7VVZ

NuA4 bound to the nucleosome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0003674	molecular_function	molecular_function
E	0003682	molecular_function	chromatin binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0006281	biological_process	DNA repair
E	0006325	biological_process	chromatin organization
E	0006351	biological_process	DNA-templated transcription
E	0006974	biological_process	DNA damage response
E	0019865	molecular_function	immunoglobulin binding
E	0035267	cellular_component	NuA4 histone acetyltransferase complex
E	0065003	biological_process	protein-containing complex assembly
F	0000785	cellular_component	chromatin
F	0000812	cellular_component	Swr1 complex
F	0003682	molecular_function	chromatin binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0006281	biological_process	DNA repair
F	0006325	biological_process	chromatin organization
F	0006338	biological_process	chromatin remodeling
F	0006351	biological_process	DNA-templated transcription
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006974	biological_process	DNA damage response
F	0010468	biological_process	regulation of gene expression
F	0016514	cellular_component	SWI/SNF complex
F	0031011	cellular_component	Ino80 complex
F	0035267	cellular_component	NuA4 histone acetyltransferase complex
F	0042393	molecular_function	histone binding
F	0051382	biological_process	kinetochore assembly
G	0000011	biological_process	vacuole inheritance
G	0000142	cellular_component	cellular bud neck contractile ring
G	0000166	molecular_function	nucleotide binding
G	0000785	cellular_component	chromatin
G	0000812	cellular_component	Swr1 complex
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005884	cellular_component	actin filament
G	0006281	biological_process	DNA repair
G	0006338	biological_process	chromatin remodeling
G	0006351	biological_process	DNA-templated transcription
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006897	biological_process	endocytosis
G	0009306	biological_process	protein secretion
G	0015629	cellular_component	actin cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0030010	biological_process	establishment of cell polarity
G	0030476	biological_process	ascospore wall assembly
G	0030479	cellular_component	actin cortical patch
G	0031011	cellular_component	Ino80 complex
G	0032432	cellular_component	actin filament bundle
G	0035267	cellular_component	NuA4 histone acetyltransferase complex
G	0042802	molecular_function	identical protein binding
G	0071944	cellular_component	cell periphery
G	1902404	biological_process	mitotic actomyosin contractile ring contraction
H	0000786	cellular_component	nucleosome
H	0004402	molecular_function	histone acetyltransferase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0006281	biological_process	DNA repair
H	0006338	biological_process	chromatin remodeling
H	0006351	biological_process	DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006974	biological_process	DNA damage response
H	0016239	biological_process	positive regulation of macroautophagy
H	0032777	cellular_component	piccolo histone acetyltransferase complex
H	0035267	cellular_component	NuA4 histone acetyltransferase complex
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0000785	cellular_component	chromatin
K	0000812	cellular_component	Swr1 complex
K	0003714	molecular_function	transcription corepressor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005694	cellular_component	chromosome
K	0006281	biological_process	DNA repair
K	0006325	biological_process	chromatin organization
K	0006338	biological_process	chromatin remodeling
K	0006351	biological_process	DNA-templated transcription
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006974	biological_process	DNA damage response
K	0035267	cellular_component	NuA4 histone acetyltransferase complex
K	0051276	biological_process	chromosome organization
L	0000124	cellular_component	SAGA complex
L	0004402	molecular_function	histone acetyltransferase activity
L	0004672	molecular_function	protein kinase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0006281	biological_process	DNA repair
L	0006325	biological_process	chromatin organization
L	0006351	biological_process	DNA-templated transcription
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0033554	biological_process	cellular response to stress
L	0035267	cellular_component	NuA4 histone acetyltransferase complex
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046695	cellular_component	SLIK (SAGA-like) complex
L	0110078	cellular_component	TTT Hsp90 cochaperone complex
L	0140861	biological_process	DNA repair-dependent chromatin remodeling
N	0000786	cellular_component	nucleosome
N	0003677	molecular_function	DNA binding
N	0005634	cellular_component	nucleus
N	0005694	cellular_component	chromosome
N	0030527	molecular_function	structural constituent of chromatin
N	0031507	biological_process	heterochromatin formation
N	0046982	molecular_function	protein heterodimerization activity
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0030527	molecular_function	structural constituent of chromatin
O	0046982	molecular_function	protein heterodimerization activity
P	0000183	biological_process	rDNA heterochromatin formation
P	0000785	cellular_component	chromatin
P	0000786	cellular_component	nucleosome
P	0003682	molecular_function	chromatin binding
P	0003712	molecular_function	transcription coregulator activity
P	0004402	molecular_function	histone acetyltransferase activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0006281	biological_process	DNA repair
P	0006325	biological_process	chromatin organization
P	0006351	biological_process	DNA-templated transcription
P	0006354	biological_process	DNA-templated transcription elongation
P	0006355	biological_process	regulation of DNA-templated transcription
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0006974	biological_process	DNA damage response
P	0008270	molecular_function	zinc ion binding
P	0010485	molecular_function	histone H4 acetyltransferase activity
P	0010629	biological_process	negative regulation of gene expression
P	0010867	biological_process	positive regulation of triglyceride biosynthetic process
P	0016239	biological_process	positive regulation of macroautophagy
P	0016740	molecular_function	transferase activity
P	0032777	cellular_component	piccolo histone acetyltransferase complex
P	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
P	0033554	biological_process	cellular response to stress
P	0035267	cellular_component	NuA4 histone acetyltransferase complex
P	0051726	biological_process	regulation of cell cycle
P	0061733	molecular_function	protein-lysine-acetyltransferase activity
P	0106226	molecular_function	peptide 2-hydroxyisobutyryltransferase activity
P	0140064	molecular_function	peptide crotonyltransferase activity
P	0140068	molecular_function	histone crotonyltransferase activity
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005694	cellular_component	chromosome
Q	0006334	biological_process	nucleosome assembly
Q	0030527	molecular_function	structural constituent of chromatin
Q	0046982	molecular_function	protein heterodimerization activity
S	0000786	cellular_component	nucleosome
S	0003677	molecular_function	DNA binding
S	0005634	cellular_component	nucleus
S	0005694	cellular_component	chromosome
S	0030527	molecular_function	structural constituent of chromatin
S	0031507	biological_process	heterochromatin formation
S	0046982	molecular_function	protein heterodimerization activity
T	0000786	cellular_component	nucleosome
T	0004402	molecular_function	histone acetyltransferase activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0006281	biological_process	DNA repair
T	0006338	biological_process	chromatin remodeling
T	0006351	biological_process	DNA-templated transcription
T	0006357	biological_process	regulation of transcription by RNA polymerase II
T	0006974	biological_process	DNA damage response
T	0016239	biological_process	positive regulation of macroautophagy
T	0032777	cellular_component	piccolo histone acetyltransferase complex
T	0035267	cellular_component	NuA4 histone acetyltransferase complex
U	0000786	cellular_component	nucleosome
U	0003677	molecular_function	DNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005694	cellular_component	chromosome
U	0030527	molecular_function	structural constituent of chromatin
U	0046982	molecular_function	protein heterodimerization activity
V	0000786	cellular_component	nucleosome
V	0004402	molecular_function	histone acetyltransferase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005829	cellular_component	cytosol
V	0006281	biological_process	DNA repair
V	0006325	biological_process	chromatin organization
V	0006338	biological_process	chromatin remodeling
V	0006351	biological_process	DNA-templated transcription
V	0006355	biological_process	regulation of DNA-templated transcription
V	0006974	biological_process	DNA damage response
V	0008270	molecular_function	zinc ion binding
V	0032777	cellular_component	piccolo histone acetyltransferase complex
V	0035267	cellular_component	NuA4 histone acetyltransferase complex
V	0046872	molecular_function	metal ion binding
V	0051321	biological_process	meiotic cell cycle
V	0140002	molecular_function	histone H3K4me3 reader activity
Y	0000123	cellular_component	histone acetyltransferase complex
Y	0004402	molecular_function	histone acetyltransferase activity
Y	0005634	cellular_component	nucleus
Y	0006281	biological_process	DNA repair
Y	0006325	biological_process	chromatin organization
Y	0006338	biological_process	chromatin remodeling
Y	0006351	biological_process	DNA-templated transcription
Y	0006974	biological_process	DNA damage response
Y	0033100	cellular_component	NuA3 histone acetyltransferase complex
Y	0035267	cellular_component	NuA4 histone acetyltransferase complex
Y	1990467	cellular_component	NuA3a histone acetyltransferase complex
Y	1990468	cellular_component	NuA3b histone acetyltransferase complex

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
S	ALA21-VAL27

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site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
Q	GLY14-HIS18

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site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
O	LYS14-LEU20

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site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
U	ARG92-GLY114

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site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
G	TYR53-GLY63

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site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
G	TRP356-GLU364

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site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
O	PRO66-ILE74

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site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApMNPksNR

Chain	Residue	Details
G	LEU104-ARG116
F	LEU109-ARG121

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site_id	PS01359
Number of Residues	44
Details	ZF_PHD_1 Zinc finger PHD-type signature. Cf.Cqrvsfgem.....................................VaCdgpnCkyewFHydCvnlkeppkgt...................................WyCpeC

Chain	Residue	Details
V	CYS225-CYS268

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250

Chain	Residue	Details
S	SER1
N	SER1
A	ARG2
A	ARG17
D	LYS5
D	LYS12
D	LYS15
D	LYS20

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250

Chain	Residue	Details
S	LYS5
N	LYS5
V	CYS238
V	CYS243
V	HIS249
V	CYS252
V	CYS265
V	CYS268

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P0C0S8

Chain	Residue	Details
S	LYS9
S	LYS95
N	LYS9
N	LYS95

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine; alternate => ECO:0000250|UniProtKB:P0C0S8

Chain	Residue	Details
S	LYS36
N	LYS36
D	LYS120

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000250|UniProtKB:P0C0S8

Chain	Residue	Details
S	LYS74
S	LYS75
N	LYS74
N	LYS75
B	LYS8
B	LYS16
B	LYS44
B	LYS79

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N5-methylglutamine => ECO:0000250

Chain	Residue	Details
S	GLN104
N	GLN104
B	LYS12
B	LYS20

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P0C0S8

Chain	Residue	Details
S	LYS118
N	LYS118
B	LYS31
B	LYS91

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250

Chain	Residue	Details
S	LYS13
B	SER47
S	LYS15
S	LYS119
N	LYS13
N	LYS15
N	LYS119

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
Q	TYR51
Q	TYR88
B	TYR51
B	TYR88

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
Q	LYS59
A	LYS64
B	LYS59
O	LYS27
O	LYS36
O	LYS64
A	LYS18
A	LYS23
A	LYS27
A	LYS36

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
Q	LYS77
B	LYS77

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
Q	LYS31
B	LYS31

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
O	LYS37
Q	LYS91
B	LYS91

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	TYR41
A	TYR41

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
O	LYS56
O	LYS79
A	LYS56
A	LYS79

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	SER57
A	SER57

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	THR80
O	THR107
A	THR80
A	THR107

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
O	SER86
A	SER86

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	LYS115
A	LYS115

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	LYS122
A	LYS122

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
O	CYS110
A	CYS110

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 525

Chain	Residue	Details
L	PHE304	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
L	SER338	activator, proton acceptor, proton donor

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