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7VIE

Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with S1P

Functional Information from GO Data
ChainGOidnamespacecontents
A0001750cellular_componentphotoreceptor outer segment
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0007265biological_processRas protein signal transduction
A0008283biological_processcell population proliferation
A0016020cellular_componentmembrane
A0030159molecular_functionsignaling receptor complex adaptor activity
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0050909biological_processsensory perception of taste
A0051020molecular_functionGTPase binding
A0060041biological_processretina development in camera-type eye
A0070062cellular_componentextracellular exosome
A0071380biological_processcellular response to prostaglandin E stimulus
A0071870biological_processcellular response to catecholamine stimulus
A0097381cellular_componentphotoreceptor disc membrane
A1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0045202cellular_componentsynapse
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
D0000287molecular_functionmagnesium ion binding
D0001664molecular_functionG protein-coupled receptor binding
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005765cellular_componentlysosomal membrane
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005834cellular_componentheterotrimeric G-protein complex
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005938cellular_componentcell cortex
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
D0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
D0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
D0010854molecular_functionadenylate cyclase regulator activity
D0016787molecular_functionhydrolase activity
D0019001molecular_functionguanyl nucleotide binding
D0019003molecular_functionGDP binding
D0030496cellular_componentmidbody
D0031683molecular_functionG-protein beta/gamma-subunit complex binding
D0031749molecular_functionD2 dopamine receptor binding
D0031821molecular_functionG protein-coupled serotonin receptor binding
D0034695biological_processresponse to prostaglandin E
D0043434biological_processresponse to peptide hormone
D0043949biological_processregulation of cAMP-mediated signaling
D0045542biological_processpositive regulation of cholesterol biosynthetic process
D0046872molecular_functionmetal ion binding
D0051301biological_processcell division
D0060236biological_processregulation of mitotic spindle organization
D0070062cellular_componentextracellular exosome
D0072678biological_processT cell migration
D1904322biological_processcellular response to forskolin
D1904778biological_processpositive regulation of protein localization to cell cortex
F0001525biological_processangiogenesis
F0001664molecular_functionG protein-coupled receptor binding
F0001955biological_processblood vessel maturation
F0003245biological_processcardiac muscle tissue growth involved in heart morphogenesis
F0003376biological_processsphingosine-1-phosphate receptor signaling pathway
F0004930molecular_functionG protein-coupled receptor activity
F0005515molecular_functionprotein binding
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005768cellular_componentendosome
F0005886cellular_componentplasma membrane
F0006935biological_processchemotaxis
F0007155biological_processcell adhesion
F0007186biological_processG protein-coupled receptor signaling pathway
F0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
F0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
F0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
F0007420biological_processbrain development
F0008283biological_processcell population proliferation
F0008284biological_processpositive regulation of cell population proliferation
F0009897cellular_componentexternal side of plasma membrane
F0016020cellular_componentmembrane
F0016477biological_processcell migration
F0019222biological_processregulation of metabolic process
F0019226biological_processtransmission of nerve impulse
F0030032biological_processlamellipodium assembly
F0030036biological_processactin cytoskeleton organization
F0030155biological_processregulation of cell adhesion
F0030182biological_processneuron differentiation
F0030335biological_processpositive regulation of cell migration
F0030500biological_processregulation of bone mineralization
F0030595biological_processleukocyte chemotaxis
F0038036molecular_functionsphingosine-1-phosphate receptor activity
F0043231cellular_componentintracellular membrane-bounded organelle
F0045121cellular_componentmembrane raft
F0045124biological_processregulation of bone resorption
F0045446biological_processendothelial cell differentiation
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0046625molecular_functionsphingolipid binding
F0048661biological_processpositive regulation of smooth muscle cell proliferation
F0050927biological_processpositive regulation of positive chemotaxis
F0051497biological_processnegative regulation of stress fiber assembly
F0061384biological_processheart trabecula morphogenesis
F0072678biological_processT cell migration
F0098793cellular_componentpresynapse
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfSLLAIAIERYItM
ChainResidueDetails
FALA130-MET146

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
ALEU69-SER83
AILE156-ILE170
ALEU284-ALA298

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
DGLU43
DASN269
FASN183-PRO196
FASP279-ILE289

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
ChainResidueDetails
DSER47
DTHR181

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q
ChainResidueDetails
DSER151
FALA139-LEU160
FTYR225-THR257
FTYR311-SER382

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
DLEU175

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:21115486
ChainResidueDetails
DASP200

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
DALA326

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
DARG178

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
DGLN204

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250
ChainResidueDetails
DCYS351

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805
ChainResidueDetails
DGLY2
FPHE265

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P10824
ChainResidueDetails
DCYS3

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:11583630
ChainResidueDetails
FTHR236

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08530
ChainResidueDetails
FSER351

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000255
ChainResidueDetails
FSER353

site_idSWS_FT_FI15
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
FCYS328

site_idSWS_FT_FI16
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15750791, ECO:0000269|PubMed:22344443
ChainResidueDetails
FASN30

site_idSWS_FT_FI17
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
FASN36

226707

PDB entries from 2024-10-30

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