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7V47

Type 1A alpha-synuclein fibril seeded by cerebrospinal fluid from a preclinical Parkinson's disease patient

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000149molecular_functionSNARE binding
A0000287molecular_functionmagnesium ion binding
A0000976molecular_functiontranscription cis-regulatory region binding
A0001774biological_processmicroglial cell activation
A0001921biological_processpositive regulation of receptor recycling
A0001956biological_processpositive regulation of neurotransmitter secretion
A0001963biological_processsynaptic transmission, dopaminergic
A0003779molecular_functionactin binding
A0004860molecular_functionprotein kinase inhibitor activity
A0005504molecular_functionfatty acid binding
A0005507molecular_functioncopper ion binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006469biological_processnegative regulation of protein kinase activity
A0006631biological_processfatty acid metabolic process
A0006638biological_processneutral lipid metabolic process
A0006644biological_processphospholipid metabolic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0007006biological_processmitochondrial membrane organization
A0007268biological_processchemical synaptic transmission
A0007269biological_processneurotransmitter secretion
A0008198molecular_functionferrous iron binding
A0008270molecular_functionzinc ion binding
A0008289molecular_functionlipid binding
A0008344biological_processadult locomotory behavior
A0009410biological_processresponse to xenobiotic stimulus
A0010040biological_processresponse to iron(II) ion
A0010517biological_processregulation of phospholipase activity
A0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
A0014048biological_processregulation of glutamate secretion
A0014059biological_processregulation of dopamine secretion
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016082biological_processsynaptic vesicle priming
A0016234cellular_componentinclusion body
A0016491molecular_functionoxidoreductase activity
A0019894molecular_functionkinesin binding
A0022898biological_processregulation of transmembrane transporter activity
A0030424cellular_componentaxon
A0030426cellular_componentgrowth cone
A0030544molecular_functionHsp70 protein binding
A0030672cellular_componentsynaptic vesicle membrane
A0031092cellular_componentplatelet alpha granule membrane
A0031115biological_processnegative regulation of microtubule polymerization
A0031623biological_processreceptor internalization
A0031648biological_processprotein destabilization
A0032026biological_processresponse to magnesium ion
A0032410biological_processnegative regulation of transporter activity
A0032496biological_processresponse to lipopolysaccharide
A0032769biological_processnegative regulation of monooxygenase activity
A0032991cellular_componentprotein-containing complex
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0034341biological_processresponse to type II interferon
A0034599biological_processcellular response to oxidative stress
A0035493biological_processSNARE complex assembly
A0035543biological_processpositive regulation of SNARE complex assembly
A0040012biological_processregulation of locomotion
A0042393molecular_functionhistone binding
A0042416biological_processdopamine biosynthetic process
A0042417biological_processdopamine metabolic process
A0042775biological_processmitochondrial ATP synthesis coupled electron transport
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043014molecular_functionalpha-tubulin binding
A0043025cellular_componentneuronal cell body
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043030biological_processregulation of macrophage activation
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0043679cellular_componentaxon terminus
A0045202cellular_componentsynapse
A0045807biological_processpositive regulation of endocytosis
A0045920biological_processnegative regulation of exocytosis
A0045921biological_processpositive regulation of exocytosis
A0046872molecular_functionmetal ion binding
A0046928biological_processregulation of neurotransmitter secretion
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048471cellular_componentperinuclear region of cytoplasm
A0048488biological_processsynaptic vesicle endocytosis
A0048489biological_processsynaptic vesicle transport
A0050729biological_processpositive regulation of inflammatory response
A0050806biological_processpositive regulation of synaptic transmission
A0050808biological_processsynapse organization
A0050812biological_processregulation of acyl-CoA biosynthetic process
A0051219molecular_functionphosphoprotein binding
A0051259biological_processprotein complex oligomerization
A0051262biological_processprotein tetramerization
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0051402biological_processneuron apoptotic process
A0051583biological_processdopamine uptake involved in synaptic transmission
A0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
A0051612biological_processnegative regulation of serotonin uptake
A0051621biological_processregulation of norepinephrine uptake
A0051622biological_processnegative regulation of norepinephrine uptake
A0055074biological_processcalcium ion homeostasis
A0060079biological_processexcitatory postsynaptic potential
A0060090molecular_functionmolecular adaptor activity
A0060291biological_processlong-term synaptic potentiation
A0060732biological_processpositive regulation of inositol phosphate biosynthetic process
A0060961molecular_functionphospholipase D inhibitor activity
A0061024biological_processmembrane organization
A0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
A0070555biological_processresponse to interleukin-1
A0070840molecular_functiondynein complex binding
A0071280biological_processcellular response to copper ion
A0071872biological_processcellular response to epinephrine stimulus
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0097435biological_processsupramolecular fiber organization
A0098794cellular_componentpostsynapse
A0099512cellular_componentsupramolecular fiber
A1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
A1903136molecular_functioncuprous ion binding
A1903284biological_processpositive regulation of glutathione peroxidase activity
A1903285biological_processpositive regulation of hydrogen peroxide catabolic process
A1903421biological_processregulation of synaptic vesicle recycling
A1903426biological_processregulation of reactive oxygen species biosynthetic process
A1904377biological_processpositive regulation of protein localization to cell periphery
A1904715biological_processnegative regulation of chaperone-mediated autophagy
A1905606biological_processregulation of presynapse assembly
A1990000biological_processamyloid fibril formation
A2000377biological_processregulation of reactive oxygen species metabolic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000149molecular_functionSNARE binding
B0000287molecular_functionmagnesium ion binding
B0000976molecular_functiontranscription cis-regulatory region binding
B0001774biological_processmicroglial cell activation
B0001921biological_processpositive regulation of receptor recycling
B0001956biological_processpositive regulation of neurotransmitter secretion
B0001963biological_processsynaptic transmission, dopaminergic
B0003779molecular_functionactin binding
B0004860molecular_functionprotein kinase inhibitor activity
B0005504molecular_functionfatty acid binding
B0005507molecular_functioncopper ion binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005764cellular_componentlysosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0006469biological_processnegative regulation of protein kinase activity
B0006631biological_processfatty acid metabolic process
B0006638biological_processneutral lipid metabolic process
B0006644biological_processphospholipid metabolic process
B0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
B0007006biological_processmitochondrial membrane organization
B0007268biological_processchemical synaptic transmission
B0007269biological_processneurotransmitter secretion
B0008198molecular_functionferrous iron binding
B0008270molecular_functionzinc ion binding
B0008289molecular_functionlipid binding
B0008344biological_processadult locomotory behavior
B0009410biological_processresponse to xenobiotic stimulus
B0010040biological_processresponse to iron(II) ion
B0010517biological_processregulation of phospholipase activity
B0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
B0014048biological_processregulation of glutamate secretion
B0014059biological_processregulation of dopamine secretion
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016079biological_processsynaptic vesicle exocytosis
B0016082biological_processsynaptic vesicle priming
B0016234cellular_componentinclusion body
B0016491molecular_functionoxidoreductase activity
B0019894molecular_functionkinesin binding
B0022898biological_processregulation of transmembrane transporter activity
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0030544molecular_functionHsp70 protein binding
B0030672cellular_componentsynaptic vesicle membrane
B0031092cellular_componentplatelet alpha granule membrane
B0031115biological_processnegative regulation of microtubule polymerization
B0031623biological_processreceptor internalization
B0031648biological_processprotein destabilization
B0032026biological_processresponse to magnesium ion
B0032410biological_processnegative regulation of transporter activity
B0032496biological_processresponse to lipopolysaccharide
B0032769biological_processnegative regulation of monooxygenase activity
B0032991cellular_componentprotein-containing complex
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0034341biological_processresponse to type II interferon
B0034599biological_processcellular response to oxidative stress
B0035493biological_processSNARE complex assembly
B0035543biological_processpositive regulation of SNARE complex assembly
B0040012biological_processregulation of locomotion
B0042393molecular_functionhistone binding
B0042416biological_processdopamine biosynthetic process
B0042417biological_processdopamine metabolic process
B0042775biological_processmitochondrial ATP synthesis coupled electron transport
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043014molecular_functionalpha-tubulin binding
B0043025cellular_componentneuronal cell body
B0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
B0043030biological_processregulation of macrophage activation
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0043679cellular_componentaxon terminus
B0045202cellular_componentsynapse
B0045807biological_processpositive regulation of endocytosis
B0045920biological_processnegative regulation of exocytosis
B0045921biological_processpositive regulation of exocytosis
B0046872molecular_functionmetal ion binding
B0046928biological_processregulation of neurotransmitter secretion
B0048156molecular_functiontau protein binding
B0048168biological_processregulation of neuronal synaptic plasticity
B0048169biological_processregulation of long-term neuronal synaptic plasticity
B0048471cellular_componentperinuclear region of cytoplasm
B0048488biological_processsynaptic vesicle endocytosis
B0048489biological_processsynaptic vesicle transport
B0050729biological_processpositive regulation of inflammatory response
B0050806biological_processpositive regulation of synaptic transmission
B0050808biological_processsynapse organization
B0050812biological_processregulation of acyl-CoA biosynthetic process
B0051219molecular_functionphosphoprotein binding
B0051259biological_processprotein complex oligomerization
B0051262biological_processprotein tetramerization
B0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
B0051402biological_processneuron apoptotic process
B0051583biological_processdopamine uptake involved in synaptic transmission
B0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
B0051612biological_processnegative regulation of serotonin uptake
B0051621biological_processregulation of norepinephrine uptake
B0051622biological_processnegative regulation of norepinephrine uptake
B0055074biological_processcalcium ion homeostasis
B0060079biological_processexcitatory postsynaptic potential
B0060090molecular_functionmolecular adaptor activity
B0060291biological_processlong-term synaptic potentiation
B0060732biological_processpositive regulation of inositol phosphate biosynthetic process
B0060961molecular_functionphospholipase D inhibitor activity
B0061024biological_processmembrane organization
B0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
B0070555biological_processresponse to interleukin-1
B0070840molecular_functiondynein complex binding
B0071280biological_processcellular response to copper ion
B0071872biological_processcellular response to epinephrine stimulus
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0097435biological_processsupramolecular fiber organization
B0098794cellular_componentpostsynapse
B0099512cellular_componentsupramolecular fiber
B1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
B1903136molecular_functioncuprous ion binding
B1903284biological_processpositive regulation of glutathione peroxidase activity
B1903285biological_processpositive regulation of hydrogen peroxide catabolic process
B1903421biological_processregulation of synaptic vesicle recycling
B1903426biological_processregulation of reactive oxygen species biosynthetic process
B1904377biological_processpositive regulation of protein localization to cell periphery
B1904715biological_processnegative regulation of chaperone-mediated autophagy
B1905606biological_processregulation of presynapse assembly
B1990000biological_processamyloid fibril formation
B2000377biological_processregulation of reactive oxygen species metabolic process
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000149molecular_functionSNARE binding
C0000287molecular_functionmagnesium ion binding
C0000976molecular_functiontranscription cis-regulatory region binding
C0001774biological_processmicroglial cell activation
C0001921biological_processpositive regulation of receptor recycling
C0001956biological_processpositive regulation of neurotransmitter secretion
C0001963biological_processsynaptic transmission, dopaminergic
C0003779molecular_functionactin binding
C0004860molecular_functionprotein kinase inhibitor activity
C0005504molecular_functionfatty acid binding
C0005507molecular_functioncopper ion binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005543molecular_functionphospholipid binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005764cellular_componentlysosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005938cellular_componentcell cortex
C0006469biological_processnegative regulation of protein kinase activity
C0006631biological_processfatty acid metabolic process
C0006638biological_processneutral lipid metabolic process
C0006644biological_processphospholipid metabolic process
C0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
C0007006biological_processmitochondrial membrane organization
C0007268biological_processchemical synaptic transmission
C0007269biological_processneurotransmitter secretion
C0008198molecular_functionferrous iron binding
C0008270molecular_functionzinc ion binding
C0008289molecular_functionlipid binding
C0008344biological_processadult locomotory behavior
C0009410biological_processresponse to xenobiotic stimulus
C0010040biological_processresponse to iron(II) ion
C0010517biological_processregulation of phospholipase activity
C0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
C0014048biological_processregulation of glutamate secretion
C0014059biological_processregulation of dopamine secretion
C0015629cellular_componentactin cytoskeleton
C0016020cellular_componentmembrane
C0016079biological_processsynaptic vesicle exocytosis
C0016082biological_processsynaptic vesicle priming
C0016234cellular_componentinclusion body
C0016491molecular_functionoxidoreductase activity
C0019894molecular_functionkinesin binding
C0022898biological_processregulation of transmembrane transporter activity
C0030424cellular_componentaxon
C0030426cellular_componentgrowth cone
C0030544molecular_functionHsp70 protein binding
C0030672cellular_componentsynaptic vesicle membrane
C0031092cellular_componentplatelet alpha granule membrane
C0031115biological_processnegative regulation of microtubule polymerization
C0031623biological_processreceptor internalization
C0031648biological_processprotein destabilization
C0032026biological_processresponse to magnesium ion
C0032410biological_processnegative regulation of transporter activity
C0032496biological_processresponse to lipopolysaccharide
C0032769biological_processnegative regulation of monooxygenase activity
C0032991cellular_componentprotein-containing complex
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0034341biological_processresponse to type II interferon
C0034599biological_processcellular response to oxidative stress
C0035493biological_processSNARE complex assembly
C0035543biological_processpositive regulation of SNARE complex assembly
C0040012biological_processregulation of locomotion
C0042393molecular_functionhistone binding
C0042416biological_processdopamine biosynthetic process
C0042417biological_processdopamine metabolic process
C0042775biological_processmitochondrial ATP synthesis coupled electron transport
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043014molecular_functionalpha-tubulin binding
C0043025cellular_componentneuronal cell body
C0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
C0043030biological_processregulation of macrophage activation
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
C0043524biological_processnegative regulation of neuron apoptotic process
C0043679cellular_componentaxon terminus
C0045202cellular_componentsynapse
C0045807biological_processpositive regulation of endocytosis
C0045920biological_processnegative regulation of exocytosis
C0045921biological_processpositive regulation of exocytosis
C0046872molecular_functionmetal ion binding
C0046928biological_processregulation of neurotransmitter secretion
C0048156molecular_functiontau protein binding
C0048168biological_processregulation of neuronal synaptic plasticity
C0048169biological_processregulation of long-term neuronal synaptic plasticity
C0048471cellular_componentperinuclear region of cytoplasm
C0048488biological_processsynaptic vesicle endocytosis
C0048489biological_processsynaptic vesicle transport
C0050729biological_processpositive regulation of inflammatory response
C0050806biological_processpositive regulation of synaptic transmission
C0050808biological_processsynapse organization
C0050812biological_processregulation of acyl-CoA biosynthetic process
C0051219molecular_functionphosphoprotein binding
C0051259biological_processprotein complex oligomerization
C0051262biological_processprotein tetramerization
C0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
C0051402biological_processneuron apoptotic process
C0051583biological_processdopamine uptake involved in synaptic transmission
C0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
C0051612biological_processnegative regulation of serotonin uptake
C0051621biological_processregulation of norepinephrine uptake
C0051622biological_processnegative regulation of norepinephrine uptake
C0055074biological_processcalcium ion homeostasis
C0060079biological_processexcitatory postsynaptic potential
C0060090molecular_functionmolecular adaptor activity
C0060291biological_processlong-term synaptic potentiation
C0060732biological_processpositive regulation of inositol phosphate biosynthetic process
C0060961molecular_functionphospholipase D inhibitor activity
C0061024biological_processmembrane organization
C0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
C0070555biological_processresponse to interleukin-1
C0070840molecular_functiondynein complex binding
C0071280biological_processcellular response to copper ion
C0071872biological_processcellular response to epinephrine stimulus
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0097435biological_processsupramolecular fiber organization
C0098794cellular_componentpostsynapse
C0099512cellular_componentsupramolecular fiber
C1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
C1903136molecular_functioncuprous ion binding
C1903284biological_processpositive regulation of glutathione peroxidase activity
C1903285biological_processpositive regulation of hydrogen peroxide catabolic process
C1903421biological_processregulation of synaptic vesicle recycling
C1903426biological_processregulation of reactive oxygen species biosynthetic process
C1904377biological_processpositive regulation of protein localization to cell periphery
C1904715biological_processnegative regulation of chaperone-mediated autophagy
C1905606biological_processregulation of presynapse assembly
C1990000biological_processamyloid fibril formation
C2000377biological_processregulation of reactive oxygen species metabolic process
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000149molecular_functionSNARE binding
D0000287molecular_functionmagnesium ion binding
D0000976molecular_functiontranscription cis-regulatory region binding
D0001774biological_processmicroglial cell activation
D0001921biological_processpositive regulation of receptor recycling
D0001956biological_processpositive regulation of neurotransmitter secretion
D0001963biological_processsynaptic transmission, dopaminergic
D0003779molecular_functionactin binding
D0004860molecular_functionprotein kinase inhibitor activity
D0005504molecular_functionfatty acid binding
D0005507molecular_functioncopper ion binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005543molecular_functionphospholipid binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005764cellular_componentlysosome
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005938cellular_componentcell cortex
D0006469biological_processnegative regulation of protein kinase activity
D0006631biological_processfatty acid metabolic process
D0006638biological_processneutral lipid metabolic process
D0006644biological_processphospholipid metabolic process
D0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
D0007006biological_processmitochondrial membrane organization
D0007268biological_processchemical synaptic transmission
D0007269biological_processneurotransmitter secretion
D0008198molecular_functionferrous iron binding
D0008270molecular_functionzinc ion binding
D0008289molecular_functionlipid binding
D0008344biological_processadult locomotory behavior
D0009410biological_processresponse to xenobiotic stimulus
D0010040biological_processresponse to iron(II) ion
D0010517biological_processregulation of phospholipase activity
D0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
D0014048biological_processregulation of glutamate secretion
D0014059biological_processregulation of dopamine secretion
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0016079biological_processsynaptic vesicle exocytosis
D0016082biological_processsynaptic vesicle priming
D0016234cellular_componentinclusion body
D0016491molecular_functionoxidoreductase activity
D0019894molecular_functionkinesin binding
D0022898biological_processregulation of transmembrane transporter activity
D0030424cellular_componentaxon
D0030426cellular_componentgrowth cone
D0030544molecular_functionHsp70 protein binding
D0030672cellular_componentsynaptic vesicle membrane
D0031092cellular_componentplatelet alpha granule membrane
D0031115biological_processnegative regulation of microtubule polymerization
D0031623biological_processreceptor internalization
D0031648biological_processprotein destabilization
D0032026biological_processresponse to magnesium ion
D0032410biological_processnegative regulation of transporter activity
D0032496biological_processresponse to lipopolysaccharide
D0032769biological_processnegative regulation of monooxygenase activity
D0032991cellular_componentprotein-containing complex
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0034341biological_processresponse to type II interferon
D0034599biological_processcellular response to oxidative stress
D0035493biological_processSNARE complex assembly
D0035543biological_processpositive regulation of SNARE complex assembly
D0040012biological_processregulation of locomotion
D0042393molecular_functionhistone binding
D0042416biological_processdopamine biosynthetic process
D0042417biological_processdopamine metabolic process
D0042775biological_processmitochondrial ATP synthesis coupled electron transport
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043014molecular_functionalpha-tubulin binding
D0043025cellular_componentneuronal cell body
D0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
D0043030biological_processregulation of macrophage activation
D0043065biological_processpositive regulation of apoptotic process
D0043066biological_processnegative regulation of apoptotic process
D0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
D0043524biological_processnegative regulation of neuron apoptotic process
D0043679cellular_componentaxon terminus
D0045202cellular_componentsynapse
D0045807biological_processpositive regulation of endocytosis
D0045920biological_processnegative regulation of exocytosis
D0045921biological_processpositive regulation of exocytosis
D0046872molecular_functionmetal ion binding
D0046928biological_processregulation of neurotransmitter secretion
D0048156molecular_functiontau protein binding
D0048168biological_processregulation of neuronal synaptic plasticity
D0048169biological_processregulation of long-term neuronal synaptic plasticity
D0048471cellular_componentperinuclear region of cytoplasm
D0048488biological_processsynaptic vesicle endocytosis
D0048489biological_processsynaptic vesicle transport
D0050729biological_processpositive regulation of inflammatory response
D0050806biological_processpositive regulation of synaptic transmission
D0050808biological_processsynapse organization
D0050812biological_processregulation of acyl-CoA biosynthetic process
D0051219molecular_functionphosphoprotein binding
D0051259biological_processprotein complex oligomerization
D0051262biological_processprotein tetramerization
D0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
D0051402biological_processneuron apoptotic process
D0051583biological_processdopamine uptake involved in synaptic transmission
D0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
D0051612biological_processnegative regulation of serotonin uptake
D0051621biological_processregulation of norepinephrine uptake
D0051622biological_processnegative regulation of norepinephrine uptake
D0055074biological_processcalcium ion homeostasis
D0060079biological_processexcitatory postsynaptic potential
D0060090molecular_functionmolecular adaptor activity
D0060291biological_processlong-term synaptic potentiation
D0060732biological_processpositive regulation of inositol phosphate biosynthetic process
D0060961molecular_functionphospholipase D inhibitor activity
D0061024biological_processmembrane organization
D0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
D0070555biological_processresponse to interleukin-1
D0070840molecular_functiondynein complex binding
D0071280biological_processcellular response to copper ion
D0071872biological_processcellular response to epinephrine stimulus
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0097435biological_processsupramolecular fiber organization
D0098794cellular_componentpostsynapse
D0099512cellular_componentsupramolecular fiber
D1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
D1903136molecular_functioncuprous ion binding
D1903284biological_processpositive regulation of glutathione peroxidase activity
D1903285biological_processpositive regulation of hydrogen peroxide catabolic process
D1903421biological_processregulation of synaptic vesicle recycling
D1903426biological_processregulation of reactive oxygen species biosynthetic process
D1904377biological_processpositive regulation of protein localization to cell periphery
D1904715biological_processnegative regulation of chaperone-mediated autophagy
D1905606biological_processregulation of presynapse assembly
D1990000biological_processamyloid fibril formation
D2000377biological_processregulation of reactive oxygen species metabolic process
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0000149molecular_functionSNARE binding
E0000287molecular_functionmagnesium ion binding
E0000976molecular_functiontranscription cis-regulatory region binding
E0001774biological_processmicroglial cell activation
E0001921biological_processpositive regulation of receptor recycling
E0001956biological_processpositive regulation of neurotransmitter secretion
E0001963biological_processsynaptic transmission, dopaminergic
E0003779molecular_functionactin binding
E0004860molecular_functionprotein kinase inhibitor activity
E0005504molecular_functionfatty acid binding
E0005507molecular_functioncopper ion binding
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005543molecular_functionphospholipid binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005764cellular_componentlysosome
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005886cellular_componentplasma membrane
E0005938cellular_componentcell cortex
E0006469biological_processnegative regulation of protein kinase activity
E0006631biological_processfatty acid metabolic process
E0006638biological_processneutral lipid metabolic process
E0006644biological_processphospholipid metabolic process
E0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
E0007006biological_processmitochondrial membrane organization
E0007268biological_processchemical synaptic transmission
E0007269biological_processneurotransmitter secretion
E0008198molecular_functionferrous iron binding
E0008270molecular_functionzinc ion binding
E0008289molecular_functionlipid binding
E0008344biological_processadult locomotory behavior
E0009410biological_processresponse to xenobiotic stimulus
E0010040biological_processresponse to iron(II) ion
E0010517biological_processregulation of phospholipase activity
E0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
E0014048biological_processregulation of glutamate secretion
E0014059biological_processregulation of dopamine secretion
E0015629cellular_componentactin cytoskeleton
E0016020cellular_componentmembrane
E0016079biological_processsynaptic vesicle exocytosis
E0016082biological_processsynaptic vesicle priming
E0016234cellular_componentinclusion body
E0016491molecular_functionoxidoreductase activity
E0019894molecular_functionkinesin binding
E0022898biological_processregulation of transmembrane transporter activity
E0030424cellular_componentaxon
E0030426cellular_componentgrowth cone
E0030544molecular_functionHsp70 protein binding
E0030672cellular_componentsynaptic vesicle membrane
E0031092cellular_componentplatelet alpha granule membrane
E0031115biological_processnegative regulation of microtubule polymerization
E0031623biological_processreceptor internalization
E0031648biological_processprotein destabilization
E0032026biological_processresponse to magnesium ion
E0032410biological_processnegative regulation of transporter activity
E0032496biological_processresponse to lipopolysaccharide
E0032769biological_processnegative regulation of monooxygenase activity
E0032991cellular_componentprotein-containing complex
E0033138biological_processpositive regulation of peptidyl-serine phosphorylation
E0034341biological_processresponse to type II interferon
E0034599biological_processcellular response to oxidative stress
E0035493biological_processSNARE complex assembly
E0035543biological_processpositive regulation of SNARE complex assembly
E0040012biological_processregulation of locomotion
E0042393molecular_functionhistone binding
E0042416biological_processdopamine biosynthetic process
E0042417biological_processdopamine metabolic process
E0042775biological_processmitochondrial ATP synthesis coupled electron transport
E0042802molecular_functionidentical protein binding
E0042995cellular_componentcell projection
E0043014molecular_functionalpha-tubulin binding
E0043025cellular_componentneuronal cell body
E0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
E0043030biological_processregulation of macrophage activation
E0043065biological_processpositive regulation of apoptotic process
E0043066biological_processnegative regulation of apoptotic process
E0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
E0043524biological_processnegative regulation of neuron apoptotic process
E0043679cellular_componentaxon terminus
E0045202cellular_componentsynapse
E0045807biological_processpositive regulation of endocytosis
E0045920biological_processnegative regulation of exocytosis
E0045921biological_processpositive regulation of exocytosis
E0046872molecular_functionmetal ion binding
E0046928biological_processregulation of neurotransmitter secretion
E0048156molecular_functiontau protein binding
E0048168biological_processregulation of neuronal synaptic plasticity
E0048169biological_processregulation of long-term neuronal synaptic plasticity
E0048471cellular_componentperinuclear region of cytoplasm
E0048488biological_processsynaptic vesicle endocytosis
E0048489biological_processsynaptic vesicle transport
E0050729biological_processpositive regulation of inflammatory response
E0050806biological_processpositive regulation of synaptic transmission
E0050808biological_processsynapse organization
E0050812biological_processregulation of acyl-CoA biosynthetic process
E0051219molecular_functionphosphoprotein binding
E0051259biological_processprotein complex oligomerization
E0051262biological_processprotein tetramerization
E0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
E0051402biological_processneuron apoptotic process
E0051583biological_processdopamine uptake involved in synaptic transmission
E0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
E0051612biological_processnegative regulation of serotonin uptake
E0051621biological_processregulation of norepinephrine uptake
E0051622biological_processnegative regulation of norepinephrine uptake
E0055074biological_processcalcium ion homeostasis
E0060079biological_processexcitatory postsynaptic potential
E0060090molecular_functionmolecular adaptor activity
E0060291biological_processlong-term synaptic potentiation
E0060732biological_processpositive regulation of inositol phosphate biosynthetic process
E0060961molecular_functionphospholipase D inhibitor activity
E0061024biological_processmembrane organization
E0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
E0070555biological_processresponse to interleukin-1
E0070840molecular_functiondynein complex binding
E0071280biological_processcellular response to copper ion
E0071872biological_processcellular response to epinephrine stimulus
E0071902biological_processpositive regulation of protein serine/threonine kinase activity
E0097435biological_processsupramolecular fiber organization
E0098794cellular_componentpostsynapse
E0099512cellular_componentsupramolecular fiber
E1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
E1903136molecular_functioncuprous ion binding
E1903284biological_processpositive regulation of glutathione peroxidase activity
E1903285biological_processpositive regulation of hydrogen peroxide catabolic process
E1903421biological_processregulation of synaptic vesicle recycling
E1903426biological_processregulation of reactive oxygen species biosynthetic process
E1904377biological_processpositive regulation of protein localization to cell periphery
E1904715biological_processnegative regulation of chaperone-mediated autophagy
E1905606biological_processregulation of presynapse assembly
E1990000biological_processamyloid fibril formation
E2000377biological_processregulation of reactive oxygen species metabolic process
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000149molecular_functionSNARE binding
F0000287molecular_functionmagnesium ion binding
F0000976molecular_functiontranscription cis-regulatory region binding
F0001774biological_processmicroglial cell activation
F0001921biological_processpositive regulation of receptor recycling
F0001956biological_processpositive regulation of neurotransmitter secretion
F0001963biological_processsynaptic transmission, dopaminergic
F0003779molecular_functionactin binding
F0004860molecular_functionprotein kinase inhibitor activity
F0005504molecular_functionfatty acid binding
F0005507molecular_functioncopper ion binding
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005543molecular_functionphospholipid binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005764cellular_componentlysosome
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0005938cellular_componentcell cortex
F0006469biological_processnegative regulation of protein kinase activity
F0006631biological_processfatty acid metabolic process
F0006638biological_processneutral lipid metabolic process
F0006644biological_processphospholipid metabolic process
F0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
F0007006biological_processmitochondrial membrane organization
F0007268biological_processchemical synaptic transmission
F0007269biological_processneurotransmitter secretion
F0008198molecular_functionferrous iron binding
F0008270molecular_functionzinc ion binding
F0008289molecular_functionlipid binding
F0008344biological_processadult locomotory behavior
F0009410biological_processresponse to xenobiotic stimulus
F0010040biological_processresponse to iron(II) ion
F0010517biological_processregulation of phospholipase activity
F0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
F0014048biological_processregulation of glutamate secretion
F0014059biological_processregulation of dopamine secretion
F0015629cellular_componentactin cytoskeleton
F0016020cellular_componentmembrane
F0016079biological_processsynaptic vesicle exocytosis
F0016082biological_processsynaptic vesicle priming
F0016234cellular_componentinclusion body
F0016491molecular_functionoxidoreductase activity
F0019894molecular_functionkinesin binding
F0022898biological_processregulation of transmembrane transporter activity
F0030424cellular_componentaxon
F0030426cellular_componentgrowth cone
F0030544molecular_functionHsp70 protein binding
F0030672cellular_componentsynaptic vesicle membrane
F0031092cellular_componentplatelet alpha granule membrane
F0031115biological_processnegative regulation of microtubule polymerization
F0031623biological_processreceptor internalization
F0031648biological_processprotein destabilization
F0032026biological_processresponse to magnesium ion
F0032410biological_processnegative regulation of transporter activity
F0032496biological_processresponse to lipopolysaccharide
F0032769biological_processnegative regulation of monooxygenase activity
F0032991cellular_componentprotein-containing complex
F0033138biological_processpositive regulation of peptidyl-serine phosphorylation
F0034341biological_processresponse to type II interferon
F0034599biological_processcellular response to oxidative stress
F0035493biological_processSNARE complex assembly
F0035543biological_processpositive regulation of SNARE complex assembly
F0040012biological_processregulation of locomotion
F0042393molecular_functionhistone binding
F0042416biological_processdopamine biosynthetic process
F0042417biological_processdopamine metabolic process
F0042775biological_processmitochondrial ATP synthesis coupled electron transport
F0042802molecular_functionidentical protein binding
F0042995cellular_componentcell projection
F0043014molecular_functionalpha-tubulin binding
F0043025cellular_componentneuronal cell body
F0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
F0043030biological_processregulation of macrophage activation
F0043065biological_processpositive regulation of apoptotic process
F0043066biological_processnegative regulation of apoptotic process
F0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
F0043524biological_processnegative regulation of neuron apoptotic process
F0043679cellular_componentaxon terminus
F0045202cellular_componentsynapse
F0045807biological_processpositive regulation of endocytosis
F0045920biological_processnegative regulation of exocytosis
F0045921biological_processpositive regulation of exocytosis
F0046872molecular_functionmetal ion binding
F0046928biological_processregulation of neurotransmitter secretion
F0048156molecular_functiontau protein binding
F0048168biological_processregulation of neuronal synaptic plasticity
F0048169biological_processregulation of long-term neuronal synaptic plasticity
F0048471cellular_componentperinuclear region of cytoplasm
F0048488biological_processsynaptic vesicle endocytosis
F0048489biological_processsynaptic vesicle transport
F0050729biological_processpositive regulation of inflammatory response
F0050806biological_processpositive regulation of synaptic transmission
F0050808biological_processsynapse organization
F0050812biological_processregulation of acyl-CoA biosynthetic process
F0051219molecular_functionphosphoprotein binding
F0051259biological_processprotein complex oligomerization
F0051262biological_processprotein tetramerization
F0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
F0051402biological_processneuron apoptotic process
F0051583biological_processdopamine uptake involved in synaptic transmission
F0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
F0051612biological_processnegative regulation of serotonin uptake
F0051621biological_processregulation of norepinephrine uptake
F0051622biological_processnegative regulation of norepinephrine uptake
F0055074biological_processcalcium ion homeostasis
F0060079biological_processexcitatory postsynaptic potential
F0060090molecular_functionmolecular adaptor activity
F0060291biological_processlong-term synaptic potentiation
F0060732biological_processpositive regulation of inositol phosphate biosynthetic process
F0060961molecular_functionphospholipase D inhibitor activity
F0061024biological_processmembrane organization
F0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
F0070555biological_processresponse to interleukin-1
F0070840molecular_functiondynein complex binding
F0071280biological_processcellular response to copper ion
F0071872biological_processcellular response to epinephrine stimulus
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0097435biological_processsupramolecular fiber organization
F0098794cellular_componentpostsynapse
F0099512cellular_componentsupramolecular fiber
F1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
F1903136molecular_functioncuprous ion binding
F1903284biological_processpositive regulation of glutathione peroxidase activity
F1903285biological_processpositive regulation of hydrogen peroxide catabolic process
F1903421biological_processregulation of synaptic vesicle recycling
F1903426biological_processregulation of reactive oxygen species biosynthetic process
F1904377biological_processpositive regulation of protein localization to cell periphery
F1904715biological_processnegative regulation of chaperone-mediated autophagy
F1905606biological_processregulation of presynapse assembly
F1990000biological_processamyloid fibril formation
F2000377biological_processregulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
AASP2
AHIS50
BASP2
BHIS50
CASP2
CHIS50
EASP2
EHIS50
DASP2
DHIS50
FASP2
FHIS50

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:22407793
ChainResidueDetails
AMET1
BMET1
CMET1
EMET1
DMET1
FMET1

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617630
ChainResidueDetails
ASER87
BSER87
CSER87
ESER87
DSER87
FSER87

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:12893833
ChainResidueDetails
ATYR125
BTYR125
CTYR125
ETYR125
DTYR125
FTYR125

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphoserine; by BARK1, PLK2, CK2, CK1 and GRK5 => ECO:0000269|PubMed:10617630, ECO:0000269|PubMed:11813001, ECO:0000269|PubMed:24936070
ChainResidueDetails
ASER129
BSER129
CSER129
ESER129
DSER129
FSER129

219869

PDB entries from 2024-05-15

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