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7V7C

CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001650cellular_componentfibrillar center
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0008180cellular_componentCOP9 signalosome
A0016567biological_processprotein ubiquitination
A0030183biological_processB cell differentiation
A0030331molecular_functionnuclear estrogen receptor binding
A0033151biological_processV(D)J recombination
A0035212biological_processcell competition in a multicellular organism
A0043687biological_processpost-translational protein modification
A0045732biological_processpositive regulation of protein catabolic process
A0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
A0106310molecular_functionprotein serine kinase activity
A1990244molecular_functionhistone H2AT120 kinase activity
A1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
B0000781cellular_componentchromosome, telomeric region
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0006281biological_processDNA repair
B0006289biological_processnucleotide-excision repair
B0006511biological_processubiquitin-dependent protein catabolic process
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0007056biological_processspindle assembly involved in female meiosis
B0010498biological_processproteasomal protein catabolic process
B0016055biological_processWnt signaling pathway
B0016567biological_processprotein ubiquitination
B0019076biological_processviral release from host cell
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
B0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
B0032991cellular_componentprotein-containing complex
B0034644biological_processcellular response to UV
B0035234biological_processectopic germ cell programmed cell death
B0035861cellular_componentsite of double-strand break
B0042752biological_processregulation of circadian rhythm
B0043066biological_processnegative regulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0044725biological_processepigenetic programming in the zygotic pronuclei
B0044877molecular_functionprotein-containing complex binding
B0045070biological_processpositive regulation of viral genome replication
B0045722biological_processpositive regulation of gluconeogenesis
B0045732biological_processpositive regulation of protein catabolic process
B0046726biological_processpositive regulation by virus of viral protein levels in host cell
B0048511biological_processrhythmic process
B0051093biological_processnegative regulation of developmental process
B0051702biological_processbiological process involved in interaction with symbiont
B0070062cellular_componentextracellular exosome
B0070914biological_processUV-damage excision repair
B0071987molecular_functionWD40-repeat domain binding
B0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
B0097602molecular_functioncullin family protein binding
B0160072molecular_functionubiquitin ligase complex scaffold activity
B1901990biological_processregulation of mitotic cell cycle phase transition
B2000242biological_processnegative regulation of reproductive process
C0005515molecular_functionprotein binding
C0006351biological_processDNA-templated transcription
C0006355biological_processregulation of DNA-templated transcription
C0006811biological_processmonoatomic ion transport
C0006915biological_processapoptotic process
C0019058biological_processviral life cycle
C0034220biological_processmonoatomic ion transmembrane transport
C0039592biological_processsymbiont-mediated arrest of host cell cycle during G2/M transition
C0042025cellular_componenthost cell nucleus
C0043655cellular_componenthost extracellular space
C0043657cellular_componenthost cell
C0044423cellular_componentvirion component
C0046718biological_processsymbiont entry into host cell
C0051260biological_processprotein homooligomerization
C0075732biological_processviral penetration into host nucleus
D0004844molecular_functionuracil DNA N-glycosylase activity
D0006281biological_processDNA repair
D0006284biological_processbase-excision repair
D0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0001650cellular_componentfibrillar center
E0004674molecular_functionprotein serine/threonine kinase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0006325biological_processchromatin organization
E0006338biological_processchromatin remodeling
E0008180cellular_componentCOP9 signalosome
E0016567biological_processprotein ubiquitination
E0030183biological_processB cell differentiation
E0030331molecular_functionnuclear estrogen receptor binding
E0033151biological_processV(D)J recombination
E0035212biological_processcell competition in a multicellular organism
E0043687biological_processpost-translational protein modification
E0045732biological_processpositive regulation of protein catabolic process
E0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
E0106310molecular_functionprotein serine kinase activity
E1990244molecular_functionhistone H2AT120 kinase activity
E1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
F0000781cellular_componentchromosome, telomeric region
F0003676molecular_functionnucleic acid binding
F0003677molecular_functionDNA binding
F0003684molecular_functiondamaged DNA binding
F0005515molecular_functionprotein binding
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0006281biological_processDNA repair
F0006289biological_processnucleotide-excision repair
F0006511biological_processubiquitin-dependent protein catabolic process
F0006915biological_processapoptotic process
F0006974biological_processDNA damage response
F0007056biological_processspindle assembly involved in female meiosis
F0010498biological_processproteasomal protein catabolic process
F0016055biological_processWnt signaling pathway
F0016567biological_processprotein ubiquitination
F0019076biological_processviral release from host cell
F0030674molecular_functionprotein-macromolecule adaptor activity
F0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
F0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
F0032991cellular_componentprotein-containing complex
F0034644biological_processcellular response to UV
F0035234biological_processectopic germ cell programmed cell death
F0035861cellular_componentsite of double-strand break
F0042752biological_processregulation of circadian rhythm
F0043066biological_processnegative regulation of apoptotic process
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0044725biological_processepigenetic programming in the zygotic pronuclei
F0044877molecular_functionprotein-containing complex binding
F0045070biological_processpositive regulation of viral genome replication
F0045722biological_processpositive regulation of gluconeogenesis
F0045732biological_processpositive regulation of protein catabolic process
F0046726biological_processpositive regulation by virus of viral protein levels in host cell
F0048511biological_processrhythmic process
F0051093biological_processnegative regulation of developmental process
F0051702biological_processbiological process involved in interaction with symbiont
F0070062cellular_componentextracellular exosome
F0070914biological_processUV-damage excision repair
F0071987molecular_functionWD40-repeat domain binding
F0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
F0097602molecular_functioncullin family protein binding
F0160072molecular_functionubiquitin ligase complex scaffold activity
F1901990biological_processregulation of mitotic cell cycle phase transition
F2000242biological_processnegative regulation of reproductive process
G0005515molecular_functionprotein binding
G0006351biological_processDNA-templated transcription
G0006355biological_processregulation of DNA-templated transcription
G0006811biological_processmonoatomic ion transport
G0006915biological_processapoptotic process
G0019058biological_processviral life cycle
G0034220biological_processmonoatomic ion transmembrane transport
G0039592biological_processsymbiont-mediated arrest of host cell cycle during G2/M transition
G0042025cellular_componenthost cell nucleus
G0043655cellular_componenthost extracellular space
G0043657cellular_componenthost cell
G0044423cellular_componentvirion component
G0046718biological_processsymbiont entry into host cell
G0051260biological_processprotein homooligomerization
G0075732biological_processviral penetration into host nucleus
H0004844molecular_functionuracil DNA N-glycosylase activity
H0006281biological_processDNA repair
H0006284biological_processbase-excision repair
H0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
Functional Information from PROSITE/UniProt
site_idPS00130
Number of Residues10
DetailsU_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. KVVIlGQDPY
ChainResidueDetails
DLYS147-TYR156

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsMOD_RES: Phosphoserine; by host => ECO:0000255|HAMAP-Rule:MF_04080
ChainResidueDetails
CSER79
CSER94
CSER96
GSER79
GSER94
GSER96

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
DLYS295
HLYS295
ASER1328
ESER255
ESER828
ESER1328

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ESW0
ChainResidueDetails
BTHR1125
FTHR1125

site_idSWS_FT_FI4
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS1121
ETHR888
FLYS1121

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER895
ESER895

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER898
ESER898

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER979
ESER979

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER1000
ESER1000

220113

PDB entries from 2024-05-22

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