7UNM
Human TMEM175 in an closed state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015252 | molecular_function | proton channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022841 | molecular_function | potassium ion leak channel activity |
| A | 0035751 | biological_process | regulation of lysosomal lumen pH |
| A | 0035752 | biological_process | lysosomal lumen pH elevation |
| A | 0050544 | molecular_function | arachidonate binding |
| A | 0070050 | biological_process | neuron cellular homeostasis |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 0090385 | biological_process | phagosome-lysosome fusion |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005764 | cellular_component | lysosome |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005768 | cellular_component | endosome |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0015252 | molecular_function | proton channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0022841 | molecular_function | potassium ion leak channel activity |
| B | 0035751 | biological_process | regulation of lysosomal lumen pH |
| B | 0035752 | biological_process | lysosomal lumen pH elevation |
| B | 0050544 | molecular_function | arachidonate binding |
| B | 0070050 | biological_process | neuron cellular homeostasis |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0090385 | biological_process | phagosome-lysosome fusion |
| B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 132 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:26317472 |
| Chain | Residue | Details |
| B | MET1-SER33 | |
| B | LEU470-CYS504 | |
| A | MET1-SER33 | |
| A | LEU470-CYS504 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=TM1-1 => ECO:0000305|PubMed:32228865, ECO:0007744|PDB:6WC9, ECO:0007744|PDB:6WCA, ECO:0007744|PDB:6WCB, ECO:0007744|PDB:6WCC |
| Chain | Residue | Details |
| B | GLN34-THR56 | |
| A | GLN34-THR56 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 148 |
| Details | TOPO_DOM: Lumenal => ECO:0000305 |
| Chain | Residue | Details |
| B | HIS57-ARG77 | |
| A | ASP283-ARG309 | |
| A | GLN361-ARG375 | |
| A | SER441-ARG442 | |
| B | LEU129-LEU138 | |
| B | PHE206-SER210 | |
| B | ASP283-ARG309 | |
| B | GLN361-ARG375 | |
| B | SER441-ARG442 | |
| A | HIS57-ARG77 | |
| A | LEU129-LEU138 | |
| A | PHE206-SER210 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=TM2-1 => ECO:0000305|PubMed:32228865, ECO:0007744|PDB:6WC9, ECO:0007744|PDB:6WCA, ECO:0007744|PDB:6WCB, ECO:0007744|PDB:6WCC |
| Chain | Residue | Details |
| B | ILE78-GLN100 | |
| A | ILE78-GLN100 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 156 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| B | VAL101-ASP106 | |
| A | ALA397-HIS416 | |
| B | ALA161-HIS184 | |
| B | ARG231-SER257 | |
| B | HIS333-THR338 | |
| B | ALA397-HIS416 | |
| A | VAL101-ASP106 | |
| A | ALA161-HIS184 | |
| A | ARG231-SER257 | |
| A | HIS333-THR338 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=TM3-1 => ECO:0000305|PubMed:32228865, ECO:0007744|PDB:6WC9, ECO:0007744|PDB:6WCA, ECO:0007744|PDB:6WCB, ECO:0007744|PDB:6WCC |
| Chain | Residue | Details |
| B | ASP107-SER128 | |
| A | ASP107-SER128 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=TM4-1 => ECO:0000305|PubMed:32228865, ECO:0007744|PDB:6WC9, ECO:0007744|PDB:6WCA, ECO:0007744|PDB:6WCB, ECO:0007744|PDB:6WCC |
| Chain | Residue | Details |
| B | GLY139-TYR160 | |
| A | GLY139-TYR160 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=TM5-1 => ECO:0000255 |
| Chain | Residue | Details |
| B | VAL185-PHE205 | |
| A | VAL185-PHE205 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=TM6-1 => ECO:0000255 |
| Chain | Residue | Details |
| B | TYR211-CYS230 | |
| A | TYR211-CYS230 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=TM1-2 => ECO:0000305|PubMed:32228865, ECO:0007744|PDB:6WC9, ECO:0007744|PDB:6WCA, ECO:0007744|PDB:6WCB, ECO:0007744|PDB:6WCC |
| Chain | Residue | Details |
| B | LYS258-GLU282 | |
| A | LYS258-GLU282 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=TM2-2 => ECO:0000305|PubMed:32228865, ECO:0007744|PDB:6WC9, ECO:0007744|PDB:6WCA, ECO:0007744|PDB:6WCB, ECO:0007744|PDB:6WCC |
| Chain | Residue | Details |
| B | PHE310-LEU332 | |
| A | PHE310-LEU332 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=TM3-2 => ECO:0000305|PubMed:32228865, ECO:0007744|PDB:6WC9, ECO:0007744|PDB:6WCA, ECO:0007744|PDB:6WCB, ECO:0007744|PDB:6WCC |
| Chain | Residue | Details |
| B | ARG339-GLN360 | |
| A | ARG339-GLN360 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=TM4-2 => ECO:0000305|PubMed:32228865, ECO:0007744|PDB:6WC9, ECO:0007744|PDB:6WCA, ECO:0007744|PDB:6WCB, ECO:0007744|PDB:6WCC |
| Chain | Residue | Details |
| B | VAL376-THR396 | |
| A | VAL376-THR396 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=TM5-2 => ECO:0000305|PubMed:32228865, ECO:0007744|PDB:6WC9, ECO:0007744|PDB:6WCA, ECO:0007744|PDB:6WCB, ECO:0007744|PDB:6WCC |
| Chain | Residue | Details |
| B | VAL417-LEU440 | |
| A | VAL417-LEU440 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical; Name=TM6-2 => ECO:0000305|PubMed:32228865, ECO:0007744|PDB:6WC9, ECO:0007744|PDB:6WCA, ECO:0007744|PDB:6WCB, ECO:0007744|PDB:6WCC |
| Chain | Residue | Details |
| B | PHE443-ALA469 | |
| A | PHE443-ALA469 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 1-1 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| B | ILE46 | |
| A | ILE46 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 2-1 => ECO:0000250|UniProtKB:K9UJK2 |
| Chain | Residue | Details |
| B | VAL50 | |
| A | VAL50 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 3-1 => ECO:0000250|UniProtKB:K9UJK2 |
| Chain | Residue | Details |
| B | LEU53 | |
| A | LEU53 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 1-2 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| B | ILE271 | |
| A | ILE271 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 2-2 => ECO:0000250|UniProtKB:K9UJK2 |
| Chain | Residue | Details |
| B | LEU275 | |
| A | LEU275 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 3-2 => ECO:0000250|UniProtKB:K9UJK2 |
| Chain | Residue | Details |
| B | LEU278 | |
| A | LEU278 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| B | THR6 | |
| A | THR6 |
