7W6N

CryoEM structure of human KChIP1-Kv4.3 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005267	molecular_function	potassium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006936	biological_process	muscle contraction
A	0007268	biological_process	chemical synaptic transmission
A	0008016	biological_process	regulation of heart contraction
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0009966	biological_process	regulation of signal transduction
A	0015459	molecular_function	potassium channel regulator activity
A	0030425	cellular_component	dendrite
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0044325	molecular_function	transmembrane transporter binding
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0071805	biological_process	potassium ion transmembrane transport
A	0086009	biological_process	membrane repolarization
A	0097623	biological_process	potassium ion export across plasma membrane
A	1901379	biological_process	regulation of potassium ion transmembrane transport
B	0001508	biological_process	action potential
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0005250	molecular_function	A-type (transient outward) potassium channel activity
B	0005267	molecular_function	potassium channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0006936	biological_process	muscle contraction
B	0007268	biological_process	chemical synaptic transmission
B	0008016	biological_process	regulation of heart contraction
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0016020	cellular_component	membrane
B	0030425	cellular_component	dendrite
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0042383	cellular_component	sarcolemma
B	0043025	cellular_component	neuronal cell body
B	0043197	cellular_component	dendritic spine
B	0045211	cellular_component	postsynaptic membrane
B	0046872	molecular_function	metal ion binding
B	0051260	biological_process	protein homooligomerization
B	0051262	biological_process	protein tetramerization
B	0055085	biological_process	transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
B	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
B	0086009	biological_process	membrane repolarization
B	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
B	0086091	biological_process	regulation of heart rate by cardiac conduction
B	0097623	biological_process	potassium ion export across plasma membrane
B	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
B	0098982	cellular_component	GABA-ergic synapse
B	0099625	biological_process	ventricular cardiac muscle cell membrane repolarization
B	0099634	cellular_component	postsynaptic specialization membrane
B	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C	0005267	molecular_function	potassium channel activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0006936	biological_process	muscle contraction
C	0007268	biological_process	chemical synaptic transmission
C	0008016	biological_process	regulation of heart contraction
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0009966	biological_process	regulation of signal transduction
C	0015459	molecular_function	potassium channel regulator activity
C	0030425	cellular_component	dendrite
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0044325	molecular_function	transmembrane transporter binding
C	0045202	cellular_component	synapse
C	0046872	molecular_function	metal ion binding
C	0071805	biological_process	potassium ion transmembrane transport
C	0086009	biological_process	membrane repolarization
C	0097623	biological_process	potassium ion export across plasma membrane
C	1901379	biological_process	regulation of potassium ion transmembrane transport
D	0001508	biological_process	action potential
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0005250	molecular_function	A-type (transient outward) potassium channel activity
D	0005267	molecular_function	potassium channel activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0006936	biological_process	muscle contraction
D	0007268	biological_process	chemical synaptic transmission
D	0008016	biological_process	regulation of heart contraction
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0016020	cellular_component	membrane
D	0030425	cellular_component	dendrite
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034702	cellular_component	monoatomic ion channel complex
D	0042383	cellular_component	sarcolemma
D	0043025	cellular_component	neuronal cell body
D	0043197	cellular_component	dendritic spine
D	0045211	cellular_component	postsynaptic membrane
D	0046872	molecular_function	metal ion binding
D	0051260	biological_process	protein homooligomerization
D	0051262	biological_process	protein tetramerization
D	0055085	biological_process	transmembrane transport
D	0071805	biological_process	potassium ion transmembrane transport
D	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
D	0086009	biological_process	membrane repolarization
D	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
D	0086091	biological_process	regulation of heart rate by cardiac conduction
D	0097623	biological_process	potassium ion export across plasma membrane
D	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
D	0098982	cellular_component	GABA-ergic synapse
D	0099625	biological_process	ventricular cardiac muscle cell membrane repolarization
D	0099634	cellular_component	postsynaptic specialization membrane
D	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
E	0005267	molecular_function	potassium channel activity
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006813	biological_process	potassium ion transport
E	0006936	biological_process	muscle contraction
E	0007268	biological_process	chemical synaptic transmission
E	0008016	biological_process	regulation of heart contraction
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0009898	cellular_component	cytoplasmic side of plasma membrane
E	0009966	biological_process	regulation of signal transduction
E	0015459	molecular_function	potassium channel regulator activity
E	0030425	cellular_component	dendrite
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034702	cellular_component	monoatomic ion channel complex
E	0044325	molecular_function	transmembrane transporter binding
E	0045202	cellular_component	synapse
E	0046872	molecular_function	metal ion binding
E	0071805	biological_process	potassium ion transmembrane transport
E	0086009	biological_process	membrane repolarization
E	0097623	biological_process	potassium ion export across plasma membrane
E	1901379	biological_process	regulation of potassium ion transmembrane transport
F	0001508	biological_process	action potential
F	0005216	molecular_function	monoatomic ion channel activity
F	0005249	molecular_function	voltage-gated potassium channel activity
F	0005250	molecular_function	A-type (transient outward) potassium channel activity
F	0005267	molecular_function	potassium channel activity
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006813	biological_process	potassium ion transport
F	0006936	biological_process	muscle contraction
F	0007268	biological_process	chemical synaptic transmission
F	0008016	biological_process	regulation of heart contraction
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0016020	cellular_component	membrane
F	0030425	cellular_component	dendrite
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034702	cellular_component	monoatomic ion channel complex
F	0042383	cellular_component	sarcolemma
F	0043025	cellular_component	neuronal cell body
F	0043197	cellular_component	dendritic spine
F	0045211	cellular_component	postsynaptic membrane
F	0046872	molecular_function	metal ion binding
F	0051260	biological_process	protein homooligomerization
F	0051262	biological_process	protein tetramerization
F	0055085	biological_process	transmembrane transport
F	0071805	biological_process	potassium ion transmembrane transport
F	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
F	0086009	biological_process	membrane repolarization
F	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
F	0086091	biological_process	regulation of heart rate by cardiac conduction
F	0097623	biological_process	potassium ion export across plasma membrane
F	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
F	0098982	cellular_component	GABA-ergic synapse
F	0099625	biological_process	ventricular cardiac muscle cell membrane repolarization
F	0099634	cellular_component	postsynaptic specialization membrane
F	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
G	0005267	molecular_function	potassium channel activity
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006813	biological_process	potassium ion transport
G	0006936	biological_process	muscle contraction
G	0007268	biological_process	chemical synaptic transmission
G	0008016	biological_process	regulation of heart contraction
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0009898	cellular_component	cytoplasmic side of plasma membrane
G	0009966	biological_process	regulation of signal transduction
G	0015459	molecular_function	potassium channel regulator activity
G	0030425	cellular_component	dendrite
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034702	cellular_component	monoatomic ion channel complex
G	0044325	molecular_function	transmembrane transporter binding
G	0045202	cellular_component	synapse
G	0046872	molecular_function	metal ion binding
G	0071805	biological_process	potassium ion transmembrane transport
G	0086009	biological_process	membrane repolarization
G	0097623	biological_process	potassium ion export across plasma membrane
G	1901379	biological_process	regulation of potassium ion transmembrane transport
H	0001508	biological_process	action potential
H	0005216	molecular_function	monoatomic ion channel activity
H	0005249	molecular_function	voltage-gated potassium channel activity
H	0005250	molecular_function	A-type (transient outward) potassium channel activity
H	0005267	molecular_function	potassium channel activity
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0006811	biological_process	monoatomic ion transport
H	0006813	biological_process	potassium ion transport
H	0006936	biological_process	muscle contraction
H	0007268	biological_process	chemical synaptic transmission
H	0008016	biological_process	regulation of heart contraction
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0016020	cellular_component	membrane
H	0030425	cellular_component	dendrite
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0034702	cellular_component	monoatomic ion channel complex
H	0042383	cellular_component	sarcolemma
H	0043025	cellular_component	neuronal cell body
H	0043197	cellular_component	dendritic spine
H	0045211	cellular_component	postsynaptic membrane
H	0046872	molecular_function	metal ion binding
H	0051260	biological_process	protein homooligomerization
H	0051262	biological_process	protein tetramerization
H	0055085	biological_process	transmembrane transport
H	0071805	biological_process	potassium ion transmembrane transport
H	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
H	0086009	biological_process	membrane repolarization
H	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
H	0086091	biological_process	regulation of heart rate by cardiac conduction
H	0097623	biological_process	potassium ion export across plasma membrane
H	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
H	0098982	cellular_component	GABA-ergic synapse
H	0099625	biological_process	ventricular cardiac muscle cell membrane repolarization
H	0099634	cellular_component	postsynaptic specialization membrane
H	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DINKDGYINkeEM

Chain	Residue	Details
A	ASP146-MET158
A	ASP194-PHE206

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	140
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	140
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	52
Details	Region: {"description":"Interaction with KCND2","evidences":[{"source":"UniProtKB","id":"Q8R426","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17057713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	124
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	68
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	92
Details	Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	52
Details	Intramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	28
Details	Intramembrane: {"evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	60
Details	Region: {"description":"Interaction with KCNIP1 and KCNIP2","evidences":[{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	32
Details	Region: {"description":"Interaction with KCNIP1","evidences":[{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	68
Details	Region: {"description":"Interaction with KCNIP1 and KCNIP2","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	60
Details	Region: {"description":"Mediates dendritic targeting","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	20
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	12
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PDB","id":"1S1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Binding site: {"description":"in chain D","evidences":[{"source":"PDB","id":"1S1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9NZV8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---