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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7W68

human single hexameric Mcm2-7 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000228cellular_componentnuclear chromosome
A0000727biological_processdouble-strand break repair via break-induced replication
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0003688molecular_functionDNA replication origin binding
A0003697molecular_functionsingle-stranded DNA binding
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005664cellular_componentnuclear origin of replication recognition complex
A0005694cellular_componentchromosome
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0006260biological_processDNA replication
A0006270biological_processDNA replication initiation
A0006915biological_processapoptotic process
A0008270molecular_functionzinc ion binding
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017116molecular_functionsingle-stranded DNA helicase activity
A0019899molecular_functionenzyme binding
A0030174biological_processregulation of DNA-templated DNA replication initiation
A0042393molecular_functionhistone binding
A0042555cellular_componentMCM complex
A0043138molecular_function3'-5' DNA helicase activity
A0046872molecular_functionmetal ion binding
A0071162cellular_componentCMG complex
A0090102biological_processcochlea development
A1902975biological_processmitotic DNA replication initiation
B0000166molecular_functionnucleotide binding
B0000727biological_processdouble-strand break repair via break-induced replication
B0000781cellular_componentchromosome, telomeric region
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003697molecular_functionsingle-stranded DNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005658cellular_componentalpha DNA polymerase:primase complex
B0005694cellular_componentchromosome
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0006260biological_processDNA replication
B0006270biological_processDNA replication initiation
B0006271biological_processDNA strand elongation involved in DNA replication
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017116molecular_functionsingle-stranded DNA helicase activity
B0030174biological_processregulation of DNA-templated DNA replication initiation
B0042555cellular_componentMCM complex
B0048471cellular_componentperinuclear region of cytoplasm
B0071162cellular_componentCMG complex
B1902975biological_processmitotic DNA replication initiation
C0000166molecular_functionnucleotide binding
C0000727biological_processdouble-strand break repair via break-induced replication
C0000781cellular_componentchromosome, telomeric region
C0003677molecular_functionDNA binding
C0003678molecular_functionDNA helicase activity
C0003697molecular_functionsingle-stranded DNA binding
C0004386molecular_functionhelicase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0006260biological_processDNA replication
C0006270biological_processDNA replication initiation
C0006271biological_processDNA strand elongation involved in DNA replication
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0017116molecular_functionsingle-stranded DNA helicase activity
C0030174biological_processregulation of DNA-templated DNA replication initiation
C0042555cellular_componentMCM complex
C0071162cellular_componentCMG complex
C1902975biological_processmitotic DNA replication initiation
D0000166molecular_functionnucleotide binding
D0000727biological_processdouble-strand break repair via break-induced replication
D0000781cellular_componentchromosome, telomeric region
D0003677molecular_functionDNA binding
D0003678molecular_functionDNA helicase activity
D0003688molecular_functionDNA replication origin binding
D0003697molecular_functionsingle-stranded DNA binding
D0004386molecular_functionhelicase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0006260biological_processDNA replication
D0006270biological_processDNA replication initiation
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0017116molecular_functionsingle-stranded DNA helicase activity
D0030174biological_processregulation of DNA-templated DNA replication initiation
D0042555cellular_componentMCM complex
D0043138molecular_function3'-5' DNA helicase activity
D0071162cellular_componentCMG complex
E0000166molecular_functionnucleotide binding
E0000727biological_processdouble-strand break repair via break-induced replication
E0000781cellular_componentchromosome, telomeric region
E0003677molecular_functionDNA binding
E0003678molecular_functionDNA helicase activity
E0003697molecular_functionsingle-stranded DNA binding
E0004386molecular_functionhelicase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005694cellular_componentchromosome
E0006260biological_processDNA replication
E0006270biological_processDNA replication initiation
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0030174biological_processregulation of DNA-templated DNA replication initiation
E0042555cellular_componentMCM complex
E0042802molecular_functionidentical protein binding
E0071162cellular_componentCMG complex
E1902969biological_processmitotic DNA replication
E1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
F0000166molecular_functionnucleotide binding
F0000727biological_processdouble-strand break repair via break-induced replication
F0000781cellular_componentchromosome, telomeric region
F0000785cellular_componentchromatin
F0003677molecular_functionDNA binding
F0003678molecular_functionDNA helicase activity
F0003697molecular_functionsingle-stranded DNA binding
F0004386molecular_functionhelicase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005694cellular_componentchromosome
F0005730cellular_componentnucleolus
F0006260biological_processDNA replication
F0006270biological_processDNA replication initiation
F0006271biological_processDNA strand elongation involved in DNA replication
F0006974biological_processDNA damage response
F0009410biological_processresponse to xenobiotic stimulus
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0016887molecular_functionATP hydrolysis activity
F0017116molecular_functionsingle-stranded DNA helicase activity
F0030174biological_processregulation of DNA-templated DNA replication initiation
F0042325biological_processregulation of phosphorylation
F0042555cellular_componentMCM complex
F0071162cellular_componentCMG complex
F0071364biological_processcellular response to epidermal growth factor stimulus
Functional Information from PROSITE/UniProt
site_idPS00847
Number of Residues9
DetailsMCM_1 MCM family signature. GICCIDEFD
ChainResidueDetails
CGLY420-ASP428
DGLY411-ASP419
EGLY438-ASP446
BGLY371-ASP379
AGLY392-ASP400
FGLY436-ASP444
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues35
DetailsMotif: {"description":"Walker A","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues18
DetailsMotif: {"description":"Walker B","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsSite: {"description":"Arginine finger","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues30
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P25206","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)","evidences":[{"source":"PubMed","id":"40940420","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P97311","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues43
DetailsRegion: {"description":"Interaction with RAD17","evidences":[{"source":"PubMed","id":"15538388","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

248636

PDB entries from 2026-02-04

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