7VON
Native alpha-2-macroglobulin monomer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001553 | biological_process | luteinization |
| A | 0001869 | biological_process | negative regulation of complement activation, lectin pathway |
| A | 0002020 | molecular_function | protease binding |
| A | 0002438 | biological_process | acute inflammatory response to antigenic stimulus |
| A | 0004866 | molecular_function | endopeptidase inhibitor activity |
| A | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006953 | biological_process | acute-phase response |
| A | 0007584 | biological_process | response to nutrient |
| A | 0010037 | biological_process | response to carbon dioxide |
| A | 0019838 | molecular_function | growth factor binding |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0019959 | molecular_function | interleukin-8 binding |
| A | 0019966 | molecular_function | interleukin-1 binding |
| A | 0031093 | cellular_component | platelet alpha granule lumen |
| A | 0034695 | biological_process | response to prostaglandin E |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043120 | molecular_function | tumor necrosis factor binding |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048403 | molecular_function | brain-derived neurotrophic factor binding |
| A | 0048406 | molecular_function | nerve growth factor binding |
| A | 0048863 | biological_process | stem cell differentiation |
| A | 0051384 | biological_process | response to glucocorticoid |
| A | 0062023 | cellular_component | collagen-containing extracellular matrix |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072562 | cellular_component | blood microparticle |
| A | 1990402 | biological_process | embryonic liver development |
Functional Information from PROSITE/UniProt
| site_id | PS00430 |
| Number of Residues | 37 |
| Details | TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. gkpqymvlvpsllhtettekgcvllsyln......................................................................................ETVTVSAS |
| Chain | Residue | Details |
| A | GLY27-SER63 |
| site_id | PS00477 |
| Number of Residues | 9 |
| Details | ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PyGCGEQnM |
| Chain | Residue | Details |
| A | PRO969-MET977 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490 |
| Chain | Residue | Details |
| A | ASN55 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:6203908 |
| Chain | Residue | Details |
| A | ASN70 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:6203908 |
| Chain | Residue | Details |
| A | ASN247 | |
| A | ASN410 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6203908 |
| Chain | Residue | Details |
| A | ASN396 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| A | ASN869 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6203908 |
| Chain | Residue | Details |
| A | ASN991 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN1424 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | CROSSLNK: Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins) => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN693 | |
| A | GLN694 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln) => ECO:0000269|PubMed:6203908 |
| Chain | Residue | Details |
| A | CYS972 | |
| A | GLN975 |
