7UTL

ALTERNATIVE MODELING OF TROPOMYOSIN IN HUMAN CARDIAC THIN FILAMENT IN THE CALCIUM FREE STATE

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001725	cellular_component	stress fiber
A	0003785	molecular_function	actin monomer binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005523	molecular_function	tropomyosin binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0010628	biological_process	positive regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0019904	molecular_function	protein domain specific binding
A	0030027	cellular_component	lamellipodium
A	0030041	biological_process	actin filament polymerization
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0031013	molecular_function	troponin I binding
A	0031432	molecular_function	titin binding
A	0031941	cellular_component	filamentous actin
A	0032036	molecular_function	myosin heavy chain binding
A	0032432	cellular_component	actin filament bundle
A	0042802	molecular_function	identical protein binding
A	0044297	cellular_component	cell body
A	0048306	molecular_function	calcium-dependent protein binding
A	0048741	biological_process	skeletal muscle fiber development
A	0051017	biological_process	actin filament bundle assembly
A	0090131	biological_process	mesenchyme migration
A	0098723	cellular_component	skeletal muscle myofibril
A	0140660	molecular_function	cytoskeletal motor activator activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0001725	cellular_component	stress fiber
B	0003785	molecular_function	actin monomer binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005523	molecular_function	tropomyosin binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0010628	biological_process	positive regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0019904	molecular_function	protein domain specific binding
B	0030027	cellular_component	lamellipodium
B	0030041	biological_process	actin filament polymerization
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0031013	molecular_function	troponin I binding
B	0031432	molecular_function	titin binding
B	0031941	cellular_component	filamentous actin
B	0032036	molecular_function	myosin heavy chain binding
B	0032432	cellular_component	actin filament bundle
B	0042802	molecular_function	identical protein binding
B	0044297	cellular_component	cell body
B	0048306	molecular_function	calcium-dependent protein binding
B	0048741	biological_process	skeletal muscle fiber development
B	0051017	biological_process	actin filament bundle assembly
B	0090131	biological_process	mesenchyme migration
B	0098723	cellular_component	skeletal muscle myofibril
B	0140660	molecular_function	cytoskeletal motor activator activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001725	cellular_component	stress fiber
C	0003785	molecular_function	actin monomer binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005523	molecular_function	tropomyosin binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0010628	biological_process	positive regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0019904	molecular_function	protein domain specific binding
C	0030027	cellular_component	lamellipodium
C	0030041	biological_process	actin filament polymerization
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0031013	molecular_function	troponin I binding
C	0031432	molecular_function	titin binding
C	0031941	cellular_component	filamentous actin
C	0032036	molecular_function	myosin heavy chain binding
C	0032432	cellular_component	actin filament bundle
C	0042802	molecular_function	identical protein binding
C	0044297	cellular_component	cell body
C	0048306	molecular_function	calcium-dependent protein binding
C	0048741	biological_process	skeletal muscle fiber development
C	0051017	biological_process	actin filament bundle assembly
C	0090131	biological_process	mesenchyme migration
C	0098723	cellular_component	skeletal muscle myofibril
C	0140660	molecular_function	cytoskeletal motor activator activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0001725	cellular_component	stress fiber
D	0003785	molecular_function	actin monomer binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005523	molecular_function	tropomyosin binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0010628	biological_process	positive regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0019904	molecular_function	protein domain specific binding
D	0030027	cellular_component	lamellipodium
D	0030041	biological_process	actin filament polymerization
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0031013	molecular_function	troponin I binding
D	0031432	molecular_function	titin binding
D	0031941	cellular_component	filamentous actin
D	0032036	molecular_function	myosin heavy chain binding
D	0032432	cellular_component	actin filament bundle
D	0042802	molecular_function	identical protein binding
D	0044297	cellular_component	cell body
D	0048306	molecular_function	calcium-dependent protein binding
D	0048741	biological_process	skeletal muscle fiber development
D	0051017	biological_process	actin filament bundle assembly
D	0090131	biological_process	mesenchyme migration
D	0098723	cellular_component	skeletal muscle myofibril
D	0140660	molecular_function	cytoskeletal motor activator activity
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0001725	cellular_component	stress fiber
E	0003785	molecular_function	actin monomer binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005523	molecular_function	tropomyosin binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0010628	biological_process	positive regulation of gene expression
E	0016787	molecular_function	hydrolase activity
E	0019904	molecular_function	protein domain specific binding
E	0030027	cellular_component	lamellipodium
E	0030041	biological_process	actin filament polymerization
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0031013	molecular_function	troponin I binding
E	0031432	molecular_function	titin binding
E	0031941	cellular_component	filamentous actin
E	0032036	molecular_function	myosin heavy chain binding
E	0032432	cellular_component	actin filament bundle
E	0042802	molecular_function	identical protein binding
E	0044297	cellular_component	cell body
E	0048306	molecular_function	calcium-dependent protein binding
E	0048741	biological_process	skeletal muscle fiber development
E	0051017	biological_process	actin filament bundle assembly
E	0090131	biological_process	mesenchyme migration
E	0098723	cellular_component	skeletal muscle myofibril
E	0140660	molecular_function	cytoskeletal motor activator activity
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0001725	cellular_component	stress fiber
F	0003785	molecular_function	actin monomer binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005523	molecular_function	tropomyosin binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005865	cellular_component	striated muscle thin filament
F	0005884	cellular_component	actin filament
F	0010628	biological_process	positive regulation of gene expression
F	0016787	molecular_function	hydrolase activity
F	0019904	molecular_function	protein domain specific binding
F	0030027	cellular_component	lamellipodium
F	0030041	biological_process	actin filament polymerization
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0031013	molecular_function	troponin I binding
F	0031432	molecular_function	titin binding
F	0031941	cellular_component	filamentous actin
F	0032036	molecular_function	myosin heavy chain binding
F	0032432	cellular_component	actin filament bundle
F	0042802	molecular_function	identical protein binding
F	0044297	cellular_component	cell body
F	0048306	molecular_function	calcium-dependent protein binding
F	0048741	biological_process	skeletal muscle fiber development
F	0051017	biological_process	actin filament bundle assembly
F	0090131	biological_process	mesenchyme migration
F	0098723	cellular_component	skeletal muscle myofibril
F	0140660	molecular_function	cytoskeletal motor activator activity
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0001725	cellular_component	stress fiber
G	0003785	molecular_function	actin monomer binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005523	molecular_function	tropomyosin binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005865	cellular_component	striated muscle thin filament
G	0005884	cellular_component	actin filament
G	0010628	biological_process	positive regulation of gene expression
G	0016787	molecular_function	hydrolase activity
G	0019904	molecular_function	protein domain specific binding
G	0030027	cellular_component	lamellipodium
G	0030041	biological_process	actin filament polymerization
G	0030175	cellular_component	filopodium
G	0030240	biological_process	skeletal muscle thin filament assembly
G	0031013	molecular_function	troponin I binding
G	0031432	molecular_function	titin binding
G	0031941	cellular_component	filamentous actin
G	0032036	molecular_function	myosin heavy chain binding
G	0032432	cellular_component	actin filament bundle
G	0042802	molecular_function	identical protein binding
G	0044297	cellular_component	cell body
G	0048306	molecular_function	calcium-dependent protein binding
G	0048741	biological_process	skeletal muscle fiber development
G	0051017	biological_process	actin filament bundle assembly
G	0090131	biological_process	mesenchyme migration
G	0098723	cellular_component	skeletal muscle myofibril
G	0140660	molecular_function	cytoskeletal motor activator activity
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0001725	cellular_component	stress fiber
H	0003785	molecular_function	actin monomer binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005523	molecular_function	tropomyosin binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005865	cellular_component	striated muscle thin filament
H	0005884	cellular_component	actin filament
H	0010628	biological_process	positive regulation of gene expression
H	0016787	molecular_function	hydrolase activity
H	0019904	molecular_function	protein domain specific binding
H	0030027	cellular_component	lamellipodium
H	0030041	biological_process	actin filament polymerization
H	0030175	cellular_component	filopodium
H	0030240	biological_process	skeletal muscle thin filament assembly
H	0031013	molecular_function	troponin I binding
H	0031432	molecular_function	titin binding
H	0031941	cellular_component	filamentous actin
H	0032036	molecular_function	myosin heavy chain binding
H	0032432	cellular_component	actin filament bundle
H	0042802	molecular_function	identical protein binding
H	0044297	cellular_component	cell body
H	0048306	molecular_function	calcium-dependent protein binding
H	0048741	biological_process	skeletal muscle fiber development
H	0051017	biological_process	actin filament bundle assembly
H	0090131	biological_process	mesenchyme migration
H	0098723	cellular_component	skeletal muscle myofibril
H	0140660	molecular_function	cytoskeletal motor activator activity
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0001725	cellular_component	stress fiber
I	0003785	molecular_function	actin monomer binding
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005523	molecular_function	tropomyosin binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005865	cellular_component	striated muscle thin filament
I	0005884	cellular_component	actin filament
I	0010628	biological_process	positive regulation of gene expression
I	0016787	molecular_function	hydrolase activity
I	0019904	molecular_function	protein domain specific binding
I	0030027	cellular_component	lamellipodium
I	0030041	biological_process	actin filament polymerization
I	0030175	cellular_component	filopodium
I	0030240	biological_process	skeletal muscle thin filament assembly
I	0031013	molecular_function	troponin I binding
I	0031432	molecular_function	titin binding
I	0031941	cellular_component	filamentous actin
I	0032036	molecular_function	myosin heavy chain binding
I	0032432	cellular_component	actin filament bundle
I	0042802	molecular_function	identical protein binding
I	0044297	cellular_component	cell body
I	0048306	molecular_function	calcium-dependent protein binding
I	0048741	biological_process	skeletal muscle fiber development
I	0051017	biological_process	actin filament bundle assembly
I	0090131	biological_process	mesenchyme migration
I	0098723	cellular_component	skeletal muscle myofibril
I	0140660	molecular_function	cytoskeletal motor activator activity
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0001725	cellular_component	stress fiber
J	0003785	molecular_function	actin monomer binding
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005523	molecular_function	tropomyosin binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005865	cellular_component	striated muscle thin filament
J	0005884	cellular_component	actin filament
J	0010628	biological_process	positive regulation of gene expression
J	0016787	molecular_function	hydrolase activity
J	0019904	molecular_function	protein domain specific binding
J	0030027	cellular_component	lamellipodium
J	0030041	biological_process	actin filament polymerization
J	0030175	cellular_component	filopodium
J	0030240	biological_process	skeletal muscle thin filament assembly
J	0031013	molecular_function	troponin I binding
J	0031432	molecular_function	titin binding
J	0031941	cellular_component	filamentous actin
J	0032036	molecular_function	myosin heavy chain binding
J	0032432	cellular_component	actin filament bundle
J	0042802	molecular_function	identical protein binding
J	0044297	cellular_component	cell body
J	0048306	molecular_function	calcium-dependent protein binding
J	0048741	biological_process	skeletal muscle fiber development
J	0051017	biological_process	actin filament bundle assembly
J	0090131	biological_process	mesenchyme migration
J	0098723	cellular_component	skeletal muscle myofibril
J	0140660	molecular_function	cytoskeletal motor activator activity
K	0000166	molecular_function	nucleotide binding
K	0000287	molecular_function	magnesium ion binding
K	0001725	cellular_component	stress fiber
K	0003785	molecular_function	actin monomer binding
K	0005509	molecular_function	calcium ion binding
K	0005515	molecular_function	protein binding
K	0005523	molecular_function	tropomyosin binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005865	cellular_component	striated muscle thin filament
K	0005884	cellular_component	actin filament
K	0010628	biological_process	positive regulation of gene expression
K	0016787	molecular_function	hydrolase activity
K	0019904	molecular_function	protein domain specific binding
K	0030027	cellular_component	lamellipodium
K	0030041	biological_process	actin filament polymerization
K	0030175	cellular_component	filopodium
K	0030240	biological_process	skeletal muscle thin filament assembly
K	0031013	molecular_function	troponin I binding
K	0031432	molecular_function	titin binding
K	0031941	cellular_component	filamentous actin
K	0032036	molecular_function	myosin heavy chain binding
K	0032432	cellular_component	actin filament bundle
K	0042802	molecular_function	identical protein binding
K	0044297	cellular_component	cell body
K	0048306	molecular_function	calcium-dependent protein binding
K	0048741	biological_process	skeletal muscle fiber development
K	0051017	biological_process	actin filament bundle assembly
K	0090131	biological_process	mesenchyme migration
K	0098723	cellular_component	skeletal muscle myofibril
K	0140660	molecular_function	cytoskeletal motor activator activity
L	0000166	molecular_function	nucleotide binding
L	0000287	molecular_function	magnesium ion binding
L	0001725	cellular_component	stress fiber
L	0003785	molecular_function	actin monomer binding
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005523	molecular_function	tropomyosin binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005865	cellular_component	striated muscle thin filament
L	0005884	cellular_component	actin filament
L	0010628	biological_process	positive regulation of gene expression
L	0016787	molecular_function	hydrolase activity
L	0019904	molecular_function	protein domain specific binding
L	0030027	cellular_component	lamellipodium
L	0030041	biological_process	actin filament polymerization
L	0030175	cellular_component	filopodium
L	0030240	biological_process	skeletal muscle thin filament assembly
L	0031013	molecular_function	troponin I binding
L	0031432	molecular_function	titin binding
L	0031941	cellular_component	filamentous actin
L	0032036	molecular_function	myosin heavy chain binding
L	0032432	cellular_component	actin filament bundle
L	0042802	molecular_function	identical protein binding
L	0044297	cellular_component	cell body
L	0048306	molecular_function	calcium-dependent protein binding
L	0048741	biological_process	skeletal muscle fiber development
L	0051017	biological_process	actin filament bundle assembly
L	0090131	biological_process	mesenchyme migration
L	0098723	cellular_component	skeletal muscle myofibril
L	0140660	molecular_function	cytoskeletal motor activator activity
M	0000166	molecular_function	nucleotide binding
M	0000287	molecular_function	magnesium ion binding
M	0001725	cellular_component	stress fiber
M	0003785	molecular_function	actin monomer binding
M	0005509	molecular_function	calcium ion binding
M	0005515	molecular_function	protein binding
M	0005523	molecular_function	tropomyosin binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005865	cellular_component	striated muscle thin filament
M	0005884	cellular_component	actin filament
M	0010628	biological_process	positive regulation of gene expression
M	0016787	molecular_function	hydrolase activity
M	0019904	molecular_function	protein domain specific binding
M	0030027	cellular_component	lamellipodium
M	0030041	biological_process	actin filament polymerization
M	0030175	cellular_component	filopodium
M	0030240	biological_process	skeletal muscle thin filament assembly
M	0031013	molecular_function	troponin I binding
M	0031432	molecular_function	titin binding
M	0031941	cellular_component	filamentous actin
M	0032036	molecular_function	myosin heavy chain binding
M	0032432	cellular_component	actin filament bundle
M	0042802	molecular_function	identical protein binding
M	0044297	cellular_component	cell body
M	0048306	molecular_function	calcium-dependent protein binding
M	0048741	biological_process	skeletal muscle fiber development
M	0051017	biological_process	actin filament bundle assembly
M	0090131	biological_process	mesenchyme migration
M	0098723	cellular_component	skeletal muscle myofibril
M	0140660	molecular_function	cytoskeletal motor activator activity
N	0000166	molecular_function	nucleotide binding
N	0000287	molecular_function	magnesium ion binding
N	0001725	cellular_component	stress fiber
N	0003785	molecular_function	actin monomer binding
N	0005509	molecular_function	calcium ion binding
N	0005515	molecular_function	protein binding
N	0005523	molecular_function	tropomyosin binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005865	cellular_component	striated muscle thin filament
N	0005884	cellular_component	actin filament
N	0010628	biological_process	positive regulation of gene expression
N	0016787	molecular_function	hydrolase activity
N	0019904	molecular_function	protein domain specific binding
N	0030027	cellular_component	lamellipodium
N	0030041	biological_process	actin filament polymerization
N	0030175	cellular_component	filopodium
N	0030240	biological_process	skeletal muscle thin filament assembly
N	0031013	molecular_function	troponin I binding
N	0031432	molecular_function	titin binding
N	0031941	cellular_component	filamentous actin
N	0032036	molecular_function	myosin heavy chain binding
N	0032432	cellular_component	actin filament bundle
N	0042802	molecular_function	identical protein binding
N	0044297	cellular_component	cell body
N	0048306	molecular_function	calcium-dependent protein binding
N	0048741	biological_process	skeletal muscle fiber development
N	0051017	biological_process	actin filament bundle assembly
N	0090131	biological_process	mesenchyme migration
N	0098723	cellular_component	skeletal muscle myofibril
N	0140660	molecular_function	cytoskeletal motor activator activity
O	0000166	molecular_function	nucleotide binding
O	0000287	molecular_function	magnesium ion binding
O	0001725	cellular_component	stress fiber
O	0003785	molecular_function	actin monomer binding
O	0005509	molecular_function	calcium ion binding
O	0005515	molecular_function	protein binding
O	0005523	molecular_function	tropomyosin binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005865	cellular_component	striated muscle thin filament
O	0005884	cellular_component	actin filament
O	0010628	biological_process	positive regulation of gene expression
O	0016787	molecular_function	hydrolase activity
O	0019904	molecular_function	protein domain specific binding
O	0030027	cellular_component	lamellipodium
O	0030041	biological_process	actin filament polymerization
O	0030175	cellular_component	filopodium
O	0030240	biological_process	skeletal muscle thin filament assembly
O	0031013	molecular_function	troponin I binding
O	0031432	molecular_function	titin binding
O	0031941	cellular_component	filamentous actin
O	0032036	molecular_function	myosin heavy chain binding
O	0032432	cellular_component	actin filament bundle
O	0042802	molecular_function	identical protein binding
O	0044297	cellular_component	cell body
O	0048306	molecular_function	calcium-dependent protein binding
O	0048741	biological_process	skeletal muscle fiber development
O	0051017	biological_process	actin filament bundle assembly
O	0090131	biological_process	mesenchyme migration
O	0098723	cellular_component	skeletal muscle myofibril
O	0140660	molecular_function	cytoskeletal motor activator activity
P	0000166	molecular_function	nucleotide binding
P	0000287	molecular_function	magnesium ion binding
P	0001725	cellular_component	stress fiber
P	0003785	molecular_function	actin monomer binding
P	0005509	molecular_function	calcium ion binding
P	0005515	molecular_function	protein binding
P	0005523	molecular_function	tropomyosin binding
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005865	cellular_component	striated muscle thin filament
P	0005884	cellular_component	actin filament
P	0010628	biological_process	positive regulation of gene expression
P	0016787	molecular_function	hydrolase activity
P	0019904	molecular_function	protein domain specific binding
P	0030027	cellular_component	lamellipodium
P	0030041	biological_process	actin filament polymerization
P	0030175	cellular_component	filopodium
P	0030240	biological_process	skeletal muscle thin filament assembly
P	0031013	molecular_function	troponin I binding
P	0031432	molecular_function	titin binding
P	0031941	cellular_component	filamentous actin
P	0032036	molecular_function	myosin heavy chain binding
P	0032432	cellular_component	actin filament bundle
P	0042802	molecular_function	identical protein binding
P	0044297	cellular_component	cell body
P	0048306	molecular_function	calcium-dependent protein binding
P	0048741	biological_process	skeletal muscle fiber development
P	0051017	biological_process	actin filament bundle assembly
P	0090131	biological_process	mesenchyme migration
P	0098723	cellular_component	skeletal muscle myofibril
P	0140660	molecular_function	cytoskeletal motor activator activity
Q	0000166	molecular_function	nucleotide binding
Q	0000287	molecular_function	magnesium ion binding
Q	0001725	cellular_component	stress fiber
Q	0003785	molecular_function	actin monomer binding
Q	0005509	molecular_function	calcium ion binding
Q	0005515	molecular_function	protein binding
Q	0005523	molecular_function	tropomyosin binding
Q	0005524	molecular_function	ATP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005865	cellular_component	striated muscle thin filament
Q	0005884	cellular_component	actin filament
Q	0010628	biological_process	positive regulation of gene expression
Q	0016787	molecular_function	hydrolase activity
Q	0019904	molecular_function	protein domain specific binding
Q	0030027	cellular_component	lamellipodium
Q	0030041	biological_process	actin filament polymerization
Q	0030175	cellular_component	filopodium
Q	0030240	biological_process	skeletal muscle thin filament assembly
Q	0031013	molecular_function	troponin I binding
Q	0031432	molecular_function	titin binding
Q	0031941	cellular_component	filamentous actin
Q	0032036	molecular_function	myosin heavy chain binding
Q	0032432	cellular_component	actin filament bundle
Q	0042802	molecular_function	identical protein binding
Q	0044297	cellular_component	cell body
Q	0048306	molecular_function	calcium-dependent protein binding
Q	0048741	biological_process	skeletal muscle fiber development
Q	0051017	biological_process	actin filament bundle assembly
Q	0090131	biological_process	mesenchyme migration
Q	0098723	cellular_component	skeletal muscle myofibril
Q	0140660	molecular_function	cytoskeletal motor activator activity
R	0000166	molecular_function	nucleotide binding
R	0000287	molecular_function	magnesium ion binding
R	0001725	cellular_component	stress fiber
R	0003785	molecular_function	actin monomer binding
R	0005509	molecular_function	calcium ion binding
R	0005515	molecular_function	protein binding
R	0005523	molecular_function	tropomyosin binding
R	0005524	molecular_function	ATP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005865	cellular_component	striated muscle thin filament
R	0005884	cellular_component	actin filament
R	0010628	biological_process	positive regulation of gene expression
R	0016787	molecular_function	hydrolase activity
R	0019904	molecular_function	protein domain specific binding
R	0030027	cellular_component	lamellipodium
R	0030041	biological_process	actin filament polymerization
R	0030175	cellular_component	filopodium
R	0030240	biological_process	skeletal muscle thin filament assembly
R	0031013	molecular_function	troponin I binding
R	0031432	molecular_function	titin binding
R	0031941	cellular_component	filamentous actin
R	0032036	molecular_function	myosin heavy chain binding
R	0032432	cellular_component	actin filament bundle
R	0042802	molecular_function	identical protein binding
R	0044297	cellular_component	cell body
R	0048306	molecular_function	calcium-dependent protein binding
R	0048741	biological_process	skeletal muscle fiber development
R	0051017	biological_process	actin filament bundle assembly
R	0090131	biological_process	mesenchyme migration
R	0098723	cellular_component	skeletal muscle myofibril
R	0140660	molecular_function	cytoskeletal motor activator activity
U	0002086	biological_process	diaphragm contraction
U	0003009	biological_process	skeletal muscle contraction
U	0005509	molecular_function	calcium ion binding
U	0005515	molecular_function	protein binding
U	0005829	cellular_component	cytosol
U	0005861	cellular_component	troponin complex
U	0006937	biological_process	regulation of muscle contraction
U	0008092	molecular_function	cytoskeletal protein binding
U	0010038	biological_process	response to metal ion
U	0014883	biological_process	transition between fast and slow fiber
U	0030017	cellular_component	sarcomere
U	0030049	biological_process	muscle filament sliding
U	0031013	molecular_function	troponin I binding
U	0031014	molecular_function	troponin T binding
U	0032972	biological_process	regulation of muscle filament sliding speed
U	0042803	molecular_function	protein homodimerization activity
U	0043292	cellular_component	contractile muscle fiber
U	0046872	molecular_function	metal ion binding
U	0048306	molecular_function	calcium-dependent protein binding
U	0051015	molecular_function	actin filament binding
U	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
U	0060048	biological_process	cardiac muscle contraction
U	0086003	biological_process	cardiac muscle cell contraction
U	1990584	cellular_component	cardiac Troponin complex
V	0001570	biological_process	vasculogenesis
V	0001980	biological_process	regulation of systemic arterial blood pressure by ischemic conditions
V	0003009	biological_process	skeletal muscle contraction
V	0003779	molecular_function	actin binding
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005861	cellular_component	troponin complex
V	0006874	biological_process	intracellular calcium ion homeostasis
V	0006937	biological_process	regulation of muscle contraction
V	0006940	biological_process	regulation of smooth muscle contraction
V	0006941	biological_process	striated muscle contraction
V	0007507	biological_process	heart development
V	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
V	0019855	molecular_function	calcium channel inhibitor activity
V	0019901	molecular_function	protein kinase binding
V	0019904	molecular_function	protein domain specific binding
V	0030016	cellular_component	myofibril
V	0030017	cellular_component	sarcomere
V	0030049	biological_process	muscle filament sliding
V	0030172	molecular_function	troponin C binding
V	0031014	molecular_function	troponin T binding
V	0032780	biological_process	negative regulation of ATP-dependent activity
V	0043292	cellular_component	contractile muscle fiber
V	0048306	molecular_function	calcium-dependent protein binding
V	0051015	molecular_function	actin filament binding
V	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
V	0060047	biological_process	heart contraction
V	0060048	biological_process	cardiac muscle contraction
V	0097512	cellular_component	cardiac myofibril
V	1990584	cellular_component	cardiac Troponin complex
W	0001725	cellular_component	stress fiber
W	0003065	biological_process	positive regulation of heart rate by epinephrine
W	0003779	molecular_function	actin binding
W	0005200	molecular_function	structural constituent of cytoskeleton
W	0005515	molecular_function	protein binding
W	0005829	cellular_component	cytosol
W	0005856	cellular_component	cytoskeleton
W	0005862	cellular_component	muscle thin filament tropomyosin
W	0005884	cellular_component	actin filament
W	0006937	biological_process	regulation of muscle contraction
W	0007010	biological_process	cytoskeleton organization
W	0007015	biological_process	actin filament organization
W	0008016	biological_process	regulation of heart contraction
W	0008092	molecular_function	cytoskeletal protein binding
W	0008307	molecular_function	structural constituent of muscle
W	0008360	biological_process	regulation of cell shape
W	0015629	cellular_component	actin cytoskeleton
W	0030017	cellular_component	sarcomere
W	0030049	biological_process	muscle filament sliding
W	0030336	biological_process	negative regulation of cell migration
W	0031529	biological_process	ruffle organization
W	0032059	cellular_component	bleb
W	0032587	cellular_component	ruffle membrane
W	0034614	biological_process	cellular response to reactive oxygen species
W	0042060	biological_process	wound healing
W	0042802	molecular_function	identical protein binding
W	0042803	molecular_function	protein homodimerization activity
W	0045214	biological_process	sarcomere organization
W	0045785	biological_process	positive regulation of cell adhesion
W	0046982	molecular_function	protein heterodimerization activity
W	0051015	molecular_function	actin filament binding
W	0051496	biological_process	positive regulation of stress fiber assembly
W	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
W	0060048	biological_process	cardiac muscle contraction
W	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
W	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
X	0003779	molecular_function	actin binding
X	0005515	molecular_function	protein binding
X	0005523	molecular_function	tropomyosin binding
X	0005829	cellular_component	cytosol
X	0005861	cellular_component	troponin complex
X	0005865	cellular_component	striated muscle thin filament
X	0006937	biological_process	regulation of muscle contraction
X	0006941	biological_process	striated muscle contraction
X	0008016	biological_process	regulation of heart contraction
X	0030017	cellular_component	sarcomere
X	0030049	biological_process	muscle filament sliding
X	0030172	molecular_function	troponin C binding
X	0031013	molecular_function	troponin I binding
X	0032780	biological_process	negative regulation of ATP-dependent activity
X	0032781	biological_process	positive regulation of ATP-dependent activity
X	0045214	biological_process	sarcomere organization
X	0051592	biological_process	response to calcium ion
X	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
X	0060048	biological_process	cardiac muscle contraction
X	0097512	cellular_component	cardiac myofibril
X	1990584	cellular_component	cardiac Troponin complex
Y	0003779	molecular_function	actin binding
Y	0005515	molecular_function	protein binding
Y	0005523	molecular_function	tropomyosin binding
Y	0005829	cellular_component	cytosol
Y	0005861	cellular_component	troponin complex
Y	0005865	cellular_component	striated muscle thin filament
Y	0006937	biological_process	regulation of muscle contraction
Y	0006941	biological_process	striated muscle contraction
Y	0008016	biological_process	regulation of heart contraction
Y	0030017	cellular_component	sarcomere
Y	0030049	biological_process	muscle filament sliding
Y	0030172	molecular_function	troponin C binding
Y	0031013	molecular_function	troponin I binding
Y	0032780	biological_process	negative regulation of ATP-dependent activity
Y	0032781	biological_process	positive regulation of ATP-dependent activity
Y	0045214	biological_process	sarcomere organization
Y	0051592	biological_process	response to calcium ion
Y	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
Y	0060048	biological_process	cardiac muscle contraction
Y	0097512	cellular_component	cardiac myofibril
Y	1990584	cellular_component	cardiac Troponin complex
Z	0001725	cellular_component	stress fiber
Z	0003065	biological_process	positive regulation of heart rate by epinephrine
Z	0003779	molecular_function	actin binding
Z	0005200	molecular_function	structural constituent of cytoskeleton
Z	0005515	molecular_function	protein binding
Z	0005829	cellular_component	cytosol
Z	0005856	cellular_component	cytoskeleton
Z	0005862	cellular_component	muscle thin filament tropomyosin
Z	0005884	cellular_component	actin filament
Z	0006937	biological_process	regulation of muscle contraction
Z	0007010	biological_process	cytoskeleton organization
Z	0007015	biological_process	actin filament organization
Z	0008016	biological_process	regulation of heart contraction
Z	0008092	molecular_function	cytoskeletal protein binding
Z	0008307	molecular_function	structural constituent of muscle
Z	0008360	biological_process	regulation of cell shape
Z	0015629	cellular_component	actin cytoskeleton
Z	0030017	cellular_component	sarcomere
Z	0030049	biological_process	muscle filament sliding
Z	0030336	biological_process	negative regulation of cell migration
Z	0031529	biological_process	ruffle organization
Z	0032059	cellular_component	bleb
Z	0032587	cellular_component	ruffle membrane
Z	0034614	biological_process	cellular response to reactive oxygen species
Z	0042060	biological_process	wound healing
Z	0042802	molecular_function	identical protein binding
Z	0042803	molecular_function	protein homodimerization activity
Z	0045214	biological_process	sarcomere organization
Z	0045785	biological_process	positive regulation of cell adhesion
Z	0046982	molecular_function	protein heterodimerization activity
Z	0051015	molecular_function	actin filament binding
Z	0051496	biological_process	positive regulation of stress fiber assembly
Z	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
Z	0060048	biological_process	cardiac muscle contraction
Z	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
Z	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
a	0001725	cellular_component	stress fiber
a	0003065	biological_process	positive regulation of heart rate by epinephrine
a	0003779	molecular_function	actin binding
a	0005200	molecular_function	structural constituent of cytoskeleton
a	0005515	molecular_function	protein binding
a	0005829	cellular_component	cytosol
a	0005856	cellular_component	cytoskeleton
a	0005862	cellular_component	muscle thin filament tropomyosin
a	0005884	cellular_component	actin filament
a	0006937	biological_process	regulation of muscle contraction
a	0007010	biological_process	cytoskeleton organization
a	0007015	biological_process	actin filament organization
a	0008016	biological_process	regulation of heart contraction
a	0008092	molecular_function	cytoskeletal protein binding
a	0008307	molecular_function	structural constituent of muscle
a	0008360	biological_process	regulation of cell shape
a	0015629	cellular_component	actin cytoskeleton
a	0030017	cellular_component	sarcomere
a	0030049	biological_process	muscle filament sliding
a	0030336	biological_process	negative regulation of cell migration
a	0031529	biological_process	ruffle organization
a	0032059	cellular_component	bleb
a	0032587	cellular_component	ruffle membrane
a	0034614	biological_process	cellular response to reactive oxygen species
a	0042060	biological_process	wound healing
a	0042802	molecular_function	identical protein binding
a	0042803	molecular_function	protein homodimerization activity
a	0045214	biological_process	sarcomere organization
a	0045785	biological_process	positive regulation of cell adhesion
a	0046982	molecular_function	protein heterodimerization activity
a	0051015	molecular_function	actin filament binding
a	0051496	biological_process	positive regulation of stress fiber assembly
a	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
a	0060048	biological_process	cardiac muscle contraction
a	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
a	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
b	0001725	cellular_component	stress fiber
b	0003065	biological_process	positive regulation of heart rate by epinephrine
b	0003779	molecular_function	actin binding
b	0005200	molecular_function	structural constituent of cytoskeleton
b	0005515	molecular_function	protein binding
b	0005829	cellular_component	cytosol
b	0005856	cellular_component	cytoskeleton
b	0005862	cellular_component	muscle thin filament tropomyosin
b	0005884	cellular_component	actin filament
b	0006937	biological_process	regulation of muscle contraction
b	0007010	biological_process	cytoskeleton organization
b	0007015	biological_process	actin filament organization
b	0008016	biological_process	regulation of heart contraction
b	0008092	molecular_function	cytoskeletal protein binding
b	0008307	molecular_function	structural constituent of muscle
b	0008360	biological_process	regulation of cell shape
b	0015629	cellular_component	actin cytoskeleton
b	0030017	cellular_component	sarcomere
b	0030049	biological_process	muscle filament sliding
b	0030336	biological_process	negative regulation of cell migration
b	0031529	biological_process	ruffle organization
b	0032059	cellular_component	bleb
b	0032587	cellular_component	ruffle membrane
b	0034614	biological_process	cellular response to reactive oxygen species
b	0042060	biological_process	wound healing
b	0042802	molecular_function	identical protein binding
b	0042803	molecular_function	protein homodimerization activity
b	0045214	biological_process	sarcomere organization
b	0045785	biological_process	positive regulation of cell adhesion
b	0046982	molecular_function	protein heterodimerization activity
b	0051015	molecular_function	actin filament binding
b	0051496	biological_process	positive regulation of stress fiber assembly
b	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
b	0060048	biological_process	cardiac muscle contraction
b	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
b	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
c	0001570	biological_process	vasculogenesis
c	0001980	biological_process	regulation of systemic arterial blood pressure by ischemic conditions
c	0003009	biological_process	skeletal muscle contraction
c	0003779	molecular_function	actin binding
c	0005515	molecular_function	protein binding
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005861	cellular_component	troponin complex
c	0006874	biological_process	intracellular calcium ion homeostasis
c	0006937	biological_process	regulation of muscle contraction
c	0006940	biological_process	regulation of smooth muscle contraction
c	0006941	biological_process	striated muscle contraction
c	0007507	biological_process	heart development
c	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
c	0019855	molecular_function	calcium channel inhibitor activity
c	0019901	molecular_function	protein kinase binding
c	0019904	molecular_function	protein domain specific binding
c	0030016	cellular_component	myofibril
c	0030017	cellular_component	sarcomere
c	0030049	biological_process	muscle filament sliding
c	0030172	molecular_function	troponin C binding
c	0031014	molecular_function	troponin T binding
c	0032780	biological_process	negative regulation of ATP-dependent activity
c	0043292	cellular_component	contractile muscle fiber
c	0048306	molecular_function	calcium-dependent protein binding
c	0051015	molecular_function	actin filament binding
c	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
c	0060047	biological_process	heart contraction
c	0060048	biological_process	cardiac muscle contraction
c	0097512	cellular_component	cardiac myofibril
c	1990584	cellular_component	cardiac Troponin complex
d	0002086	biological_process	diaphragm contraction
d	0003009	biological_process	skeletal muscle contraction
d	0005509	molecular_function	calcium ion binding
d	0005515	molecular_function	protein binding
d	0005829	cellular_component	cytosol
d	0005861	cellular_component	troponin complex
d	0006937	biological_process	regulation of muscle contraction
d	0008092	molecular_function	cytoskeletal protein binding
d	0010038	biological_process	response to metal ion
d	0014883	biological_process	transition between fast and slow fiber
d	0030017	cellular_component	sarcomere
d	0030049	biological_process	muscle filament sliding
d	0031013	molecular_function	troponin I binding
d	0031014	molecular_function	troponin T binding
d	0032972	biological_process	regulation of muscle filament sliding speed
d	0042803	molecular_function	protein homodimerization activity
d	0043292	cellular_component	contractile muscle fiber
d	0046872	molecular_function	metal ion binding
d	0048306	molecular_function	calcium-dependent protein binding
d	0051015	molecular_function	actin filament binding
d	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
d	0060048	biological_process	cardiac muscle contraction
d	0086003	biological_process	cardiac muscle cell contraction
d	1990584	cellular_component	cardiac Troponin complex
e	0003779	molecular_function	actin binding
e	0005515	molecular_function	protein binding
e	0005523	molecular_function	tropomyosin binding
e	0005829	cellular_component	cytosol
e	0005861	cellular_component	troponin complex
e	0005865	cellular_component	striated muscle thin filament
e	0006937	biological_process	regulation of muscle contraction
e	0006941	biological_process	striated muscle contraction
e	0008016	biological_process	regulation of heart contraction
e	0030017	cellular_component	sarcomere
e	0030049	biological_process	muscle filament sliding
e	0030172	molecular_function	troponin C binding
e	0031013	molecular_function	troponin I binding
e	0032780	biological_process	negative regulation of ATP-dependent activity
e	0032781	biological_process	positive regulation of ATP-dependent activity
e	0045214	biological_process	sarcomere organization
e	0051592	biological_process	response to calcium ion
e	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
e	0060048	biological_process	cardiac muscle contraction
e	0097512	cellular_component	cardiac myofibril
e	1990584	cellular_component	cardiac Troponin complex
f	0003779	molecular_function	actin binding
f	0005515	molecular_function	protein binding
f	0005523	molecular_function	tropomyosin binding
f	0005829	cellular_component	cytosol
f	0005861	cellular_component	troponin complex
f	0005865	cellular_component	striated muscle thin filament
f	0006937	biological_process	regulation of muscle contraction
f	0006941	biological_process	striated muscle contraction
f	0008016	biological_process	regulation of heart contraction
f	0030017	cellular_component	sarcomere
f	0030049	biological_process	muscle filament sliding
f	0030172	molecular_function	troponin C binding
f	0031013	molecular_function	troponin I binding
f	0032780	biological_process	negative regulation of ATP-dependent activity
f	0032781	biological_process	positive regulation of ATP-dependent activity
f	0045214	biological_process	sarcomere organization
f	0051592	biological_process	response to calcium ion
f	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
f	0060048	biological_process	cardiac muscle contraction
f	0097512	cellular_component	cardiac myofibril
f	1990584	cellular_component	cardiac Troponin complex
g	0001725	cellular_component	stress fiber
g	0003065	biological_process	positive regulation of heart rate by epinephrine
g	0003779	molecular_function	actin binding
g	0005200	molecular_function	structural constituent of cytoskeleton
g	0005515	molecular_function	protein binding
g	0005829	cellular_component	cytosol
g	0005856	cellular_component	cytoskeleton
g	0005862	cellular_component	muscle thin filament tropomyosin
g	0005884	cellular_component	actin filament
g	0006937	biological_process	regulation of muscle contraction
g	0007010	biological_process	cytoskeleton organization
g	0007015	biological_process	actin filament organization
g	0008016	biological_process	regulation of heart contraction
g	0008092	molecular_function	cytoskeletal protein binding
g	0008307	molecular_function	structural constituent of muscle
g	0008360	biological_process	regulation of cell shape
g	0015629	cellular_component	actin cytoskeleton
g	0030017	cellular_component	sarcomere
g	0030049	biological_process	muscle filament sliding
g	0030336	biological_process	negative regulation of cell migration
g	0031529	biological_process	ruffle organization
g	0032059	cellular_component	bleb
g	0032587	cellular_component	ruffle membrane
g	0034614	biological_process	cellular response to reactive oxygen species
g	0042060	biological_process	wound healing
g	0042802	molecular_function	identical protein binding
g	0042803	molecular_function	protein homodimerization activity
g	0045214	biological_process	sarcomere organization
g	0045785	biological_process	positive regulation of cell adhesion
g	0046982	molecular_function	protein heterodimerization activity
g	0051015	molecular_function	actin filament binding
g	0051496	biological_process	positive regulation of stress fiber assembly
g	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
g	0060048	biological_process	cardiac muscle contraction
g	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
g	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
h	0001725	cellular_component	stress fiber
h	0003065	biological_process	positive regulation of heart rate by epinephrine
h	0003779	molecular_function	actin binding
h	0005200	molecular_function	structural constituent of cytoskeleton
h	0005515	molecular_function	protein binding
h	0005829	cellular_component	cytosol
h	0005856	cellular_component	cytoskeleton
h	0005862	cellular_component	muscle thin filament tropomyosin
h	0005884	cellular_component	actin filament
h	0006937	biological_process	regulation of muscle contraction
h	0007010	biological_process	cytoskeleton organization
h	0007015	biological_process	actin filament organization
h	0008016	biological_process	regulation of heart contraction
h	0008092	molecular_function	cytoskeletal protein binding
h	0008307	molecular_function	structural constituent of muscle
h	0008360	biological_process	regulation of cell shape
h	0015629	cellular_component	actin cytoskeleton
h	0030017	cellular_component	sarcomere
h	0030049	biological_process	muscle filament sliding
h	0030336	biological_process	negative regulation of cell migration
h	0031529	biological_process	ruffle organization
h	0032059	cellular_component	bleb
h	0032587	cellular_component	ruffle membrane
h	0034614	biological_process	cellular response to reactive oxygen species
h	0042060	biological_process	wound healing
h	0042802	molecular_function	identical protein binding
h	0042803	molecular_function	protein homodimerization activity
h	0045214	biological_process	sarcomere organization
h	0045785	biological_process	positive regulation of cell adhesion
h	0046982	molecular_function	protein heterodimerization activity
h	0051015	molecular_function	actin filament binding
h	0051496	biological_process	positive regulation of stress fiber assembly
h	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
h	0060048	biological_process	cardiac muscle contraction
h	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
h	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
i	0001725	cellular_component	stress fiber
i	0003065	biological_process	positive regulation of heart rate by epinephrine
i	0003779	molecular_function	actin binding
i	0005200	molecular_function	structural constituent of cytoskeleton
i	0005515	molecular_function	protein binding
i	0005829	cellular_component	cytosol
i	0005856	cellular_component	cytoskeleton
i	0005862	cellular_component	muscle thin filament tropomyosin
i	0005884	cellular_component	actin filament
i	0006937	biological_process	regulation of muscle contraction
i	0007010	biological_process	cytoskeleton organization
i	0007015	biological_process	actin filament organization
i	0008016	biological_process	regulation of heart contraction
i	0008092	molecular_function	cytoskeletal protein binding
i	0008307	molecular_function	structural constituent of muscle
i	0008360	biological_process	regulation of cell shape
i	0015629	cellular_component	actin cytoskeleton
i	0030017	cellular_component	sarcomere
i	0030049	biological_process	muscle filament sliding
i	0030336	biological_process	negative regulation of cell migration
i	0031529	biological_process	ruffle organization
i	0032059	cellular_component	bleb
i	0032587	cellular_component	ruffle membrane
i	0034614	biological_process	cellular response to reactive oxygen species
i	0042060	biological_process	wound healing
i	0042802	molecular_function	identical protein binding
i	0042803	molecular_function	protein homodimerization activity
i	0045214	biological_process	sarcomere organization
i	0045785	biological_process	positive regulation of cell adhesion
i	0046982	molecular_function	protein heterodimerization activity
i	0051015	molecular_function	actin filament binding
i	0051496	biological_process	positive regulation of stress fiber assembly
i	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
i	0060048	biological_process	cardiac muscle contraction
i	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
i	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
j	0001725	cellular_component	stress fiber
j	0003065	biological_process	positive regulation of heart rate by epinephrine
j	0003779	molecular_function	actin binding
j	0005200	molecular_function	structural constituent of cytoskeleton
j	0005515	molecular_function	protein binding
j	0005829	cellular_component	cytosol
j	0005856	cellular_component	cytoskeleton
j	0005862	cellular_component	muscle thin filament tropomyosin
j	0005884	cellular_component	actin filament
j	0006937	biological_process	regulation of muscle contraction
j	0007010	biological_process	cytoskeleton organization
j	0007015	biological_process	actin filament organization
j	0008016	biological_process	regulation of heart contraction
j	0008092	molecular_function	cytoskeletal protein binding
j	0008307	molecular_function	structural constituent of muscle
j	0008360	biological_process	regulation of cell shape
j	0015629	cellular_component	actin cytoskeleton
j	0030017	cellular_component	sarcomere
j	0030049	biological_process	muscle filament sliding
j	0030336	biological_process	negative regulation of cell migration
j	0031529	biological_process	ruffle organization
j	0032059	cellular_component	bleb
j	0032587	cellular_component	ruffle membrane
j	0034614	biological_process	cellular response to reactive oxygen species
j	0042060	biological_process	wound healing
j	0042802	molecular_function	identical protein binding
j	0042803	molecular_function	protein homodimerization activity
j	0045214	biological_process	sarcomere organization
j	0045785	biological_process	positive regulation of cell adhesion
j	0046982	molecular_function	protein heterodimerization activity
j	0051015	molecular_function	actin filament binding
j	0051496	biological_process	positive regulation of stress fiber assembly
j	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
j	0060048	biological_process	cardiac muscle contraction
j	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
j	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DEDGSGTVDfdEF

Chain	Residue	Details
d	ASP65-PHE77
d	ASP105-LEU117
d	ASP141-PHE153

---

site_id	PS00326
Number of Residues	9
Details	TROPOMYOSIN Tropomyosins signature. LKEAEtRAE

Chain	Residue	Details
i	LEU232-GLU240

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	450
Details	Region: {"description":"Interaction with alpha-actinin","evidences":[{"source":"PubMed","id":"8449927","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Modified residue: {"description":"N-acetylaspartate; in Actin, alpha skeletal muscle","evidences":[{"source":"PubMed","id":"1150665","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68134","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	Modified residue: {"description":"N6-malonyllysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"1150665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"213279","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2395459","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"499690","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ATN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NWK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68133","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	18
Details	Modified residue: {"description":"ADP-ribosylarginine; by SpvB","evidences":[{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	228
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	18
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P58771","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P04692","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by DAPK1","evidences":[{"source":"PubMed","id":"17895359","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	104
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"3548719","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P04692","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKC/PRKCA and RAF1","evidences":[{"source":"UniProtKB","id":"P13789","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	40
Details	Region: {"description":"Involved in binding TNC and actin"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Site: {"description":"Involved in TNI-TNT interactions"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKC/PRKCE","evidences":[{"source":"UniProtKB","id":"P48787","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by STK4/MST1","evidences":[{"source":"PubMed","id":"18986304","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22972900","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22972900","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"22972900","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by STK4/MST1","evidences":[{"source":"PubMed","id":"18986304","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PAK3","evidences":[{"source":"PubMed","id":"12242269","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	70
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	70
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	66
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P19123","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---