7UNE

The V1 region of bovine V-ATPase in complex with human mEAK7 (focused refinement)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
b	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
b	0005768	cellular_component	endosome
b	0005829	cellular_component	cytosol
b	0006811	biological_process	monoatomic ion transport
b	0016324	cellular_component	apical plasma membrane
b	0030665	cellular_component	clathrin-coated vesicle membrane
b	0030672	cellular_component	synaptic vesicle membrane
b	0031410	cellular_component	cytoplasmic vesicle
b	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
b	0045851	biological_process	pH reduction
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	1902600	biological_process	proton transmembrane transport
c	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
c	0005768	cellular_component	endosome
c	0005829	cellular_component	cytosol
c	0006811	biological_process	monoatomic ion transport
c	0016324	cellular_component	apical plasma membrane
c	0030665	cellular_component	clathrin-coated vesicle membrane
c	0030672	cellular_component	synaptic vesicle membrane
c	0031410	cellular_component	cytoplasmic vesicle
c	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
c	0045851	biological_process	pH reduction
c	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
c	1902600	biological_process	proton transmembrane transport
d	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
d	0005768	cellular_component	endosome
d	0005829	cellular_component	cytosol
d	0006811	biological_process	monoatomic ion transport
d	0016324	cellular_component	apical plasma membrane
d	0030665	cellular_component	clathrin-coated vesicle membrane
d	0030672	cellular_component	synaptic vesicle membrane
d	0031410	cellular_component	cytoplasmic vesicle
d	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
d	0045851	biological_process	pH reduction
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	1902600	biological_process	proton transmembrane transport
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
e	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
e	0006811	biological_process	monoatomic ion transport
e	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
e	0030665	cellular_component	clathrin-coated vesicle membrane
e	0030672	cellular_component	synaptic vesicle membrane
e	0031410	cellular_component	cytoplasmic vesicle
e	0042470	cellular_component	melanosome
e	0045851	biological_process	pH reduction
e	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
e	0097401	biological_process	synaptic vesicle lumen acidification
e	1902600	biological_process	proton transmembrane transport
f	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
f	0006811	biological_process	monoatomic ion transport
f	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
f	0030665	cellular_component	clathrin-coated vesicle membrane
f	0030672	cellular_component	synaptic vesicle membrane
f	0031410	cellular_component	cytoplasmic vesicle
f	0042470	cellular_component	melanosome
f	0045851	biological_process	pH reduction
f	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
f	0097401	biological_process	synaptic vesicle lumen acidification
f	1902600	biological_process	proton transmembrane transport
g	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
g	0006811	biological_process	monoatomic ion transport
g	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
g	0030665	cellular_component	clathrin-coated vesicle membrane
g	0030672	cellular_component	synaptic vesicle membrane
g	0031410	cellular_component	cytoplasmic vesicle
g	0042470	cellular_component	melanosome
g	0045851	biological_process	pH reduction
g	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
g	0097401	biological_process	synaptic vesicle lumen acidification
g	1902600	biological_process	proton transmembrane transport
L	0000166	molecular_function	nucleotide binding
L	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006811	biological_process	monoatomic ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0016887	molecular_function	ATP hydrolysis activity
L	0030133	cellular_component	transport vesicle
L	0030665	cellular_component	clathrin-coated vesicle membrane
L	0031410	cellular_component	cytoplasmic vesicle
L	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
L	0036295	biological_process	cellular response to increased oxygen levels
L	0042592	biological_process	homeostatic process
L	0045851	biological_process	pH reduction
L	0046034	biological_process	ATP metabolic process
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0000166	molecular_function	nucleotide binding
M	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005764	cellular_component	lysosome
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006811	biological_process	monoatomic ion transport
M	0006879	biological_process	intracellular iron ion homeostasis
M	0016887	molecular_function	ATP hydrolysis activity
M	0030133	cellular_component	transport vesicle
M	0030665	cellular_component	clathrin-coated vesicle membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
M	0036295	biological_process	cellular response to increased oxygen levels
M	0042592	biological_process	homeostatic process
M	0045851	biological_process	pH reduction
M	0046034	biological_process	ATP metabolic process
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0000166	molecular_function	nucleotide binding
N	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005764	cellular_component	lysosome
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006811	biological_process	monoatomic ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0016887	molecular_function	ATP hydrolysis activity
N	0030133	cellular_component	transport vesicle
N	0030665	cellular_component	clathrin-coated vesicle membrane
N	0031410	cellular_component	cytoplasmic vesicle
N	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
N	0036295	biological_process	cellular response to increased oxygen levels
N	0042592	biological_process	homeostatic process
N	0045851	biological_process	pH reduction
N	0046034	biological_process	ATP metabolic process
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	1902600	biological_process	proton transmembrane transport
O	0000166	molecular_function	nucleotide binding
O	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005886	cellular_component	plasma membrane
O	0006811	biological_process	monoatomic ion transport
O	0007035	biological_process	vacuolar acidification
O	0016324	cellular_component	apical plasma membrane
O	0030665	cellular_component	clathrin-coated vesicle membrane
O	0030672	cellular_component	synaptic vesicle membrane
O	0031410	cellular_component	cytoplasmic vesicle
O	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
O	0042470	cellular_component	melanosome
O	0045851	biological_process	pH reduction
O	0046034	biological_process	ATP metabolic process
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
P	0000166	molecular_function	nucleotide binding
P	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0006811	biological_process	monoatomic ion transport
P	0007035	biological_process	vacuolar acidification
P	0016324	cellular_component	apical plasma membrane
P	0030665	cellular_component	clathrin-coated vesicle membrane
P	0030672	cellular_component	synaptic vesicle membrane
P	0031410	cellular_component	cytoplasmic vesicle
P	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
P	0042470	cellular_component	melanosome
P	0045851	biological_process	pH reduction
P	0046034	biological_process	ATP metabolic process
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
Q	0000166	molecular_function	nucleotide binding
Q	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
Q	0005524	molecular_function	ATP binding
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005886	cellular_component	plasma membrane
Q	0006811	biological_process	monoatomic ion transport
Q	0007035	biological_process	vacuolar acidification
Q	0016324	cellular_component	apical plasma membrane
Q	0030665	cellular_component	clathrin-coated vesicle membrane
Q	0030672	cellular_component	synaptic vesicle membrane
Q	0031410	cellular_component	cytoplasmic vesicle
Q	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
Q	0042470	cellular_component	melanosome
Q	0045851	biological_process	pH reduction
Q	0046034	biological_process	ATP metabolic process
Q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Q	1902600	biological_process	proton transmembrane transport
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005764	cellular_component	lysosome
U	0005765	cellular_component	lysosomal membrane
U	0005829	cellular_component	cytosol
U	0006979	biological_process	response to oxidative stress
U	0016020	cellular_component	membrane
U	0030334	biological_process	regulation of cell migration
U	0031667	biological_process	response to nutrient levels
U	0031929	biological_process	TOR signaling
U	0032868	biological_process	response to insulin
U	0042127	biological_process	regulation of cell population proliferation
U	0043200	biological_process	response to amino acid
U	0150032	biological_process	positive regulation of protein localization to lysosome

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PPINVLPSLS

Chain	Residue	Details
Q	PRO390-SER399
L	PRO446-SER455

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32764564","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6XBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P38606","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"P50516","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	168
Details	Domain: {"description":"TLDc","evidences":[{"source":"PROSITE-ProRule","id":"PRU01234","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P50518","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32764564","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6XBW","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6XBY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	65
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	49
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	72
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---