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7UM9

Human ALDH1A1 with bound compound CM38

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001523biological_processretinoid metabolic process
A0001758molecular_functionretinal dehydrogenase (NAD+) activity
A0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
A0005096molecular_functionGTPase activator activity
A0005497molecular_functionandrogen binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006081biological_processaldehyde metabolic process
A0006629biological_processlipid metabolic process
A0009449biological_processgamma-aminobutyric acid biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A0018479molecular_functionbenzaldehyde dehydrogenase (NAD+) activity
A0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
A0030392biological_processfructosamine catabolic process
A0030424cellular_componentaxon
A0036438biological_processmaintenance of lens transparency
A0042572biological_processretinol metabolic process
A0042995cellular_componentcell projection
A0045202cellular_componentsynapse
A0051287molecular_functionNAD binding
A0070062cellular_componentextracellular exosome
A0106373molecular_function3-deoxyglucosone dehydrogenase activity
A0110095biological_processcellular detoxification of aldehyde
A0120163biological_processnegative regulation of cold-induced thermogenesis
A0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
Functional Information from PROSITE/UniProt
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FyHQGQCCIAAS
ChainResidueDetails
APHE296-SER307

site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP
ChainResidueDetails
ALEU268-PRO275

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues165
DetailsRegion: {"description":"Mediates interaction with PRMT3","evidences":[{"source":"PubMed","id":"33495566","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3676276","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3676276","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25450233","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25634381","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WB9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4L","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsSite: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P20000","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues9
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-07-23

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