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7UHY

Human GATOR2 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0016020cellular_componentmembrane
A0030054cellular_componentcell junction
A0031503biological_processprotein-containing complex localization
A0031669biological_processcellular response to nutrient levels
A0032289biological_processcentral nervous system myelin formation
A0034198biological_processcellular response to amino acid starvation
A0046872molecular_functionmetal ion binding
A0048709biological_processoligodendrocyte differentiation
A0061700cellular_componentGATOR2 complex
A0070444biological_processoligodendrocyte progenitor proliferation
A1904262biological_processnegative regulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0016020cellular_componentmembrane
B0030054cellular_componentcell junction
B0031503biological_processprotein-containing complex localization
B0031669biological_processcellular response to nutrient levels
B0032289biological_processcentral nervous system myelin formation
B0034198biological_processcellular response to amino acid starvation
B0046872molecular_functionmetal ion binding
B0048709biological_processoligodendrocyte differentiation
B0061700cellular_componentGATOR2 complex
B0070444biological_processoligodendrocyte progenitor proliferation
B1904262biological_processnegative regulation of TORC1 signaling
B1904263biological_processpositive regulation of TORC1 signaling
C0005515molecular_functionprotein binding
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005774cellular_componentvacuolar membrane
C0005829cellular_componentcytosol
C0006914biological_processautophagy
C0010506biological_processregulation of autophagy
C0016020cellular_componentmembrane
C0016239biological_processpositive regulation of macroautophagy
C0016567biological_processprotein ubiquitination
C0016740molecular_functiontransferase activity
C0031669biological_processcellular response to nutrient levels
C0032008biological_processpositive regulation of TOR signaling
C0034198biological_processcellular response to amino acid starvation
C0043231cellular_componentintracellular membrane-bounded organelle
C0046872molecular_functionmetal ion binding
C0061630molecular_functionubiquitin protein ligase activity
C0061700cellular_componentGATOR2 complex
C0085020biological_processprotein K6-linked ubiquitination
C1904262biological_processnegative regulation of TORC1 signaling
C1904263biological_processpositive regulation of TORC1 signaling
D0005515molecular_functionprotein binding
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005774cellular_componentvacuolar membrane
D0005829cellular_componentcytosol
D0016020cellular_componentmembrane
D0031669biological_processcellular response to nutrient levels
D0034198biological_processcellular response to amino acid starvation
D0035591molecular_functionsignaling adaptor activity
D0035859cellular_componentSeh1-associated complex
D0043231cellular_componentintracellular membrane-bounded organelle
D0046872molecular_functionmetal ion binding
D0061700cellular_componentGATOR2 complex
D1904262biological_processnegative regulation of TORC1 signaling
D1904263biological_processpositive regulation of TORC1 signaling
E0000775cellular_componentchromosome, centromeric region
E0000776cellular_componentkinetochore
E0005198molecular_functionstructural molecule activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005635cellular_componentnuclear envelope
E0005643cellular_componentnuclear pore
E0005694cellular_componentchromosome
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0006913biological_processnucleocytoplasmic transport
E0006999biological_processnuclear pore organization
E0007059biological_processchromosome segregation
E0007080biological_processmitotic metaphase chromosome alignment
E0015031biological_processprotein transport
E0016020cellular_componentmembrane
E0031080cellular_componentnuclear pore outer ring
E0031503biological_processprotein-containing complex localization
E0031669biological_processcellular response to nutrient levels
E0034198biological_processcellular response to amino acid starvation
E0035859cellular_componentSeh1-associated complex
E0050830biological_processdefense response to Gram-positive bacterium
E0051028biological_processmRNA transport
E0051301biological_processcell division
E0051315biological_processattachment of mitotic spindle microtubules to kinetochore
E0061700cellular_componentGATOR2 complex
E1904262biological_processnegative regulation of TORC1 signaling
E1904263biological_processpositive regulation of TORC1 signaling
F0000775cellular_componentchromosome, centromeric region
F0000776cellular_componentkinetochore
F0005198molecular_functionstructural molecule activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005635cellular_componentnuclear envelope
F0005643cellular_componentnuclear pore
F0005694cellular_componentchromosome
F0005764cellular_componentlysosome
F0005765cellular_componentlysosomal membrane
F0005829cellular_componentcytosol
F0006913biological_processnucleocytoplasmic transport
F0006999biological_processnuclear pore organization
F0007059biological_processchromosome segregation
F0007080biological_processmitotic metaphase chromosome alignment
F0015031biological_processprotein transport
F0016020cellular_componentmembrane
F0031080cellular_componentnuclear pore outer ring
F0031503biological_processprotein-containing complex localization
F0031669biological_processcellular response to nutrient levels
F0034198biological_processcellular response to amino acid starvation
F0035859cellular_componentSeh1-associated complex
F0050830biological_processdefense response to Gram-positive bacterium
F0051028biological_processmRNA transport
F0051301biological_processcell division
F0051315biological_processattachment of mitotic spindle microtubules to kinetochore
F0061700cellular_componentGATOR2 complex
F1904262biological_processnegative regulation of TORC1 signaling
F1904263biological_processpositive regulation of TORC1 signaling
G0000775cellular_componentchromosome, centromeric region
G0000776cellular_componentkinetochore
G0005198molecular_functionstructural molecule activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005635cellular_componentnuclear envelope
G0005643cellular_componentnuclear pore
G0005694cellular_componentchromosome
G0005764cellular_componentlysosome
G0005765cellular_componentlysosomal membrane
G0005829cellular_componentcytosol
G0006913biological_processnucleocytoplasmic transport
G0006999biological_processnuclear pore organization
G0007059biological_processchromosome segregation
G0007080biological_processmitotic metaphase chromosome alignment
G0015031biological_processprotein transport
G0016020cellular_componentmembrane
G0031080cellular_componentnuclear pore outer ring
G0031503biological_processprotein-containing complex localization
G0031669biological_processcellular response to nutrient levels
G0034198biological_processcellular response to amino acid starvation
G0035859cellular_componentSeh1-associated complex
G0050830biological_processdefense response to Gram-positive bacterium
G0051028biological_processmRNA transport
G0051301biological_processcell division
G0051315biological_processattachment of mitotic spindle microtubules to kinetochore
G0061700cellular_componentGATOR2 complex
G1904262biological_processnegative regulation of TORC1 signaling
G1904263biological_processpositive regulation of TORC1 signaling
H0000776cellular_componentkinetochore
H0005198molecular_functionstructural molecule activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005635cellular_componentnuclear envelope
H0005643cellular_componentnuclear pore
H0005654cellular_componentnucleoplasm
H0005764cellular_componentlysosome
H0005765cellular_componentlysosomal membrane
H0005783cellular_componentendoplasmic reticulum
H0005789cellular_componentendoplasmic reticulum membrane
H0005829cellular_componentcytosol
H0006606biological_processprotein import into nucleus
H0006886biological_processintracellular protein transport
H0006913biological_processnucleocytoplasmic transport
H0012507cellular_componentER to Golgi transport vesicle membrane
H0015031biological_processprotein transport
H0016020cellular_componentmembrane
H0016192biological_processvesicle-mediated transport
H0030127cellular_componentCOPII vesicle coat
H0031080cellular_componentnuclear pore outer ring
H0031410cellular_componentcytoplasmic vesicle
H0031669biological_processcellular response to nutrient levels
H0032008biological_processpositive regulation of TOR signaling
H0032527biological_processprotein exit from endoplasmic reticulum
H0042802molecular_functionidentical protein binding
H0043231cellular_componentintracellular membrane-bounded organelle
H0051028biological_processmRNA transport
H0061700cellular_componentGATOR2 complex
H0070062cellular_componentextracellular exosome
H0090110biological_processCOPII-coated vesicle cargo loading
H0090114biological_processCOPII-coated vesicle budding
H1904262biological_processnegative regulation of TORC1 signaling
H1904263biological_processpositive regulation of TORC1 signaling
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LATAatNgVVVTWNL
ChainResidueDetails
CLEU90-LEU104
CLEU223-MET237
CTHR269-VAL283
DLEU121-ILE135

site_idPS01248
Number of Residues37
DetailsEGF_LAM_1 Laminin-type EGF-like (LE) domain signature. CshCrsevrGtqCaiCkgftFqcaichvavrgssnfC
ChainResidueDetails
DCYS902-CYS938

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylvaline => ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895
ChainResidueDetails
HVAL2
ESER190
FSER179
FSER190
GSER179
GSER190

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
HSER184
BLEU782-THR863
FLYS12
GLYS12

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
HSER309
DCYS960
DCYS964
DCYS966
DCYS968
CHIS785
CCYS787
BCYS775
BCYS778
BCYS788
BCYS827
DCYS905
BCYS830
BHIS832
BHIS835
BHIS838
BCYS849
BCYS854
BCYS858
DCYS914
DCYS917
DCYS927
DCYS938
DHIS943
DHIS946
DHIS949

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
DSER564
BSER759

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
DSER821
CSER496

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER822

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER830

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8CFJ9
ChainResidueDetails
CSER598

222415

PDB entries from 2024-07-10

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