7URE
Human PORCN in complex with palmitoleoylated WNT3A peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006497 | biological_process | protein lipidation |
| A | 0009100 | biological_process | glycoprotein metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0017147 | molecular_function | Wnt-protein binding |
| A | 0030258 | biological_process | lipid modification |
| A | 0032281 | cellular_component | AMPA glutamate receptor complex |
| A | 0045234 | biological_process | protein palmitoleylation |
| A | 0061355 | biological_process | Wnt protein secretion |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099072 | biological_process | regulation of postsynaptic membrane neurotransmitter receptor levels |
| A | 1990698 | molecular_function | palmitoleoyltransferase activity |
| B | 0005102 | molecular_function | signaling receptor binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0007275 | biological_process | multicellular organism development |
| B | 0016055 | biological_process | Wnt signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR212-HIS218 | |
| H | TYR219-HIS225 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 99 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 94 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"24292069","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"24292069","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"O-palmitoleoyl serine; by PORCN","evidences":[{"source":"PubMed","id":"20826466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21244856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24292069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25731175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
