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7VHP

Structural insights into the membrane microdomain organization by SPFH family proteins

Functional Information from GO Data
ChainGOidnamespacecontents
a0000166molecular_functionnucleotide binding
a0004176molecular_functionATP-dependent peptidase activity
a0004222molecular_functionmetalloendopeptidase activity
a0005515molecular_functionprotein binding
a0005524molecular_functionATP binding
a0005886cellular_componentplasma membrane
a0006508biological_processproteolysis
a0008233molecular_functionpeptidase activity
a0008237molecular_functionmetallopeptidase activity
a0008270molecular_functionzinc ion binding
a0016020cellular_componentmembrane
a0016787molecular_functionhydrolase activity
a0016887molecular_functionATP hydrolysis activity
a0030163biological_processprotein catabolic process
a0046872molecular_functionmetal ion binding
a0098796cellular_componentmembrane protein complex
A0000166molecular_functionnucleotide binding
A0004176molecular_functionATP-dependent peptidase activity
A0004222molecular_functionmetalloendopeptidase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0030163biological_processprotein catabolic process
A0046872molecular_functionmetal ion binding
A0098796cellular_componentmembrane protein complex
b0000166molecular_functionnucleotide binding
b0004176molecular_functionATP-dependent peptidase activity
b0004222molecular_functionmetalloendopeptidase activity
b0005515molecular_functionprotein binding
b0005524molecular_functionATP binding
b0005886cellular_componentplasma membrane
b0006508biological_processproteolysis
b0008233molecular_functionpeptidase activity
b0008237molecular_functionmetallopeptidase activity
b0008270molecular_functionzinc ion binding
b0016020cellular_componentmembrane
b0016787molecular_functionhydrolase activity
b0016887molecular_functionATP hydrolysis activity
b0030163biological_processprotein catabolic process
b0046872molecular_functionmetal ion binding
b0098796cellular_componentmembrane protein complex
B0000166molecular_functionnucleotide binding
B0004176molecular_functionATP-dependent peptidase activity
B0004222molecular_functionmetalloendopeptidase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0030163biological_processprotein catabolic process
B0046872molecular_functionmetal ion binding
B0098796cellular_componentmembrane protein complex
c0000166molecular_functionnucleotide binding
c0004176molecular_functionATP-dependent peptidase activity
c0004222molecular_functionmetalloendopeptidase activity
c0005515molecular_functionprotein binding
c0005524molecular_functionATP binding
c0005886cellular_componentplasma membrane
c0006508biological_processproteolysis
c0008233molecular_functionpeptidase activity
c0008237molecular_functionmetallopeptidase activity
c0008270molecular_functionzinc ion binding
c0016020cellular_componentmembrane
c0016787molecular_functionhydrolase activity
c0016887molecular_functionATP hydrolysis activity
c0030163biological_processprotein catabolic process
c0046872molecular_functionmetal ion binding
c0098796cellular_componentmembrane protein complex
C0000166molecular_functionnucleotide binding
C0004176molecular_functionATP-dependent peptidase activity
C0004222molecular_functionmetalloendopeptidase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0008233molecular_functionpeptidase activity
C0008237molecular_functionmetallopeptidase activity
C0008270molecular_functionzinc ion binding
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0030163biological_processprotein catabolic process
C0046872molecular_functionmetal ion binding
C0098796cellular_componentmembrane protein complex
d0000166molecular_functionnucleotide binding
d0004176molecular_functionATP-dependent peptidase activity
d0004222molecular_functionmetalloendopeptidase activity
d0005515molecular_functionprotein binding
d0005524molecular_functionATP binding
d0005886cellular_componentplasma membrane
d0006508biological_processproteolysis
d0008233molecular_functionpeptidase activity
d0008237molecular_functionmetallopeptidase activity
d0008270molecular_functionzinc ion binding
d0016020cellular_componentmembrane
d0016787molecular_functionhydrolase activity
d0016887molecular_functionATP hydrolysis activity
d0030163biological_processprotein catabolic process
d0046872molecular_functionmetal ion binding
d0098796cellular_componentmembrane protein complex
D0000166molecular_functionnucleotide binding
D0004176molecular_functionATP-dependent peptidase activity
D0004222molecular_functionmetalloendopeptidase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0006508biological_processproteolysis
D0008233molecular_functionpeptidase activity
D0008237molecular_functionmetallopeptidase activity
D0008270molecular_functionzinc ion binding
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0030163biological_processprotein catabolic process
D0046872molecular_functionmetal ion binding
D0098796cellular_componentmembrane protein complex
e0000166molecular_functionnucleotide binding
e0004176molecular_functionATP-dependent peptidase activity
e0004222molecular_functionmetalloendopeptidase activity
e0005515molecular_functionprotein binding
e0005524molecular_functionATP binding
e0005886cellular_componentplasma membrane
e0006508biological_processproteolysis
e0008233molecular_functionpeptidase activity
e0008237molecular_functionmetallopeptidase activity
e0008270molecular_functionzinc ion binding
e0016020cellular_componentmembrane
e0016787molecular_functionhydrolase activity
e0016887molecular_functionATP hydrolysis activity
e0030163biological_processprotein catabolic process
e0046872molecular_functionmetal ion binding
e0098796cellular_componentmembrane protein complex
E0005515molecular_functionprotein binding
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0009408biological_processresponse to heat
E0016020cellular_componentmembrane
E0098796cellular_componentmembrane protein complex
f0000166molecular_functionnucleotide binding
f0004176molecular_functionATP-dependent peptidase activity
f0004222molecular_functionmetalloendopeptidase activity
f0005515molecular_functionprotein binding
f0005524molecular_functionATP binding
f0005886cellular_componentplasma membrane
f0006508biological_processproteolysis
f0008233molecular_functionpeptidase activity
f0008237molecular_functionmetallopeptidase activity
f0008270molecular_functionzinc ion binding
f0016020cellular_componentmembrane
f0016787molecular_functionhydrolase activity
f0016887molecular_functionATP hydrolysis activity
f0030163biological_processprotein catabolic process
f0046872molecular_functionmetal ion binding
f0098796cellular_componentmembrane protein complex
F0005515molecular_functionprotein binding
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0009408biological_processresponse to heat
F0016020cellular_componentmembrane
F0098796cellular_componentmembrane protein complex
g0005515molecular_functionprotein binding
g0005829cellular_componentcytosol
g0005886cellular_componentplasma membrane
g0009408biological_processresponse to heat
g0016020cellular_componentmembrane
g0098796cellular_componentmembrane protein complex
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0009408biological_processresponse to heat
G0016020cellular_componentmembrane
G0052547biological_processregulation of peptidase activity
G0098796cellular_componentmembrane protein complex
G0098797cellular_componentplasma membrane protein complex
h0005515molecular_functionprotein binding
h0005829cellular_componentcytosol
h0005886cellular_componentplasma membrane
h0009408biological_processresponse to heat
h0016020cellular_componentmembrane
h0098796cellular_componentmembrane protein complex
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0009408biological_processresponse to heat
H0016020cellular_componentmembrane
H0052547biological_processregulation of peptidase activity
H0098796cellular_componentmembrane protein complex
H0098797cellular_componentplasma membrane protein complex
i0005515molecular_functionprotein binding
i0005829cellular_componentcytosol
i0005886cellular_componentplasma membrane
i0009408biological_processresponse to heat
i0016020cellular_componentmembrane
i0098796cellular_componentmembrane protein complex
I0005515molecular_functionprotein binding
I0005886cellular_componentplasma membrane
I0009408biological_processresponse to heat
I0016020cellular_componentmembrane
I0052547biological_processregulation of peptidase activity
I0098796cellular_componentmembrane protein complex
I0098797cellular_componentplasma membrane protein complex
j0005515molecular_functionprotein binding
j0005829cellular_componentcytosol
j0005886cellular_componentplasma membrane
j0009408biological_processresponse to heat
j0016020cellular_componentmembrane
j0098796cellular_componentmembrane protein complex
J0000166molecular_functionnucleotide binding
J0004176molecular_functionATP-dependent peptidase activity
J0004222molecular_functionmetalloendopeptidase activity
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005886cellular_componentplasma membrane
J0006508biological_processproteolysis
J0008233molecular_functionpeptidase activity
J0008237molecular_functionmetallopeptidase activity
J0008270molecular_functionzinc ion binding
J0016020cellular_componentmembrane
J0016787molecular_functionhydrolase activity
J0016887molecular_functionATP hydrolysis activity
J0030163biological_processprotein catabolic process
J0046872molecular_functionmetal ion binding
J0098796cellular_componentmembrane protein complex
k0005515molecular_functionprotein binding
k0005886cellular_componentplasma membrane
k0009408biological_processresponse to heat
k0016020cellular_componentmembrane
k0052547biological_processregulation of peptidase activity
k0098796cellular_componentmembrane protein complex
k0098797cellular_componentplasma membrane protein complex
K0000166molecular_functionnucleotide binding
K0004176molecular_functionATP-dependent peptidase activity
K0004222molecular_functionmetalloendopeptidase activity
K0005515molecular_functionprotein binding
K0005524molecular_functionATP binding
K0005886cellular_componentplasma membrane
K0006508biological_processproteolysis
K0008233molecular_functionpeptidase activity
K0008237molecular_functionmetallopeptidase activity
K0008270molecular_functionzinc ion binding
K0016020cellular_componentmembrane
K0016787molecular_functionhydrolase activity
K0016887molecular_functionATP hydrolysis activity
K0030163biological_processprotein catabolic process
K0046872molecular_functionmetal ion binding
K0098796cellular_componentmembrane protein complex
l0005515molecular_functionprotein binding
l0005886cellular_componentplasma membrane
l0009408biological_processresponse to heat
l0016020cellular_componentmembrane
l0052547biological_processregulation of peptidase activity
l0098796cellular_componentmembrane protein complex
l0098797cellular_componentplasma membrane protein complex
L0000166molecular_functionnucleotide binding
L0004176molecular_functionATP-dependent peptidase activity
L0004222molecular_functionmetalloendopeptidase activity
L0005515molecular_functionprotein binding
L0005524molecular_functionATP binding
L0005886cellular_componentplasma membrane
L0006508biological_processproteolysis
L0008233molecular_functionpeptidase activity
L0008237molecular_functionmetallopeptidase activity
L0008270molecular_functionzinc ion binding
L0016020cellular_componentmembrane
L0016787molecular_functionhydrolase activity
L0016887molecular_functionATP hydrolysis activity
L0030163biological_processprotein catabolic process
L0046872molecular_functionmetal ion binding
L0098796cellular_componentmembrane protein complex
m0005515molecular_functionprotein binding
m0005886cellular_componentplasma membrane
m0009408biological_processresponse to heat
m0016020cellular_componentmembrane
m0052547biological_processregulation of peptidase activity
m0098796cellular_componentmembrane protein complex
m0098797cellular_componentplasma membrane protein complex
M0000166molecular_functionnucleotide binding
M0004176molecular_functionATP-dependent peptidase activity
M0004222molecular_functionmetalloendopeptidase activity
M0005515molecular_functionprotein binding
M0005524molecular_functionATP binding
M0005886cellular_componentplasma membrane
M0006508biological_processproteolysis
M0008233molecular_functionpeptidase activity
M0008237molecular_functionmetallopeptidase activity
M0008270molecular_functionzinc ion binding
M0016020cellular_componentmembrane
M0016787molecular_functionhydrolase activity
M0016887molecular_functionATP hydrolysis activity
M0030163biological_processprotein catabolic process
M0046872molecular_functionmetal ion binding
M0098796cellular_componentmembrane protein complex
n0005515molecular_functionprotein binding
n0005886cellular_componentplasma membrane
n0009408biological_processresponse to heat
n0016020cellular_componentmembrane
n0052547biological_processregulation of peptidase activity
n0098796cellular_componentmembrane protein complex
n0098797cellular_componentplasma membrane protein complex
N0005515molecular_functionprotein binding
N0005829cellular_componentcytosol
N0005886cellular_componentplasma membrane
N0009408biological_processresponse to heat
N0016020cellular_componentmembrane
N0098796cellular_componentmembrane protein complex
o0005515molecular_functionprotein binding
o0005886cellular_componentplasma membrane
o0009408biological_processresponse to heat
o0016020cellular_componentmembrane
o0052547biological_processregulation of peptidase activity
o0098796cellular_componentmembrane protein complex
o0098797cellular_componentplasma membrane protein complex
O0005515molecular_functionprotein binding
O0005829cellular_componentcytosol
O0005886cellular_componentplasma membrane
O0009408biological_processresponse to heat
O0016020cellular_componentmembrane
O0098796cellular_componentmembrane protein complex
p0005515molecular_functionprotein binding
p0005886cellular_componentplasma membrane
p0009408biological_processresponse to heat
p0016020cellular_componentmembrane
p0052547biological_processregulation of peptidase activity
p0098796cellular_componentmembrane protein complex
p0098797cellular_componentplasma membrane protein complex
P0005515molecular_functionprotein binding
P0005886cellular_componentplasma membrane
P0009408biological_processresponse to heat
P0016020cellular_componentmembrane
P0052547biological_processregulation of peptidase activity
P0098796cellular_componentmembrane protein complex
P0098797cellular_componentplasma membrane protein complex
q0005515molecular_functionprotein binding
q0005829cellular_componentcytosol
q0005886cellular_componentplasma membrane
q0009408biological_processresponse to heat
q0016020cellular_componentmembrane
q0098796cellular_componentmembrane protein complex
Q0005515molecular_functionprotein binding
Q0005886cellular_componentplasma membrane
Q0009408biological_processresponse to heat
Q0016020cellular_componentmembrane
Q0052547biological_processregulation of peptidase activity
Q0098796cellular_componentmembrane protein complex
Q0098797cellular_componentplasma membrane protein complex
r0005515molecular_functionprotein binding
r0005829cellular_componentcytosol
r0005886cellular_componentplasma membrane
r0009408biological_processresponse to heat
r0016020cellular_componentmembrane
r0098796cellular_componentmembrane protein complex
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0009408biological_processresponse to heat
R0016020cellular_componentmembrane
R0052547biological_processregulation of peptidase activity
R0098796cellular_componentmembrane protein complex
R0098797cellular_componentplasma membrane protein complex
s0000166molecular_functionnucleotide binding
s0004176molecular_functionATP-dependent peptidase activity
s0004222molecular_functionmetalloendopeptidase activity
s0005515molecular_functionprotein binding
s0005524molecular_functionATP binding
s0005886cellular_componentplasma membrane
s0006508biological_processproteolysis
s0008233molecular_functionpeptidase activity
s0008237molecular_functionmetallopeptidase activity
s0008270molecular_functionzinc ion binding
s0016020cellular_componentmembrane
s0016787molecular_functionhydrolase activity
s0016887molecular_functionATP hydrolysis activity
s0030163biological_processprotein catabolic process
s0046872molecular_functionmetal ion binding
s0098796cellular_componentmembrane protein complex
S0005515molecular_functionprotein binding
S0005829cellular_componentcytosol
S0005886cellular_componentplasma membrane
S0009408biological_processresponse to heat
S0016020cellular_componentmembrane
S0098796cellular_componentmembrane protein complex
t0000166molecular_functionnucleotide binding
t0004176molecular_functionATP-dependent peptidase activity
t0004222molecular_functionmetalloendopeptidase activity
t0005515molecular_functionprotein binding
t0005524molecular_functionATP binding
t0005886cellular_componentplasma membrane
t0006508biological_processproteolysis
t0008233molecular_functionpeptidase activity
t0008237molecular_functionmetallopeptidase activity
t0008270molecular_functionzinc ion binding
t0016020cellular_componentmembrane
t0016787molecular_functionhydrolase activity
t0016887molecular_functionATP hydrolysis activity
t0030163biological_processprotein catabolic process
t0046872molecular_functionmetal ion binding
t0098796cellular_componentmembrane protein complex
T0000166molecular_functionnucleotide binding
T0004176molecular_functionATP-dependent peptidase activity
T0004222molecular_functionmetalloendopeptidase activity
T0005515molecular_functionprotein binding
T0005524molecular_functionATP binding
T0005886cellular_componentplasma membrane
T0006508biological_processproteolysis
T0008233molecular_functionpeptidase activity
T0008237molecular_functionmetallopeptidase activity
T0008270molecular_functionzinc ion binding
T0016020cellular_componentmembrane
T0016787molecular_functionhydrolase activity
T0016887molecular_functionATP hydrolysis activity
T0030163biological_processprotein catabolic process
T0046872molecular_functionmetal ion binding
T0098796cellular_componentmembrane protein complex
u0000166molecular_functionnucleotide binding
u0004176molecular_functionATP-dependent peptidase activity
u0004222molecular_functionmetalloendopeptidase activity
u0005515molecular_functionprotein binding
u0005524molecular_functionATP binding
u0005886cellular_componentplasma membrane
u0006508biological_processproteolysis
u0008233molecular_functionpeptidase activity
u0008237molecular_functionmetallopeptidase activity
u0008270molecular_functionzinc ion binding
u0016020cellular_componentmembrane
u0016787molecular_functionhydrolase activity
u0016887molecular_functionATP hydrolysis activity
u0030163biological_processprotein catabolic process
u0046872molecular_functionmetal ion binding
u0098796cellular_componentmembrane protein complex
U0005515molecular_functionprotein binding
U0005829cellular_componentcytosol
U0005886cellular_componentplasma membrane
U0009408biological_processresponse to heat
U0016020cellular_componentmembrane
U0098796cellular_componentmembrane protein complex
v0000166molecular_functionnucleotide binding
v0004176molecular_functionATP-dependent peptidase activity
v0004222molecular_functionmetalloendopeptidase activity
v0005515molecular_functionprotein binding
v0005524molecular_functionATP binding
v0005886cellular_componentplasma membrane
v0006508biological_processproteolysis
v0008233molecular_functionpeptidase activity
v0008237molecular_functionmetallopeptidase activity
v0008270molecular_functionzinc ion binding
v0016020cellular_componentmembrane
v0016787molecular_functionhydrolase activity
v0016887molecular_functionATP hydrolysis activity
v0030163biological_processprotein catabolic process
v0046872molecular_functionmetal ion binding
v0098796cellular_componentmembrane protein complex
V0000166molecular_functionnucleotide binding
V0004176molecular_functionATP-dependent peptidase activity
V0004222molecular_functionmetalloendopeptidase activity
V0005515molecular_functionprotein binding
V0005524molecular_functionATP binding
V0005886cellular_componentplasma membrane
V0006508biological_processproteolysis
V0008233molecular_functionpeptidase activity
V0008237molecular_functionmetallopeptidase activity
V0008270molecular_functionzinc ion binding
V0016020cellular_componentmembrane
V0016787molecular_functionhydrolase activity
V0016887molecular_functionATP hydrolysis activity
V0030163biological_processprotein catabolic process
V0046872molecular_functionmetal ion binding
V0098796cellular_componentmembrane protein complex
W0000166molecular_functionnucleotide binding
W0004176molecular_functionATP-dependent peptidase activity
W0004222molecular_functionmetalloendopeptidase activity
W0005515molecular_functionprotein binding
W0005524molecular_functionATP binding
W0005886cellular_componentplasma membrane
W0006508biological_processproteolysis
W0008233molecular_functionpeptidase activity
W0008237molecular_functionmetallopeptidase activity
W0008270molecular_functionzinc ion binding
W0016020cellular_componentmembrane
W0016787molecular_functionhydrolase activity
W0016887molecular_functionATP hydrolysis activity
W0030163biological_processprotein catabolic process
W0046872molecular_functionmetal ion binding
W0098796cellular_componentmembrane protein complex
X0000166molecular_functionnucleotide binding
X0004176molecular_functionATP-dependent peptidase activity
X0004222molecular_functionmetalloendopeptidase activity
X0005515molecular_functionprotein binding
X0005524molecular_functionATP binding
X0005886cellular_componentplasma membrane
X0006508biological_processproteolysis
X0008233molecular_functionpeptidase activity
X0008237molecular_functionmetallopeptidase activity
X0008270molecular_functionzinc ion binding
X0016020cellular_componentmembrane
X0016787molecular_functionhydrolase activity
X0016887molecular_functionATP hydrolysis activity
X0030163biological_processprotein catabolic process
X0046872molecular_functionmetal ion binding
X0098796cellular_componentmembrane protein complex
Y0000166molecular_functionnucleotide binding
Y0004176molecular_functionATP-dependent peptidase activity
Y0004222molecular_functionmetalloendopeptidase activity
Y0005515molecular_functionprotein binding
Y0005524molecular_functionATP binding
Y0005886cellular_componentplasma membrane
Y0006508biological_processproteolysis
Y0008233molecular_functionpeptidase activity
Y0008237molecular_functionmetallopeptidase activity
Y0008270molecular_functionzinc ion binding
Y0016020cellular_componentmembrane
Y0016787molecular_functionhydrolase activity
Y0016887molecular_functionATP hydrolysis activity
Y0030163biological_processprotein catabolic process
Y0046872molecular_functionmetal ion binding
Y0098796cellular_componentmembrane protein complex
Z0000166molecular_functionnucleotide binding
Z0004176molecular_functionATP-dependent peptidase activity
Z0004222molecular_functionmetalloendopeptidase activity
Z0005515molecular_functionprotein binding
Z0005524molecular_functionATP binding
Z0005886cellular_componentplasma membrane
Z0006508biological_processproteolysis
Z0008233molecular_functionpeptidase activity
Z0008237molecular_functionmetallopeptidase activity
Z0008270molecular_functionzinc ion binding
Z0016020cellular_componentmembrane
Z0016787molecular_functionhydrolase activity
Z0016887molecular_functionATP hydrolysis activity
Z0030163biological_processprotein catabolic process
Z0046872molecular_functionmetal ion binding
Z0098796cellular_componentmembrane protein complex
Functional Information from PROSITE/UniProt
site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. IiVIaATNrpdvLDpALl.R
ChainResidueDetails
AILE291-ARG309

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues480
DetailsTransmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues12
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"9159109","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

248636

PDB entries from 2026-02-04

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