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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7VDD

Human TOM complex with cross-linking

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005742cellular_componentmitochondrial outer membrane translocase complex
A0015031biological_processprotein transport
A0045040biological_processprotein insertion into mitochondrial outer membrane
A0140596cellular_componentTOM complex
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005742cellular_componentmitochondrial outer membrane translocase complex
B0005743cellular_componentmitochondrial inner membrane
B0005829cellular_componentcytosol
B0006626biological_processprotein targeting to mitochondrion
B0006811biological_processmonoatomic ion transport
B0008320molecular_functionprotein transmembrane transporter activity
B0015031biological_processprotein transport
B0015288molecular_functionporin activity
B0016020cellular_componentmembrane
B0030150biological_processprotein import into mitochondrial matrix
B0044233cellular_componentmitochondria-associated endoplasmic reticulum membrane contact site
B0045040biological_processprotein insertion into mitochondrial outer membrane
B0046930cellular_componentpore complex
B0055085biological_processtransmembrane transport
B0140596cellular_componentTOM complex
C0005515molecular_functionprotein binding
C0005739cellular_componentmitochondrion
C0005741cellular_componentmitochondrial outer membrane
C0005742cellular_componentmitochondrial outer membrane translocase complex
C0006626biological_processprotein targeting to mitochondrion
C0006886biological_processintracellular protein transport
C0008320molecular_functionprotein transmembrane transporter activity
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0030150biological_processprotein import into mitochondrial matrix
C0030943molecular_functionmitochondrion targeting sequence binding
C0045040biological_processprotein insertion into mitochondrial outer membrane
C0140596cellular_componentTOM complex
D0005739cellular_componentmitochondrion
D0005741cellular_componentmitochondrial outer membrane
D0005742cellular_componentmitochondrial outer membrane translocase complex
D0006626biological_processprotein targeting to mitochondrion
D0015031biological_processprotein transport
D0045040biological_processprotein insertion into mitochondrial outer membrane
D0140596cellular_componentTOM complex
E0005739cellular_componentmitochondrion
E0005741cellular_componentmitochondrial outer membrane
E0005742cellular_componentmitochondrial outer membrane translocase complex
E0006626biological_processprotein targeting to mitochondrion
E0015031biological_processprotein transport
E0045040biological_processprotein insertion into mitochondrial outer membrane
E0140596cellular_componentTOM complex
F0005515molecular_functionprotein binding
F0005739cellular_componentmitochondrion
F0005741cellular_componentmitochondrial outer membrane
F0005742cellular_componentmitochondrial outer membrane translocase complex
F0015031biological_processprotein transport
F0045040biological_processprotein insertion into mitochondrial outer membrane
F0140596cellular_componentTOM complex
G0005515molecular_functionprotein binding
G0005739cellular_componentmitochondrion
G0005741cellular_componentmitochondrial outer membrane
G0005742cellular_componentmitochondrial outer membrane translocase complex
G0008320molecular_functionprotein transmembrane transporter activity
G0015031biological_processprotein transport
G0030150biological_processprotein import into mitochondrial matrix
G0031647biological_processregulation of protein stability
G0045040biological_processprotein insertion into mitochondrial outer membrane
G0140596cellular_componentTOM complex
G1903955biological_processpositive regulation of protein targeting to mitochondrion
G1905091biological_processpositive regulation of type 2 mitophagy
H0005515molecular_functionprotein binding
H0005739cellular_componentmitochondrion
H0005741cellular_componentmitochondrial outer membrane
H0005742cellular_componentmitochondrial outer membrane translocase complex
H0006626biological_processprotein targeting to mitochondrion
H0006886biological_processintracellular protein transport
H0008320molecular_functionprotein transmembrane transporter activity
H0015031biological_processprotein transport
H0016020cellular_componentmembrane
H0030150biological_processprotein import into mitochondrial matrix
H0030943molecular_functionmitochondrion targeting sequence binding
H0045040biological_processprotein insertion into mitochondrial outer membrane
H0140596cellular_componentTOM complex
I0005515molecular_functionprotein binding
I0005739cellular_componentmitochondrion
I0005741cellular_componentmitochondrial outer membrane
I0005742cellular_componentmitochondrial outer membrane translocase complex
I0005743cellular_componentmitochondrial inner membrane
I0005829cellular_componentcytosol
I0006626biological_processprotein targeting to mitochondrion
I0006811biological_processmonoatomic ion transport
I0008320molecular_functionprotein transmembrane transporter activity
I0015031biological_processprotein transport
I0015288molecular_functionporin activity
I0016020cellular_componentmembrane
I0030150biological_processprotein import into mitochondrial matrix
I0044233cellular_componentmitochondria-associated endoplasmic reticulum membrane contact site
I0045040biological_processprotein insertion into mitochondrial outer membrane
I0046930cellular_componentpore complex
I0055085biological_processtransmembrane transport
I0140596cellular_componentTOM complex
J0005515molecular_functionprotein binding
J0005739cellular_componentmitochondrion
J0005741cellular_componentmitochondrial outer membrane
J0005742cellular_componentmitochondrial outer membrane translocase complex
J0008320molecular_functionprotein transmembrane transporter activity
J0015031biological_processprotein transport
J0030150biological_processprotein import into mitochondrial matrix
J0031647biological_processregulation of protein stability
J0045040biological_processprotein insertion into mitochondrial outer membrane
J0140596cellular_componentTOM complex
J1903955biological_processpositive regulation of protein targeting to mitochondrion
J1905091biological_processpositive regulation of type 2 mitophagy
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues104
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues18
DetailsRegion: {"description":"Import sequence; necessary for mitochondrion outer membrane localization and integration in the TOM complex","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues40
DetailsRegion: {"description":"TMD; necessary for mitochondrion outer membrane localization and integration in the TOM complex","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CPQ3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues38
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"12198123","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues36
DetailsTopological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"12198123","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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