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7W3Y

CryoEM structure of human Kv4.3

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005250molecular_functionA-type (transient outward) potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006936biological_processmuscle contraction
A0007268biological_processchemical synaptic transmission
A0008016biological_processregulation of heart contraction
A0008076cellular_componentvoltage-gated potassium channel complex
A0016020cellular_componentmembrane
A0030425cellular_componentdendrite
A0034702cellular_componentmonoatomic ion channel complex
A0042383cellular_componentsarcolemma
A0042995cellular_componentcell projection
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0045211cellular_componentpostsynaptic membrane
A0046872molecular_functionmetal ion binding
A0051260biological_processprotein homooligomerization
A0051262biological_processprotein tetramerization
A0055085biological_processtransmembrane transport
A0071196cellular_componentKv4.3-KChIP1 channel complex
A0071805biological_processpotassium ion transmembrane transport
A0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
A0086009biological_processmembrane repolarization
A0086013biological_processmembrane repolarization during cardiac muscle cell action potential
A0086091biological_processregulation of heart rate by cardiac conduction
A0097623biological_processpotassium ion export across plasma membrane
A0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
A0098982cellular_componentGABA-ergic synapse
A0099625biological_processventricular cardiac muscle cell membrane repolarization
A0099634cellular_componentpostsynaptic specialization membrane
A1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005250molecular_functionA-type (transient outward) potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006936biological_processmuscle contraction
B0007268biological_processchemical synaptic transmission
B0008016biological_processregulation of heart contraction
B0008076cellular_componentvoltage-gated potassium channel complex
B0016020cellular_componentmembrane
B0030425cellular_componentdendrite
B0034702cellular_componentmonoatomic ion channel complex
B0042383cellular_componentsarcolemma
B0042995cellular_componentcell projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0045211cellular_componentpostsynaptic membrane
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0051262biological_processprotein tetramerization
B0055085biological_processtransmembrane transport
B0071196cellular_componentKv4.3-KChIP1 channel complex
B0071805biological_processpotassium ion transmembrane transport
B0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
B0086009biological_processmembrane repolarization
B0086013biological_processmembrane repolarization during cardiac muscle cell action potential
B0086091biological_processregulation of heart rate by cardiac conduction
B0097623biological_processpotassium ion export across plasma membrane
B0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
B0098982cellular_componentGABA-ergic synapse
B0099625biological_processventricular cardiac muscle cell membrane repolarization
B0099634cellular_componentpostsynaptic specialization membrane
B1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C0001508biological_processaction potential
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005250molecular_functionA-type (transient outward) potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006936biological_processmuscle contraction
C0007268biological_processchemical synaptic transmission
C0008016biological_processregulation of heart contraction
C0008076cellular_componentvoltage-gated potassium channel complex
C0016020cellular_componentmembrane
C0030425cellular_componentdendrite
C0034702cellular_componentmonoatomic ion channel complex
C0042383cellular_componentsarcolemma
C0042995cellular_componentcell projection
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0045211cellular_componentpostsynaptic membrane
C0046872molecular_functionmetal ion binding
C0051260biological_processprotein homooligomerization
C0051262biological_processprotein tetramerization
C0055085biological_processtransmembrane transport
C0071196cellular_componentKv4.3-KChIP1 channel complex
C0071805biological_processpotassium ion transmembrane transport
C0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
C0086009biological_processmembrane repolarization
C0086013biological_processmembrane repolarization during cardiac muscle cell action potential
C0086091biological_processregulation of heart rate by cardiac conduction
C0097623biological_processpotassium ion export across plasma membrane
C0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
C0098982cellular_componentGABA-ergic synapse
C0099625biological_processventricular cardiac muscle cell membrane repolarization
C0099634cellular_componentpostsynaptic specialization membrane
C1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005250molecular_functionA-type (transient outward) potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006936biological_processmuscle contraction
D0007268biological_processchemical synaptic transmission
D0008016biological_processregulation of heart contraction
D0008076cellular_componentvoltage-gated potassium channel complex
D0016020cellular_componentmembrane
D0030425cellular_componentdendrite
D0034702cellular_componentmonoatomic ion channel complex
D0042383cellular_componentsarcolemma
D0042995cellular_componentcell projection
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0045211cellular_componentpostsynaptic membrane
D0046872molecular_functionmetal ion binding
D0051260biological_processprotein homooligomerization
D0051262biological_processprotein tetramerization
D0055085biological_processtransmembrane transport
D0071196cellular_componentKv4.3-KChIP1 channel complex
D0071805biological_processpotassium ion transmembrane transport
D0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
D0086009biological_processmembrane repolarization
D0086013biological_processmembrane repolarization during cardiac muscle cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0097623biological_processpotassium ion export across plasma membrane
D0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
D0098982cellular_componentGABA-ergic synapse
D0099625biological_processventricular cardiac muscle cell membrane repolarization
D0099634cellular_componentpostsynaptic specialization membrane
D1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues792
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:34997220
ChainResidueDetails
AMET1-ALA182
DMET1-ALA182
DALA247-ARG253
DLEU307-ALA318
AALA247-ARG253
ALEU307-ALA318
BMET1-ALA182
BALA247-ARG253
BLEU307-ALA318
CMET1-ALA182
CALA247-ARG253
CLEU307-ALA318

site_idSWS_FT_FI2
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
ALEU183-THR204
BLEU183-THR204
CLEU183-THR204
DLEU183-THR204

site_idSWS_FT_FI3
Number of Residues124
DetailsTOPO_DOM: Extracellular => ECO:0000305|PubMed:34997220
ChainResidueDetails
AVAL205-SER223
DVAL205-SER223
DASN278-SER283
DLYS344-THR352
AASN278-SER283
ALYS344-THR352
BVAL205-SER223
BASN278-SER283
BLYS344-THR352
CVAL205-SER223
CASN278-SER283
CLYS344-THR352

site_idSWS_FT_FI4
Number of Residues88
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
AVAL224-PHE246
BVAL224-PHE246
CVAL224-PHE246
DVAL224-PHE246

site_idSWS_FT_FI5
Number of Residues92
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
APHE254-THR277
BPHE254-THR277
CPHE254-THR277
DPHE254-THR277

site_idSWS_FT_FI6
Number of Residues88
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
AGLY284-GLY306
BGLY284-GLY306
CGLY284-GLY306
DGLY284-GLY306

site_idSWS_FT_FI7
Number of Residues96
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
ASER319-GLU343
BSER319-GLU343
CSER319-GLU343
DSER319-GLU343

site_idSWS_FT_FI8
Number of Residues52
DetailsINTRAMEM: Helical; Name=Pore helix => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
ASER353-THR366
BSER353-THR366
CSER353-THR366
DSER353-THR366

site_idSWS_FT_FI9
Number of Residues28
DetailsINTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
ATHR367-VAL374
BTHR367-VAL374
CTHR367-VAL374
DTHR367-VAL374

site_idSWS_FT_FI10
Number of Residues88
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:34997220, ECO:0007744|PDB:7W3Y
ChainResidueDetails
AILE378-PRO400
BILE378-PRO400
CILE378-PRO400
DILE378-PRO400

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: in chain B => ECO:0007744|PDB:1S1G, ECO:0007744|PDB:2NZ0
ChainResidueDetails
AHIS104
DHIS104
DCYS131
DCYS132
ACYS131
ACYS132
BHIS104
BCYS131
BCYS132
CHIS104
CCYS131
CCYS132

site_idSWS_FT_FI12
Number of Residues4
DetailsBINDING: in chain D => ECO:0007744|PDB:1S1G, ECO:0007744|PDB:2NZ0
ChainResidueDetails
ACYS110
BCYS110
CCYS110
DCYS110

site_idSWS_FT_FI13
Number of Residues16
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9NZV8
ChainResidueDetails
ATHR367
CLEU368
CGLY369
CTYR370
DTHR367
DLEU368
DGLY369
DTYR370
ALEU368
AGLY369
ATYR370
BTHR367
BLEU368
BGLY369
BTYR370
CTHR367

site_idSWS_FT_FI14
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z0V1
ChainResidueDetails
ASER153
AASN585
BSER153
BASN585
CSER153
CASN585
DSER153
DASN585

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9Z0V1
ChainResidueDetails
ATHR459
BTHR459
CTHR459
DTHR459

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphoserine; by CaMK2D => ECO:0000250|UniProtKB:Q62897
ChainResidueDetails
ATHR569
BTHR569
CTHR569
DTHR569

227344

PDB entries from 2024-11-13

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