7UIL

Mediator-PIC Early (Tail A/B Dimer)

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000122	biological_process	negative regulation of transcription by RNA polymerase II
1	0003713	molecular_function	transcription coactivator activity
1	0005634	cellular_component	nucleus
1	0005829	cellular_component	cytosol
1	0016592	cellular_component	mediator complex
1	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
1	0034976	biological_process	response to endoplasmic reticulum stress
1	0045944	biological_process	positive regulation of transcription by RNA polymerase II
1	0051123	biological_process	RNA polymerase II preinitiation complex assembly
1	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
1	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
1	0070847	cellular_component	core mediator complex
1	0090399	biological_process	replicative senescence
2	0000122	biological_process	negative regulation of transcription by RNA polymerase II
2	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
2	0003712	molecular_function	transcription coregulator activity
2	0003713	molecular_function	transcription coactivator activity
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0006357	biological_process	regulation of transcription by RNA polymerase II
2	0016592	cellular_component	mediator complex
2	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
2	0034605	biological_process	cellular response to heat
2	0045944	biological_process	positive regulation of transcription by RNA polymerase II
2	0051123	biological_process	RNA polymerase II preinitiation complex assembly
2	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
2	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
2	0070847	cellular_component	core mediator complex
3	0003674	molecular_function	molecular_function
3	0003712	molecular_function	transcription coregulator activity
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005739	cellular_component	mitochondrion
3	0006357	biological_process	regulation of transcription by RNA polymerase II
3	0006366	biological_process	transcription by RNA polymerase II
3	0016592	cellular_component	mediator complex
3	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
3	0051123	biological_process	RNA polymerase II preinitiation complex assembly
3	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
3	0070847	cellular_component	core mediator complex
4	0000122	biological_process	negative regulation of transcription by RNA polymerase II
4	0001093	molecular_function	TFIIB-class transcription factor binding
4	0003712	molecular_function	transcription coregulator activity
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0006357	biological_process	regulation of transcription by RNA polymerase II
4	0016592	cellular_component	mediator complex
4	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
4	0032991	cellular_component	protein-containing complex
4	0045944	biological_process	positive regulation of transcription by RNA polymerase II
4	0051123	biological_process	RNA polymerase II preinitiation complex assembly
4	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
4	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
4	0070847	cellular_component	core mediator complex
5	0000122	biological_process	negative regulation of transcription by RNA polymerase II
5	0001095	molecular_function	TFIIE-class transcription factor complex binding
5	0001097	molecular_function	TFIIH-class transcription factor complex binding
5	0003712	molecular_function	transcription coregulator activity
5	0003713	molecular_function	transcription coactivator activity
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0006355	biological_process	regulation of DNA-templated transcription
5	0006357	biological_process	regulation of transcription by RNA polymerase II
5	0016592	cellular_component	mediator complex
5	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
5	0034605	biological_process	cellular response to heat
5	0045944	biological_process	positive regulation of transcription by RNA polymerase II
5	0051123	biological_process	RNA polymerase II preinitiation complex assembly
5	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
5	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
5	0070202	biological_process	regulation of establishment of protein localization to chromosome
5	0070847	cellular_component	core mediator complex
5	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
6	0000122	biological_process	negative regulation of transcription by RNA polymerase II
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0016592	cellular_component	mediator complex
6	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
6	0034605	biological_process	cellular response to heat
6	0045944	biological_process	positive regulation of transcription by RNA polymerase II
6	0051123	biological_process	RNA polymerase II preinitiation complex assembly
6	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
6	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
6	0070202	biological_process	regulation of establishment of protein localization to chromosome
6	0070847	cellular_component	core mediator complex
a	0000122	biological_process	negative regulation of transcription by RNA polymerase II
a	0003674	molecular_function	molecular_function
a	0003712	molecular_function	transcription coregulator activity
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0006357	biological_process	regulation of transcription by RNA polymerase II
a	0016592	cellular_component	mediator complex
a	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
a	0045944	biological_process	positive regulation of transcription by RNA polymerase II
a	0051123	biological_process	RNA polymerase II preinitiation complex assembly
a	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
a	0070847	cellular_component	core mediator complex
b	0000122	biological_process	negative regulation of transcription by RNA polymerase II
b	0003713	molecular_function	transcription coactivator activity
b	0005634	cellular_component	nucleus
b	0005829	cellular_component	cytosol
b	0016592	cellular_component	mediator complex
b	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
b	0034976	biological_process	response to endoplasmic reticulum stress
b	0045944	biological_process	positive regulation of transcription by RNA polymerase II
b	0051123	biological_process	RNA polymerase II preinitiation complex assembly
b	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
b	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
b	0070847	cellular_component	core mediator complex
b	0090399	biological_process	replicative senescence
c	0000122	biological_process	negative regulation of transcription by RNA polymerase II
c	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
c	0003712	molecular_function	transcription coregulator activity
c	0003713	molecular_function	transcription coactivator activity
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0006357	biological_process	regulation of transcription by RNA polymerase II
c	0016592	cellular_component	mediator complex
c	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
c	0034605	biological_process	cellular response to heat
c	0045944	biological_process	positive regulation of transcription by RNA polymerase II
c	0051123	biological_process	RNA polymerase II preinitiation complex assembly
c	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
c	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
c	0070847	cellular_component	core mediator complex
e	0003674	molecular_function	molecular_function
e	0003712	molecular_function	transcription coregulator activity
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005739	cellular_component	mitochondrion
e	0006357	biological_process	regulation of transcription by RNA polymerase II
e	0006366	biological_process	transcription by RNA polymerase II
e	0016592	cellular_component	mediator complex
e	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
e	0051123	biological_process	RNA polymerase II preinitiation complex assembly
e	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
e	0070847	cellular_component	core mediator complex
n	0000122	biological_process	negative regulation of transcription by RNA polymerase II
n	0001093	molecular_function	TFIIB-class transcription factor binding
n	0003712	molecular_function	transcription coregulator activity
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0006357	biological_process	regulation of transcription by RNA polymerase II
n	0016592	cellular_component	mediator complex
n	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
n	0032991	cellular_component	protein-containing complex
n	0045944	biological_process	positive regulation of transcription by RNA polymerase II
n	0051123	biological_process	RNA polymerase II preinitiation complex assembly
n	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
n	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
n	0070847	cellular_component	core mediator complex
o	0000122	biological_process	negative regulation of transcription by RNA polymerase II
o	0001095	molecular_function	TFIIE-class transcription factor complex binding
o	0001097	molecular_function	TFIIH-class transcription factor complex binding
o	0003712	molecular_function	transcription coregulator activity
o	0003713	molecular_function	transcription coactivator activity
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0006355	biological_process	regulation of DNA-templated transcription
o	0006357	biological_process	regulation of transcription by RNA polymerase II
o	0016592	cellular_component	mediator complex
o	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
o	0034605	biological_process	cellular response to heat
o	0045944	biological_process	positive regulation of transcription by RNA polymerase II
o	0051123	biological_process	RNA polymerase II preinitiation complex assembly
o	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
o	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
o	0070202	biological_process	regulation of establishment of protein localization to chromosome
o	0070847	cellular_component	core mediator complex
o	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
p	0000122	biological_process	negative regulation of transcription by RNA polymerase II
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0016592	cellular_component	mediator complex
p	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
p	0034605	biological_process	cellular response to heat
p	0045944	biological_process	positive regulation of transcription by RNA polymerase II
p	0051123	biological_process	RNA polymerase II preinitiation complex assembly
p	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
p	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
p	0070202	biological_process	regulation of establishment of protein localization to chromosome
p	0070847	cellular_component	core mediator complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
a	SER155
5	SER2

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
a	SER423
o	SER736
o	SER752
5	SER335
5	SER736
5	SER752

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:15665377, ECO:0007744|PubMed:19779198

Chain	Residue	Details
o	SER783
5	SER783

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site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
o	SER785
o	SER789
o	SER831
o	SER1008
5	SER785
5	SER789
5	SER831
5	SER1008

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
o	THR793
5	THR793

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site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
o	SER1003
o	SER1018
5	SER1003
5	SER1018

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
o	SER1034
5	SER1034

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