7UNK
Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000785 | cellular_component | chromatin |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0008139 | molecular_function | nuclear localization sequence binding |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034504 | biological_process | protein localization to nucleus |
| A | 0061608 | molecular_function | nuclear import signal receptor activity |
| C | 0000786 | cellular_component | nucleosome |
| C | 0003677 | molecular_function | DNA binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005694 | cellular_component | chromosome |
| C | 0030527 | molecular_function | structural constituent of chromatin |
| C | 0031492 | molecular_function | nucleosomal DNA binding |
| C | 0031507 | biological_process | heterochromatin formation |
| C | 0046982 | molecular_function | protein heterodimerization activity |
| D | 0000781 | cellular_component | chromosome, telomeric region |
| D | 0000785 | cellular_component | chromatin |
| D | 0001932 | biological_process | regulation of protein phosphorylation |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005829 | cellular_component | cytosol |
| D | 0006282 | biological_process | regulation of DNA repair |
| D | 0006325 | biological_process | chromatin organization |
| D | 0006334 | biological_process | nucleosome assembly |
| D | 0006335 | biological_process | DNA replication-dependent chromatin assembly |
| D | 0006337 | biological_process | nucleosome disassembly |
| D | 0006338 | biological_process | chromatin remodeling |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| D | 0010468 | biological_process | regulation of gene expression |
| D | 0010698 | molecular_function | acetyltransferase activator activity |
| D | 0030466 | biological_process | silent mating-type cassette heterochromatin formation |
| D | 0031509 | biological_process | subtelomeric heterochromatin formation |
| D | 0032968 | biological_process | positive regulation of transcription elongation by RNA polymerase II |
| D | 0033554 | biological_process | cellular response to stress |
| D | 0042393 | molecular_function | histone binding |
| D | 0070775 | cellular_component | H3 histone acetyltransferase complex |
| D | 2000002 | biological_process | negative regulation of DNA damage checkpoint |
| E | 0000786 | cellular_component | nucleosome |
| E | 0003677 | molecular_function | DNA binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005694 | cellular_component | chromosome |
| E | 0006334 | biological_process | nucleosome assembly |
| E | 0030527 | molecular_function | structural constituent of chromatin |
| E | 0031507 | biological_process | heterochromatin formation |
| E | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PROSITE/UniProt
| site_id | PS00047 |
| Number of Residues | 5 |
| Details | HISTONE_H4 Histone H4 signature. GAKRH |
| Chain | Residue | Details |
| E | GLY14-HIS18 |
| site_id | PS00118 |
| Number of Residues | 8 |
| Details | PA2_HIS Phospholipase A2 histidine active site. CCAlHKaC |
| Chain | Residue | Details |
| A | CYS725-CYS732 |
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| C | LYS14-LEU20 |
| site_id | PS00959 |
| Number of Residues | 9 |
| Details | HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI |
| Chain | Residue | Details |
| C | PRO66-ILE74 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"HEAT 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 154 |
| Details | Region: {"description":"Interaction with histone H3, histone H4, RAD53 and the RF-C complex"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 142 |
| Details | Region: {"description":"Interaction with HIR1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
