7UP4

Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound pyrrolopyrimidine compound 20 (co-crystal)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGSFSICRkCvhkksnqa..........FAVK

Chain	Residue	Details
A	LEU432-LYS455

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpeNLLF

Chain	Residue	Details
A	VAL540-PHE552

---

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VKLHEVFHDQ

Chain	Residue	Details
A	VAL482-GLN491

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	ASP544
B	ASP544

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU432
A	LYS455
B	LEU432
B	LYS455

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by MAPK1, MAPK3 and MAPK14 => ECO:0000269|PubMed:15568999

Chain	Residue	Details
A	GLU600
B	GLU600

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:17117922

Chain	Residue	Details
A	LEU666
A	LYS676
A	VAL714
B	LEU666
B	LYS676
B	VAL714

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8C050

Chain	Residue	Details
A	VAL710
B	VAL710

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by MAPK1, MAPK3 and MAPK14 => ECO:0000269|PubMed:17117922

Chain	Residue	Details
A	HIS719
B	HIS719

---