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7W6N

CryoEM structure of human KChIP1-Kv4.3 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005267molecular_functionpotassium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006936biological_processmuscle contraction
A0007268biological_processchemical synaptic transmission
A0008016biological_processregulation of heart contraction
A0008076cellular_componentvoltage-gated potassium channel complex
A0009898cellular_componentcytoplasmic side of plasma membrane
A0015459molecular_functionpotassium channel regulator activity
A0030425cellular_componentdendrite
A0034702cellular_componentmonoatomic ion channel complex
A0042995cellular_componentcell projection
A0044325molecular_functiontransmembrane transporter binding
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0071196cellular_componentKv4.3-KChIP1 channel complex
A0071805biological_processpotassium ion transmembrane transport
A0086009biological_processmembrane repolarization
A0097623biological_processpotassium ion export across plasma membrane
A1901379biological_processregulation of potassium ion transmembrane transport
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005250molecular_functionA-type (transient outward) potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006936biological_processmuscle contraction
B0007268biological_processchemical synaptic transmission
B0008016biological_processregulation of heart contraction
B0008076cellular_componentvoltage-gated potassium channel complex
B0016020cellular_componentmembrane
B0030425cellular_componentdendrite
B0034702cellular_componentmonoatomic ion channel complex
B0042383cellular_componentsarcolemma
B0042995cellular_componentcell projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0044325molecular_functiontransmembrane transporter binding
B0045211cellular_componentpostsynaptic membrane
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0051262biological_processprotein tetramerization
B0055085biological_processtransmembrane transport
B0071196cellular_componentKv4.3-KChIP1 channel complex
B0071805biological_processpotassium ion transmembrane transport
B0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
B0086009biological_processmembrane repolarization
B0086013biological_processmembrane repolarization during cardiac muscle cell action potential
B0086091biological_processregulation of heart rate by cardiac conduction
B0097623biological_processpotassium ion export across plasma membrane
B0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
B0098982cellular_componentGABA-ergic synapse
B0099625biological_processventricular cardiac muscle cell membrane repolarization
B0099634cellular_componentpostsynaptic specialization membrane
B1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C0005267molecular_functionpotassium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006936biological_processmuscle contraction
C0007268biological_processchemical synaptic transmission
C0008016biological_processregulation of heart contraction
C0008076cellular_componentvoltage-gated potassium channel complex
C0009898cellular_componentcytoplasmic side of plasma membrane
C0015459molecular_functionpotassium channel regulator activity
C0030425cellular_componentdendrite
C0034702cellular_componentmonoatomic ion channel complex
C0042995cellular_componentcell projection
C0044325molecular_functiontransmembrane transporter binding
C0045202cellular_componentsynapse
C0046872molecular_functionmetal ion binding
C0071196cellular_componentKv4.3-KChIP1 channel complex
C0071805biological_processpotassium ion transmembrane transport
C0086009biological_processmembrane repolarization
C0097623biological_processpotassium ion export across plasma membrane
C1901379biological_processregulation of potassium ion transmembrane transport
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005250molecular_functionA-type (transient outward) potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006936biological_processmuscle contraction
D0007268biological_processchemical synaptic transmission
D0008016biological_processregulation of heart contraction
D0008076cellular_componentvoltage-gated potassium channel complex
D0016020cellular_componentmembrane
D0030425cellular_componentdendrite
D0034702cellular_componentmonoatomic ion channel complex
D0042383cellular_componentsarcolemma
D0042995cellular_componentcell projection
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0044325molecular_functiontransmembrane transporter binding
D0045211cellular_componentpostsynaptic membrane
D0046872molecular_functionmetal ion binding
D0051260biological_processprotein homooligomerization
D0051262biological_processprotein tetramerization
D0055085biological_processtransmembrane transport
D0071196cellular_componentKv4.3-KChIP1 channel complex
D0071805biological_processpotassium ion transmembrane transport
D0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
D0086009biological_processmembrane repolarization
D0086013biological_processmembrane repolarization during cardiac muscle cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0097623biological_processpotassium ion export across plasma membrane
D0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
D0098982cellular_componentGABA-ergic synapse
D0099625biological_processventricular cardiac muscle cell membrane repolarization
D0099634cellular_componentpostsynaptic specialization membrane
D1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
E0005267molecular_functionpotassium channel activity
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005886cellular_componentplasma membrane
E0006936biological_processmuscle contraction
E0007268biological_processchemical synaptic transmission
E0008016biological_processregulation of heart contraction
E0008076cellular_componentvoltage-gated potassium channel complex
E0009898cellular_componentcytoplasmic side of plasma membrane
E0015459molecular_functionpotassium channel regulator activity
E0030425cellular_componentdendrite
E0034702cellular_componentmonoatomic ion channel complex
E0042995cellular_componentcell projection
E0044325molecular_functiontransmembrane transporter binding
E0045202cellular_componentsynapse
E0046872molecular_functionmetal ion binding
E0071196cellular_componentKv4.3-KChIP1 channel complex
E0071805biological_processpotassium ion transmembrane transport
E0086009biological_processmembrane repolarization
E0097623biological_processpotassium ion export across plasma membrane
E1901379biological_processregulation of potassium ion transmembrane transport
F0001508biological_processaction potential
F0005216molecular_functionmonoatomic ion channel activity
F0005249molecular_functionvoltage-gated potassium channel activity
F0005250molecular_functionA-type (transient outward) potassium channel activity
F0005267molecular_functionpotassium channel activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0006813biological_processpotassium ion transport
F0006936biological_processmuscle contraction
F0007268biological_processchemical synaptic transmission
F0008016biological_processregulation of heart contraction
F0008076cellular_componentvoltage-gated potassium channel complex
F0016020cellular_componentmembrane
F0030425cellular_componentdendrite
F0034702cellular_componentmonoatomic ion channel complex
F0042383cellular_componentsarcolemma
F0042995cellular_componentcell projection
F0043025cellular_componentneuronal cell body
F0043197cellular_componentdendritic spine
F0044325molecular_functiontransmembrane transporter binding
F0045211cellular_componentpostsynaptic membrane
F0046872molecular_functionmetal ion binding
F0051260biological_processprotein homooligomerization
F0051262biological_processprotein tetramerization
F0055085biological_processtransmembrane transport
F0071196cellular_componentKv4.3-KChIP1 channel complex
F0071805biological_processpotassium ion transmembrane transport
F0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
F0086009biological_processmembrane repolarization
F0086013biological_processmembrane repolarization during cardiac muscle cell action potential
F0086091biological_processregulation of heart rate by cardiac conduction
F0097623biological_processpotassium ion export across plasma membrane
F0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
F0098982cellular_componentGABA-ergic synapse
F0099625biological_processventricular cardiac muscle cell membrane repolarization
F0099634cellular_componentpostsynaptic specialization membrane
F1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
G0005267molecular_functionpotassium channel activity
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005886cellular_componentplasma membrane
G0006936biological_processmuscle contraction
G0007268biological_processchemical synaptic transmission
G0008016biological_processregulation of heart contraction
G0008076cellular_componentvoltage-gated potassium channel complex
G0009898cellular_componentcytoplasmic side of plasma membrane
G0015459molecular_functionpotassium channel regulator activity
G0030425cellular_componentdendrite
G0034702cellular_componentmonoatomic ion channel complex
G0042995cellular_componentcell projection
G0044325molecular_functiontransmembrane transporter binding
G0045202cellular_componentsynapse
G0046872molecular_functionmetal ion binding
G0071196cellular_componentKv4.3-KChIP1 channel complex
G0071805biological_processpotassium ion transmembrane transport
G0086009biological_processmembrane repolarization
G0097623biological_processpotassium ion export across plasma membrane
G1901379biological_processregulation of potassium ion transmembrane transport
H0001508biological_processaction potential
H0005216molecular_functionmonoatomic ion channel activity
H0005249molecular_functionvoltage-gated potassium channel activity
H0005250molecular_functionA-type (transient outward) potassium channel activity
H0005267molecular_functionpotassium channel activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0006813biological_processpotassium ion transport
H0006936biological_processmuscle contraction
H0007268biological_processchemical synaptic transmission
H0008016biological_processregulation of heart contraction
H0008076cellular_componentvoltage-gated potassium channel complex
H0016020cellular_componentmembrane
H0030425cellular_componentdendrite
H0034702cellular_componentmonoatomic ion channel complex
H0042383cellular_componentsarcolemma
H0042995cellular_componentcell projection
H0043025cellular_componentneuronal cell body
H0043197cellular_componentdendritic spine
H0044325molecular_functiontransmembrane transporter binding
H0045211cellular_componentpostsynaptic membrane
H0046872molecular_functionmetal ion binding
H0051260biological_processprotein homooligomerization
H0051262biological_processprotein tetramerization
H0055085biological_processtransmembrane transport
H0071196cellular_componentKv4.3-KChIP1 channel complex
H0071805biological_processpotassium ion transmembrane transport
H0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
H0086009biological_processmembrane repolarization
H0086013biological_processmembrane repolarization during cardiac muscle cell action potential
H0086091biological_processregulation of heart rate by cardiac conduction
H0097623biological_processpotassium ion export across plasma membrane
H0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
H0098982cellular_componentGABA-ergic synapse
H0099625biological_processventricular cardiac muscle cell membrane repolarization
H0099634cellular_componentpostsynaptic specialization membrane
H1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DINKDGYINkeEM
ChainResidueDetails
AASP146-MET158
AASP194-PHE206

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues792
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:34997220
ChainResidueDetails
BMET1-ALA182
HMET1-ALA182
HALA247-ARG253
HLEU307-ALA318
CTYR152
CGLU157
CASP194
CASN196
CASP198
CGLU205
EASP146
BALA247-ARG253
EASN148
EASP150
ETYR152
EGLU157
EASP194
EASN196
EASP198
EGLU205
GASP146
GASN148
BLEU307-ALA318
GASP150
GTYR152
GGLU157
GASP194
GASN196
GASP198
GGLU205
DMET1-ALA182
DALA247-ARG253
DLEU307-ALA318
FMET1-ALA182
FALA247-ARG253
FLEU307-ALA318

site_idSWS_FT_FI2
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
BLEU183-THR204
DLEU183-THR204
FLEU183-THR204
HLEU183-THR204

site_idSWS_FT_FI3
Number of Residues124
DetailsTOPO_DOM: Extracellular => ECO:0000305|PubMed:34997220
ChainResidueDetails
BVAL205-SER223
HVAL205-SER223
HASN278-SER283
HLYS344-THR352
BASN278-SER283
BLYS344-THR352
DVAL205-SER223
DASN278-SER283
DLYS344-THR352
FVAL205-SER223
FASN278-SER283
FLYS344-THR352

site_idSWS_FT_FI4
Number of Residues88
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
BVAL224-PHE246
DVAL224-PHE246
FVAL224-PHE246
HVAL224-PHE246

site_idSWS_FT_FI5
Number of Residues92
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
BPHE254-THR277
DPHE254-THR277
FPHE254-THR277
HPHE254-THR277

site_idSWS_FT_FI6
Number of Residues88
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
BGLY284-GLY306
DGLY284-GLY306
FGLY284-GLY306
HGLY284-GLY306

site_idSWS_FT_FI7
Number of Residues96
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
BSER319-GLU343
DSER319-GLU343
FSER319-GLU343
HSER319-GLU343

site_idSWS_FT_FI8
Number of Residues52
DetailsINTRAMEM: Helical; Name=Pore helix => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
BSER353-THR366
DSER353-THR366
FSER353-THR366
HSER353-THR366

site_idSWS_FT_FI9
Number of Residues28
DetailsINTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
BTHR367-VAL374
DTHR367-VAL374
FTHR367-VAL374
HTHR367-VAL374

site_idSWS_FT_FI10
Number of Residues88
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
BILE378-PRO400
DILE378-PRO400
FILE378-PRO400
HILE378-PRO400

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: in chain B => ECO:0007744|PDB:1S1G, ECO:0007744|PDB:2NZ0
ChainResidueDetails
BHIS104
HHIS104
HCYS131
HCYS132
BCYS131
BCYS132
DHIS104
DCYS131
DCYS132
FHIS104
FCYS131
FCYS132

site_idSWS_FT_FI12
Number of Residues4
DetailsBINDING: in chain D => ECO:0007744|PDB:1S1G, ECO:0007744|PDB:2NZ0
ChainResidueDetails
BCYS110
DCYS110
FCYS110
HCYS110

site_idSWS_FT_FI13
Number of Residues16
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9NZV8
ChainResidueDetails
BTHR367
FLEU368
FGLY369
FTYR370
HTHR367
HLEU368
HGLY369
HTYR370
BLEU368
BGLY369
BTYR370
DTHR367
DLEU368
DGLY369
DTYR370
FTHR367

site_idSWS_FT_FI14
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z0V1
ChainResidueDetails
BSER153
BASN585
DSER153
DASN585
FSER153
FASN585
HSER153
HASN585

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9Z0V1
ChainResidueDetails
BTHR459
DTHR459
FTHR459
HTHR459

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphoserine; by CaMK2D => ECO:0000250|UniProtKB:Q62897
ChainResidueDetails
BTHR569
DTHR569
FTHR569
HTHR569

223166

PDB entries from 2024-07-31

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