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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7W3Y

CryoEM structure of human Kv4.3

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005250molecular_functionA-type (transient outward) potassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006936biological_processmuscle contraction
A0007268biological_processchemical synaptic transmission
A0008016biological_processregulation of heart contraction
A0008076cellular_componentvoltage-gated potassium channel complex
A0016020cellular_componentmembrane
A0030425cellular_componentdendrite
A0042383cellular_componentsarcolemma
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0045211cellular_componentpostsynaptic membrane
A0051260biological_processprotein homooligomerization
A0051262biological_processprotein tetramerization
A0055085biological_processtransmembrane transport
A0071805biological_processpotassium ion transmembrane transport
A0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
A0086009biological_processmembrane repolarization
A0086013biological_processmembrane repolarization during cardiac muscle cell action potential
A0086091biological_processregulation of heart rate by cardiac conduction
A0097623biological_processpotassium ion export across plasma membrane
A0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
A0098982cellular_componentGABA-ergic synapse
A0099625biological_processventricular cardiac muscle cell membrane repolarization
A0099634cellular_componentpostsynaptic specialization membrane
A1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005250molecular_functionA-type (transient outward) potassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006936biological_processmuscle contraction
B0007268biological_processchemical synaptic transmission
B0008016biological_processregulation of heart contraction
B0008076cellular_componentvoltage-gated potassium channel complex
B0016020cellular_componentmembrane
B0030425cellular_componentdendrite
B0042383cellular_componentsarcolemma
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0045211cellular_componentpostsynaptic membrane
B0051260biological_processprotein homooligomerization
B0051262biological_processprotein tetramerization
B0055085biological_processtransmembrane transport
B0071805biological_processpotassium ion transmembrane transport
B0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
B0086009biological_processmembrane repolarization
B0086013biological_processmembrane repolarization during cardiac muscle cell action potential
B0086091biological_processregulation of heart rate by cardiac conduction
B0097623biological_processpotassium ion export across plasma membrane
B0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
B0098982cellular_componentGABA-ergic synapse
B0099625biological_processventricular cardiac muscle cell membrane repolarization
B0099634cellular_componentpostsynaptic specialization membrane
B1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C0001508biological_processaction potential
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005250molecular_functionA-type (transient outward) potassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006936biological_processmuscle contraction
C0007268biological_processchemical synaptic transmission
C0008016biological_processregulation of heart contraction
C0008076cellular_componentvoltage-gated potassium channel complex
C0016020cellular_componentmembrane
C0030425cellular_componentdendrite
C0042383cellular_componentsarcolemma
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0045211cellular_componentpostsynaptic membrane
C0051260biological_processprotein homooligomerization
C0051262biological_processprotein tetramerization
C0055085biological_processtransmembrane transport
C0071805biological_processpotassium ion transmembrane transport
C0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
C0086009biological_processmembrane repolarization
C0086013biological_processmembrane repolarization during cardiac muscle cell action potential
C0086091biological_processregulation of heart rate by cardiac conduction
C0097623biological_processpotassium ion export across plasma membrane
C0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
C0098982cellular_componentGABA-ergic synapse
C0099625biological_processventricular cardiac muscle cell membrane repolarization
C0099634cellular_componentpostsynaptic specialization membrane
C1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005250molecular_functionA-type (transient outward) potassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006936biological_processmuscle contraction
D0007268biological_processchemical synaptic transmission
D0008016biological_processregulation of heart contraction
D0008076cellular_componentvoltage-gated potassium channel complex
D0016020cellular_componentmembrane
D0030425cellular_componentdendrite
D0042383cellular_componentsarcolemma
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0045211cellular_componentpostsynaptic membrane
D0051260biological_processprotein homooligomerization
D0051262biological_processprotein tetramerization
D0055085biological_processtransmembrane transport
D0071805biological_processpotassium ion transmembrane transport
D0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
D0086009biological_processmembrane repolarization
D0086013biological_processmembrane repolarization during cardiac muscle cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0097623biological_processpotassium ion export across plasma membrane
D0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
D0098982cellular_componentGABA-ergic synapse
D0099625biological_processventricular cardiac muscle cell membrane repolarization
D0099634cellular_componentpostsynaptic specialization membrane
D1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues124
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues68
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues92
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues52
DetailsIntramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues28
DetailsIntramembrane: {"evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W3Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues32
DetailsRegion: {"description":"Interaction with KCNIP1","evidences":[{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues12
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PDB","id":"1S1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NZ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsBinding site: {"description":"in chain D","evidences":[{"source":"PDB","id":"1S1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NZ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9NZV8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2026-04-01

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