Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7VCQ

structure of viral protein BKRF4 in complex with H3.3-H4-ASF1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
B	0000781	cellular_component	chromosome, telomeric region
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0016020	cellular_component	membrane
B	0030527	molecular_function	structural constituent of chromatin
B	0032200	biological_process	telomere organization
B	0032991	cellular_component	protein-containing complex
B	0043505	cellular_component	CENP-A containing nucleosome
B	0045653	biological_process	negative regulation of megakaryocyte differentiation
B	0046982	molecular_function	protein heterodimerization activity
B	0061644	biological_process	protein localization to CENP-A containing chromatin
B	0070062	cellular_component	extracellular exosome
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity
D	0005634	cellular_component	nucleus
D	0006325	biological_process	chromatin organization
E	0000781	cellular_component	chromosome, telomeric region
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0016020	cellular_component	membrane
E	0030527	molecular_function	structural constituent of chromatin
E	0032200	biological_process	telomere organization
E	0032991	cellular_component	protein-containing complex
E	0043505	cellular_component	CENP-A containing nucleosome
E	0045653	biological_process	negative regulation of megakaryocyte differentiation
E	0046982	molecular_function	protein heterodimerization activity
E	0061644	biological_process	protein localization to CENP-A containing chromatin
E	0070062	cellular_component	extracellular exosome
F	0005634	cellular_component	nucleus
F	0006325	biological_process	chromatin organization
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000781	cellular_component	chromosome, telomeric region
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0006325	biological_process	chromatin organization
H	0006334	biological_process	nucleosome assembly
H	0016020	cellular_component	membrane
H	0030527	molecular_function	structural constituent of chromatin
H	0032200	biological_process	telomere organization
H	0032991	cellular_component	protein-containing complex
H	0043505	cellular_component	CENP-A containing nucleosome
H	0045653	biological_process	negative regulation of megakaryocyte differentiation
H	0046982	molecular_function	protein heterodimerization activity
H	0061644	biological_process	protein localization to CENP-A containing chromatin
H	0070062	cellular_component	extracellular exosome
I	0005634	cellular_component	nucleus
I	0006325	biological_process	chromatin organization

Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	DNA_BIND:

Chain	Residue	Details
B	LYS16-LYS20
E	LYS16-LYS20
H	LYS16-LYS20

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:17967882

Chain	Residue	Details
B	SER1
E	SER1
H	SER1

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate => ECO:0000250\|UniProtKB:P62806

Chain	Residue	Details
B	ARG3
E	ARG3
H	ARG3

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: N6-lactoyllysine; alternate => ECO:0000269\|PubMed:31645732

Chain	Residue	Details
B	LYS5
E	LYS5
H	LYS5

site_id	SWS_FT_FI5
Number of Residues	9
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000269\|PubMed:17267393

Chain	Residue	Details
B	LYS8
B	LYS16
B	LYS44
E	LYS8
E	LYS16
E	LYS44
H	LYS8
H	LYS16
H	LYS44

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
B	LYS12
H	LYS31
H	LYS77
H	LYS91
B	LYS31
B	LYS77
B	LYS91
E	LYS12
E	LYS31
E	LYS77
E	LYS91
H	LYS12

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269\|PubMed:12086618, ECO:0000269\|PubMed:15964846, ECO:0000269\|PubMed:17967882, ECO:0000269\|PubMed:27338793

Chain	Residue	Details
B	LYS20
E	LYS20
H	LYS20

site_id	SWS_FT_FI8
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PAK2 => ECO:0000269\|PubMed:21724829, ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
B	SER47
E	SER47
H	SER47

site_id	SWS_FT_FI9
Number of Residues	3
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:15592455, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
B	TYR51
E	TYR51
H	TYR51

site_id	SWS_FT_FI10
Number of Residues	3
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000269\|PubMed:31542297

Chain	Residue	Details
B	LYS59
E	LYS59
H	LYS59

site_id	SWS_FT_FI11
Number of Residues	3
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P62806

Chain	Residue	Details
B	LYS79
E	LYS79
H	LYS79

site_id	SWS_FT_FI12
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P62806

Chain	Residue	Details
B	THR80
E	THR80
H	THR80

site_id	SWS_FT_FI13
Number of Residues	3
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
B	TYR88
E	TYR88
H	TYR88

site_id	SWS_FT_FI14
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:25218447

Chain	Residue	Details
B	LYS12
E	LYS12
H	LYS12

site_id	SWS_FT_FI15
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269\|PubMed:19818714

Chain	Residue	Details
B	LYS91
E	LYS91
H	LYS91

site_id	SWS_FT_FI16
Number of Residues	9
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
B	LYS20
B	LYS59
B	LYS79
E	LYS20
E	LYS59
E	LYS79
H	LYS20
H	LYS59
H	LYS79

site_id	SWS_FT_FI17
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000269\|PubMed:30886146

Chain	Residue	Details
B	LYS31
E	LYS31
H	LYS31

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)