7UHY

Human GATOR2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005765	cellular_component	lysosomal membrane
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0031503	biological_process	protein-containing complex localization
A	0031669	biological_process	cellular response to nutrient levels
A	0032289	biological_process	central nervous system myelin formation
A	0034198	biological_process	cellular response to amino acid starvation
A	0046872	molecular_function	metal ion binding
A	0048709	biological_process	oligodendrocyte differentiation
A	0061700	cellular_component	GATOR2 complex
A	0070444	biological_process	oligodendrocyte progenitor proliferation
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904263	biological_process	positive regulation of TORC1 signaling
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005765	cellular_component	lysosomal membrane
B	0005829	cellular_component	cytosol
B	0008270	molecular_function	zinc ion binding
B	0031503	biological_process	protein-containing complex localization
B	0031669	biological_process	cellular response to nutrient levels
B	0032289	biological_process	central nervous system myelin formation
B	0034198	biological_process	cellular response to amino acid starvation
B	0046872	molecular_function	metal ion binding
B	0048709	biological_process	oligodendrocyte differentiation
B	0061700	cellular_component	GATOR2 complex
B	0070444	biological_process	oligodendrocyte progenitor proliferation
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1904263	biological_process	positive regulation of TORC1 signaling
C	0005515	molecular_function	protein binding
C	0005765	cellular_component	lysosomal membrane
C	0005774	cellular_component	vacuolar membrane
C	0005829	cellular_component	cytosol
C	0006914	biological_process	autophagy
C	0008270	molecular_function	zinc ion binding
C	0010506	biological_process	regulation of autophagy
C	0016239	biological_process	positive regulation of macroautophagy
C	0016567	biological_process	protein ubiquitination
C	0016740	molecular_function	transferase activity
C	0031669	biological_process	cellular response to nutrient levels
C	0032008	biological_process	positive regulation of TOR signaling
C	0034198	biological_process	cellular response to amino acid starvation
C	0046872	molecular_function	metal ion binding
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0061700	cellular_component	GATOR2 complex
C	0072659	biological_process	protein localization to plasma membrane
C	0085020	biological_process	protein K6-linked ubiquitination
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0005515	molecular_function	protein binding
D	0005765	cellular_component	lysosomal membrane
D	0005774	cellular_component	vacuolar membrane
D	0008270	molecular_function	zinc ion binding
D	0031669	biological_process	cellular response to nutrient levels
D	0034198	biological_process	cellular response to amino acid starvation
D	0035591	molecular_function	signaling adaptor activity
D	0035859	cellular_component	Seh1-associated complex
D	0046872	molecular_function	metal ion binding
D	0061700	cellular_component	GATOR2 complex
D	0072659	biological_process	protein localization to plasma membrane
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1904263	biological_process	positive regulation of TORC1 signaling
E	0000776	cellular_component	kinetochore
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005635	cellular_component	nuclear envelope
E	0005643	cellular_component	nuclear pore
E	0005765	cellular_component	lysosomal membrane
E	0005829	cellular_component	cytosol
E	0006913	biological_process	nucleocytoplasmic transport
E	0006999	biological_process	nuclear pore organization
E	0007059	biological_process	chromosome segregation
E	0007080	biological_process	mitotic metaphase chromosome alignment
E	0015031	biological_process	protein transport
E	0031080	cellular_component	nuclear pore outer ring
E	0031503	biological_process	protein-containing complex localization
E	0031669	biological_process	cellular response to nutrient levels
E	0034198	biological_process	cellular response to amino acid starvation
E	0035859	cellular_component	Seh1-associated complex
E	0051028	biological_process	mRNA transport
E	0051301	biological_process	cell division
E	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
E	0061700	cellular_component	GATOR2 complex
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1904263	biological_process	positive regulation of TORC1 signaling
F	0000776	cellular_component	kinetochore
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005635	cellular_component	nuclear envelope
F	0005643	cellular_component	nuclear pore
F	0005765	cellular_component	lysosomal membrane
F	0005829	cellular_component	cytosol
F	0006913	biological_process	nucleocytoplasmic transport
F	0006999	biological_process	nuclear pore organization
F	0007059	biological_process	chromosome segregation
F	0007080	biological_process	mitotic metaphase chromosome alignment
F	0015031	biological_process	protein transport
F	0031080	cellular_component	nuclear pore outer ring
F	0031503	biological_process	protein-containing complex localization
F	0031669	biological_process	cellular response to nutrient levels
F	0034198	biological_process	cellular response to amino acid starvation
F	0035859	cellular_component	Seh1-associated complex
F	0051028	biological_process	mRNA transport
F	0051301	biological_process	cell division
F	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
F	0061700	cellular_component	GATOR2 complex
F	1904262	biological_process	negative regulation of TORC1 signaling
F	1904263	biological_process	positive regulation of TORC1 signaling
G	0000776	cellular_component	kinetochore
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005635	cellular_component	nuclear envelope
G	0005643	cellular_component	nuclear pore
G	0005765	cellular_component	lysosomal membrane
G	0005829	cellular_component	cytosol
G	0006913	biological_process	nucleocytoplasmic transport
G	0006999	biological_process	nuclear pore organization
G	0007059	biological_process	chromosome segregation
G	0007080	biological_process	mitotic metaphase chromosome alignment
G	0015031	biological_process	protein transport
G	0031080	cellular_component	nuclear pore outer ring
G	0031503	biological_process	protein-containing complex localization
G	0031669	biological_process	cellular response to nutrient levels
G	0034198	biological_process	cellular response to amino acid starvation
G	0035859	cellular_component	Seh1-associated complex
G	0051028	biological_process	mRNA transport
G	0051301	biological_process	cell division
G	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
G	0061700	cellular_component	GATOR2 complex
G	1904262	biological_process	negative regulation of TORC1 signaling
G	1904263	biological_process	positive regulation of TORC1 signaling
H	0000776	cellular_component	kinetochore
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005635	cellular_component	nuclear envelope
H	0005643	cellular_component	nuclear pore
H	0005654	cellular_component	nucleoplasm
H	0005765	cellular_component	lysosomal membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005829	cellular_component	cytosol
H	0006606	biological_process	protein import into nucleus
H	0006886	biological_process	intracellular protein transport
H	0006913	biological_process	nucleocytoplasmic transport
H	0012507	cellular_component	ER to Golgi transport vesicle membrane
H	0015031	biological_process	protein transport
H	0016192	biological_process	vesicle-mediated transport
H	0030127	cellular_component	COPII vesicle coat
H	0031080	cellular_component	nuclear pore outer ring
H	0031410	cellular_component	cytoplasmic vesicle
H	0031669	biological_process	cellular response to nutrient levels
H	0032008	biological_process	positive regulation of TOR signaling
H	0032527	biological_process	protein exit from endoplasmic reticulum
H	0042802	molecular_function	identical protein binding
H	0051028	biological_process	mRNA transport
H	0061700	cellular_component	GATOR2 complex
H	0070062	cellular_component	extracellular exosome
H	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
H	0090110	biological_process	COPII-coated vesicle cargo loading
H	0090114	biological_process	COPII-coated vesicle budding
H	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
H	1904262	biological_process	negative regulation of TORC1 signaling
H	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATAatNgVVVTWNL

Chain	Residue	Details
C	LEU90-LEU104
C	LEU223-MET237
C	THR269-VAL283
D	LEU121-ILE135

---

site_id	PS01248
Number of Residues	37
Details	EGF_LAM_1 Laminin-type EGF-like (LE) domain signature. CshCrsevrGtqCaiCkgftFqcaichvavrgssnfC

Chain	Residue	Details
D	CYS902-CYS938

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Repeat: {"description":"WD 1"}

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site_id	SWS_FT_FI2
Number of Residues	244
Details	Repeat: {"description":"WD 3"}

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Residue

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---

site_id	SWS_FT_FI3
Number of Residues	226
Details	Repeat: {"description":"WD 4"}

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Residue

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---

site_id	SWS_FT_FI4
Number of Residues	240
Details	Repeat: {"description":"WD 6"}

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Residue

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---

site_id	SWS_FT_FI5
Number of Residues	54
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35831510","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UHY","evidenceCode":"ECO:0007744"}]}

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Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	Repeat: {"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

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---

site_id	SWS_FT_FI7
Number of Residues	40
Details	Repeat: {"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

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---

site_id	SWS_FT_FI8
Number of Residues	40
Details	Repeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

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---

site_id	SWS_FT_FI9
Number of Residues	40
Details	Repeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

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---

site_id	SWS_FT_FI10
Number of Residues	42
Details	Repeat: {"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

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---

site_id	SWS_FT_FI11
Number of Residues	43
Details	Repeat: {"description":"WD 6","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

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---

site_id	SWS_FT_FI12
Number of Residues	41
Details	Zinc finger: {"description":"C4-type","evidences":[{"source":"PubMed","id":"35831510","evidenceCode":"ECO:0000305"}]}

Chain

Residue

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---

site_id	SWS_FT_FI13
Number of Residues	101
Details	Zinc finger: {"description":"RING-type; atypical","evidences":[{"source":"PubMed","id":"35831510","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"PubMed","id":"36732624","evidenceCode":"ECO:0000269"}]}

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Residue

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---

site_id	SWS_FT_FI15
Number of Residues	38
Details	Repeat: {"description":"WD 8"}

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Residue

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---

site_id	SWS_FT_FI16
Number of Residues	16
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

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Residue

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---

site_id	SWS_FT_FI17
Number of Residues	166
Details	Repeat: {"description":"WD 5"}

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Residue

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---

site_id	SWS_FT_FI18
Number of Residues	7
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

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Residue

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---

site_id	SWS_FT_FI19
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

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---

site_id	SWS_FT_FI20
Number of Residues	41
Details	Repeat: {"description":"WD 2"}

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---