Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7VVU

NuA4 HAT module bound to the nucleosome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
N	0000786	cellular_component	nucleosome
N	0003677	molecular_function	DNA binding
N	0005634	cellular_component	nucleus
N	0005694	cellular_component	chromosome
N	0030527	molecular_function	structural constituent of chromatin
N	0046982	molecular_function	protein heterodimerization activity
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0030527	molecular_function	structural constituent of chromatin
O	0046982	molecular_function	protein heterodimerization activity
P	0000123	cellular_component	histone acetyltransferase complex
P	0000183	biological_process	rDNA heterochromatin formation
P	0000785	cellular_component	chromatin
P	0000786	cellular_component	nucleosome
P	0003682	molecular_function	chromatin binding
P	0003712	molecular_function	transcription coregulator activity
P	0004402	molecular_function	histone acetyltransferase activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0006281	biological_process	DNA repair
P	0006325	biological_process	chromatin organization
P	0006351	biological_process	DNA-templated transcription
P	0006354	biological_process	DNA-templated transcription elongation
P	0006355	biological_process	regulation of DNA-templated transcription
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0008270	molecular_function	zinc ion binding
P	0010468	biological_process	regulation of gene expression
P	0010485	molecular_function	histone H4 acetyltransferase activity
P	0010867	biological_process	positive regulation of triglyceride biosynthetic process
P	0016239	biological_process	positive regulation of macroautophagy
P	0016740	molecular_function	transferase activity
P	0032777	cellular_component	piccolo histone acetyltransferase complex
P	0032931	molecular_function	histone H3K56 acetyltransferase activity
P	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
P	0034212	molecular_function	peptide N-acetyltransferase activity
P	0035267	cellular_component	NuA4 histone acetyltransferase complex
P	0036408	molecular_function	histone H3K14 acetyltransferase activity
P	0043992	molecular_function	histone H3K9 acetyltransferase activity
P	0043993	molecular_function	histone H3K18 acetyltransferase activity
P	0043994	molecular_function	histone H3K23 acetyltransferase activity
P	0043995	molecular_function	histone H4K5 acetyltransferase activity
P	0043996	molecular_function	histone H4K8 acetyltransferase activity
P	0043997	molecular_function	histone H4K12 acetyltransferase activity
P	0043999	molecular_function	histone H2AK5 acetyltransferase activity
P	0044012	molecular_function	histone H2AK9 acetyltransferase activity
P	0044014	molecular_function	histone H2BK5 acetyltransferase activity
P	0044015	molecular_function	histone H2BK12 acetyltransferase activity
P	0044016	molecular_function	histone H3K4 acetyltransferase activity
P	0044017	molecular_function	histone H3K27 acetyltransferase activity
P	0044018	molecular_function	histone H3K36 acetyltransferase activity
P	0046972	molecular_function	histone H4K16 acetyltransferase activity
P	0051726	biological_process	regulation of cell cycle
P	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
P	0106226	molecular_function	peptide 2-hydroxyisobutyryltransferase activity
P	0140068	molecular_function	histone crotonyltransferase activity
P	0140908	molecular_function	histone H3K122 acetyltransferase activity
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005694	cellular_component	chromosome
Q	0030527	molecular_function	structural constituent of chromatin
Q	0046982	molecular_function	protein heterodimerization activity
S	0000786	cellular_component	nucleosome
S	0003677	molecular_function	DNA binding
S	0005634	cellular_component	nucleus
S	0005694	cellular_component	chromosome
S	0030527	molecular_function	structural constituent of chromatin
S	0046982	molecular_function	protein heterodimerization activity
T	0000786	cellular_component	nucleosome
T	0004402	molecular_function	histone acetyltransferase activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0006281	biological_process	DNA repair
T	0006338	biological_process	chromatin remodeling
T	0006351	biological_process	DNA-templated transcription
T	0006357	biological_process	regulation of transcription by RNA polymerase II
T	0016239	biological_process	positive regulation of macroautophagy
T	0032777	cellular_component	piccolo histone acetyltransferase complex
T	0035267	cellular_component	NuA4 histone acetyltransferase complex
U	0000786	cellular_component	nucleosome
U	0003677	molecular_function	DNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005694	cellular_component	chromosome
U	0030527	molecular_function	structural constituent of chromatin
U	0046982	molecular_function	protein heterodimerization activity
V	0000785	cellular_component	chromatin
V	0000786	cellular_component	nucleosome
V	0004402	molecular_function	histone acetyltransferase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005829	cellular_component	cytosol
V	0006281	biological_process	DNA repair
V	0006325	biological_process	chromatin organization
V	0006338	biological_process	chromatin remodeling
V	0006351	biological_process	DNA-templated transcription
V	0006355	biological_process	regulation of DNA-templated transcription
V	0008270	molecular_function	zinc ion binding
V	0032777	cellular_component	piccolo histone acetyltransferase complex
V	0035064	molecular_function	methylated histone binding
V	0035267	cellular_component	NuA4 histone acetyltransferase complex
V	0046872	molecular_function	metal ion binding
V	0051321	biological_process	meiotic cell cycle
X	0000786	cellular_component	nucleosome
X	0004402	molecular_function	histone acetyltransferase activity
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0006281	biological_process	DNA repair
X	0006338	biological_process	chromatin remodeling
X	0006351	biological_process	DNA-templated transcription
X	0006357	biological_process	regulation of transcription by RNA polymerase II
X	0016239	biological_process	positive regulation of macroautophagy
X	0032777	cellular_component	piccolo histone acetyltransferase complex
X	0035267	cellular_component	NuA4 histone acetyltransferase complex
Y	0000123	cellular_component	histone acetyltransferase complex
Y	0004402	molecular_function	histone acetyltransferase activity
Y	0005634	cellular_component	nucleus
Y	0006281	biological_process	DNA repair
Y	0006325	biological_process	chromatin organization
Y	0006338	biological_process	chromatin remodeling
Y	0006351	biological_process	DNA-templated transcription
Y	0033100	cellular_component	NuA3 histone acetyltransferase complex
Y	0035267	cellular_component	NuA4 histone acetyltransferase complex
Y	1990467	cellular_component	NuA3a histone acetyltransferase complex
Y	1990468	cellular_component	NuA3b histone acetyltransferase complex

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
S	ALA21-VAL27

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
Q	GLY14-HIS18

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
O	LYS14-LEU20

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
U	ARG92-GLY114

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
O	PRO66-ILE74

site_id	PS01359
Number of Residues	44
Details	ZF_PHD_1 Zinc finger PHD-type signature. Cf.Cqrvsfgem.....................................VaCdgpnCkyewFHydCvnlkeppkgt...................................WyCpeC

Chain	Residue	Details
V	CYS225-CYS268

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	ZN_FING: C2HC MYST-type; degenerate => ECO:0000255\|PROSITE-ProRule:PRU01063

Chain	Residue	Details
P	ILE195-LEU220
N	SER1
A	ARG2
A	ARG17
D	LYS5
D	LYS12
D	LYS15
D	LYS20

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000303\|PubMed:12368900, ECO:0000303\|PubMed:17223684, ECO:0000303\|PubMed:18245364, ECO:0000303\|PubMed:22020126, ECO:0000305

Chain	Residue	Details
P	GLU338
N	LYS5
V	CYS238
V	CYS243
V	HIS249
V	CYS252
V	CYS265
V	CYS268

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:11106757, ECO:0000269\|PubMed:12368900, ECO:0000269\|PubMed:22020126

Chain	Residue	Details
P	ALA303
P	GLN312
P	SER342
N	LYS95

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Important for catalytic activity => ECO:0000305

Chain	Residue	Details
P	CYS304
N	LYS36
D	LYS120

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956

Chain	Residue	Details
P	SER17
S	LYS75
N	LYS74
N	LYS75
B	LYS8
B	LYS16
B	LYS44
B	LYS79

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269\|PubMed:22020126

Chain	Residue	Details
P	LYS262
N	GLN104
B	LYS12
B	LYS20

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250\|UniProtKB:P0C0S8

Chain	Residue	Details
S	LYS118
N	LYS118
B	LYS31
B	LYS91

site_id	SWS_FT_FI8
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250

Chain	Residue	Details
S	LYS13
B	SER47
S	LYS15
S	LYS119
N	LYS13
N	LYS15
N	LYS119

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
Q	TYR51
Q	TYR88
B	TYR51
B	TYR88

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
Q	LYS59
A	LYS64
B	LYS59
O	LYS27
O	LYS36
O	LYS64
A	LYS18
A	LYS23
A	LYS27
A	LYS36

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
Q	LYS77
B	LYS77

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
Q	LYS31
B	LYS31

site_id	SWS_FT_FI13
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
O	LYS37
Q	LYS91
B	LYS91

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
O	TYR41
A	TYR41

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P84228

Chain	Residue	Details
O	LYS56
O	LYS79
A	LYS56
A	LYS79

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
O	SER57
A	SER57

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
O	THR80
O	THR107
A	THR80
A	THR107

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P84243

Chain	Residue	Details
O	SER86
A	SER86

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
O	LYS115
A	LYS115

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
O	LYS122
A	LYS122

site_id	SWS_FT_FI21
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
O	CYS110
A	CYS110

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 525

Chain	Residue	Details
P	CYS304	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
P	GLU338	activator, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)