7USY
Structure of C. elegans TMC-1 complex with ARRD-6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007606 | biological_process | sensory perception of chemical stimulus |
| A | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0050906 | biological_process | detection of stimulus involved in sensory perception |
| A | 0097730 | cellular_component | non-motile cilium |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005272 | molecular_function | sodium channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007606 | biological_process | sensory perception of chemical stimulus |
| B | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0050906 | biological_process | detection of stimulus involved in sensory perception |
| B | 0097730 | cellular_component | non-motile cilium |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0055074 | biological_process | calcium ion homeostasis |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016020 | cellular_component | membrane |
| D | 0055120 | cellular_component | striated muscle dense body |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0005509 | molecular_function | calcium ion binding |
| E | 0055074 | biological_process | calcium ion homeostasis |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0016020 | cellular_component | membrane |
| F | 0055120 | cellular_component | striated muscle dense body |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0015031 | biological_process | protein transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1302 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-GLY164 | |
| B | SER706-LYS724 | |
| B | ASN772-SER785 | |
| B | VAL887-ASP1285 | |
| A | LYS293-ARG349 | |
| A | GLU417-HIS420 | |
| A | SER706-LYS724 | |
| A | ASN772-SER785 | |
| A | VAL887-ASP1285 | |
| B | MET1-GLY164 | |
| B | LYS293-ARG349 | |
| B | GLU417-HIS420 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 590 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:36224384, ECO:0007744|PDB:7USW, ECO:0007744|PDB:7USX, ECO:0007744|PDB:7USY |
| Chain | Residue | Details |
| A | SER165-VAL202 | |
| A | VAL853-LEU886 | |
| B | SER165-VAL202 | |
| B | ALA261-SER292 | |
| B | LEU350-SER381 | |
| B | LEU389-MET416 | |
| B | PRO421-ARG455 | |
| B | TRP668-CYS705 | |
| B | VAL725-PHE745 | |
| B | LEU749-CYS771 | |
| B | ASN786-SER809 | |
| A | ALA261-SER292 | |
| B | VAL853-LEU886 | |
| A | LEU350-SER381 | |
| A | LEU389-MET416 | |
| A | PRO421-ARG455 | |
| A | TRP668-CYS705 | |
| A | VAL725-PHE745 | |
| A | LEU749-CYS771 | |
| A | ASN786-SER809 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 636 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | ALA203-TYR260 | |
| B | MET810-GLY852 | |
| A | GLN382-ASN388 | |
| A | ASP456-CYS667 | |
| A | ALA746-LEU748 | |
| A | MET810-GLY852 | |
| B | ALA203-TYR260 | |
| B | GLN382-ASN388 | |
| B | ASP456-CYS667 | |
| B | ALA746-LEU748 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: Required for interaction with calm-1 => ECO:0000269|PubMed:36224384, ECO:0007744|PDB:7USW, ECO:0007744|PDB:7USX, ECO:0007744|PDB:7USY |
| Chain | Residue | Details |
| A | GLU160 | |
| A | ASP313 | |
| A | ARG780 | |
| B | GLU160 | |
| B | ASP313 | |
| B | ARG780 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GalNAc...) asparagine => ECO:0000269|PubMed:36224384, ECO:0007744|PDB:7USW, ECO:0007744|PDB:7USX, ECO:0007744|PDB:7USY |
| Chain | Residue | Details |
| A | ASN209 | |
| B | ASN209 |
