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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7W7G

Structure of Mammalian NALCN-FAM155A-UNC79-UNC80 quanternary complex

Functional Information from GO Data
ChainGOidnamespacecontents
B0001518cellular_componentvoltage-gated sodium channel complex
B0005261molecular_functionmonoatomic cation channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0034706cellular_componentsodium channel complex
B0035725biological_processsodium ion transmembrane transport
B0055080biological_processmonoatomic cation homeostasis
B0098908biological_processregulation of neuronal action potential
C0001518cellular_componentvoltage-gated sodium channel complex
C0005216molecular_functionmonoatomic ion channel activity
C0005248molecular_functionvoltage-gated sodium channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0008150biological_processbiological_process
C0016020cellular_componentmembrane
C0022840molecular_functionleak channel activity
C0032224biological_processpositive regulation of synaptic transmission, cholinergic
C0032230biological_processpositive regulation of synaptic transmission, GABAergic
C0035725biological_processsodium ion transmembrane transport
C0042391biological_processregulation of membrane potential
C0055085biological_processtransmembrane transport
C0060075biological_processregulation of resting membrane potential
C0070588biological_processcalcium ion transmembrane transport
C0071805biological_processpotassium ion transmembrane transport
C0098908biological_processregulation of neuronal action potential
D0001518cellular_componentvoltage-gated sodium channel complex
D0005886cellular_componentplasma membrane
D0016247molecular_functionchannel regulator activity
D0035725biological_processsodium ion transmembrane transport
D0098659biological_processinorganic cation import across plasma membrane
D0098908biological_processregulation of neuronal action potential
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues40
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S1 of VSD1","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues189
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=S2 of VSD1","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=S3 of VSD1","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of VSD1","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues120
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S5 of VSD1","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues76
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues27
DetailsTransmembrane: {"description":"Helical; Name=S6 of VSD1","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S1 of VSD2","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=S2 of VSD2","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S3 of VSD2","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of VSD2","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues27
DetailsTransmembrane: {"description":"Helical; Name=S5 of VSD2","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues29
DetailsTransmembrane: {"description":"Helical; Name=S6 of VSD2","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S1 of VSD3","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=S2 of VSD3","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=S3 of VSD3","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of VSD3","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=S5 of VSD3","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues64
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues29
DetailsTransmembrane: {"description":"Helical; Name=S6 of VSD3","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=S1 of VSD4","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=S2 of VSD4","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S3 of VSD4","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of VSD4","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S5 of VSD4","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=S6 of VSD4","evidences":[{"source":"UniProtKB","id":"Q8IZF0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33273469","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CU3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2026-09-23

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