7W68

human single hexameric Mcm2-7 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003688	molecular_function	DNA replication origin binding
A	0003689	molecular_function	DNA clamp loader activity
A	0003697	molecular_function	single-stranded DNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005664	cellular_component	nuclear origin of replication recognition complex
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006260	biological_process	DNA replication
A	0006268	biological_process	DNA unwinding involved in DNA replication
A	0006270	biological_process	DNA replication initiation
A	0006334	biological_process	nucleosome assembly
A	0006915	biological_process	apoptotic process
A	0009378	molecular_function	four-way junction helicase activity
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0017116	molecular_function	single-stranded DNA helicase activity
A	0019899	molecular_function	enzyme binding
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0032508	biological_process	DNA duplex unwinding
A	0036121	molecular_function	double-stranded DNA helicase activity
A	0042393	molecular_function	histone binding
A	0042555	cellular_component	MCM complex
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0046872	molecular_function	metal ion binding
A	0061749	molecular_function	forked DNA-dependent helicase activity
A	0061775	molecular_function	cohesin loader activity
A	0071162	cellular_component	CMG complex
A	0071353	biological_process	cellular response to interleukin-4
A	0090102	biological_process	cochlea development
A	0140584	molecular_function	chromatin extrusion motor activity
A	0140588	biological_process	chromatin looping
A	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
A	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
A	1902975	biological_process	mitotic DNA replication initiation
A	1905775	biological_process	negative regulation of DNA helicase activity
A	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000781	cellular_component	chromosome, telomeric region
B	0003677	molecular_function	DNA binding
B	0003689	molecular_function	DNA clamp loader activity
B	0003697	molecular_function	single-stranded DNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005658	cellular_component	alpha DNA polymerase:primase complex
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0006260	biological_process	DNA replication
B	0006268	biological_process	DNA unwinding involved in DNA replication
B	0006270	biological_process	DNA replication initiation
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006338	biological_process	chromatin remodeling
B	0009378	molecular_function	four-way junction helicase activity
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0017116	molecular_function	single-stranded DNA helicase activity
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0032508	biological_process	DNA duplex unwinding
B	0036121	molecular_function	double-stranded DNA helicase activity
B	0042555	cellular_component	MCM complex
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0061749	molecular_function	forked DNA-dependent helicase activity
B	0061775	molecular_function	cohesin loader activity
B	0071162	cellular_component	CMG complex
B	0140584	molecular_function	chromatin extrusion motor activity
B	0140588	biological_process	chromatin looping
B	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
B	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
B	1902975	biological_process	mitotic DNA replication initiation
B	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0000781	cellular_component	chromosome, telomeric region
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0003689	molecular_function	DNA clamp loader activity
C	0003697	molecular_function	single-stranded DNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0006260	biological_process	DNA replication
C	0006268	biological_process	DNA unwinding involved in DNA replication
C	0006270	biological_process	DNA replication initiation
C	0006271	biological_process	DNA strand elongation involved in DNA replication
C	0006338	biological_process	chromatin remodeling
C	0009378	molecular_function	four-way junction helicase activity
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0017116	molecular_function	single-stranded DNA helicase activity
C	0030174	biological_process	regulation of DNA-templated DNA replication initiation
C	0032508	biological_process	DNA duplex unwinding
C	0036121	molecular_function	double-stranded DNA helicase activity
C	0042555	cellular_component	MCM complex
C	0061749	molecular_function	forked DNA-dependent helicase activity
C	0061775	molecular_function	cohesin loader activity
C	0071162	cellular_component	CMG complex
C	0140584	molecular_function	chromatin extrusion motor activity
C	0140588	biological_process	chromatin looping
C	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
C	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
C	1902975	biological_process	mitotic DNA replication initiation
C	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
D	0000727	biological_process	double-strand break repair via break-induced replication
D	0000781	cellular_component	chromosome, telomeric region
D	0003677	molecular_function	DNA binding
D	0003688	molecular_function	DNA replication origin binding
D	0003689	molecular_function	DNA clamp loader activity
D	0003697	molecular_function	single-stranded DNA binding
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006268	biological_process	DNA unwinding involved in DNA replication
D	0006270	biological_process	DNA replication initiation
D	0006338	biological_process	chromatin remodeling
D	0009378	molecular_function	four-way junction helicase activity
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0017116	molecular_function	single-stranded DNA helicase activity
D	0030174	biological_process	regulation of DNA-templated DNA replication initiation
D	0032508	biological_process	DNA duplex unwinding
D	0036121	molecular_function	double-stranded DNA helicase activity
D	0042555	cellular_component	MCM complex
D	0043138	molecular_function	3'-5' DNA helicase activity
D	0061749	molecular_function	forked DNA-dependent helicase activity
D	0061775	molecular_function	cohesin loader activity
D	0071162	cellular_component	CMG complex
D	0140584	molecular_function	chromatin extrusion motor activity
D	0140588	biological_process	chromatin looping
D	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
D	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
D	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
E	0000727	biological_process	double-strand break repair via break-induced replication
E	0000781	cellular_component	chromosome, telomeric region
E	0003677	molecular_function	DNA binding
E	0003678	molecular_function	DNA helicase activity
E	0003689	molecular_function	DNA clamp loader activity
E	0003697	molecular_function	single-stranded DNA binding
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006260	biological_process	DNA replication
E	0006268	biological_process	DNA unwinding involved in DNA replication
E	0006270	biological_process	DNA replication initiation
E	0006338	biological_process	chromatin remodeling
E	0009378	molecular_function	four-way junction helicase activity
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030174	biological_process	regulation of DNA-templated DNA replication initiation
E	0032508	biological_process	DNA duplex unwinding
E	0036121	molecular_function	double-stranded DNA helicase activity
E	0042555	cellular_component	MCM complex
E	0042802	molecular_function	identical protein binding
E	0061749	molecular_function	forked DNA-dependent helicase activity
E	0061775	molecular_function	cohesin loader activity
E	0071162	cellular_component	CMG complex
E	0140584	molecular_function	chromatin extrusion motor activity
E	0140588	biological_process	chromatin looping
E	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
E	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
E	1902969	biological_process	mitotic DNA replication
E	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
F	0000727	biological_process	double-strand break repair via break-induced replication
F	0000781	cellular_component	chromosome, telomeric region
F	0000785	cellular_component	chromatin
F	0003677	molecular_function	DNA binding
F	0003678	molecular_function	DNA helicase activity
F	0003689	molecular_function	DNA clamp loader activity
F	0003697	molecular_function	single-stranded DNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005730	cellular_component	nucleolus
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0006268	biological_process	DNA unwinding involved in DNA replication
F	0006270	biological_process	DNA replication initiation
F	0006271	biological_process	DNA strand elongation involved in DNA replication
F	0006338	biological_process	chromatin remodeling
F	0006974	biological_process	DNA damage response
F	0008283	biological_process	cell population proliferation
F	0009378	molecular_function	four-way junction helicase activity
F	0009410	biological_process	response to xenobiotic stimulus
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0017116	molecular_function	single-stranded DNA helicase activity
F	0030174	biological_process	regulation of DNA-templated DNA replication initiation
F	0032508	biological_process	DNA duplex unwinding
F	0036121	molecular_function	double-stranded DNA helicase activity
F	0042325	biological_process	regulation of phosphorylation
F	0042555	cellular_component	MCM complex
F	0061749	molecular_function	forked DNA-dependent helicase activity
F	0061775	molecular_function	cohesin loader activity
F	0071162	cellular_component	CMG complex
F	0071364	biological_process	cellular response to epidermal growth factor stimulus
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	0140584	molecular_function	chromatin extrusion motor activity
F	0140588	biological_process	chromatin looping
F	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
F	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
F	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVCCIDEFD

Chain	Residue	Details
F	GLY436-ASP444
B	GLY371-ASP379
A	GLY392-ASP400
D	GLY411-ASP419
E	GLY438-ASP446
C	GLY420-ASP428

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:32453425, ECO:0007744|PDB:6XTX

Chain	Residue	Details
C	TYR322
C	ARG348
C	LYS367
C	SER368
C	ASN469
C	ARG494
C	ARG583
C	GLU586
E	GLU605

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22814378

Chain	Residue	Details
C	SER-147
A	GLN341

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDC7 => ECO:0000269|PubMed:27401717

Chain	Residue	Details
C	SER-143
D	SER576

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:27401717

Chain	Residue	Details
C	THR-142
B	SER578
D	LYS667

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P49717

Chain	Residue	Details
C	THR-130
B	LYS514

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER-123

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
C	SER-118
C	SER-115
F	LYS24

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER-117

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	THR-47
C	THR-39

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER-44

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER-29

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER-18

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
C	SER-7
C	SER-4

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS71
C	LYS301

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P49717

Chain	Residue	Details
C	LYS709

---

site_id	SWS_FT_FI16
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
C	LYS290
B	SER701
C	LYS649

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:16899510, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER-51

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS26

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	SER191

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS-12

---