Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7UXM

Structure of PPIA in complex with FP29092, a Helicon Polypeptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000413	biological_process	protein peptidyl-prolyl isomerization
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0003723	molecular_function	RNA binding
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006457	biological_process	protein folding
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006915	biological_process	apoptotic process
A	0016018	molecular_function	cyclosporin A binding
A	0016020	cellular_component	membrane
A	0019076	biological_process	viral release from host cell
A	0030168	biological_process	platelet activation
A	0030182	biological_process	neuron differentiation
A	0030593	biological_process	neutrophil chemotaxis
A	0030595	biological_process	leukocyte chemotaxis
A	0031982	cellular_component	vesicle
A	0032148	biological_process	activation of protein kinase B activity
A	0032873	biological_process	negative regulation of stress-activated MAPK cascade
A	0032991	cellular_component	protein-containing complex
A	0034389	biological_process	lipid droplet organization
A	0034599	biological_process	cellular response to oxidative stress
A	0034774	cellular_component	secretory granule lumen
A	0042118	biological_process	endothelial cell activation
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045069	biological_process	regulation of viral genome replication
A	0045070	biological_process	positive regulation of viral genome replication
A	0046790	molecular_function	virion binding
A	0050714	biological_process	positive regulation of protein secretion
A	0051082	molecular_function	unfolded protein binding
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0060352	biological_process	cell adhesion molecule production
A	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
A	0070062	cellular_component	extracellular exosome
A	0070527	biological_process	platelet aggregation
A	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
A	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
A	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A	1903901	biological_process	negative regulation of viral life cycle
A	1904399	molecular_function	heparan sulfate binding
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2001233	biological_process	regulation of apoptotic signaling pathway
B	0000413	biological_process	protein peptidyl-prolyl isomerization
B	0001933	biological_process	negative regulation of protein phosphorylation
B	0001934	biological_process	positive regulation of protein phosphorylation
B	0003723	molecular_function	RNA binding
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0005178	molecular_function	integrin binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006457	biological_process	protein folding
B	0006469	biological_process	negative regulation of protein kinase activity
B	0006915	biological_process	apoptotic process
B	0016018	molecular_function	cyclosporin A binding
B	0016020	cellular_component	membrane
B	0019076	biological_process	viral release from host cell
B	0030168	biological_process	platelet activation
B	0030182	biological_process	neuron differentiation
B	0030593	biological_process	neutrophil chemotaxis
B	0030595	biological_process	leukocyte chemotaxis
B	0031982	cellular_component	vesicle
B	0032148	biological_process	activation of protein kinase B activity
B	0032873	biological_process	negative regulation of stress-activated MAPK cascade
B	0032991	cellular_component	protein-containing complex
B	0034389	biological_process	lipid droplet organization
B	0034599	biological_process	cellular response to oxidative stress
B	0034774	cellular_component	secretory granule lumen
B	0042118	biological_process	endothelial cell activation
B	0043410	biological_process	positive regulation of MAPK cascade
B	0045069	biological_process	regulation of viral genome replication
B	0045070	biological_process	positive regulation of viral genome replication
B	0046790	molecular_function	virion binding
B	0050714	biological_process	positive regulation of protein secretion
B	0051082	molecular_function	unfolded protein binding
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0060352	biological_process	cell adhesion molecule production
B	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
B	0070062	cellular_component	extracellular exosome
B	0070527	biological_process	platelet aggregation
B	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
B	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
B	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B	1903901	biological_process	negative regulation of viral life cycle
B	1904399	molecular_function	heparan sulfate binding
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2001233	biological_process	regulation of apoptotic signaling pathway
C	0000413	biological_process	protein peptidyl-prolyl isomerization
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0003723	molecular_function	RNA binding
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0005178	molecular_function	integrin binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005925	cellular_component	focal adhesion
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006457	biological_process	protein folding
C	0006469	biological_process	negative regulation of protein kinase activity
C	0006915	biological_process	apoptotic process
C	0016018	molecular_function	cyclosporin A binding
C	0016020	cellular_component	membrane
C	0019076	biological_process	viral release from host cell
C	0030168	biological_process	platelet activation
C	0030182	biological_process	neuron differentiation
C	0030593	biological_process	neutrophil chemotaxis
C	0030595	biological_process	leukocyte chemotaxis
C	0031982	cellular_component	vesicle
C	0032148	biological_process	activation of protein kinase B activity
C	0032873	biological_process	negative regulation of stress-activated MAPK cascade
C	0032991	cellular_component	protein-containing complex
C	0034389	biological_process	lipid droplet organization
C	0034599	biological_process	cellular response to oxidative stress
C	0034774	cellular_component	secretory granule lumen
C	0042118	biological_process	endothelial cell activation
C	0043410	biological_process	positive regulation of MAPK cascade
C	0045069	biological_process	regulation of viral genome replication
C	0045070	biological_process	positive regulation of viral genome replication
C	0046790	molecular_function	virion binding
C	0050714	biological_process	positive regulation of protein secretion
C	0051082	molecular_function	unfolded protein binding
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0060352	biological_process	cell adhesion molecule production
C	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
C	0070062	cellular_component	extracellular exosome
C	0070527	biological_process	platelet aggregation
C	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
C	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
C	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C	1903901	biological_process	negative regulation of viral life cycle
C	1904399	molecular_function	heparan sulfate binding
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2001233	biological_process	regulation of apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgScFHRIIpgFMcQGG

Chain	Residue	Details
A	TYR48-GLY65

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
A	MET1
B	MET1
C	MET1

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N-acetylvaline; partial; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed => ECO:0000269\|PubMed:25489052, ECO:0000269\|Ref.12, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
A	VAL2
B	VAL2
C	VAL2

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS28
A	LYS82
B	LYS28
B	LYS82
C	LYS28
C	LYS82

site_id	SWS_FT_FI4
Number of Residues	9
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS44
A	LYS76
A	LYS131
B	LYS44
B	LYS76
B	LYS131
C	LYS44
C	LYS76
C	LYS131

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER77
B	SER77
C	SER77

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	THR93
B	THR93
C	THR93

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:20364129, ECO:0000269\|PubMed:25678563, ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS125
B	LYS125
C	LYS125

site_id	SWS_FT_FI8
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P17742

Chain	Residue	Details
A	LYS133
B	LYS133
C	LYS133

site_id	SWS_FT_FI9
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN108
B	ASN108
C	ASN108

site_id	SWS_FT_FI10
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
A	LYS28
B	LYS28
C	LYS28

site_id	SWS_FT_FI11
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS82
B	LYS82
C	LYS82

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
A	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
A	PHE60	polar/non-polar interaction, steric role
A	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	PHE113	polar/non-polar interaction, steric role
A	LEU122	polar/non-polar interaction, steric role
A	HIS126	polar/non-polar interaction, steric role

site_id	MCSA2
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
B	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
B	PHE60	polar/non-polar interaction, steric role
B	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
B	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
B	PHE113	polar/non-polar interaction, steric role
B	LEU122	polar/non-polar interaction, steric role
B	HIS126	polar/non-polar interaction, steric role

site_id	MCSA3
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
C	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
C	PHE60	polar/non-polar interaction, steric role
C	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
C	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
C	PHE113	polar/non-polar interaction, steric role
C	LEU122	polar/non-polar interaction, steric role
C	HIS126	polar/non-polar interaction, steric role

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)