7UI9

Core Mediator-PICearly (Copy A)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000122	biological_process	negative regulation of transcription by RNA polymerase II
a	0003674	molecular_function	molecular_function
a	0003712	molecular_function	transcription coregulator activity
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0006351	biological_process	DNA-templated transcription
a	0006357	biological_process	regulation of transcription by RNA polymerase II
a	0016592	cellular_component	mediator complex
a	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
a	0045944	biological_process	positive regulation of transcription by RNA polymerase II
a	0051123	biological_process	RNA polymerase II preinitiation complex assembly
a	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
a	0070847	cellular_component	core mediator complex
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0006351	biological_process	DNA-templated transcription
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0001172	biological_process	RNA-templated transcription
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003729	molecular_function	mRNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005665	cellular_component	RNA polymerase II, core complex
B	0005739	cellular_component	mitochondrion
B	0006351	biological_process	DNA-templated transcription
B	0006354	biological_process	DNA-templated transcription elongation
B	0006366	biological_process	transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0008270	molecular_function	zinc ion binding
B	0010494	cellular_component	cytoplasmic stress granule
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0001172	biological_process	RNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0003968	molecular_function	RNA-directed RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0006369	biological_process	termination of RNA polymerase II transcription
C	0008270	molecular_function	zinc ion binding
C	0046872	molecular_function	metal ion binding
C	0046983	molecular_function	protein dimerization activity
d	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
d	0003712	molecular_function	transcription coregulator activity
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0006351	biological_process	DNA-templated transcription
d	0006357	biological_process	regulation of transcription by RNA polymerase II
d	0006366	biological_process	transcription by RNA polymerase II
d	0016592	cellular_component	mediator complex
d	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
d	0034605	biological_process	cellular response to heat
d	0051123	biological_process	RNA polymerase II preinitiation complex assembly
d	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
d	0070847	cellular_component	core mediator complex
D	0000166	molecular_function	nucleotide binding
D	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0000932	cellular_component	P-body
D	0001172	biological_process	RNA-templated transcription
D	0003697	molecular_function	single-stranded DNA binding
D	0003727	molecular_function	single-stranded RNA binding
D	0003968	molecular_function	RNA-directed RNA polymerase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005665	cellular_component	RNA polymerase II, core complex
D	0005737	cellular_component	cytoplasm
D	0006352	biological_process	DNA-templated transcription initiation
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0006397	biological_process	mRNA processing
D	0030880	cellular_component	RNA polymerase complex
D	0031369	molecular_function	translation initiation factor binding
D	0045948	biological_process	positive regulation of translational initiation
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0001172	biological_process	RNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0003968	molecular_function	RNA-directed RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006360	biological_process	transcription by RNA polymerase I
E	0006361	biological_process	transcription initiation at RNA polymerase I promoter
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006363	biological_process	termination of RNA polymerase I transcription
E	0006366	biological_process	transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0006383	biological_process	transcription by RNA polymerase III
E	0006384	biological_process	transcription initiation at RNA polymerase III promoter
E	0006386	biological_process	termination of RNA polymerase III transcription
E	0042254	biological_process	ribosome biogenesis
E	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
E	0042797	biological_process	tRNA transcription by RNA polymerase III
f	0003712	molecular_function	transcription coregulator activity
f	0003713	molecular_function	transcription coactivator activity
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0006351	biological_process	DNA-templated transcription
f	0006357	biological_process	regulation of transcription by RNA polymerase II
f	0016592	cellular_component	mediator complex
f	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
f	0045944	biological_process	positive regulation of transcription by RNA polymerase II
f	0051123	biological_process	RNA polymerase II preinitiation complex assembly
f	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
f	0070847	cellular_component	core mediator complex
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001172	biological_process	RNA-templated transcription
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0003968	molecular_function	RNA-directed RNA polymerase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0005737	cellular_component	cytoplasm
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006361	biological_process	transcription initiation at RNA polymerase I promoter
F	0006362	biological_process	transcription elongation by RNA polymerase I
F	0006363	biological_process	termination of RNA polymerase I transcription
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0006383	biological_process	transcription by RNA polymerase III
F	0006384	biological_process	transcription initiation at RNA polymerase III promoter
F	0006386	biological_process	termination of RNA polymerase III transcription
F	0042254	biological_process	ribosome biogenesis
F	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
F	0042797	biological_process	tRNA transcription by RNA polymerase III
g	0000122	biological_process	negative regulation of transcription by RNA polymerase II
g	0003712	molecular_function	transcription coregulator activity
g	0003713	molecular_function	transcription coactivator activity
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0006351	biological_process	DNA-templated transcription
g	0006357	biological_process	regulation of transcription by RNA polymerase II
g	0016592	cellular_component	mediator complex
g	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
g	0045944	biological_process	positive regulation of transcription by RNA polymerase II
g	0051123	biological_process	RNA polymerase II preinitiation complex assembly
g	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
g	0070847	cellular_component	core mediator complex
G	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0000932	cellular_component	P-body
G	0000956	biological_process	nuclear-transcribed mRNA catabolic process
G	0001172	biological_process	RNA-templated transcription
G	0003676	molecular_function	nucleic acid binding
G	0003697	molecular_function	single-stranded DNA binding
G	0003727	molecular_function	single-stranded RNA binding
G	0003968	molecular_function	RNA-directed RNA polymerase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005665	cellular_component	RNA polymerase II, core complex
G	0005737	cellular_component	cytoplasm
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0031369	molecular_function	translation initiation factor binding
G	0045948	biological_process	positive regulation of translational initiation
G	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
h	0000122	biological_process	negative regulation of transcription by RNA polymerase II
h	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
h	0003677	molecular_function	DNA binding
h	0003712	molecular_function	transcription coregulator activity
h	0003714	molecular_function	transcription corepressor activity
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0006351	biological_process	DNA-templated transcription
h	0006357	biological_process	regulation of transcription by RNA polymerase II
h	0016592	cellular_component	mediator complex
h	0017025	molecular_function	TBP-class protein binding
h	0030674	molecular_function	protein-macromolecule adaptor activity
h	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
h	0045944	biological_process	positive regulation of transcription by RNA polymerase II
h	0051123	biological_process	RNA polymerase II preinitiation complex assembly
h	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
h	0070847	cellular_component	core mediator complex
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0001172	biological_process	RNA-templated transcription
H	0003677	molecular_function	DNA binding
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0003968	molecular_function	RNA-directed RNA polymerase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005736	cellular_component	RNA polymerase I complex
H	0006351	biological_process	DNA-templated transcription
H	0006360	biological_process	transcription by RNA polymerase I
H	0006361	biological_process	transcription initiation at RNA polymerase I promoter
H	0006362	biological_process	transcription elongation by RNA polymerase I
H	0006363	biological_process	termination of RNA polymerase I transcription
H	0006366	biological_process	transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0006383	biological_process	transcription by RNA polymerase III
H	0006384	biological_process	transcription initiation at RNA polymerase III promoter
H	0006386	biological_process	termination of RNA polymerase III transcription
H	0042254	biological_process	ribosome biogenesis
H	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
H	0042797	biological_process	tRNA transcription by RNA polymerase III
i	0000122	biological_process	negative regulation of transcription by RNA polymerase II
i	0003712	molecular_function	transcription coregulator activity
i	0003713	molecular_function	transcription coactivator activity
i	0005198	molecular_function	structural molecule activity
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005829	cellular_component	cytosol
i	0006351	biological_process	DNA-templated transcription
i	0006357	biological_process	regulation of transcription by RNA polymerase II
i	0016592	cellular_component	mediator complex
i	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
i	0045944	biological_process	positive regulation of transcription by RNA polymerase II
i	0051123	biological_process	RNA polymerase II preinitiation complex assembly
i	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
i	0070847	cellular_component	core mediator complex
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001172	biological_process	RNA-templated transcription
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0003968	molecular_function	RNA-directed RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006281	biological_process	DNA repair
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0006974	biological_process	DNA damage response
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
j	0000122	biological_process	negative regulation of transcription by RNA polymerase II
j	0003674	molecular_function	molecular_function
j	0003712	molecular_function	transcription coregulator activity
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0006351	biological_process	DNA-templated transcription
j	0006357	biological_process	regulation of transcription by RNA polymerase II
j	0016592	cellular_component	mediator complex
j	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
j	0045944	biological_process	positive regulation of transcription by RNA polymerase II
j	0051123	biological_process	RNA polymerase II preinitiation complex assembly
j	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
j	0070847	cellular_component	core mediator complex
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0001172	biological_process	RNA-templated transcription
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0003968	molecular_function	RNA-directed RNA polymerase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005730	cellular_component	nucleolus
J	0005736	cellular_component	RNA polymerase I complex
J	0006351	biological_process	DNA-templated transcription
J	0006360	biological_process	transcription by RNA polymerase I
J	0006361	biological_process	transcription initiation at RNA polymerase I promoter
J	0006362	biological_process	transcription elongation by RNA polymerase I
J	0006363	biological_process	termination of RNA polymerase I transcription
J	0006366	biological_process	transcription by RNA polymerase II
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0006383	biological_process	transcription by RNA polymerase III
J	0006384	biological_process	transcription initiation at RNA polymerase III promoter
J	0006386	biological_process	termination of RNA polymerase III transcription
J	0008270	molecular_function	zinc ion binding
J	0042254	biological_process	ribosome biogenesis
J	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
k	0000122	biological_process	negative regulation of transcription by RNA polymerase II
k	0001097	molecular_function	TFIIH-class transcription factor complex binding
k	0003712	molecular_function	transcription coregulator activity
k	0003713	molecular_function	transcription coactivator activity
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0006351	biological_process	DNA-templated transcription
k	0006357	biological_process	regulation of transcription by RNA polymerase II
k	0016592	cellular_component	mediator complex
k	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
k	0045944	biological_process	positive regulation of transcription by RNA polymerase II
k	0051123	biological_process	RNA polymerase II preinitiation complex assembly
k	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
k	0070847	cellular_component	core mediator complex
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0001172	biological_process	RNA-templated transcription
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0003968	molecular_function	RNA-directed RNA polymerase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0006367	biological_process	transcription initiation at RNA polymerase II promoter
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0006369	biological_process	termination of RNA polymerase II transcription
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0001172	biological_process	RNA-templated transcription
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0003968	molecular_function	RNA-directed RNA polymerase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0005737	cellular_component	cytoplasm
L	0005777	cellular_component	peroxisome
L	0006351	biological_process	DNA-templated transcription
L	0006360	biological_process	transcription by RNA polymerase I
L	0006361	biological_process	transcription initiation at RNA polymerase I promoter
L	0006362	biological_process	transcription elongation by RNA polymerase I
L	0006363	biological_process	termination of RNA polymerase I transcription
L	0006366	biological_process	transcription by RNA polymerase II
L	0006367	biological_process	transcription initiation at RNA polymerase II promoter
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0006383	biological_process	transcription by RNA polymerase III
L	0006384	biological_process	transcription initiation at RNA polymerase III promoter
L	0006386	biological_process	termination of RNA polymerase III transcription
L	0008270	molecular_function	zinc ion binding
L	0042254	biological_process	ribosome biogenesis
L	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
L	0042797	biological_process	tRNA transcription by RNA polymerase III
L	0046872	molecular_function	metal ion binding
M	0000993	molecular_function	RNA polymerase II complex binding
M	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
M	0001139	molecular_function	RNA polymerase II complex recruiting activity
M	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0006351	biological_process	DNA-templated transcription
M	0006352	biological_process	DNA-templated transcription initiation
M	0008270	molecular_function	zinc ion binding
M	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
M	0017025	molecular_function	TBP-class protein binding
M	0046872	molecular_function	metal ion binding
M	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0070897	biological_process	transcription preinitiation complex assembly
M	0097550	cellular_component	transcription preinitiation complex
n	0000122	biological_process	negative regulation of transcription by RNA polymerase II
n	0001093	molecular_function	TFIIB-class transcription factor binding
n	0003712	molecular_function	transcription coregulator activity
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0006351	biological_process	DNA-templated transcription
n	0006357	biological_process	regulation of transcription by RNA polymerase II
n	0016592	cellular_component	mediator complex
n	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
n	0045944	biological_process	positive regulation of transcription by RNA polymerase II
n	0051123	biological_process	RNA polymerase II preinitiation complex assembly
n	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
n	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
n	0070847	cellular_component	core mediator complex
P	0001096	molecular_function	TFIIF-class transcription factor complex binding
P	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005674	cellular_component	transcription factor TFIIF complex
P	0006351	biological_process	DNA-templated transcription
P	0006355	biological_process	regulation of DNA-templated transcription
P	0006367	biological_process	transcription initiation at RNA polymerase II promoter
P	0006368	biological_process	transcription elongation by RNA polymerase II
P	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
P	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
P	0051123	biological_process	RNA polymerase II preinitiation complex assembly
P	0072542	molecular_function	protein phosphatase activator activity
q	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
q	0001139	molecular_function	RNA polymerase II complex recruiting activity
q	0003712	molecular_function	transcription coregulator activity
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0006351	biological_process	DNA-templated transcription
q	0006357	biological_process	regulation of transcription by RNA polymerase II
q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
q	0016592	cellular_component	mediator complex
q	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
q	0034605	biological_process	cellular response to heat
q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
q	0051123	biological_process	RNA polymerase II preinitiation complex assembly
q	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
q	0070847	cellular_component	core mediator complex
q	0140297	molecular_function	DNA-binding transcription factor binding
Q	0000166	molecular_function	nucleotide binding
Q	0000993	molecular_function	RNA polymerase II complex binding
Q	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005674	cellular_component	transcription factor TFIIF complex
Q	0006351	biological_process	DNA-templated transcription
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0006366	biological_process	transcription by RNA polymerase II
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0006368	biological_process	transcription elongation by RNA polymerase II
Q	0051123	biological_process	RNA polymerase II preinitiation complex assembly
r	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
r	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
r	0003712	molecular_function	transcription coregulator activity
r	0003713	molecular_function	transcription coactivator activity
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0006351	biological_process	DNA-templated transcription
r	0006357	biological_process	regulation of transcription by RNA polymerase II
r	0006369	biological_process	termination of RNA polymerase II transcription
r	0016592	cellular_component	mediator complex
r	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
r	0034605	biological_process	cellular response to heat
r	0045944	biological_process	positive regulation of transcription by RNA polymerase II
r	0051123	biological_process	RNA polymerase II preinitiation complex assembly
r	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
r	0070847	cellular_component	core mediator complex
s	0000122	biological_process	negative regulation of transcription by RNA polymerase II
s	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
s	0003712	molecular_function	transcription coregulator activity
s	0003713	molecular_function	transcription coactivator activity
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0006351	biological_process	DNA-templated transcription
s	0006357	biological_process	regulation of transcription by RNA polymerase II
s	0016592	cellular_component	mediator complex
s	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
s	0045944	biological_process	positive regulation of transcription by RNA polymerase II
s	0051123	biological_process	RNA polymerase II preinitiation complex assembly
s	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
s	0070847	cellular_component	core mediator complex
S	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
S	0000993	molecular_function	RNA polymerase II complex binding
S	0001139	molecular_function	RNA polymerase II complex recruiting activity
S	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
S	0003676	molecular_function	nucleic acid binding
S	0003677	molecular_function	DNA binding
S	0003711	molecular_function	transcription elongation factor activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0006351	biological_process	DNA-templated transcription
S	0006362	biological_process	transcription elongation by RNA polymerase I
S	0006367	biological_process	transcription initiation at RNA polymerase II promoter
S	0006368	biological_process	transcription elongation by RNA polymerase II
S	0006383	biological_process	transcription by RNA polymerase III
S	0008270	molecular_function	zinc ion binding
S	0031440	biological_process	regulation of mRNA 3'-end processing
S	0031564	biological_process	transcription antitermination
S	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
S	0042797	biological_process	tRNA transcription by RNA polymerase III
S	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
S	0046872	molecular_function	metal ion binding
S	0051123	biological_process	RNA polymerase II preinitiation complex assembly
t	0001094	molecular_function	TFIID-class transcription factor complex binding
t	0003712	molecular_function	transcription coregulator activity
t	0003713	molecular_function	transcription coactivator activity
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0006351	biological_process	DNA-templated transcription
t	0006357	biological_process	regulation of transcription by RNA polymerase II
t	0010688	biological_process	negative regulation of ribosomal protein gene transcription by RNA polymerase II
t	0016592	cellular_component	mediator complex
t	0019904	molecular_function	protein domain specific binding
t	0031669	biological_process	cellular response to nutrient levels
t	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
t	0032991	cellular_component	protein-containing complex
t	0045944	biological_process	positive regulation of transcription by RNA polymerase II
t	0051123	biological_process	RNA polymerase II preinitiation complex assembly
t	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
t	0070847	cellular_component	core mediator complex
u	0000122	biological_process	negative regulation of transcription by RNA polymerase II
u	0003712	molecular_function	transcription coregulator activity
u	0003713	molecular_function	transcription coactivator activity
u	0003714	molecular_function	transcription corepressor activity
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0006351	biological_process	DNA-templated transcription
u	0006357	biological_process	regulation of transcription by RNA polymerase II
u	0016592	cellular_component	mediator complex
u	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
u	0045944	biological_process	positive regulation of transcription by RNA polymerase II
u	0051123	biological_process	RNA polymerase II preinitiation complex assembly
u	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
u	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
u	0070847	cellular_component	core mediator complex
v	0003674	molecular_function	molecular_function
v	0003712	molecular_function	transcription coregulator activity
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0006351	biological_process	DNA-templated transcription
v	0006357	biological_process	regulation of transcription by RNA polymerase II
v	0016592	cellular_component	mediator complex
v	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
v	0045944	biological_process	positive regulation of transcription by RNA polymerase II
v	0051123	biological_process	RNA polymerase II preinitiation complex assembly
v	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
v	0070847	cellular_component	core mediator complex
w	0003712	molecular_function	transcription coregulator activity
w	0003713	molecular_function	transcription coactivator activity
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0006281	biological_process	DNA repair
w	0006310	biological_process	DNA recombination
w	0006311	biological_process	meiotic gene conversion
w	0006351	biological_process	DNA-templated transcription
w	0006355	biological_process	regulation of DNA-templated transcription
w	0006357	biological_process	regulation of transcription by RNA polymerase II
w	0006366	biological_process	transcription by RNA polymerase II
w	0016592	cellular_component	mediator complex
w	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
w	0051123	biological_process	RNA polymerase II preinitiation complex assembly
w	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
w	0070847	cellular_component	core mediator complex
z	0003677	molecular_function	DNA binding
z	0006366	biological_process	transcription by RNA polymerase II

Functional Information from PROSITE/UniProt

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPS

Chain	Residue	Details
z	TYR3-SER9
z	TYR10-SER16
z	TYR17-SER23

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSLRRvmiaeiptlAidsVevetNtTvlaDEfIAhRLGLIP

Chain	Residue	Details
C	ASN31-PRO71

---

site_id	PS00466
Number of Residues	36
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CgkCkekkvsyyqLQTRSaDEPlttfctCea...CgnrW

Chain	Residue	Details
S	CYS271-TRP306
I	CYS75-PHE110

---

site_id	PS00782
Number of Residues	16
Details	TFIIB Transcription factor TFIIB repeat signature. GKsmeSIMAASILIGC

Chain	Residue	Details
M	GLY165-CYS180

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCRDCNNMLypredkennrllfeCrtC

Chain	Residue	Details
I	PHE6-CYS32

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHirLssDE

Chain	Residue	Details
E	HIS147-GLU160

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ

Chain	Residue	Details
F	THR86-GLN100

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IVPVrCFSCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. FekEdHTLgNlIraeLlndrkVlfaaYkveHP

Chain	Residue	Details
K	PHE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY977-THR989

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00469","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	116
Details	Domain: {"description":"TFIIS central","evidences":[{"source":"PROSITE-ProRule","id":"PRU00651","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	Zinc finger: {"description":"TFIIS-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	66
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	35
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Repeat: {"description":"18"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Repeat: {"description":"19"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	Repeat: {"description":"20"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	12
Details	Region: {"description":"Lid loop"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	17
Details	Region: {"description":"Rudder loop"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	12
Details	Region: {"description":"Bridging helix"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23151482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25652824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V1M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	5
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"32142654","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	42
Details	Zinc finger: {"description":"C4-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	11
Details	Region: {"description":"Fork loop 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	13
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	21
Details	Region: {"description":"Leucine-zipper"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	23
Details	Region: {"description":"Non-specific ssDNA binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	25
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11313498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11805306","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15537538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11313499","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11313498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11805306","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15537538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11313499","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15537538","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TWF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 788

Chain

Residue

Details

---