Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7W6N

CryoEM structure of human KChIP1-Kv4.3 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005267	molecular_function	potassium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0015459	molecular_function	potassium channel regulator activity
A	0030425	cellular_component	dendrite
A	0034702	cellular_component	monoatomic ion channel complex
A	0042995	cellular_component	cell projection
A	0044325	molecular_function	transmembrane transporter binding
A	0046872	molecular_function	metal ion binding
A	0071805	biological_process	potassium ion transmembrane transport
A	1901379	biological_process	regulation of potassium ion transmembrane transport
B	0001508	biological_process	action potential
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0005250	molecular_function	A-type (transient outward) potassium channel activity
B	0005267	molecular_function	potassium channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0016020	cellular_component	membrane
B	0030425	cellular_component	dendrite
B	0034702	cellular_component	monoatomic ion channel complex
B	0042383	cellular_component	sarcolemma
B	0042995	cellular_component	cell projection
B	0043025	cellular_component	neuronal cell body
B	0043197	cellular_component	dendritic spine
B	0044325	molecular_function	transmembrane transporter binding
B	0045211	cellular_component	postsynaptic membrane
B	0046872	molecular_function	metal ion binding
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
B	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
B	0086009	biological_process	membrane repolarization
B	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
B	0086091	biological_process	regulation of heart rate by cardiac conduction
B	0097623	biological_process	potassium ion export across plasma membrane
B	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
B	0098982	cellular_component	GABA-ergic synapse
B	0099625	biological_process	ventricular cardiac muscle cell membrane repolarization
B	0099634	cellular_component	postsynaptic specialization membrane
B	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C	0005267	molecular_function	potassium channel activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0015459	molecular_function	potassium channel regulator activity
C	0030425	cellular_component	dendrite
C	0034702	cellular_component	monoatomic ion channel complex
C	0042995	cellular_component	cell projection
C	0044325	molecular_function	transmembrane transporter binding
C	0046872	molecular_function	metal ion binding
C	0071805	biological_process	potassium ion transmembrane transport
C	1901379	biological_process	regulation of potassium ion transmembrane transport
D	0001508	biological_process	action potential
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0005250	molecular_function	A-type (transient outward) potassium channel activity
D	0005267	molecular_function	potassium channel activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0016020	cellular_component	membrane
D	0030425	cellular_component	dendrite
D	0034702	cellular_component	monoatomic ion channel complex
D	0042383	cellular_component	sarcolemma
D	0042995	cellular_component	cell projection
D	0043025	cellular_component	neuronal cell body
D	0043197	cellular_component	dendritic spine
D	0044325	molecular_function	transmembrane transporter binding
D	0045211	cellular_component	postsynaptic membrane
D	0046872	molecular_function	metal ion binding
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
D	0071805	biological_process	potassium ion transmembrane transport
D	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
D	0086009	biological_process	membrane repolarization
D	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
D	0086091	biological_process	regulation of heart rate by cardiac conduction
D	0097623	biological_process	potassium ion export across plasma membrane
D	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
D	0098982	cellular_component	GABA-ergic synapse
D	0099625	biological_process	ventricular cardiac muscle cell membrane repolarization
D	0099634	cellular_component	postsynaptic specialization membrane
D	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
E	0005267	molecular_function	potassium channel activity
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0009898	cellular_component	cytoplasmic side of plasma membrane
E	0015459	molecular_function	potassium channel regulator activity
E	0030425	cellular_component	dendrite
E	0034702	cellular_component	monoatomic ion channel complex
E	0042995	cellular_component	cell projection
E	0044325	molecular_function	transmembrane transporter binding
E	0046872	molecular_function	metal ion binding
E	0071805	biological_process	potassium ion transmembrane transport
E	1901379	biological_process	regulation of potassium ion transmembrane transport
F	0001508	biological_process	action potential
F	0005216	molecular_function	monoatomic ion channel activity
F	0005249	molecular_function	voltage-gated potassium channel activity
F	0005250	molecular_function	A-type (transient outward) potassium channel activity
F	0005267	molecular_function	potassium channel activity
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006813	biological_process	potassium ion transport
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0016020	cellular_component	membrane
F	0030425	cellular_component	dendrite
F	0034702	cellular_component	monoatomic ion channel complex
F	0042383	cellular_component	sarcolemma
F	0042995	cellular_component	cell projection
F	0043025	cellular_component	neuronal cell body
F	0043197	cellular_component	dendritic spine
F	0044325	molecular_function	transmembrane transporter binding
F	0045211	cellular_component	postsynaptic membrane
F	0046872	molecular_function	metal ion binding
F	0051260	biological_process	protein homooligomerization
F	0055085	biological_process	transmembrane transport
F	0071805	biological_process	potassium ion transmembrane transport
F	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
F	0086009	biological_process	membrane repolarization
F	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
F	0086091	biological_process	regulation of heart rate by cardiac conduction
F	0097623	biological_process	potassium ion export across plasma membrane
F	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
F	0098982	cellular_component	GABA-ergic synapse
F	0099625	biological_process	ventricular cardiac muscle cell membrane repolarization
F	0099634	cellular_component	postsynaptic specialization membrane
F	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
G	0005267	molecular_function	potassium channel activity
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005886	cellular_component	plasma membrane
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0009898	cellular_component	cytoplasmic side of plasma membrane
G	0015459	molecular_function	potassium channel regulator activity
G	0030425	cellular_component	dendrite
G	0034702	cellular_component	monoatomic ion channel complex
G	0042995	cellular_component	cell projection
G	0044325	molecular_function	transmembrane transporter binding
G	0046872	molecular_function	metal ion binding
G	0071805	biological_process	potassium ion transmembrane transport
G	1901379	biological_process	regulation of potassium ion transmembrane transport
H	0001508	biological_process	action potential
H	0005216	molecular_function	monoatomic ion channel activity
H	0005249	molecular_function	voltage-gated potassium channel activity
H	0005250	molecular_function	A-type (transient outward) potassium channel activity
H	0005267	molecular_function	potassium channel activity
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0006811	biological_process	monoatomic ion transport
H	0006813	biological_process	potassium ion transport
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0016020	cellular_component	membrane
H	0030425	cellular_component	dendrite
H	0034702	cellular_component	monoatomic ion channel complex
H	0042383	cellular_component	sarcolemma
H	0042995	cellular_component	cell projection
H	0043025	cellular_component	neuronal cell body
H	0043197	cellular_component	dendritic spine
H	0044325	molecular_function	transmembrane transporter binding
H	0045211	cellular_component	postsynaptic membrane
H	0046872	molecular_function	metal ion binding
H	0051260	biological_process	protein homooligomerization
H	0055085	biological_process	transmembrane transport
H	0071805	biological_process	potassium ion transmembrane transport
H	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
H	0086009	biological_process	membrane repolarization
H	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
H	0086091	biological_process	regulation of heart rate by cardiac conduction
H	0097623	biological_process	potassium ion export across plasma membrane
H	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
H	0098982	cellular_component	GABA-ergic synapse
H	0099625	biological_process	ventricular cardiac muscle cell membrane repolarization
H	0099634	cellular_component	postsynaptic specialization membrane
H	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DINKDGYINkeEM

Chain	Residue	Details
A	ASP146-MET158
A	ASP194-PHE206

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	820
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
B	MET1-LEU181
H	MET1-LEU181
H	LEU243-ARG256
H	ARG308-GLU320
C	TYR152
C	GLU157
C	ASP194
C	ASN196
C	ASP198
C	GLU205
E	ASP146
B	LEU243-ARG256
E	ASN148
E	ASP150
E	TYR152
E	GLU157
E	ASP194
E	ASN196
E	ASP198
E	GLU205
G	ASP146
G	ASN148
B	ARG308-GLU320
G	ASP150
G	TYR152
G	GLU157
G	ASP194
G	ASN196
G	ASP198
G	GLU205
D	MET1-LEU181
D	LEU243-ARG256
D	ARG308-GLU320
F	MET1-LEU181
F	LEU243-ARG256
F	ARG308-GLU320

site_id	SWS_FT_FI2
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S1 => ECO:0000255

Chain	Residue	Details
B	ALA182-VAL202
D	ALA182-VAL202
F	ALA182-VAL202
H	ALA182-VAL202

site_id	SWS_FT_FI3
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S2 => ECO:0000255

Chain	Residue	Details
B	TYR222-LEU242
D	TYR222-LEU242
F	TYR222-LEU242
H	TYR222-LEU242

site_id	SWS_FT_FI4
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S3 => ECO:0000255

Chain	Residue	Details
B	SER257-THR277
D	SER257-THR277
F	SER257-THR277
H	SER257-THR277

site_id	SWS_FT_FI5
Number of Residues	80
Details	TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255

Chain	Residue	Details
B	VAL287-LEU307
D	VAL287-LEU307
F	VAL287-LEU307
H	VAL287-LEU307

site_id	SWS_FT_FI6
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S5 => ECO:0000255

Chain	Residue	Details
B	LEU321-TYR341
D	LEU321-TYR341
F	LEU321-TYR341
H	LEU321-TYR341

site_id	SWS_FT_FI7
Number of Residues	80
Details	INTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000255

Chain	Residue	Details
B	TYR360-GLY380
D	TYR360-GLY380
F	TYR360-GLY380
H	TYR360-GLY380

site_id	SWS_FT_FI8
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S6 => ECO:0000255

Chain	Residue	Details
B	ILE382-ILE402
D	ILE382-ILE402
F	ILE382-ILE402
H	ILE382-ILE402

site_id	SWS_FT_FI9
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
B	HIS104
H	HIS104
H	CYS131
H	CYS132
B	CYS131
B	CYS132
D	HIS104
D	CYS131
D	CYS132
F	HIS104
F	CYS131
F	CYS132

site_id	SWS_FT_FI10
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q9Z0V1

Chain	Residue	Details
B	SER153
B	ASN585
D	SER153
D	ASN585
F	SER153
F	ASN585
H	SER153
H	ASN585

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:Q9Z0V1

Chain	Residue	Details
B	THR459
D	THR459
F	THR459
H	THR459

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CaMK2D => ECO:0000250\|UniProtKB:Q62897

Chain	Residue	Details
B	THR569
D	THR569
F	THR569
H	THR569

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)