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7V4C

Heparin-induced alpha-synuclein fibrils polymorph 4

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000149molecular_functionSNARE binding
A0000287molecular_functionmagnesium ion binding
A0000976molecular_functiontranscription cis-regulatory region binding
A0001774biological_processmicroglial cell activation
A0001921biological_processpositive regulation of receptor recycling
A0001956biological_processpositive regulation of neurotransmitter secretion
A0001963biological_processsynaptic transmission, dopaminergic
A0003779molecular_functionactin binding
A0004857molecular_functionenzyme inhibitor activity
A0004860molecular_functionprotein kinase inhibitor activity
A0004869molecular_functioncysteine-type endopeptidase inhibitor activity
A0005504molecular_functionfatty acid binding
A0005507molecular_functioncopper ion binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005640cellular_componentnuclear outer membrane
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005840cellular_componentribosome
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006631biological_processfatty acid metabolic process
A0006638biological_processneutral lipid metabolic process
A0006644biological_processphospholipid metabolic process
A0006749biological_processglutathione metabolic process
A0007006biological_processmitochondrial membrane organization
A0007268biological_processchemical synaptic transmission
A0007269biological_processneurotransmitter secretion
A0008017molecular_functionmicrotubule binding
A0008021cellular_componentsynaptic vesicle
A0008047molecular_functionenzyme activator activity
A0008198molecular_functionferrous iron binding
A0008270molecular_functionzinc ion binding
A0008289molecular_functionlipid binding
A0008344biological_processadult locomotory behavior
A0009410biological_processresponse to xenobiotic stimulus
A0010040biological_processresponse to iron(II) ion
A0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
A0014048biological_processregulation of glutamate secretion
A0014059biological_processregulation of dopamine secretion
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016082biological_processsynaptic vesicle priming
A0016234cellular_componentinclusion body
A0016491molecular_functionoxidoreductase activity
A0019894molecular_functionkinesin binding
A0019899molecular_functionenzyme binding
A0019904molecular_functionprotein domain specific binding
A0030424cellular_componentaxon
A0030426cellular_componentgrowth cone
A0030544molecular_functionHsp70 protein binding
A0030659cellular_componentcytoplasmic vesicle membrane
A0030672cellular_componentsynaptic vesicle membrane
A0031092cellular_componentplatelet alpha granule membrane
A0031115biological_processnegative regulation of microtubule polymerization
A0031623biological_processreceptor internalization
A0031648biological_processprotein destabilization
A0032026biological_processresponse to magnesium ion
A0032496biological_processresponse to lipopolysaccharide
A0032991cellular_componentprotein-containing complex
A0034341biological_processresponse to type II interferon
A0034599biological_processcellular response to oxidative stress
A0035493biological_processSNARE complex assembly
A0035543biological_processpositive regulation of SNARE complex assembly
A0040012biological_processregulation of locomotion
A0042220biological_processresponse to cocaine
A0042393molecular_functionhistone binding
A0042416biological_processdopamine biosynthetic process
A0042417biological_processdopamine metabolic process
A0042775biological_processmitochondrial ATP synthesis coupled electron transport
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043014molecular_functionalpha-tubulin binding
A0043025cellular_componentneuronal cell body
A0043030biological_processregulation of macrophage activation
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043195cellular_componentterminal bouton
A0043274molecular_functionphospholipase binding
A0043524biological_processnegative regulation of neuron apoptotic process
A0043679cellular_componentaxon terminus
A0044344biological_processcellular response to fibroblast growth factor stimulus
A0045202cellular_componentsynapse
A0045807biological_processpositive regulation of endocytosis
A0045920biological_processnegative regulation of exocytosis
A0045921biological_processpositive regulation of exocytosis
A0045963biological_processnegative regulation of dopamine metabolic process
A0046872molecular_functionmetal ion binding
A0046928biological_processregulation of neurotransmitter secretion
A0048148biological_processbehavioral response to cocaine
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048471cellular_componentperinuclear region of cytoplasm
A0048487molecular_functionbeta-tubulin binding
A0048488biological_processsynaptic vesicle endocytosis
A0048489biological_processsynaptic vesicle transport
A0050729biological_processpositive regulation of inflammatory response
A0050806biological_processpositive regulation of synaptic transmission
A0050808biological_processsynapse organization
A0050812biological_processregulation of acyl-CoA biosynthetic process
A0051219molecular_functionphosphoprotein binding
A0051259biological_processprotein complex oligomerization
A0051262biological_processprotein tetramerization
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0051402biological_processneuron apoptotic process
A0051583biological_processdopamine uptake involved in synaptic transmission
A0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
A0051612biological_processnegative regulation of serotonin uptake
A0051621biological_processregulation of norepinephrine uptake
A0051622biological_processnegative regulation of norepinephrine uptake
A0055074biological_processcalcium ion homeostasis
A0060079biological_processexcitatory postsynaptic potential
A0060090molecular_functionmolecular adaptor activity
A0060291biological_processlong-term synaptic potentiation
A0060732biological_processpositive regulation of inositol phosphate biosynthetic process
A0060961molecular_functionphospholipase D inhibitor activity
A0061024biological_processmembrane organization
A0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
A0070507biological_processregulation of microtubule cytoskeleton organization
A0070555biological_processresponse to interleukin-1
A0070840molecular_functiondynein complex binding
A0071280biological_processcellular response to copper ion
A0071872biological_processcellular response to epinephrine stimulus
A0097435biological_processsupramolecular fiber organization
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0099512cellular_componentsupramolecular fiber
A0140311molecular_functionprotein sequestering activity
A0141108molecular_functiontransporter regulator activity
A1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
A1903136molecular_functioncuprous ion binding
A1903285biological_processpositive regulation of hydrogen peroxide catabolic process
A1903421biological_processregulation of synaptic vesicle recycling
A1903426biological_processregulation of reactive oxygen species biosynthetic process
A1904307biological_processresponse to desipramine
A1904377biological_processpositive regulation of protein localization to cell periphery
A1904715biological_processnegative regulation of chaperone-mediated autophagy
A1905606biological_processregulation of presynapse assembly
A1990000biological_processamyloid fibril formation
A2000377biological_processregulation of reactive oxygen species metabolic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000149molecular_functionSNARE binding
B0000287molecular_functionmagnesium ion binding
B0000976molecular_functiontranscription cis-regulatory region binding
B0001774biological_processmicroglial cell activation
B0001921biological_processpositive regulation of receptor recycling
B0001956biological_processpositive regulation of neurotransmitter secretion
B0001963biological_processsynaptic transmission, dopaminergic
B0003779molecular_functionactin binding
B0004857molecular_functionenzyme inhibitor activity
B0004860molecular_functionprotein kinase inhibitor activity
B0004869molecular_functioncysteine-type endopeptidase inhibitor activity
B0005504molecular_functionfatty acid binding
B0005507molecular_functioncopper ion binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005640cellular_componentnuclear outer membrane
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005743cellular_componentmitochondrial inner membrane
B0005759cellular_componentmitochondrial matrix
B0005764cellular_componentlysosome
B0005829cellular_componentcytosol
B0005840cellular_componentribosome
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0006631biological_processfatty acid metabolic process
B0006638biological_processneutral lipid metabolic process
B0006644biological_processphospholipid metabolic process
B0006749biological_processglutathione metabolic process
B0007006biological_processmitochondrial membrane organization
B0007268biological_processchemical synaptic transmission
B0007269biological_processneurotransmitter secretion
B0008017molecular_functionmicrotubule binding
B0008021cellular_componentsynaptic vesicle
B0008047molecular_functionenzyme activator activity
B0008198molecular_functionferrous iron binding
B0008270molecular_functionzinc ion binding
B0008289molecular_functionlipid binding
B0008344biological_processadult locomotory behavior
B0009410biological_processresponse to xenobiotic stimulus
B0010040biological_processresponse to iron(II) ion
B0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
B0014048biological_processregulation of glutamate secretion
B0014059biological_processregulation of dopamine secretion
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016079biological_processsynaptic vesicle exocytosis
B0016082biological_processsynaptic vesicle priming
B0016234cellular_componentinclusion body
B0016491molecular_functionoxidoreductase activity
B0019894molecular_functionkinesin binding
B0019899molecular_functionenzyme binding
B0019904molecular_functionprotein domain specific binding
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0030544molecular_functionHsp70 protein binding
B0030659cellular_componentcytoplasmic vesicle membrane
B0030672cellular_componentsynaptic vesicle membrane
B0031092cellular_componentplatelet alpha granule membrane
B0031115biological_processnegative regulation of microtubule polymerization
B0031623biological_processreceptor internalization
B0031648biological_processprotein destabilization
B0032026biological_processresponse to magnesium ion
B0032496biological_processresponse to lipopolysaccharide
B0032991cellular_componentprotein-containing complex
B0034341biological_processresponse to type II interferon
B0034599biological_processcellular response to oxidative stress
B0035493biological_processSNARE complex assembly
B0035543biological_processpositive regulation of SNARE complex assembly
B0040012biological_processregulation of locomotion
B0042220biological_processresponse to cocaine
B0042393molecular_functionhistone binding
B0042416biological_processdopamine biosynthetic process
B0042417biological_processdopamine metabolic process
B0042775biological_processmitochondrial ATP synthesis coupled electron transport
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043014molecular_functionalpha-tubulin binding
B0043025cellular_componentneuronal cell body
B0043030biological_processregulation of macrophage activation
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043195cellular_componentterminal bouton
B0043274molecular_functionphospholipase binding
B0043524biological_processnegative regulation of neuron apoptotic process
B0043679cellular_componentaxon terminus
B0044344biological_processcellular response to fibroblast growth factor stimulus
B0045202cellular_componentsynapse
B0045807biological_processpositive regulation of endocytosis
B0045920biological_processnegative regulation of exocytosis
B0045921biological_processpositive regulation of exocytosis
B0045963biological_processnegative regulation of dopamine metabolic process
B0046872molecular_functionmetal ion binding
B0046928biological_processregulation of neurotransmitter secretion
B0048148biological_processbehavioral response to cocaine
B0048156molecular_functiontau protein binding
B0048168biological_processregulation of neuronal synaptic plasticity
B0048169biological_processregulation of long-term neuronal synaptic plasticity
B0048471cellular_componentperinuclear region of cytoplasm
B0048487molecular_functionbeta-tubulin binding
B0048488biological_processsynaptic vesicle endocytosis
B0048489biological_processsynaptic vesicle transport
B0050729biological_processpositive regulation of inflammatory response
B0050806biological_processpositive regulation of synaptic transmission
B0050808biological_processsynapse organization
B0050812biological_processregulation of acyl-CoA biosynthetic process
B0051219molecular_functionphosphoprotein binding
B0051259biological_processprotein complex oligomerization
B0051262biological_processprotein tetramerization
B0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
B0051402biological_processneuron apoptotic process
B0051583biological_processdopamine uptake involved in synaptic transmission
B0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
B0051612biological_processnegative regulation of serotonin uptake
B0051621biological_processregulation of norepinephrine uptake
B0051622biological_processnegative regulation of norepinephrine uptake
B0055074biological_processcalcium ion homeostasis
B0060079biological_processexcitatory postsynaptic potential
B0060090molecular_functionmolecular adaptor activity
B0060291biological_processlong-term synaptic potentiation
B0060732biological_processpositive regulation of inositol phosphate biosynthetic process
B0060961molecular_functionphospholipase D inhibitor activity
B0061024biological_processmembrane organization
B0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
B0070507biological_processregulation of microtubule cytoskeleton organization
B0070555biological_processresponse to interleukin-1
B0070840molecular_functiondynein complex binding
B0071280biological_processcellular response to copper ion
B0071872biological_processcellular response to epinephrine stimulus
B0097435biological_processsupramolecular fiber organization
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0099512cellular_componentsupramolecular fiber
B0140311molecular_functionprotein sequestering activity
B0141108molecular_functiontransporter regulator activity
B1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
B1903136molecular_functioncuprous ion binding
B1903285biological_processpositive regulation of hydrogen peroxide catabolic process
B1903421biological_processregulation of synaptic vesicle recycling
B1903426biological_processregulation of reactive oxygen species biosynthetic process
B1904307biological_processresponse to desipramine
B1904377biological_processpositive regulation of protein localization to cell periphery
B1904715biological_processnegative regulation of chaperone-mediated autophagy
B1905606biological_processregulation of presynapse assembly
B1990000biological_processamyloid fibril formation
B2000377biological_processregulation of reactive oxygen species metabolic process
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000149molecular_functionSNARE binding
F0000287molecular_functionmagnesium ion binding
F0000976molecular_functiontranscription cis-regulatory region binding
F0001774biological_processmicroglial cell activation
F0001921biological_processpositive regulation of receptor recycling
F0001956biological_processpositive regulation of neurotransmitter secretion
F0001963biological_processsynaptic transmission, dopaminergic
F0003779molecular_functionactin binding
F0004857molecular_functionenzyme inhibitor activity
F0004860molecular_functionprotein kinase inhibitor activity
F0004869molecular_functioncysteine-type endopeptidase inhibitor activity
F0005504molecular_functionfatty acid binding
F0005507molecular_functioncopper ion binding
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005543molecular_functionphospholipid binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005640cellular_componentnuclear outer membrane
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005741cellular_componentmitochondrial outer membrane
F0005743cellular_componentmitochondrial inner membrane
F0005759cellular_componentmitochondrial matrix
F0005764cellular_componentlysosome
F0005829cellular_componentcytosol
F0005840cellular_componentribosome
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0005938cellular_componentcell cortex
F0006631biological_processfatty acid metabolic process
F0006638biological_processneutral lipid metabolic process
F0006644biological_processphospholipid metabolic process
F0006749biological_processglutathione metabolic process
F0007006biological_processmitochondrial membrane organization
F0007268biological_processchemical synaptic transmission
F0007269biological_processneurotransmitter secretion
F0008017molecular_functionmicrotubule binding
F0008021cellular_componentsynaptic vesicle
F0008047molecular_functionenzyme activator activity
F0008198molecular_functionferrous iron binding
F0008270molecular_functionzinc ion binding
F0008289molecular_functionlipid binding
F0008344biological_processadult locomotory behavior
F0009410biological_processresponse to xenobiotic stimulus
F0010040biological_processresponse to iron(II) ion
F0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
F0014048biological_processregulation of glutamate secretion
F0014059biological_processregulation of dopamine secretion
F0015629cellular_componentactin cytoskeleton
F0016020cellular_componentmembrane
F0016079biological_processsynaptic vesicle exocytosis
F0016082biological_processsynaptic vesicle priming
F0016234cellular_componentinclusion body
F0016491molecular_functionoxidoreductase activity
F0019894molecular_functionkinesin binding
F0019899molecular_functionenzyme binding
F0019904molecular_functionprotein domain specific binding
F0030424cellular_componentaxon
F0030426cellular_componentgrowth cone
F0030544molecular_functionHsp70 protein binding
F0030659cellular_componentcytoplasmic vesicle membrane
F0030672cellular_componentsynaptic vesicle membrane
F0031092cellular_componentplatelet alpha granule membrane
F0031115biological_processnegative regulation of microtubule polymerization
F0031623biological_processreceptor internalization
F0031648biological_processprotein destabilization
F0032026biological_processresponse to magnesium ion
F0032496biological_processresponse to lipopolysaccharide
F0032991cellular_componentprotein-containing complex
F0034341biological_processresponse to type II interferon
F0034599biological_processcellular response to oxidative stress
F0035493biological_processSNARE complex assembly
F0035543biological_processpositive regulation of SNARE complex assembly
F0040012biological_processregulation of locomotion
F0042220biological_processresponse to cocaine
F0042393molecular_functionhistone binding
F0042416biological_processdopamine biosynthetic process
F0042417biological_processdopamine metabolic process
F0042775biological_processmitochondrial ATP synthesis coupled electron transport
F0042802molecular_functionidentical protein binding
F0042995cellular_componentcell projection
F0043014molecular_functionalpha-tubulin binding
F0043025cellular_componentneuronal cell body
F0043030biological_processregulation of macrophage activation
F0043065biological_processpositive regulation of apoptotic process
F0043066biological_processnegative regulation of apoptotic process
F0043195cellular_componentterminal bouton
F0043274molecular_functionphospholipase binding
F0043524biological_processnegative regulation of neuron apoptotic process
F0043679cellular_componentaxon terminus
F0044344biological_processcellular response to fibroblast growth factor stimulus
F0045202cellular_componentsynapse
F0045807biological_processpositive regulation of endocytosis
F0045920biological_processnegative regulation of exocytosis
F0045921biological_processpositive regulation of exocytosis
F0045963biological_processnegative regulation of dopamine metabolic process
F0046872molecular_functionmetal ion binding
F0046928biological_processregulation of neurotransmitter secretion
F0048148biological_processbehavioral response to cocaine
F0048156molecular_functiontau protein binding
F0048168biological_processregulation of neuronal synaptic plasticity
F0048169biological_processregulation of long-term neuronal synaptic plasticity
F0048471cellular_componentperinuclear region of cytoplasm
F0048487molecular_functionbeta-tubulin binding
F0048488biological_processsynaptic vesicle endocytosis
F0048489biological_processsynaptic vesicle transport
F0050729biological_processpositive regulation of inflammatory response
F0050806biological_processpositive regulation of synaptic transmission
F0050808biological_processsynapse organization
F0050812biological_processregulation of acyl-CoA biosynthetic process
F0051219molecular_functionphosphoprotein binding
F0051259biological_processprotein complex oligomerization
F0051262biological_processprotein tetramerization
F0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
F0051402biological_processneuron apoptotic process
F0051583biological_processdopamine uptake involved in synaptic transmission
F0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
F0051612biological_processnegative regulation of serotonin uptake
F0051621biological_processregulation of norepinephrine uptake
F0051622biological_processnegative regulation of norepinephrine uptake
F0055074biological_processcalcium ion homeostasis
F0060079biological_processexcitatory postsynaptic potential
F0060090molecular_functionmolecular adaptor activity
F0060291biological_processlong-term synaptic potentiation
F0060732biological_processpositive regulation of inositol phosphate biosynthetic process
F0060961molecular_functionphospholipase D inhibitor activity
F0061024biological_processmembrane organization
F0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
F0070507biological_processregulation of microtubule cytoskeleton organization
F0070555biological_processresponse to interleukin-1
F0070840molecular_functiondynein complex binding
F0071280biological_processcellular response to copper ion
F0071872biological_processcellular response to epinephrine stimulus
F0097435biological_processsupramolecular fiber organization
F0098793cellular_componentpresynapse
F0098794cellular_componentpostsynapse
F0099512cellular_componentsupramolecular fiber
F0140311molecular_functionprotein sequestering activity
F0141108molecular_functiontransporter regulator activity
F1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
F1903136molecular_functioncuprous ion binding
F1903285biological_processpositive regulation of hydrogen peroxide catabolic process
F1903421biological_processregulation of synaptic vesicle recycling
F1903426biological_processregulation of reactive oxygen species biosynthetic process
F1904307biological_processresponse to desipramine
F1904377biological_processpositive regulation of protein localization to cell periphery
F1904715biological_processnegative regulation of chaperone-mediated autophagy
F1905606biological_processregulation of presynapse assembly
F1990000biological_processamyloid fibril formation
F2000377biological_processregulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
FASP2
FHIS50
AASP2
AHIS50
BASP2
BHIS50

site_idSWS_FT_FI2
Number of Residues3
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:22407793
ChainResidueDetails
FMET1
AMET1
BMET1

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617630
ChainResidueDetails
FSER87
ASER87
BSER87

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:12893833
ChainResidueDetails
FTYR125
ATYR125
BTYR125

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Phosphoserine; by BARK1, PLK2, CK2, CK1 and GRK5 => ECO:0000269|PubMed:10617630, ECO:0000269|PubMed:11813001, ECO:0000269|PubMed:24936070
ChainResidueDetails
FSER129
ASER129
BSER129

236371

PDB entries from 2025-05-21

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