7USM
Integrin alphaM/beta2 ectodomain
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001540 | molecular_function | amyloid-beta binding |
A | 0001774 | biological_process | microglial cell activation |
A | 0001851 | molecular_function | complement component C3b binding |
A | 0002376 | biological_process | immune system process |
A | 0002430 | biological_process | complement receptor mediated signaling pathway |
A | 0002931 | biological_process | response to ischemia |
A | 0005178 | molecular_function | integrin binding |
A | 0005515 | molecular_function | protein binding |
A | 0005615 | cellular_component | extracellular space |
A | 0005886 | cellular_component | plasma membrane |
A | 0006898 | biological_process | receptor-mediated endocytosis |
A | 0006911 | biological_process | phagocytosis, engulfment |
A | 0007155 | biological_process | cell adhesion |
A | 0007160 | biological_process | cell-matrix adhesion |
A | 0007229 | biological_process | integrin-mediated signaling pathway |
A | 0008305 | cellular_component | integrin complex |
A | 0009612 | biological_process | response to mechanical stimulus |
A | 0009893 | biological_process | positive regulation of metabolic process |
A | 0009897 | cellular_component | external side of plasma membrane |
A | 0009986 | cellular_component | cell surface |
A | 0010668 | biological_process | ectodermal cell differentiation |
A | 0016020 | cellular_component | membrane |
A | 0030900 | biological_process | forebrain development |
A | 0031072 | molecular_function | heat shock protein binding |
A | 0032355 | biological_process | response to estradiol |
A | 0032930 | biological_process | positive regulation of superoxide anion generation |
A | 0034113 | biological_process | heterotypic cell-cell adhesion |
A | 0034688 | cellular_component | integrin alphaM-beta2 complex |
A | 0035579 | cellular_component | specific granule membrane |
A | 0038023 | molecular_function | signaling receptor activity |
A | 0038024 | molecular_function | cargo receptor activity |
A | 0043315 | biological_process | positive regulation of neutrophil degranulation |
A | 0044853 | cellular_component | plasma membrane raft |
A | 0044877 | molecular_function | protein-containing complex binding |
A | 0045087 | biological_process | innate immune response |
A | 0045121 | cellular_component | membrane raft |
A | 0045963 | biological_process | negative regulation of dopamine metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0070821 | cellular_component | tertiary granule membrane |
A | 0090314 | biological_process | positive regulation of protein targeting to membrane |
A | 0097242 | biological_process | amyloid-beta clearance |
A | 0098609 | biological_process | cell-cell adhesion |
A | 0098742 | biological_process | cell-cell adhesion via plasma-membrane adhesion molecules |
A | 0140459 | biological_process | response to Gram-positive bacterium |
A | 0150062 | biological_process | complement-mediated synapse pruning |
A | 0150064 | biological_process | vertebrate eye-specific patterning |
A | 1904151 | biological_process | positive regulation of microglial cell mediated cytotoxicity |
A | 1904643 | biological_process | response to curcumin |
B | 0001540 | molecular_function | amyloid-beta binding |
B | 0001774 | biological_process | microglial cell activation |
B | 0001851 | molecular_function | complement component C3b binding |
B | 0002523 | biological_process | leukocyte migration involved in inflammatory response |
B | 0005178 | molecular_function | integrin binding |
B | 0005515 | molecular_function | protein binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0005925 | cellular_component | focal adhesion |
B | 0006898 | biological_process | receptor-mediated endocytosis |
B | 0006909 | biological_process | phagocytosis |
B | 0006911 | biological_process | phagocytosis, engulfment |
B | 0006915 | biological_process | apoptotic process |
B | 0006954 | biological_process | inflammatory response |
B | 0007155 | biological_process | cell adhesion |
B | 0007159 | biological_process | leukocyte cell-cell adhesion |
B | 0007160 | biological_process | cell-matrix adhesion |
B | 0007229 | biological_process | integrin-mediated signaling pathway |
B | 0007267 | biological_process | cell-cell signaling |
B | 0008305 | cellular_component | integrin complex |
B | 0008360 | biological_process | regulation of cell shape |
B | 0009897 | cellular_component | external side of plasma membrane |
B | 0009986 | cellular_component | cell surface |
B | 0016020 | cellular_component | membrane |
B | 0019901 | molecular_function | protein kinase binding |
B | 0030369 | molecular_function | ICAM-3 receptor activity |
B | 0030593 | biological_process | neutrophil chemotaxis |
B | 0031072 | molecular_function | heat shock protein binding |
B | 0031623 | biological_process | receptor internalization |
B | 0032930 | biological_process | positive regulation of superoxide anion generation |
B | 0033627 | biological_process | cell adhesion mediated by integrin |
B | 0034113 | biological_process | heterotypic cell-cell adhesion |
B | 0034687 | cellular_component | integrin alphaL-beta2 complex |
B | 0034688 | cellular_component | integrin alphaM-beta2 complex |
B | 0034689 | cellular_component | integrin alphaX-beta2 complex |
B | 0035579 | cellular_component | specific granule membrane |
B | 0035987 | biological_process | endodermal cell differentiation |
B | 0038024 | molecular_function | cargo receptor activity |
B | 0043113 | biological_process | receptor clustering |
B | 0043235 | cellular_component | receptor complex |
B | 0043315 | biological_process | positive regulation of neutrophil degranulation |
B | 0043542 | biological_process | endothelial cell migration |
B | 0044853 | cellular_component | plasma membrane raft |
B | 0044877 | molecular_function | protein-containing complex binding |
B | 0045121 | cellular_component | membrane raft |
B | 0045123 | biological_process | cellular extravasation |
B | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
B | 0045766 | biological_process | positive regulation of angiogenesis |
B | 0045963 | biological_process | negative regulation of dopamine metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0050730 | biological_process | regulation of peptidyl-tyrosine phosphorylation |
B | 0050839 | molecular_function | cell adhesion molecule binding |
B | 0070062 | cellular_component | extracellular exosome |
B | 0070821 | cellular_component | tertiary granule membrane |
B | 0071404 | biological_process | cellular response to low-density lipoprotein particle stimulus |
B | 0090314 | biological_process | positive regulation of protein targeting to membrane |
B | 0097242 | biological_process | amyloid-beta clearance |
B | 0098609 | biological_process | cell-cell adhesion |
B | 0098742 | biological_process | cell-cell adhesion via plasma-membrane adhesion molecules |
B | 0101003 | cellular_component | ficolin-1-rich granule membrane |
B | 1903561 | cellular_component | extracellular vesicle |
B | 1904996 | biological_process | positive regulation of leukocyte adhesion to vascular endothelial cell |
B | 1990266 | biological_process | neutrophil migration |
Functional Information from PROSITE/UniProt
site_id | PS00022 |
Number of Residues | 12 |
Details | EGF_1 EGF-like domain signature 1. CrCdtGyiGKnC |
Chain | Residue | Details |
B | CYS448-CYS459 | |
B | CYS540-CYS551 |
site_id | PS00243 |
Number of Residues | 14 |
Details | I_EGF_1 Integrins beta chain EGF (I-EGF) domain signature. CsGl..GdCvCgqClC |
Chain | Residue | Details |
B | CYS484-CYS497 | |
B | CYS527-CYS542 | |
B | CYS568-CYS581 |
site_id | PS01186 |
Number of Residues | 14 |
Details | EGF_2 EGF-like domain signature 2. CrCdtGYigknce..C |
Chain | Residue | Details |
B | CYS448-CYS461 | |
B | CYS540-CYS553 | |
B | CYS579-CYS593 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 57 |
Details | Repeat: {"description":"FG-GAP 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 59 |
Details | Repeat: {"description":"FG-GAP 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 51 |
Details | Repeat: {"description":"FG-GAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 60 |
Details | Repeat: {"description":"FG-GAP 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 58 |
Details | Repeat: {"description":"FG-GAP 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 60 |
Details | Repeat: {"description":"FG-GAP 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 11 |
Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P08648","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 17 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 3 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI10 |
Number of Residues | 50 |
Details | Domain: {"description":"PSI","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI12 |
Number of Residues | 239 |
Details | Domain: {"description":"VWFA","evidences":[{"source":"UniProtKB","id":"P05106","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI13 |
Number of Residues | 33 |
Details | Domain: {"description":"I-EGF 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01392","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI14 |
Number of Residues | 52 |
Details | Domain: {"description":"I-EGF 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01392","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI15 |
Number of Residues | 38 |
Details | Domain: {"description":"I-EGF 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01392","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI16 |
Number of Residues | 38 |
Details | Domain: {"description":"I-EGF 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01392","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | Motif: {"description":"Cell attachment site","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI18 |
Number of Residues | 3 |
Details | Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"24385486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NEH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NEN","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI19 |
Number of Residues | 1 |
Details | Binding site: {"description":"in ADMIDAS binding site","evidences":[{"source":"PubMed","id":"20033057","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3K6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K72","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI20 |
Number of Residues | 1 |
Details | Binding site: {"description":"in ADMIDAS binding site","evidences":[{"source":"PubMed","id":"20033057","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24385486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3K6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NEH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NEN","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI21 |
Number of Residues | 4 |
Details | Binding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"24385486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NEH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NEN","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI22 |
Number of Residues | 1 |
Details | Binding site: {"description":"in ADMIDAS binding site and liganded-open conformation","evidences":[{"source":"PubMed","id":"24385486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NEN","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI23 |
Number of Residues | 1 |
Details | Binding site: {"description":"in ADMIDAS binding site and unliganded-closed conformation","evidences":[{"source":"PubMed","id":"20033057","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24385486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3K6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NEH","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI24 |
Number of Residues | 1 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI25 |
Number of Residues | 1 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20033057","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24385486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NEH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NEN","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI26 |
Number of Residues | 1 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI27 |
Number of Residues | 1 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24385486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NEH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NEN","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |