break-induced replication
D0003677molecular_functionDNA binding
D0003678molecular_functionDNA helicase activity
D0003688molecular_functionDNA replication origin binding
D0003697molecular_functionsingle-stranded DNA binding
D0004386molecular_functionhelicase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005656cellular_componentnuclear pre-replicative complex
D0005737cellular_componentcytoplasm
D0006260biological_processDNA replication
D0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
D0006268biological_processDNA unwinding involved in DNA replication
D0006270biological_processDNA replication initiation
D0006271biological_processDNA strand elongation involved in DNA replication
D0006279biological_processpremeiotic DNA replication
D0008270molecular_functionzinc ion binding
D0009378molecular_functionfour-way junction helicase activity
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0017116molecular_functionsingle-stranded DNA helicase activity
D0031261cellular_componentDNA replication preinitiation complex
D0031298cellular_componentreplication fork protection complex
D0032508biological_processDNA duplex unwinding
D0033260biological_processnuclear DNA replication
D0042555cellular_componentMCM complex
D0043138molecular_function3'-5' DNA helicase activity
D0043596cellular_componentnuclear replication fork
D0071162cellular_componentCMG complex
D0097373cellular_componentMCM core complex
D1902975biological_processmitotic DNA replication initiation
E0000727biological_processdouble-strand break repair via break-induced replication
E0000781cellular_componentchromosome, telomeric region
E0003677molecular_functionDNA binding
E0003682molecular_functionchromatin binding
E0003688molecular_functionDNA replication origin binding
E0003697molecular_functionsingle-stranded DNA binding
E0004386molecular_functionhelicase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005656cellular_componentnuclear pre-replicative complex
E0005737cellular_componentcytoplasm
E0006260biological_processDNA replication
E0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
E0006268biological_processDNA unwinding involved in DNA replication
E0006270biological_processDNA replication initiation
E0006279biological_processpremeiotic DNA replication
E0006368biological_processtranscription elongation by RNA polymerase II
E0008270molecular_functionzinc ion binding
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0017116molecular_functionsingle-stranded DNA helicase activity
E0030174biological_processregulation of DNA-templated DNA replication initiation
E0031261cellular_componentDNA replication preinitiation complex
E0031298cellular_componentreplication fork protection complex
E0031507biological_processheterochromatin formation
E0031509biological_processsubtelomeric heterochromatin formation
E0032508biological_processDNA duplex unwinding
E0033260biological_processnuclear DNA replication
E0042555cellular_componentMCM complex
E0043138molecular_function3'-5' DNA helicase activity
E0043596cellular_componentnuclear replication fork
E0071162cellular_componentCMG complex
F0000727biological_processdouble-strand break repair via break-induced replication
F0003677molecular_functionDNA binding
F0003678molecular_functionDNA helicase activity
F0003688molecular_functionDNA replication origin binding
F0003697molecular_functionsingle-stranded DNA binding
F0004386molecular_functionhelicase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005656cellular_componentnuclear pre-replicative complex
F0005737cellular_componentcytoplasm
F0006260biological_processDNA replication
F0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
F0006268biological_processDNA unwinding involved in DNA replication
F0006270biological_processDNA replication initiation
F0006271biological_processDNA strand elongation involved in DNA replication
F0006279biological_processpremeiotic DNA replication
F0008270molecular_functionzinc ion binding
F0009378molecular_functionfour-way junction helicase activity
F0016787molecular_functionhydrolase activity
F0016887molecular_functionATP hydrolysis activity
F0017116molecular_functionsingle-stranded DNA helicase activity
F0031261cellular_componentDNA replication preinitiation complex
F0031298cellular_componentreplication fork protection complex
F0032508biological_processDNA duplex unwinding
F0042555cellular_componentMCM complex
F0043138molecular_function3'-5' DNA helicase activity
F0043596cellular_componentnuclear replication fork
F0071162cellular_componentCMG complex
F0097373cellular_componentMCM core complex
F1902969biological_processmitotic DNA replication
F1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
G0000727biological_processdouble-strand break repair via break-induced replication
G0000781cellular_componentchromosome, telomeric region
G0003677molecular_functionDNA binding
G0003678molecular_functionDNA helicase activity
G0003682molecular_functionchromatin binding
G0003688molecular_functionDNA replication origin binding
G0003697molecular_functionsingle-stranded DNA binding
G0004386molecular_functionhelicase activity
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005656cellular_componentnuclear pre-replicative complex
G0005737cellular_componentcytoplasm
G0006260biological_processDNA replication
G0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
G0006268biological_processDNA unwinding involved in DNA replication
G0006270biological_processDNA replication initiation
G0006271biological_processDNA strand elongation involved in DNA replication
G0006279biological_processpremeiotic DNA replication
G0008270molecular_functionzinc ion binding
G0009378molecular_functionfour-way junction helicase activity
G0016787molecular_functionhydrolase activity
G0016887molecular_functionATP hydrolysis activity
G0017116molecular_functionsingle-stranded DNA helicase activity
G0030466biological_processsilent mating-type cassette heterochromatin formation
G0031261cellular_componentDNA replication preinitiation complex
G0031298cellular_componentreplication fork protection complex
G0031509biological_processsubtelomeric heterochromatin formation
G0032508biological_processDNA duplex unwinding
G0033260biological_processnuclear DNA replication
G0042555cellular_componentMCM complex
G0043138molecular_function3'-5' DNA helicase activity
G0043596cellular_componentnuclear replication fork
G0071162cellular_componentCMG complex
G0097373cellular_componentMCM core complex
G1904931molecular_functionMCM complex binding
Functional Information from PROSITE/UniProt
site_idPS00847
Number of Residues9
DetailsMCM_1 MCM family signature. GICCIDEFD
ChainResidueDetails
7GLY519-ASP527
6GLY634-ASP642
5GLY475-ASP483
2GLY602-ASP610
4GLY627-ASP635
3GLY468-ASP476

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P33993
ChainResidueDetails
7TYR423
GGLY463
GALA465
GLYS466
GSER467
GASN568
GARG593
GARG687
7GLY463
7ALA465
7LYS466
7SER467
7ASN568
7ARG593
7ARG687
GTYR423

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956
ChainResidueDetails
7THR811
GTHR811
FSER78
FSER372

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
7SER819
BSER170
GSER819
2SER23
2SER164
2SER170
BSER14
BSER16
BSER23
BSER164

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198
ChainResidueDetails
7SER838
GSER838

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950
ChainResidueDetails
3THR868
CTHR868

219140

PDB entries from 2024-05-01

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