Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7VFV

Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001540	molecular_function	amyloid-beta binding
A	0005216	molecular_function	monoatomic ion channel activity
A	0005245	molecular_function	voltage-gated calcium channel activity
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0005891	cellular_component	voltage-gated calcium channel complex
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0007268	biological_process	chemical synaptic transmission
A	0008331	molecular_function	high voltage-gated calcium channel activity
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0043025	cellular_component	neuronal cell body
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0098703	biological_process	calcium ion import across plasma membrane
A	1903235	biological_process	positive regulation of calcium ion-dependent exocytosis of neurotransmitter
A	1904645	biological_process	response to amyloid-beta
D	0005245	molecular_function	voltage-gated calcium channel activity
D	0005246	molecular_function	calcium channel regulator activity
D	0005262	molecular_function	calcium channel activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0005891	cellular_component	voltage-gated calcium channel complex
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0007268	biological_process	chemical synaptic transmission
D	0008331	molecular_function	high voltage-gated calcium channel activity
D	0030315	cellular_component	T-tubule
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034702	cellular_component	monoatomic ion channel complex
D	0042383	cellular_component	sarcolemma
D	0045202	cellular_component	synapse
D	0045933	biological_process	positive regulation of muscle contraction
D	0070588	biological_process	calcium ion transmembrane transport
D	1902514	biological_process	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
D	1904646	biological_process	cellular response to amyloid-beta

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	345
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	102
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	12
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	277
Details	Repeat: {"description":"I"}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	244
Details	Repeat: {"description":"II"}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	255
Details	Repeat: {"description":"IV"}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	17
Details	Region: {"description":"Binding to the beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	4
Details	Site: {"description":"Calcium ion selectivity and permeability","evidences":[{"source":"UniProtKB","id":"P15381","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O55017","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	11
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	177
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	4
Details	Motif: {"description":"MIDAS-like motif"}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P54290","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)