7W0C
Dicer2-Loqs-PD-dsRNA complex at early-translocation state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002230 | biological_process | positive regulation of defense response to virus by host |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003730 | molecular_function | mRNA 3'-UTR binding |
| A | 0004386 | molecular_function | helicase activity |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004525 | molecular_function | ribonuclease III activity |
| A | 0004530 | molecular_function | deoxyribonuclease I activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006309 | biological_process | apoptotic DNA fragmentation |
| A | 0006396 | biological_process | RNA processing |
| A | 0007626 | biological_process | locomotory behavior |
| A | 0008186 | molecular_function | ATP-dependent activity, acting on RNA |
| A | 0009047 | biological_process | dosage compensation by hyperactivation of X chromosome |
| A | 0009597 | biological_process | detection of virus |
| A | 0009616 | biological_process | RNAi-mediated antiviral immune response |
| A | 0016442 | cellular_component | RISC complex |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0016891 | molecular_function | RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism |
| A | 0030422 | biological_process | siRNA processing |
| A | 0031047 | biological_process | regulatory ncRNA-mediated gene silencing |
| A | 0031054 | biological_process | pre-miRNA processing |
| A | 0031507 | biological_process | heterochromatin formation |
| A | 0035194 | biological_process | regulatory ncRNA-mediated post-transcriptional gene silencing |
| A | 0035197 | molecular_function | siRNA binding |
| A | 0036464 | cellular_component | cytoplasmic ribonucleoprotein granule |
| A | 0045089 | biological_process | positive regulation of innate immune response |
| A | 0045752 | biological_process | positive regulation of Toll signaling pathway |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0051607 | biological_process | defense response to virus |
| A | 0070578 | cellular_component | RISC-loading complex |
| A | 0070922 | biological_process | RISC complex assembly |
| A | 0098586 | biological_process | cellular response to virus |
| A | 0098795 | biological_process | global gene silencing by mRNA cleavage |
| A | 0110064 | biological_process | lncRNA catabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 178 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 170 |
| Details | Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 102 |
| Details | Domain: {"description":"Dicer dsRNA-binding fold","evidences":[{"source":"PROSITE-ProRule","id":"PRU00657","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 54 |
| Details | Domain: {"description":"PAZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00142","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 205 |
| Details | Domain: {"description":"RNase III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00177","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 117 |
| Details | Region: {"description":"Helicase insertion domain; involved in homodimerization","evidences":[{"source":"PubMed","id":"35768513","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | Region: {"description":"Sufficient for interaction with loqs isoform PD (loqs-PD)","evidences":[{"source":"PubMed","id":"28874570","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 142 |
| Details | Region: {"description":"Platform domain","evidences":[{"source":"PubMed","id":"35768513","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 94 |
| Details | Region: {"description":"RNase III insertion domain a; involved in homodimerization","evidences":[{"source":"PubMed","id":"35768513","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
