7US1

Structure of parkin (R0RB) bound to two phospho-ubiquitin molecules

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0016567	biological_process	protein ubiquitination

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	55
Details	ZN_FING: RING-type 1 => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS238-CYS293

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site_id	SWS_FT_FI2
Number of Residues	64
Details	ZN_FING: IBR-type => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	ASN313-CYS377

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site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS238
A	CYS241
A	CYS253
A	HIS257
A	CYS260
A	CYS263
A	CYS289
A	CYS293
A	CYS332
A	CYS337
A	CYS352
A	CYS360
A	CYS365
A	CYS368
A	HIS373
A	CYS377

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PINK1 => ECO:0000250|UniProtKB:O60260

Chain	Residue	Details
A	THR175

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O60260

Chain	Residue	Details
A	THR217

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site_id	SWS_FT_FI6
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000250|UniProtKB:O60260

Chain	Residue	Details
A	LYS349
A	LYS369

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