7UKG
Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005249 | molecular_function | voltage-gated potassium channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006813 | biological_process | potassium ion transport |
A | 0008076 | cellular_component | voltage-gated potassium channel complex |
A | 0016020 | cellular_component | membrane |
A | 0051260 | biological_process | protein homooligomerization |
A | 0055085 | biological_process | transmembrane transport |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005249 | molecular_function | voltage-gated potassium channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0006813 | biological_process | potassium ion transport |
B | 0008076 | cellular_component | voltage-gated potassium channel complex |
B | 0016020 | cellular_component | membrane |
B | 0051260 | biological_process | protein homooligomerization |
B | 0055085 | biological_process | transmembrane transport |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005249 | molecular_function | voltage-gated potassium channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0006813 | biological_process | potassium ion transport |
C | 0008076 | cellular_component | voltage-gated potassium channel complex |
C | 0016020 | cellular_component | membrane |
C | 0051260 | biological_process | protein homooligomerization |
C | 0055085 | biological_process | transmembrane transport |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005249 | molecular_function | voltage-gated potassium channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0006813 | biological_process | potassium ion transport |
D | 0008076 | cellular_component | voltage-gated potassium channel complex |
D | 0016020 | cellular_component | membrane |
D | 0051260 | biological_process | protein homooligomerization |
D | 0055085 | biological_process | transmembrane transport |
I | 0005515 | molecular_function | protein binding |
I | 0005886 | cellular_component | plasma membrane |
I | 0006508 | biological_process | proteolysis |
I | 0008076 | cellular_component | voltage-gated potassium channel complex |
I | 0008236 | molecular_function | serine-type peptidase activity |
I | 0008239 | molecular_function | dipeptidyl-peptidase activity |
I | 0015459 | molecular_function | potassium channel regulator activity |
I | 0016020 | cellular_component | membrane |
I | 0072659 | biological_process | protein localization to plasma membrane |
I | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
J | 0005515 | molecular_function | protein binding |
J | 0005886 | cellular_component | plasma membrane |
J | 0006508 | biological_process | proteolysis |
J | 0008076 | cellular_component | voltage-gated potassium channel complex |
J | 0008236 | molecular_function | serine-type peptidase activity |
J | 0008239 | molecular_function | dipeptidyl-peptidase activity |
J | 0015459 | molecular_function | potassium channel regulator activity |
J | 0016020 | cellular_component | membrane |
J | 0072659 | biological_process | protein localization to plasma membrane |
J | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
K | 0005515 | molecular_function | protein binding |
K | 0005886 | cellular_component | plasma membrane |
K | 0006508 | biological_process | proteolysis |
K | 0008076 | cellular_component | voltage-gated potassium channel complex |
K | 0008236 | molecular_function | serine-type peptidase activity |
K | 0008239 | molecular_function | dipeptidyl-peptidase activity |
K | 0015459 | molecular_function | potassium channel regulator activity |
K | 0016020 | cellular_component | membrane |
K | 0072659 | biological_process | protein localization to plasma membrane |
K | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
L | 0005515 | molecular_function | protein binding |
L | 0005886 | cellular_component | plasma membrane |
L | 0006508 | biological_process | proteolysis |
L | 0008076 | cellular_component | voltage-gated potassium channel complex |
L | 0008236 | molecular_function | serine-type peptidase activity |
L | 0008239 | molecular_function | dipeptidyl-peptidase activity |
L | 0015459 | molecular_function | potassium channel regulator activity |
L | 0016020 | cellular_component | membrane |
L | 0072659 | biological_process | protein localization to plasma membrane |
L | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255 |
Chain | Residue | Details |
I | ILE96-LEU116 | |
D | MET1-ALA184 | |
D | ALA250-ARG256 | |
D | GLN308-ALA321 | |
J | ILE96-LEU116 | |
K | ILE96-LEU116 | |
L | ILE96-LEU116 | |
B | ALA250-ARG256 | |
B | GLN308-ALA321 | |
C | MET1-ALA184 | |
C | ALA250-ARG256 | |
C | GLN308-ALA321 |
site_id | SWS_FT_FI2 |
Number of Residues | 2992 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
I | LEU117-ASP865 | |
J | LEU117-ASP865 | |
K | LEU117-ASP865 | |
L | LEU117-ASP865 |
site_id | SWS_FT_FI3 |
Number of Residues | 24 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15476821 |
Chain | Residue | Details |
I | ASN173 | |
J | ASN535 | |
J | ASN566 | |
J | ASN813 | |
K | ASN173 | |
K | ASN319 | |
K | ASN404 | |
K | ASN535 | |
K | ASN566 | |
K | ASN813 | |
L | ASN173 | |
I | ASN319 | |
L | ASN319 | |
L | ASN404 | |
L | ASN535 | |
L | ASN566 | |
L | ASN813 | |
I | ASN404 | |
I | ASN535 | |
I | ASN566 | |
I | ASN813 | |
J | ASN173 | |
J | ASN319 | |
J | ASN404 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
I | ASN471 | |
J | ASN471 | |
K | ASN471 | |
L | ASN471 |
site_id | SWS_FT_FI5 |
Number of Residues | 96 |
Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
Chain | Residue | Details |
A | PHE257-ASP281 | |
B | PHE257-ASP281 | |
C | PHE257-ASP281 | |
D | PHE257-ASP281 |
site_id | SWS_FT_FI6 |
Number of Residues | 76 |
Details | TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
Chain | Residue | Details |
A | ALA288-SER307 | |
B | ALA288-SER307 | |
C | ALA288-SER307 | |
D | ALA288-SER307 |
site_id | SWS_FT_FI7 |
Number of Residues | 92 |
Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
Chain | Residue | Details |
A | SER322-ALA345 | |
B | SER322-ALA345 | |
C | SER322-ALA345 | |
D | SER322-ALA345 |
site_id | SWS_FT_FI8 |
Number of Residues | 44 |
Details | INTRAMEM: Helical; Name=Pore helix => ECO:0000250|UniProtKB:P63142 |
Chain | Residue | Details |
A | PRO358-THR369 | |
B | PRO358-THR369 | |
C | PRO358-THR369 | |
D | PRO358-THR369 |
site_id | SWS_FT_FI9 |
Number of Residues | 28 |
Details | INTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:P63142 |
Chain | Residue | Details |
A | THR370-VAL377 | |
B | THR370-VAL377 | |
C | THR370-VAL377 | |
D | THR370-VAL377 |
site_id | SWS_FT_FI10 |
Number of Residues | 88 |
Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
Chain | Residue | Details |
A | ILE381-PRO403 | |
B | ILE381-PRO403 | |
C | ILE381-PRO403 | |
D | ILE381-PRO403 |
site_id | SWS_FT_FI11 |
Number of Residues | 12 |
Details | BINDING: in chain A => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
Chain | Residue | Details |
A | HIS105 | |
D | HIS105 | |
D | CYS132 | |
D | CYS133 | |
A | CYS132 | |
A | CYS133 | |
B | HIS105 | |
B | CYS132 | |
B | CYS133 | |
C | HIS105 | |
C | CYS132 | |
C | CYS133 |
site_id | SWS_FT_FI12 |
Number of Residues | 4 |
Details | BINDING: in chain B => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
Chain | Residue | Details |
A | CYS111 | |
B | CYS111 | |
C | CYS111 | |
D | CYS111 |
site_id | SWS_FT_FI13 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:35597238, ECO:0007744|PDB:7UK5, ECO:0007744|PDB:7UKD, ECO:0007744|PDB:7UKE, ECO:0007744|PDB:7UKF |
Chain | Residue | Details |
A | THR370 | |
A | TYR373 | |
B | THR370 | |
B | TYR373 | |
C | THR370 | |
C | TYR373 | |
D | THR370 | |
D | TYR373 |
site_id | SWS_FT_FI14 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:35597238, ECO:0007744|PDB:7UKC, ECO:0007744|PDB:7UKG |
Chain | Residue | Details |
A | LEU371 | |
B | LEU371 | |
C | LEU371 | |
D | LEU371 |
site_id | SWS_FT_FI15 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:35597238, ECO:0007744|PDB:7UK5, ECO:0007744|PDB:7UKC, ECO:0007744|PDB:7UKD, ECO:0007744|PDB:7UKE, ECO:0007744|PDB:7UKF, ECO:0007744|PDB:7UKG |
Chain | Residue | Details |
A | GLY372 | |
B | GLY372 | |
C | GLY372 | |
D | GLY372 |
site_id | SWS_FT_FI16 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q63881 |
Chain | Residue | Details |
A | THR38 | |
B | THR38 | |
C | THR38 | |
D | THR38 |
site_id | SWS_FT_FI17 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q63881 |
Chain | Residue | Details |
A | SER438 | |
B | SER438 | |
C | SER438 | |
D | SER438 |