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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7W6T

CryoEM structure of human KChIP1-Kv4.3-DPP6 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005267molecular_functionpotassium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006936biological_processmuscle contraction
A0007268biological_processchemical synaptic transmission
A0008016biological_processregulation of heart contraction
A0008076cellular_componentvoltage-gated potassium channel complex
A0009898cellular_componentcytoplasmic side of plasma membrane
A0009966biological_processregulation of signal transduction
A0015459molecular_functionpotassium channel regulator activity
A0030425cellular_componentdendrite
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0044325molecular_functiontransmembrane transporter binding
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0071196cellular_componentKv4.3-KChIP1 channel complex
A0071805biological_processpotassium ion transmembrane transport
A0086009biological_processmembrane repolarization
A0097623biological_processpotassium ion export across plasma membrane
A1901379biological_processregulation of potassium ion transmembrane transport
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005250molecular_functionA-type (transient outward) potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006936biological_processmuscle contraction
B0007268biological_processchemical synaptic transmission
B0008016biological_processregulation of heart contraction
B0008076cellular_componentvoltage-gated potassium channel complex
B0016020cellular_componentmembrane
B0030425cellular_componentdendrite
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0042383cellular_componentsarcolemma
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0045211cellular_componentpostsynaptic membrane
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0051262biological_processprotein tetramerization
B0055085biological_processtransmembrane transport
B0071196cellular_componentKv4.3-KChIP1 channel complex
B0071805biological_processpotassium ion transmembrane transport
B0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
B0086009biological_processmembrane repolarization
B0086013biological_processmembrane repolarization during cardiac muscle cell action potential
B0086091biological_processregulation of heart rate by cardiac conduction
B0097623biological_processpotassium ion export across plasma membrane
B0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
B0098982cellular_componentGABA-ergic synapse
B0099625biological_processventricular cardiac muscle cell membrane repolarization
B0099634cellular_componentpostsynaptic specialization membrane
B1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C0005267molecular_functionpotassium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006936biological_processmuscle contraction
C0007268biological_processchemical synaptic transmission
C0008016biological_processregulation of heart contraction
C0008076cellular_componentvoltage-gated potassium channel complex
C0009898cellular_componentcytoplasmic side of plasma membrane
C0009966biological_processregulation of signal transduction
C0015459molecular_functionpotassium channel regulator activity
C0030425cellular_componentdendrite
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0044325molecular_functiontransmembrane transporter binding
C0045202cellular_componentsynapse
C0046872molecular_functionmetal ion binding
C0071196cellular_componentKv4.3-KChIP1 channel complex
C0071805biological_processpotassium ion transmembrane transport
C0086009biological_processmembrane repolarization
C0097623biological_processpotassium ion export across plasma membrane
C1901379biological_processregulation of potassium ion transmembrane transport
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005250molecular_functionA-type (transient outward) potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006936biological_processmuscle contraction
D0007268biological_processchemical synaptic transmission
D0008016biological_processregulation of heart contraction
D0008076cellular_componentvoltage-gated potassium channel complex
D0016020cellular_componentmembrane
D0030425cellular_componentdendrite
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0042383cellular_componentsarcolemma
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0045211cellular_componentpostsynaptic membrane
D0046872molecular_functionmetal ion binding
D0051260biological_processprotein homooligomerization
D0051262biological_processprotein tetramerization
D0055085biological_processtransmembrane transport
D0071196cellular_componentKv4.3-KChIP1 channel complex
D0071805biological_processpotassium ion transmembrane transport
D0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
D0086009biological_processmembrane repolarization
D0086013biological_processmembrane repolarization during cardiac muscle cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0097623biological_processpotassium ion export across plasma membrane
D0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
D0098982cellular_componentGABA-ergic synapse
D0099625biological_processventricular cardiac muscle cell membrane repolarization
D0099634cellular_componentpostsynaptic specialization membrane
D1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
E0005267molecular_functionpotassium channel activity
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006813biological_processpotassium ion transport
E0006936biological_processmuscle contraction
E0007268biological_processchemical synaptic transmission
E0008016biological_processregulation of heart contraction
E0008076cellular_componentvoltage-gated potassium channel complex
E0009898cellular_componentcytoplasmic side of plasma membrane
E0009966biological_processregulation of signal transduction
E0015459molecular_functionpotassium channel regulator activity
E0030425cellular_componentdendrite
E0034220biological_processmonoatomic ion transmembrane transport
E0034702cellular_componentmonoatomic ion channel complex
E0044325molecular_functiontransmembrane transporter binding
E0045202cellular_componentsynapse
E0046872molecular_functionmetal ion binding
E0071196cellular_componentKv4.3-KChIP1 channel complex
E0071805biological_processpotassium ion transmembrane transport
E0086009biological_processmembrane repolarization
E0097623biological_processpotassium ion export across plasma membrane
E1901379biological_processregulation of potassium ion transmembrane transport
F0001508biological_processaction potential
F0005216molecular_functionmonoatomic ion channel activity
F0005249molecular_functionvoltage-gated potassium channel activity
F0005250molecular_functionA-type (transient outward) potassium channel activity
F0005267molecular_functionpotassium channel activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0006813biological_processpotassium ion transport
F0006936biological_processmuscle contraction
F0007268biological_processchemical synaptic transmission
F0008016biological_processregulation of heart contraction
F0008076cellular_componentvoltage-gated potassium channel complex
F0016020cellular_componentmembrane
F0030425cellular_componentdendrite
F0034220biological_processmonoatomic ion transmembrane transport
F0034702cellular_componentmonoatomic ion channel complex
F0042383cellular_componentsarcolemma
F0043025cellular_componentneuronal cell body
F0043197cellular_componentdendritic spine
F0045211cellular_componentpostsynaptic membrane
F0046872molecular_functionmetal ion binding
F0051260biological_processprotein homooligomerization
F0051262biological_processprotein tetramerization
F0055085biological_processtransmembrane transport
F0071196cellular_componentKv4.3-KChIP1 channel complex
F0071805biological_processpotassium ion transmembrane transport
F0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
F0086009biological_processmembrane repolarization
F0086013biological_processmembrane repolarization during cardiac muscle cell action potential
F0086091biological_processregulation of heart rate by cardiac conduction
F0097623biological_processpotassium ion export across plasma membrane
F0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
F0098982cellular_componentGABA-ergic synapse
F0099625biological_processventricular cardiac muscle cell membrane repolarization
F0099634cellular_componentpostsynaptic specialization membrane
F1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
G0005267molecular_functionpotassium channel activity
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0006813biological_processpotassium ion transport
G0006936biological_processmuscle contraction
G0007268biological_processchemical synaptic transmission
G0008016biological_processregulation of heart contraction
G0008076cellular_componentvoltage-gated potassium channel complex
G0009898cellular_componentcytoplasmic side of plasma membrane
G0009966biological_processregulation of signal transduction
G0015459molecular_functionpotassium channel regulator activity
G0030425cellular_componentdendrite
G0034220biological_processmonoatomic ion transmembrane transport
G0034702cellular_componentmonoatomic ion channel complex
G0044325molecular_functiontransmembrane transporter binding
G0045202cellular_componentsynapse
G0046872molecular_functionmetal ion binding
G0071196cellular_componentKv4.3-KChIP1 channel complex
G0071805biological_processpotassium ion transmembrane transport
G0086009biological_processmembrane repolarization
G0097623biological_processpotassium ion export across plasma membrane
G1901379biological_processregulation of potassium ion transmembrane transport
H0001508biological_processaction potential
H0005216molecular_functionmonoatomic ion channel activity
H0005249molecular_functionvoltage-gated potassium channel activity
H0005250molecular_functionA-type (transient outward) potassium channel activity
H0005267molecular_functionpotassium channel activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0006813biological_processpotassium ion transport
H0006936biological_processmuscle contraction
H0007268biological_processchemical synaptic transmission
H0008016biological_processregulation of heart contraction
H0008076cellular_componentvoltage-gated potassium channel complex
H0016020cellular_componentmembrane
H0030425cellular_componentdendrite
H0034220biological_processmonoatomic ion transmembrane transport
H0034702cellular_componentmonoatomic ion channel complex
H0042383cellular_componentsarcolemma
H0043025cellular_componentneuronal cell body
H0043197cellular_componentdendritic spine
H0045211cellular_componentpostsynaptic membrane
H0046872molecular_functionmetal ion binding
H0051260biological_processprotein homooligomerization
H0051262biological_processprotein tetramerization
H0055085biological_processtransmembrane transport
H0071196cellular_componentKv4.3-KChIP1 channel complex
H0071805biological_processpotassium ion transmembrane transport
H0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
H0086009biological_processmembrane repolarization
H0086013biological_processmembrane repolarization during cardiac muscle cell action potential
H0086091biological_processregulation of heart rate by cardiac conduction
H0097623biological_processpotassium ion export across plasma membrane
H0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
H0098982cellular_componentGABA-ergic synapse
H0099625biological_processventricular cardiac muscle cell membrane repolarization
H0099634cellular_componentpostsynaptic specialization membrane
H1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
I0005515molecular_functionprotein binding
I0005886cellular_componentplasma membrane
I0006508biological_processproteolysis
I0008076cellular_componentvoltage-gated potassium channel complex
I0008236molecular_functionserine-type peptidase activity
I0008239molecular_functiondipeptidyl-peptidase activity
I0009986cellular_componentcell surface
I0015459molecular_functionpotassium channel regulator activity
I0016020cellular_componentmembrane
I0019228biological_processneuronal action potential
I0042391biological_processregulation of membrane potential
I0043025cellular_componentneuronal cell body
I0043266biological_processregulation of potassium ion transport
I0043268biological_processpositive regulation of potassium ion transport
I0045202cellular_componentsynapse
I0060078biological_processregulation of postsynaptic membrane potential
I0072659biological_processprotein localization to plasma membrane
I1901379biological_processregulation of potassium ion transmembrane transport
I1901381biological_processpositive regulation of potassium ion transmembrane transport
I1903078biological_processpositive regulation of protein localization to plasma membrane
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0006508biological_processproteolysis
J0008076cellular_componentvoltage-gated potassium channel complex
J0008236molecular_functionserine-type peptidase activity
J0008239molecular_functiondipeptidyl-peptidase activity
J0009986cellular_componentcell surface
J0015459molecular_functionpotassium channel regulator activity
J0016020cellular_componentmembrane
J0019228biological_processneuronal action potential
J0042391biological_processregulation of membrane potential
J0043025cellular_componentneuronal cell body
J0043266biological_processregulation of potassium ion transport
J0043268biological_processpositive regulation of potassium ion transport
J0045202cellular_componentsynapse
J0060078biological_processregulation of postsynaptic membrane potential
J0072659biological_processprotein localization to plasma membrane
J1901379biological_processregulation of potassium ion transmembrane transport
J1901381biological_processpositive regulation of potassium ion transmembrane transport
J1903078biological_processpositive regulation of protein localization to plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DINKDGYINkeEM
ChainResidueDetails
AASP146-MET158
AASP194-PHE206
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues140
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues140
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues140
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues52
DetailsRegion: {"description":"Interaction with KCND2","evidences":[{"source":"UniProtKB","id":"Q8R426","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17057713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues124
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues68
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues92
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues52
DetailsIntramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues28
DetailsIntramembrane: {"evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues60
DetailsRegion: {"description":"Interaction with KCNIP1 and KCNIP2","evidences":[{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues32
DetailsRegion: {"description":"Interaction with KCNIP1","evidences":[{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues68
DetailsRegion: {"description":"Interaction with KCNIP1 and KCNIP2","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues60
DetailsRegion: {"description":"Mediates dendritic targeting","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues12
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PDB","id":"1S1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NZ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsBinding site: {"description":"in chain D","evidences":[{"source":"PDB","id":"1S1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NZ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9NZV8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues16
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-10-08

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