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7V7B

CryoEM structure of DDB1-VprBP complex in ARM-up conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001650cellular_componentfibrillar center
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0008180cellular_componentCOP9 signalosome
A0016567biological_processprotein ubiquitination
A0030183biological_processB cell differentiation
A0030331molecular_functionnuclear estrogen receptor binding
A0033151biological_processV(D)J recombination
A0035212biological_processcell competition in a multicellular organism
A0043687biological_processpost-translational protein modification
A0045732biological_processpositive regulation of protein catabolic process
A0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
A0106310molecular_functionprotein serine kinase activity
A1990244molecular_functionhistone H2AT120 kinase activity
A1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
B0000781cellular_componentchromosome, telomeric region
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0006281biological_processDNA repair
B0006289biological_processnucleotide-excision repair
B0006511biological_processubiquitin-dependent protein catabolic process
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0007056biological_processspindle assembly involved in female meiosis
B0010498biological_processproteasomal protein catabolic process
B0016055biological_processWnt signaling pathway
B0016567biological_processprotein ubiquitination
B0019076biological_processviral release from host cell
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
B0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
B0032991cellular_componentprotein-containing complex
B0034644biological_processcellular response to UV
B0035234biological_processectopic germ cell programmed cell death
B0035861cellular_componentsite of double-strand break
B0042752biological_processregulation of circadian rhythm
B0043066biological_processnegative regulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0044725biological_processepigenetic programming in the zygotic pronuclei
B0044877molecular_functionprotein-containing complex binding
B0045070biological_processpositive regulation of viral genome replication
B0045722biological_processpositive regulation of gluconeogenesis
B0045732biological_processpositive regulation of protein catabolic process
B0046726biological_processpositive regulation by virus of viral protein levels in host cell
B0048511biological_processrhythmic process
B0051093biological_processnegative regulation of developmental process
B0051702biological_processbiological process involved in interaction with symbiont
B0070062cellular_componentextracellular exosome
B0070914biological_processUV-damage excision repair
B0071987molecular_functionWD40-repeat domain binding
B0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
B0097602molecular_functioncullin family protein binding
B0160072molecular_functionubiquitin ligase complex scaffold activity
B1901990biological_processregulation of mitotic cell cycle phase transition
B2000242biological_processnegative regulation of reproductive process
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001650cellular_componentfibrillar center
C0004674molecular_functionprotein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0006325biological_processchromatin organization
C0006338biological_processchromatin remodeling
C0008180cellular_componentCOP9 signalosome
C0016567biological_processprotein ubiquitination
C0030183biological_processB cell differentiation
C0030331molecular_functionnuclear estrogen receptor binding
C0033151biological_processV(D)J recombination
C0035212biological_processcell competition in a multicellular organism
C0043687biological_processpost-translational protein modification
C0045732biological_processpositive regulation of protein catabolic process
C0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
C0106310molecular_functionprotein serine kinase activity
C1990244molecular_functionhistone H2AT120 kinase activity
C1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
D0000781cellular_componentchromosome, telomeric region
D0003676molecular_functionnucleic acid binding
D0003677molecular_functionDNA binding
D0003684molecular_functiondamaged DNA binding
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0006281biological_processDNA repair
D0006289biological_processnucleotide-excision repair
D0006511biological_processubiquitin-dependent protein catabolic process
D0006915biological_processapoptotic process
D0006974biological_processDNA damage response
D0007056biological_processspindle assembly involved in female meiosis
D0010498biological_processproteasomal protein catabolic process
D0016055biological_processWnt signaling pathway
D0016567biological_processprotein ubiquitination
D0019076biological_processviral release from host cell
D0030674molecular_functionprotein-macromolecule adaptor activity
D0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
D0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
D0032991cellular_componentprotein-containing complex
D0034644biological_processcellular response to UV
D0035234biological_processectopic germ cell programmed cell death
D0035861cellular_componentsite of double-strand break
D0042752biological_processregulation of circadian rhythm
D0043066biological_processnegative regulation of apoptotic process
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0044725biological_processepigenetic programming in the zygotic pronuclei
D0044877molecular_functionprotein-containing complex binding
D0045070biological_processpositive regulation of viral genome replication
D0045722biological_processpositive regulation of gluconeogenesis
D0045732biological_processpositive regulation of protein catabolic process
D0046726biological_processpositive regulation by virus of viral protein levels in host cell
D0048511biological_processrhythmic process
D0051093biological_processnegative regulation of developmental process
D0051702biological_processbiological process involved in interaction with symbiont
D0070062cellular_componentextracellular exosome
D0070914biological_processUV-damage excision repair
D0071987molecular_functionWD40-repeat domain binding
D0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
D0097602molecular_functioncullin family protein binding
D0160072molecular_functionubiquitin ligase complex scaffold activity
D1901990biological_processregulation of mitotic cell cycle phase transition
D2000242biological_processnegative regulation of reproductive process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330
ChainResidueDetails
BSER2
DSER2

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS1067
DLYS1067
ASER1328
CSER255
CSER828
CSER1328

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ESW0
ChainResidueDetails
BTHR1125
DTHR1125

site_idSWS_FT_FI4
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS1121
CTHR888
DLYS1121

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER895
CSER895

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER898
CSER898

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER979
CSER979

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER1000
CSER1000

220113

PDB entries from 2024-05-22

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