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7UK5

Human Kv4.2-KChIP2 channel complex in an open state, transmembrane region

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005250molecular_functionA-type (transient outward) potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006936biological_processmuscle contraction
A0007268biological_processchemical synaptic transmission
A0008016biological_processregulation of heart contraction
A0008076cellular_componentvoltage-gated potassium channel complex
A0016020cellular_componentmembrane
A0019228biological_processneuronal action potential
A0019233biological_processsensory perception of pain
A0030425cellular_componentdendrite
A0032809cellular_componentneuronal cell body membrane
A0034702cellular_componentmonoatomic ion channel complex
A0042995cellular_componentcell projection
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0043204cellular_componentperikaryon
A0044853cellular_componentplasma membrane raft
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045475biological_processlocomotor rhythm
A0046872molecular_functionmetal ion binding
A0051260biological_processprotein homooligomerization
A0055085biological_processtransmembrane transport
A0060078biological_processregulation of postsynaptic membrane potential
A0070161cellular_componentanchoring junction
A0071193cellular_componentKv4.2-KChIP2 channel complex
A0071456biological_processcellular response to hypoxia
A0071805biological_processpotassium ion transmembrane transport
A0086009biological_processmembrane repolarization
A0098978cellular_componentglutamatergic synapse
A0098982cellular_componentGABA-ergic synapse
A0099634cellular_componentpostsynaptic specialization membrane
A1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005250molecular_functionA-type (transient outward) potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006936biological_processmuscle contraction
B0007268biological_processchemical synaptic transmission
B0008016biological_processregulation of heart contraction
B0008076cellular_componentvoltage-gated potassium channel complex
B0016020cellular_componentmembrane
B0019228biological_processneuronal action potential
B0019233biological_processsensory perception of pain
B0030425cellular_componentdendrite
B0032809cellular_componentneuronal cell body membrane
B0034702cellular_componentmonoatomic ion channel complex
B0042995cellular_componentcell projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043204cellular_componentperikaryon
B0044853cellular_componentplasma membrane raft
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045475biological_processlocomotor rhythm
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B0060078biological_processregulation of postsynaptic membrane potential
B0070161cellular_componentanchoring junction
B0071193cellular_componentKv4.2-KChIP2 channel complex
B0071456biological_processcellular response to hypoxia
B0071805biological_processpotassium ion transmembrane transport
B0086009biological_processmembrane repolarization
B0098978cellular_componentglutamatergic synapse
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C0001508biological_processaction potential
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005250molecular_functionA-type (transient outward) potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006936biological_processmuscle contraction
C0007268biological_processchemical synaptic transmission
C0008016biological_processregulation of heart contraction
C0008076cellular_componentvoltage-gated potassium channel complex
C0016020cellular_componentmembrane
C0019228biological_processneuronal action potential
C0019233biological_processsensory perception of pain
C0030425cellular_componentdendrite
C0032809cellular_componentneuronal cell body membrane
C0034702cellular_componentmonoatomic ion channel complex
C0042995cellular_componentcell projection
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0043204cellular_componentperikaryon
C0044853cellular_componentplasma membrane raft
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045475biological_processlocomotor rhythm
C0046872molecular_functionmetal ion binding
C0051260biological_processprotein homooligomerization
C0055085biological_processtransmembrane transport
C0060078biological_processregulation of postsynaptic membrane potential
C0070161cellular_componentanchoring junction
C0071193cellular_componentKv4.2-KChIP2 channel complex
C0071456biological_processcellular response to hypoxia
C0071805biological_processpotassium ion transmembrane transport
C0086009biological_processmembrane repolarization
C0098978cellular_componentglutamatergic synapse
C0098982cellular_componentGABA-ergic synapse
C0099634cellular_componentpostsynaptic specialization membrane
C1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005250molecular_functionA-type (transient outward) potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006936biological_processmuscle contraction
D0007268biological_processchemical synaptic transmission
D0008016biological_processregulation of heart contraction
D0008076cellular_componentvoltage-gated potassium channel complex
D0016020cellular_componentmembrane
D0019228biological_processneuronal action potential
D0019233biological_processsensory perception of pain
D0030425cellular_componentdendrite
D0032809cellular_componentneuronal cell body membrane
D0034702cellular_componentmonoatomic ion channel complex
D0042995cellular_componentcell projection
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0043204cellular_componentperikaryon
D0044853cellular_componentplasma membrane raft
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0045475biological_processlocomotor rhythm
D0046872molecular_functionmetal ion binding
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
D0060078biological_processregulation of postsynaptic membrane potential
D0070161cellular_componentanchoring junction
D0071193cellular_componentKv4.2-KChIP2 channel complex
D0071456biological_processcellular response to hypoxia
D0071805biological_processpotassium ion transmembrane transport
D0086009biological_processmembrane repolarization
D0098978cellular_componentglutamatergic synapse
D0098982cellular_componentGABA-ergic synapse
D0099634cellular_componentpostsynaptic specialization membrane
D1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1684
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
AMET1-THR182
CALA251-VAL261
CSER307-ALA321
CHIS414-LEU630
DMET1-THR182
DALA251-VAL261
DSER307-ALA321
DHIS414-LEU630
AALA251-VAL261
ASER307-ALA321
AHIS414-LEU630
BMET1-THR182
BALA251-VAL261
BSER307-ALA321
BHIS414-LEU630
CMET1-THR182

site_idSWS_FT_FI2
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
AMET183-VAL204
BMET183-VAL204
CMET183-VAL204
DMET183-VAL204

site_idSWS_FT_FI3
Number of Residues192
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
AGLU205-ALA228
CTHR280-SER286
CTYR344-ILE357
CPRO378-LYS384
DGLU205-ALA228
DTHR280-SER286
DTYR344-ILE357
DPRO378-LYS384
ATHR280-SER286
ATYR344-ILE357
APRO378-LYS384
BGLU205-ALA228
BTHR280-SER286
BTYR344-ILE357
BPRO378-LYS384
CGLU205-ALA228

site_idSWS_FT_FI4
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
APHE229-ALA250
BPHE229-ALA250
CPHE229-ALA250
DPHE229-ALA250

site_idSWS_FT_FI5
Number of Residues68
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
AMET262-MET279
BMET262-MET279
CMET262-MET279
DMET262-MET279

site_idSWS_FT_FI6
Number of Residues76
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
AGLY287-HIS306
BGLY287-HIS306
CGLY287-HIS306
DGLY287-HIS306

site_idSWS_FT_FI7
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
ASER322-PHE343
BSER322-PHE343
CSER322-PHE343
DSER322-PHE343

site_idSWS_FT_FI8
Number of Residues44
DetailsINTRAMEM: Helical; Name=Pore helix => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
APRO358-THR369
BPRO358-THR369
CPRO358-THR369
DPRO358-THR369

site_idSWS_FT_FI9
Number of Residues28
DetailsINTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
ATHR370-VAL377
BTHR370-VAL377
CTHR370-VAL377
DTHR370-VAL377

site_idSWS_FT_FI10
Number of Residues112
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
AILE385-TYR413
BILE385-TYR413
CILE385-TYR413
DILE385-TYR413

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q63881
ChainResidueDetails
AHIS105
DHIS105
DCYS132
DCYS133
ACYS132
ACYS133
BHIS105
BCYS132
BCYS133
CHIS105
CCYS132
CCYS133

site_idSWS_FT_FI12
Number of Residues12
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q63881
ChainResidueDetails
ATHR38
DTHR38
DTHR602
DTHR607
ATHR602
ATHR607
BTHR38
BTHR602
BTHR607
CTHR38
CTHR602
CTHR607

site_idSWS_FT_FI13
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q63881
ChainResidueDetails
ASER438
ASER548
BSER438
BSER548
CSER438
CSER548
DSER438
DSER548

site_idSWS_FT_FI14
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z0V2
ChainResidueDetails
ASER552
CSER572
CSER575
CSER616
DSER552
DSER572
DSER575
DSER616
ASER572
ASER575
ASER616
BSER552
BSER572
BSER575
BSER616
CSER552

222036

PDB entries from 2024-07-03

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