7VF2
Human m6A-METTL associated complex (WTAP, VIRMA, ZC3H13, and HAKAI)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008380 | biological_process | RNA splicing |
| A | 0016556 | biological_process | mRNA modification |
| A | 0016604 | cellular_component | nuclear body |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0036396 | cellular_component | RNA N6-methyladenosine methyltransferase complex |
| C | 0000381 | biological_process | regulation of alternative mRNA splicing, via spliceosome |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006397 | biological_process | mRNA processing |
| C | 0008380 | biological_process | RNA splicing |
| C | 0016556 | biological_process | mRNA modification |
| C | 0016607 | cellular_component | nuclear speck |
| C | 0031965 | cellular_component | nuclear membrane |
| C | 0036396 | cellular_component | RNA N6-methyladenosine methyltransferase complex |
| C | 0042802 | molecular_function | identical protein binding |
| D | 0000381 | biological_process | regulation of alternative mRNA splicing, via spliceosome |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006397 | biological_process | mRNA processing |
| D | 0008380 | biological_process | RNA splicing |
| D | 0016556 | biological_process | mRNA modification |
| D | 0016607 | cellular_component | nuclear speck |
| D | 0031965 | cellular_component | nuclear membrane |
| D | 0036396 | cellular_component | RNA N6-methyladenosine methyltransferase complex |
| D | 0042802 | molecular_function | identical protein binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000269|Ref.7, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| C | MET1 | |
| D | MET1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER14 | |
| D | SER14 | |
| B | SER1465 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER305 | |
| D | SER305 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| C | SER306 | |
| D | SER306 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9ER69 |
| Chain | Residue | Details |
| C | SER341 | |
| D | SER341 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ER69 |
| Chain | Residue | Details |
| C | THR350 | |
| D | THR350 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| C | SER388 | |
| D | SER388 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER1386 | |
| B | SER1406 | |
| B | SER1409 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | THR1708 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| A | ARG1723 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Omega-N-methylarginine; alternate => ECO:0000250|UniProtKB:A2AIV2 |
| Chain | Residue | Details |
| A | ARG1741 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | MOD_RES: Asymmetric dimethylarginine => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| A | ARG1773 | |
| A | ARG1775 | |
| A | ARG1793 |
