7UKG
Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0008076 | cellular_component | voltage-gated potassium channel complex |
| A | 0016020 | cellular_component | membrane |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0008076 | cellular_component | voltage-gated potassium channel complex |
| B | 0016020 | cellular_component | membrane |
| B | 0051260 | biological_process | protein homooligomerization |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0008076 | cellular_component | voltage-gated potassium channel complex |
| C | 0016020 | cellular_component | membrane |
| C | 0051260 | biological_process | protein homooligomerization |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0008076 | cellular_component | voltage-gated potassium channel complex |
| D | 0016020 | cellular_component | membrane |
| D | 0051260 | biological_process | protein homooligomerization |
| D | 0055085 | biological_process | transmembrane transport |
| I | 0005515 | molecular_function | protein binding |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0006508 | biological_process | proteolysis |
| I | 0008076 | cellular_component | voltage-gated potassium channel complex |
| I | 0008236 | molecular_function | serine-type peptidase activity |
| I | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| I | 0015459 | molecular_function | potassium channel regulator activity |
| I | 0016020 | cellular_component | membrane |
| I | 0072659 | biological_process | protein localization to plasma membrane |
| I | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
| J | 0005515 | molecular_function | protein binding |
| J | 0005886 | cellular_component | plasma membrane |
| J | 0006508 | biological_process | proteolysis |
| J | 0008076 | cellular_component | voltage-gated potassium channel complex |
| J | 0008236 | molecular_function | serine-type peptidase activity |
| J | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| J | 0015459 | molecular_function | potassium channel regulator activity |
| J | 0016020 | cellular_component | membrane |
| J | 0072659 | biological_process | protein localization to plasma membrane |
| J | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
| K | 0005515 | molecular_function | protein binding |
| K | 0005886 | cellular_component | plasma membrane |
| K | 0006508 | biological_process | proteolysis |
| K | 0008076 | cellular_component | voltage-gated potassium channel complex |
| K | 0008236 | molecular_function | serine-type peptidase activity |
| K | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| K | 0015459 | molecular_function | potassium channel regulator activity |
| K | 0016020 | cellular_component | membrane |
| K | 0072659 | biological_process | protein localization to plasma membrane |
| K | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
| L | 0005515 | molecular_function | protein binding |
| L | 0005886 | cellular_component | plasma membrane |
| L | 0006508 | biological_process | proteolysis |
| L | 0008076 | cellular_component | voltage-gated potassium channel complex |
| L | 0008236 | molecular_function | serine-type peptidase activity |
| L | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| L | 0015459 | molecular_function | potassium channel regulator activity |
| L | 0016020 | cellular_component | membrane |
| L | 0072659 | biological_process | protein localization to plasma membrane |
| L | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255 |
| Chain | Residue | Details |
| I | ILE96-LEU116 | |
| D | MET1-ALA184 | |
| D | ALA250-ARG256 | |
| D | GLN308-ALA321 | |
| J | ILE96-LEU116 | |
| K | ILE96-LEU116 | |
| L | ILE96-LEU116 | |
| B | ALA250-ARG256 | |
| B | GLN308-ALA321 | |
| C | MET1-ALA184 | |
| C | ALA250-ARG256 | |
| C | GLN308-ALA321 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2992 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| I | LEU117-ASP865 | |
| J | LEU117-ASP865 | |
| K | LEU117-ASP865 | |
| L | LEU117-ASP865 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15476821 |
| Chain | Residue | Details |
| I | ASN173 | |
| J | ASN535 | |
| J | ASN566 | |
| J | ASN813 | |
| K | ASN173 | |
| K | ASN319 | |
| K | ASN404 | |
| K | ASN535 | |
| K | ASN566 | |
| K | ASN813 | |
| L | ASN173 | |
| I | ASN319 | |
| L | ASN319 | |
| L | ASN404 | |
| L | ASN535 | |
| L | ASN566 | |
| L | ASN813 | |
| I | ASN404 | |
| I | ASN535 | |
| I | ASN566 | |
| I | ASN813 | |
| J | ASN173 | |
| J | ASN319 | |
| J | ASN404 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| I | ASN471 | |
| J | ASN471 | |
| K | ASN471 | |
| L | ASN471 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 96 |
| Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | PHE257-ASP281 | |
| B | PHE257-ASP281 | |
| C | PHE257-ASP281 | |
| D | PHE257-ASP281 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 76 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | ALA288-SER307 | |
| B | ALA288-SER307 | |
| C | ALA288-SER307 | |
| D | ALA288-SER307 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 92 |
| Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | SER322-ALA345 | |
| B | SER322-ALA345 | |
| C | SER322-ALA345 | |
| D | SER322-ALA345 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | INTRAMEM: Helical; Name=Pore helix => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | PRO358-THR369 | |
| B | PRO358-THR369 | |
| C | PRO358-THR369 | |
| D | PRO358-THR369 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 28 |
| Details | INTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | THR370-VAL377 | |
| B | THR370-VAL377 | |
| C | THR370-VAL377 | |
| D | THR370-VAL377 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 88 |
| Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | ILE381-PRO403 | |
| B | ILE381-PRO403 | |
| C | ILE381-PRO403 | |
| D | ILE381-PRO403 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | HIS105 | |
| D | HIS105 | |
| D | CYS132 | |
| D | CYS133 | |
| A | CYS132 | |
| A | CYS133 | |
| B | HIS105 | |
| B | CYS132 | |
| B | CYS133 | |
| C | HIS105 | |
| C | CYS132 | |
| C | CYS133 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | BINDING: in chain B => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | CYS111 | |
| B | CYS111 | |
| C | CYS111 | |
| D | CYS111 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35597238, ECO:0007744|PDB:7UK5, ECO:0007744|PDB:7UKD, ECO:0007744|PDB:7UKE, ECO:0007744|PDB:7UKF |
| Chain | Residue | Details |
| A | THR370 | |
| A | TYR373 | |
| B | THR370 | |
| B | TYR373 | |
| C | THR370 | |
| C | TYR373 | |
| D | THR370 | |
| D | TYR373 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35597238, ECO:0007744|PDB:7UKC, ECO:0007744|PDB:7UKG |
| Chain | Residue | Details |
| A | LEU371 | |
| B | LEU371 | |
| C | LEU371 | |
| D | LEU371 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35597238, ECO:0007744|PDB:7UK5, ECO:0007744|PDB:7UKC, ECO:0007744|PDB:7UKD, ECO:0007744|PDB:7UKE, ECO:0007744|PDB:7UKF, ECO:0007744|PDB:7UKG |
| Chain | Residue | Details |
| A | GLY372 | |
| B | GLY372 | |
| C | GLY372 | |
| D | GLY372 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q63881 |
| Chain | Residue | Details |
| A | THR38 | |
| B | THR38 | |
| C | THR38 | |
| D | THR38 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q63881 |
| Chain | Residue | Details |
| A | SER438 | |
| B | SER438 | |
| C | SER438 | |
| D | SER438 |
