Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7UOL

Endogenous dihydrolipoamide succinyltransferase (E2) core of 2-oxoglutarate dehydrogenase complex from bovine kidney

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
a	0005634	cellular_component	nucleus
a	0005739	cellular_component	mitochondrion
a	0005759	cellular_component	mitochondrial matrix
a	0006099	biological_process	tricarboxylic acid cycle
a	0006103	biological_process	2-oxoglutarate metabolic process
a	0006104	biological_process	succinyl-CoA metabolic process
a	0016746	molecular_function	acyltransferase activity
a	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
a	0045252	cellular_component	oxoglutarate dehydrogenase complex
b	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
b	0005634	cellular_component	nucleus
b	0005739	cellular_component	mitochondrion
b	0005759	cellular_component	mitochondrial matrix
b	0006099	biological_process	tricarboxylic acid cycle
b	0006103	biological_process	2-oxoglutarate metabolic process
b	0006104	biological_process	succinyl-CoA metabolic process
b	0016746	molecular_function	acyltransferase activity
b	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
b	0045252	cellular_component	oxoglutarate dehydrogenase complex
c	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
c	0005634	cellular_component	nucleus
c	0005739	cellular_component	mitochondrion
c	0005759	cellular_component	mitochondrial matrix
c	0006099	biological_process	tricarboxylic acid cycle
c	0006103	biological_process	2-oxoglutarate metabolic process
c	0006104	biological_process	succinyl-CoA metabolic process
c	0016746	molecular_function	acyltransferase activity
c	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
c	0045252	cellular_component	oxoglutarate dehydrogenase complex
d	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
d	0005634	cellular_component	nucleus
d	0005739	cellular_component	mitochondrion
d	0005759	cellular_component	mitochondrial matrix
d	0006099	biological_process	tricarboxylic acid cycle
d	0006103	biological_process	2-oxoglutarate metabolic process
d	0006104	biological_process	succinyl-CoA metabolic process
d	0016746	molecular_function	acyltransferase activity
d	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
d	0045252	cellular_component	oxoglutarate dehydrogenase complex
D	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006099	biological_process	tricarboxylic acid cycle
D	0006103	biological_process	2-oxoglutarate metabolic process
D	0006104	biological_process	succinyl-CoA metabolic process
D	0016746	molecular_function	acyltransferase activity
D	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
D	0045252	cellular_component	oxoglutarate dehydrogenase complex
E	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
E	0005634	cellular_component	nucleus
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006099	biological_process	tricarboxylic acid cycle
E	0006103	biological_process	2-oxoglutarate metabolic process
E	0006104	biological_process	succinyl-CoA metabolic process
E	0016746	molecular_function	acyltransferase activity
E	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
E	0045252	cellular_component	oxoglutarate dehydrogenase complex
F	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
F	0005634	cellular_component	nucleus
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006099	biological_process	tricarboxylic acid cycle
F	0006103	biological_process	2-oxoglutarate metabolic process
F	0006104	biological_process	succinyl-CoA metabolic process
F	0016746	molecular_function	acyltransferase activity
F	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
F	0045252	cellular_component	oxoglutarate dehydrogenase complex
J	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
J	0005634	cellular_component	nucleus
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0006099	biological_process	tricarboxylic acid cycle
J	0006103	biological_process	2-oxoglutarate metabolic process
J	0006104	biological_process	succinyl-CoA metabolic process
J	0016746	molecular_function	acyltransferase activity
J	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
J	0045252	cellular_component	oxoglutarate dehydrogenase complex
K	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
K	0005634	cellular_component	nucleus
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0006099	biological_process	tricarboxylic acid cycle
K	0006103	biological_process	2-oxoglutarate metabolic process
K	0006104	biological_process	succinyl-CoA metabolic process
K	0016746	molecular_function	acyltransferase activity
K	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
K	0045252	cellular_component	oxoglutarate dehydrogenase complex
L	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
L	0005634	cellular_component	nucleus
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0006099	biological_process	tricarboxylic acid cycle
L	0006103	biological_process	2-oxoglutarate metabolic process
L	0006104	biological_process	succinyl-CoA metabolic process
L	0016746	molecular_function	acyltransferase activity
L	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
L	0045252	cellular_component	oxoglutarate dehydrogenase complex
M	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
M	0005634	cellular_component	nucleus
M	0005739	cellular_component	mitochondrion
M	0005759	cellular_component	mitochondrial matrix
M	0006099	biological_process	tricarboxylic acid cycle
M	0006103	biological_process	2-oxoglutarate metabolic process
M	0006104	biological_process	succinyl-CoA metabolic process
M	0016746	molecular_function	acyltransferase activity
M	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
M	0045252	cellular_component	oxoglutarate dehydrogenase complex
N	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
N	0005634	cellular_component	nucleus
N	0005739	cellular_component	mitochondrion
N	0005759	cellular_component	mitochondrial matrix
N	0006099	biological_process	tricarboxylic acid cycle
N	0006103	biological_process	2-oxoglutarate metabolic process
N	0006104	biological_process	succinyl-CoA metabolic process
N	0016746	molecular_function	acyltransferase activity
N	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
N	0045252	cellular_component	oxoglutarate dehydrogenase complex
O	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
O	0005634	cellular_component	nucleus
O	0005739	cellular_component	mitochondrion
O	0005759	cellular_component	mitochondrial matrix
O	0006099	biological_process	tricarboxylic acid cycle
O	0006103	biological_process	2-oxoglutarate metabolic process
O	0006104	biological_process	succinyl-CoA metabolic process
O	0016746	molecular_function	acyltransferase activity
O	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
O	0045252	cellular_component	oxoglutarate dehydrogenase complex
P	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
P	0005634	cellular_component	nucleus
P	0005739	cellular_component	mitochondrion
P	0005759	cellular_component	mitochondrial matrix
P	0006099	biological_process	tricarboxylic acid cycle
P	0006103	biological_process	2-oxoglutarate metabolic process
P	0006104	biological_process	succinyl-CoA metabolic process
P	0016746	molecular_function	acyltransferase activity
P	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
P	0045252	cellular_component	oxoglutarate dehydrogenase complex
Q	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
Q	0005634	cellular_component	nucleus
Q	0005739	cellular_component	mitochondrion
Q	0005759	cellular_component	mitochondrial matrix
Q	0006099	biological_process	tricarboxylic acid cycle
Q	0006103	biological_process	2-oxoglutarate metabolic process
Q	0006104	biological_process	succinyl-CoA metabolic process
Q	0016746	molecular_function	acyltransferase activity
Q	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
Q	0045252	cellular_component	oxoglutarate dehydrogenase complex
R	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
R	0005634	cellular_component	nucleus
R	0005739	cellular_component	mitochondrion
R	0005759	cellular_component	mitochondrial matrix
R	0006099	biological_process	tricarboxylic acid cycle
R	0006103	biological_process	2-oxoglutarate metabolic process
R	0006104	biological_process	succinyl-CoA metabolic process
R	0016746	molecular_function	acyltransferase activity
R	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
R	0045252	cellular_component	oxoglutarate dehydrogenase complex
S	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
S	0005634	cellular_component	nucleus
S	0005739	cellular_component	mitochondrion
S	0005759	cellular_component	mitochondrial matrix
S	0006099	biological_process	tricarboxylic acid cycle
S	0006103	biological_process	2-oxoglutarate metabolic process
S	0006104	biological_process	succinyl-CoA metabolic process
S	0016746	molecular_function	acyltransferase activity
S	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
S	0045252	cellular_component	oxoglutarate dehydrogenase complex
T	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
T	0005634	cellular_component	nucleus
T	0005739	cellular_component	mitochondrion
T	0005759	cellular_component	mitochondrial matrix
T	0006099	biological_process	tricarboxylic acid cycle
T	0006103	biological_process	2-oxoglutarate metabolic process
T	0006104	biological_process	succinyl-CoA metabolic process
T	0016746	molecular_function	acyltransferase activity
T	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
T	0045252	cellular_component	oxoglutarate dehydrogenase complex
U	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
U	0005634	cellular_component	nucleus
U	0005739	cellular_component	mitochondrion
U	0005759	cellular_component	mitochondrial matrix
U	0006099	biological_process	tricarboxylic acid cycle
U	0006103	biological_process	2-oxoglutarate metabolic process
U	0006104	biological_process	succinyl-CoA metabolic process
U	0016746	molecular_function	acyltransferase activity
U	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
U	0045252	cellular_component	oxoglutarate dehydrogenase complex
V	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
V	0005634	cellular_component	nucleus
V	0005739	cellular_component	mitochondrion
V	0005759	cellular_component	mitochondrial matrix
V	0006099	biological_process	tricarboxylic acid cycle
V	0006103	biological_process	2-oxoglutarate metabolic process
V	0006104	biological_process	succinyl-CoA metabolic process
V	0016746	molecular_function	acyltransferase activity
V	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
V	0045252	cellular_component	oxoglutarate dehydrogenase complex
W	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
W	0005634	cellular_component	nucleus
W	0005739	cellular_component	mitochondrion
W	0005759	cellular_component	mitochondrial matrix
W	0006099	biological_process	tricarboxylic acid cycle
W	0006103	biological_process	2-oxoglutarate metabolic process
W	0006104	biological_process	succinyl-CoA metabolic process
W	0016746	molecular_function	acyltransferase activity
W	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
W	0045252	cellular_component	oxoglutarate dehydrogenase complex
X	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
X	0005634	cellular_component	nucleus
X	0005739	cellular_component	mitochondrion
X	0005759	cellular_component	mitochondrial matrix
X	0006099	biological_process	tricarboxylic acid cycle
X	0006103	biological_process	2-oxoglutarate metabolic process
X	0006104	biological_process	succinyl-CoA metabolic process
X	0016746	molecular_function	acyltransferase activity
X	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
X	0045252	cellular_component	oxoglutarate dehydrogenase complex
Y	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
Y	0005634	cellular_component	nucleus
Y	0005739	cellular_component	mitochondrion
Y	0005759	cellular_component	mitochondrial matrix
Y	0006099	biological_process	tricarboxylic acid cycle
Y	0006103	biological_process	2-oxoglutarate metabolic process
Y	0006104	biological_process	succinyl-CoA metabolic process
Y	0016746	molecular_function	acyltransferase activity
Y	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
Y	0045252	cellular_component	oxoglutarate dehydrogenase complex
Z	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
Z	0005634	cellular_component	nucleus
Z	0005739	cellular_component	mitochondrion
Z	0005759	cellular_component	mitochondrial matrix
Z	0006099	biological_process	tricarboxylic acid cycle
Z	0006103	biological_process	2-oxoglutarate metabolic process
Z	0006104	biological_process	succinyl-CoA metabolic process
Z	0016746	molecular_function	acyltransferase activity
Z	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
Z	0045252	cellular_component	oxoglutarate dehydrogenase complex

Functional Information from PROSITE/UniProt

site_id	PS00189
Number of Residues	30
Details	LIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GdtVaedEVVceIETdKTSvqVpspanGvI

Chain	Residue	Details
D	GLY95-ILE124

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	ACT_SITE: ACT_SITE => ECO:0000250\|UniProtKB:Q9N0F1

Chain	Residue	Details
D	HIS426
K	ASP430
L	HIS426
L	ASP430
M	HIS426
M	ASP430
N	HIS426
N	ASP430
O	HIS426
O	ASP430
P	HIS426
D	ASP430
P	ASP430
Q	HIS426
Q	ASP430
R	HIS426
R	ASP430
S	HIS426
S	ASP430
T	HIS426
T	ASP430
U	HIS426
E	HIS426
U	ASP430
V	HIS426
V	ASP430
W	HIS426
W	ASP430
X	HIS426
X	ASP430
Y	HIS426
Y	ASP430
Z	HIS426
E	ASP430
Z	ASP430
a	HIS426
a	ASP430
b	HIS426
b	ASP430
c	HIS426
c	ASP430
d	HIS426
d	ASP430
F	HIS426
F	ASP430
J	HIS426
J	ASP430
K	HIS426

site_id	SWS_FT_FI2
Number of Residues	24
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q9D2G2

Chain	Residue	Details
D	SER82
P	SER82
Q	SER82
R	SER82
S	SER82
T	SER82
U	SER82
V	SER82
W	SER82
X	SER82
Y	SER82
E	SER82
Z	SER82
a	SER82
b	SER82
c	SER82
d	SER82
F	SER82
J	SER82
K	SER82
L	SER82
M	SER82
N	SER82
O	SER82

site_id	SWS_FT_FI3
Number of Residues	24
Details	MOD_RES: N6-lipoyllysine => ECO:0000255\|PROSITE-ProRule:PRU01066, ECO:0000269\|PubMed:3115829

Chain	Residue	Details
D	LYS111
P	LYS111
Q	LYS111
R	LYS111
S	LYS111
T	LYS111
U	LYS111
V	LYS111
W	LYS111
X	LYS111
Y	LYS111
E	LYS111
Z	LYS111
a	LYS111
b	LYS111
c	LYS111
d	LYS111
F	LYS111
J	LYS111
K	LYS111
L	LYS111
M	LYS111
N	LYS111
O	LYS111

site_id	SWS_FT_FI4
Number of Residues	144
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9D2G2

Chain	Residue	Details
D	LYS155
E	LYS275
W	LYS275
W	LYS279
W	LYS309
X	LYS155
X	LYS269
X	LYS274
X	LYS275
X	LYS279
X	LYS309
Y	LYS155
E	LYS279
Y	LYS269
Y	LYS274
Y	LYS275
Y	LYS279
Y	LYS309
Z	LYS155
Z	LYS269
Z	LYS274
Z	LYS275
Z	LYS279
E	LYS309
Z	LYS309
a	LYS155
a	LYS269
a	LYS274
a	LYS275
a	LYS279
a	LYS309
b	LYS155
b	LYS269
b	LYS274
F	LYS155
b	LYS275
b	LYS279
b	LYS309
c	LYS155
c	LYS269
c	LYS274
c	LYS275
c	LYS279
c	LYS309
d	LYS155
F	LYS269
d	LYS269
d	LYS274
d	LYS275
d	LYS279
d	LYS309
F	LYS274
F	LYS275
F	LYS279
F	LYS309
J	LYS155
D	LYS269
J	LYS269
J	LYS274
J	LYS275
J	LYS279
J	LYS309
K	LYS155
K	LYS269
K	LYS274
K	LYS275
K	LYS279
D	LYS274
K	LYS309
L	LYS155
L	LYS269
L	LYS274
L	LYS275
L	LYS279
L	LYS309
M	LYS155
M	LYS269
M	LYS274
D	LYS275
M	LYS275
M	LYS279
M	LYS309
N	LYS155
N	LYS269
N	LYS274
N	LYS275
N	LYS279
N	LYS309
O	LYS155
D	LYS279
O	LYS269
O	LYS274
O	LYS275
O	LYS279
O	LYS309
P	LYS155
P	LYS269
P	LYS274
P	LYS275
P	LYS279
D	LYS309
P	LYS309
Q	LYS155
Q	LYS269
Q	LYS274
Q	LYS275
Q	LYS279
Q	LYS309
R	LYS155
R	LYS269
R	LYS274
E	LYS155
R	LYS275
R	LYS279
R	LYS309
S	LYS155
S	LYS269
S	LYS274
S	LYS275
S	LYS279
S	LYS309
T	LYS155
E	LYS269
T	LYS269
T	LYS274
T	LYS275
T	LYS279
T	LYS309
U	LYS155
U	LYS269
U	LYS274
U	LYS275
U	LYS279
E	LYS274
U	LYS309
V	LYS155
V	LYS269
V	LYS274
V	LYS275
V	LYS279
V	LYS309
W	LYS155
W	LYS269
W	LYS274

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)