7US7
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(4-(dimethylamino)but-1-yn-1-yl)-4-methylpyridin-2-amine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004517 | molecular_function | nitric-oxide synthase activity |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| B | 0004517 | molecular_function | nitric-oxide synthase activity |
| B | 0006809 | biological_process | nitric oxide biosynthetic process |
| C | 0004517 | molecular_function | nitric-oxide synthase activity |
| C | 0006809 | biological_process | nitric oxide biosynthetic process |
| D | 0004517 | molecular_function | nitric-oxide synthase activity |
| D | 0006809 | biological_process | nitric oxide biosynthetic process |
Functional Information from PROSITE/UniProt
| site_id | PS60001 |
| Number of Residues | 8 |
| Details | NOS Nitric oxide synthase (NOS) signature. RCVGRIqW |
| Chain | Residue | Details |
| A | ARG419-TRP426 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N |
| Chain | Residue | Details |
| A | GLU597 | |
| A | VAL682 | |
| A | TRP683 | |
| A | PHE696 | |
| A | TYR711 | |
| B | SER339 | |
| B | GLN483 | |
| B | TRP592 | |
| B | TYR593 | |
| B | GLU597 | |
| B | VAL682 | |
| B | TRP683 | |
| B | PHE696 | |
| B | TYR711 | |
| C | SER339 | |
| C | GLN483 | |
| C | TRP592 | |
| C | TYR593 | |
| C | GLU597 | |
| C | VAL682 | |
| C | TRP683 | |
| C | PHE696 | |
| C | TYR711 | |
| D | SER339 | |
| D | GLN483 | |
| D | TRP592 | |
| D | TYR593 | |
| D | GLU597 | |
| D | VAL682 | |
| D | TRP683 | |
| D | PHE696 | |
| D | TYR711 | |
| A | SER339 | |
| A | GLN483 | |
| A | TRP592 | |
| A | TYR593 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N |
| Chain | Residue | Details |
| A | CYS420 | |
| B | CYS420 | |
| C | CYS420 | |
| D | CYS420 |
