7U9T

Structure of PKA phosphorylated human RyR2 in the closed state in the presence of Calmodulin

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001666	biological_process	response to hypoxia
A	0002027	biological_process	regulation of heart rate
A	0003143	biological_process	embryonic heart tube morphogenesis
A	0003220	biological_process	left ventricular cardiac muscle tissue morphogenesis
A	0003300	biological_process	cardiac muscle hypertrophy
A	0005216	molecular_function	monoatomic ion channel activity
A	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005513	biological_process	detection of calcium ion
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005790	cellular_component	smooth endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0006941	biological_process	striated muscle contraction
A	0010460	biological_process	positive regulation of heart rate
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
A	0014701	cellular_component	junctional sarcoplasmic reticulum membrane
A	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0014850	biological_process	response to muscle activity
A	0015278	molecular_function	intracellularly gated calcium channel activity
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0019722	biological_process	calcium-mediated signaling
A	0019899	molecular_function	enzyme binding
A	0019901	molecular_function	protein kinase binding
A	0030017	cellular_component	sarcomere
A	0030018	cellular_component	Z disc
A	0031000	biological_process	response to caffeine
A	0032991	cellular_component	protein-containing complex
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0034236	molecular_function	protein kinase A catalytic subunit binding
A	0034237	molecular_function	protein kinase A regulatory subunit binding
A	0034704	cellular_component	calcium channel complex
A	0035994	biological_process	response to muscle stretch
A	0042383	cellular_component	sarcolemma
A	0042802	molecular_function	identical protein binding
A	0043924	molecular_function	suramin binding
A	0044325	molecular_function	transmembrane transporter binding
A	0048763	molecular_function	calcium-induced calcium release activity
A	0051209	biological_process	release of sequestered calcium ion into cytosol
A	0051284	biological_process	positive regulation of sequestering of calcium ion
A	0051480	biological_process	regulation of cytosolic calcium ion concentration
A	0051649	biological_process	establishment of localization in cell
A	0051775	biological_process	response to redox state
A	0055085	biological_process	transmembrane transport
A	0055117	biological_process	regulation of cardiac muscle contraction
A	0060048	biological_process	cardiac muscle contraction
A	0060402	biological_process	calcium ion transport into cytosol
A	0070296	biological_process	sarcoplasmic reticulum calcium ion transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0071313	biological_process	cellular response to caffeine
A	0071872	biological_process	cellular response to epinephrine stimulus
A	0072599	biological_process	establishment of protein localization to endoplasmic reticulum
A	0086005	biological_process	ventricular cardiac muscle cell action potential
A	0086029	biological_process	Purkinje myocyte to ventricular cardiac muscle cell signaling
A	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
A	0097050	biological_process	type B pancreatic cell apoptotic process
A	0097159	molecular_function	organic cyclic compound binding
A	0097553	biological_process	calcium ion transmembrane import into cytosol
A	0098735	biological_process	positive regulation of the force of heart contraction
A	0098904	biological_process	regulation of AV node cell action potential
A	0098907	biological_process	regulation of SA node cell action potential
A	0098910	biological_process	regulation of atrial cardiac muscle cell action potential
A	0098911	biological_process	regulation of ventricular cardiac muscle cell action potential
B	0001666	biological_process	response to hypoxia
B	0002027	biological_process	regulation of heart rate
B	0003143	biological_process	embryonic heart tube morphogenesis
B	0003220	biological_process	left ventricular cardiac muscle tissue morphogenesis
B	0003300	biological_process	cardiac muscle hypertrophy
B	0005216	molecular_function	monoatomic ion channel activity
B	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
B	0005262	molecular_function	calcium channel activity
B	0005509	molecular_function	calcium ion binding
B	0005513	biological_process	detection of calcium ion
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005790	cellular_component	smooth endoplasmic reticulum
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0006941	biological_process	striated muscle contraction
B	0010460	biological_process	positive regulation of heart rate
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
B	0014701	cellular_component	junctional sarcoplasmic reticulum membrane
B	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0014850	biological_process	response to muscle activity
B	0015278	molecular_function	intracellularly gated calcium channel activity
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0019722	biological_process	calcium-mediated signaling
B	0019899	molecular_function	enzyme binding
B	0019901	molecular_function	protein kinase binding
B	0030017	cellular_component	sarcomere
B	0030018	cellular_component	Z disc
B	0031000	biological_process	response to caffeine
B	0032991	cellular_component	protein-containing complex
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0034236	molecular_function	protein kinase A catalytic subunit binding
B	0034237	molecular_function	protein kinase A regulatory subunit binding
B	0034704	cellular_component	calcium channel complex
B	0035994	biological_process	response to muscle stretch
B	0042383	cellular_component	sarcolemma
B	0042802	molecular_function	identical protein binding
B	0043924	molecular_function	suramin binding
B	0044325	molecular_function	transmembrane transporter binding
B	0048763	molecular_function	calcium-induced calcium release activity
B	0051209	biological_process	release of sequestered calcium ion into cytosol
B	0051284	biological_process	positive regulation of sequestering of calcium ion
B	0051480	biological_process	regulation of cytosolic calcium ion concentration
B	0051649	biological_process	establishment of localization in cell
B	0051775	biological_process	response to redox state
B	0055085	biological_process	transmembrane transport
B	0055117	biological_process	regulation of cardiac muscle contraction
B	0060048	biological_process	cardiac muscle contraction
B	0060402	biological_process	calcium ion transport into cytosol
B	0070296	biological_process	sarcoplasmic reticulum calcium ion transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0071313	biological_process	cellular response to caffeine
B	0071872	biological_process	cellular response to epinephrine stimulus
B	0072599	biological_process	establishment of protein localization to endoplasmic reticulum
B	0086005	biological_process	ventricular cardiac muscle cell action potential
B	0086029	biological_process	Purkinje myocyte to ventricular cardiac muscle cell signaling
B	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
B	0097050	biological_process	type B pancreatic cell apoptotic process
B	0097159	molecular_function	organic cyclic compound binding
B	0097553	biological_process	calcium ion transmembrane import into cytosol
B	0098735	biological_process	positive regulation of the force of heart contraction
B	0098904	biological_process	regulation of AV node cell action potential
B	0098907	biological_process	regulation of SA node cell action potential
B	0098910	biological_process	regulation of atrial cardiac muscle cell action potential
B	0098911	biological_process	regulation of ventricular cardiac muscle cell action potential
C	0001666	biological_process	response to hypoxia
C	0002027	biological_process	regulation of heart rate
C	0003143	biological_process	embryonic heart tube morphogenesis
C	0003220	biological_process	left ventricular cardiac muscle tissue morphogenesis
C	0003300	biological_process	cardiac muscle hypertrophy
C	0005216	molecular_function	monoatomic ion channel activity
C	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
C	0005262	molecular_function	calcium channel activity
C	0005509	molecular_function	calcium ion binding
C	0005513	biological_process	detection of calcium ion
C	0005515	molecular_function	protein binding
C	0005516	molecular_function	calmodulin binding
C	0005790	cellular_component	smooth endoplasmic reticulum
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0006874	biological_process	intracellular calcium ion homeostasis
C	0006941	biological_process	striated muscle contraction
C	0010460	biological_process	positive regulation of heart rate
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
C	0014701	cellular_component	junctional sarcoplasmic reticulum membrane
C	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0014850	biological_process	response to muscle activity
C	0015278	molecular_function	intracellularly gated calcium channel activity
C	0016020	cellular_component	membrane
C	0016529	cellular_component	sarcoplasmic reticulum
C	0019722	biological_process	calcium-mediated signaling
C	0019899	molecular_function	enzyme binding
C	0019901	molecular_function	protein kinase binding
C	0030017	cellular_component	sarcomere
C	0030018	cellular_component	Z disc
C	0031000	biological_process	response to caffeine
C	0032991	cellular_component	protein-containing complex
C	0033017	cellular_component	sarcoplasmic reticulum membrane
C	0034236	molecular_function	protein kinase A catalytic subunit binding
C	0034237	molecular_function	protein kinase A regulatory subunit binding
C	0034704	cellular_component	calcium channel complex
C	0035994	biological_process	response to muscle stretch
C	0042383	cellular_component	sarcolemma
C	0042802	molecular_function	identical protein binding
C	0043924	molecular_function	suramin binding
C	0044325	molecular_function	transmembrane transporter binding
C	0048763	molecular_function	calcium-induced calcium release activity
C	0051209	biological_process	release of sequestered calcium ion into cytosol
C	0051284	biological_process	positive regulation of sequestering of calcium ion
C	0051480	biological_process	regulation of cytosolic calcium ion concentration
C	0051649	biological_process	establishment of localization in cell
C	0051775	biological_process	response to redox state
C	0055085	biological_process	transmembrane transport
C	0055117	biological_process	regulation of cardiac muscle contraction
C	0060048	biological_process	cardiac muscle contraction
C	0060402	biological_process	calcium ion transport into cytosol
C	0070296	biological_process	sarcoplasmic reticulum calcium ion transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0071313	biological_process	cellular response to caffeine
C	0071872	biological_process	cellular response to epinephrine stimulus
C	0072599	biological_process	establishment of protein localization to endoplasmic reticulum
C	0086005	biological_process	ventricular cardiac muscle cell action potential
C	0086029	biological_process	Purkinje myocyte to ventricular cardiac muscle cell signaling
C	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
C	0097050	biological_process	type B pancreatic cell apoptotic process
C	0097159	molecular_function	organic cyclic compound binding
C	0097553	biological_process	calcium ion transmembrane import into cytosol
C	0098735	biological_process	positive regulation of the force of heart contraction
C	0098904	biological_process	regulation of AV node cell action potential
C	0098907	biological_process	regulation of SA node cell action potential
C	0098910	biological_process	regulation of atrial cardiac muscle cell action potential
C	0098911	biological_process	regulation of ventricular cardiac muscle cell action potential
D	0001666	biological_process	response to hypoxia
D	0002027	biological_process	regulation of heart rate
D	0003143	biological_process	embryonic heart tube morphogenesis
D	0003220	biological_process	left ventricular cardiac muscle tissue morphogenesis
D	0003300	biological_process	cardiac muscle hypertrophy
D	0005216	molecular_function	monoatomic ion channel activity
D	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
D	0005262	molecular_function	calcium channel activity
D	0005509	molecular_function	calcium ion binding
D	0005513	biological_process	detection of calcium ion
D	0005515	molecular_function	protein binding
D	0005516	molecular_function	calmodulin binding
D	0005790	cellular_component	smooth endoplasmic reticulum
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0006874	biological_process	intracellular calcium ion homeostasis
D	0006941	biological_process	striated muscle contraction
D	0010460	biological_process	positive regulation of heart rate
D	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
D	0014701	cellular_component	junctional sarcoplasmic reticulum membrane
D	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D	0014850	biological_process	response to muscle activity
D	0015278	molecular_function	intracellularly gated calcium channel activity
D	0016020	cellular_component	membrane
D	0016529	cellular_component	sarcoplasmic reticulum
D	0019722	biological_process	calcium-mediated signaling
D	0019899	molecular_function	enzyme binding
D	0019901	molecular_function	protein kinase binding
D	0030017	cellular_component	sarcomere
D	0030018	cellular_component	Z disc
D	0031000	biological_process	response to caffeine
D	0032991	cellular_component	protein-containing complex
D	0033017	cellular_component	sarcoplasmic reticulum membrane
D	0034236	molecular_function	protein kinase A catalytic subunit binding
D	0034237	molecular_function	protein kinase A regulatory subunit binding
D	0034704	cellular_component	calcium channel complex
D	0035994	biological_process	response to muscle stretch
D	0042383	cellular_component	sarcolemma
D	0042802	molecular_function	identical protein binding
D	0043924	molecular_function	suramin binding
D	0044325	molecular_function	transmembrane transporter binding
D	0048763	molecular_function	calcium-induced calcium release activity
D	0051209	biological_process	release of sequestered calcium ion into cytosol
D	0051284	biological_process	positive regulation of sequestering of calcium ion
D	0051480	biological_process	regulation of cytosolic calcium ion concentration
D	0051649	biological_process	establishment of localization in cell
D	0051775	biological_process	response to redox state
D	0055085	biological_process	transmembrane transport
D	0055117	biological_process	regulation of cardiac muscle contraction
D	0060048	biological_process	cardiac muscle contraction
D	0060402	biological_process	calcium ion transport into cytosol
D	0070296	biological_process	sarcoplasmic reticulum calcium ion transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0071313	biological_process	cellular response to caffeine
D	0071872	biological_process	cellular response to epinephrine stimulus
D	0072599	biological_process	establishment of protein localization to endoplasmic reticulum
D	0086005	biological_process	ventricular cardiac muscle cell action potential
D	0086029	biological_process	Purkinje myocyte to ventricular cardiac muscle cell signaling
D	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
D	0097050	biological_process	type B pancreatic cell apoptotic process
D	0097159	molecular_function	organic cyclic compound binding
D	0097553	biological_process	calcium ion transmembrane import into cytosol
D	0098735	biological_process	positive regulation of the force of heart contraction
D	0098904	biological_process	regulation of AV node cell action potential
D	0098907	biological_process	regulation of SA node cell action potential
D	0098910	biological_process	regulation of atrial cardiac muscle cell action potential
D	0098911	biological_process	regulation of ventricular cardiac muscle cell action potential
E	0002027	biological_process	regulation of heart rate
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0005102	molecular_function	signaling receptor binding
E	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
E	0005515	molecular_function	protein binding
E	0005528	molecular_function	FK506 binding
E	0005737	cellular_component	cytoplasm
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006458	biological_process	'de novo' protein folding
E	0006939	biological_process	smooth muscle contraction
E	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
E	0009749	biological_process	response to glucose
E	0010459	biological_process	negative regulation of heart rate
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0016247	molecular_function	channel regulator activity
E	0016529	cellular_component	sarcoplasmic reticulum
E	0019227	biological_process	neuronal action potential propagation
E	0019722	biological_process	calcium-mediated signaling
E	0019855	molecular_function	calcium channel inhibitor activity
E	0022417	biological_process	protein maturation by protein folding
E	0030018	cellular_component	Z disc
E	0030073	biological_process	insulin secretion
E	0030551	molecular_function	cyclic nucleotide binding
E	0033017	cellular_component	sarcoplasmic reticulum membrane
E	0033197	biological_process	response to vitamin E
E	0034704	cellular_component	calcium channel complex
E	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
E	0042026	biological_process	protein refolding
E	0042098	biological_process	T cell proliferation
E	0042542	biological_process	response to hydrogen peroxide
E	0044325	molecular_function	transmembrane transporter binding
E	0048680	biological_process	positive regulation of axon regeneration
E	0050849	biological_process	negative regulation of calcium-mediated signaling
E	0051209	biological_process	release of sequestered calcium ion into cytosol
E	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
E	0051284	biological_process	positive regulation of sequestering of calcium ion
E	0051775	biological_process	response to redox state
E	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
E	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
E	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
F	0002027	biological_process	regulation of heart rate
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0005102	molecular_function	signaling receptor binding
F	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
F	0005515	molecular_function	protein binding
F	0005528	molecular_function	FK506 binding
F	0005737	cellular_component	cytoplasm
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006458	biological_process	'de novo' protein folding
F	0006939	biological_process	smooth muscle contraction
F	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
F	0009749	biological_process	response to glucose
F	0010459	biological_process	negative regulation of heart rate
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0016247	molecular_function	channel regulator activity
F	0016529	cellular_component	sarcoplasmic reticulum
F	0019227	biological_process	neuronal action potential propagation
F	0019722	biological_process	calcium-mediated signaling
F	0019855	molecular_function	calcium channel inhibitor activity
F	0022417	biological_process	protein maturation by protein folding
F	0030018	cellular_component	Z disc
F	0030073	biological_process	insulin secretion
F	0030551	molecular_function	cyclic nucleotide binding
F	0033017	cellular_component	sarcoplasmic reticulum membrane
F	0033197	biological_process	response to vitamin E
F	0034704	cellular_component	calcium channel complex
F	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
F	0042026	biological_process	protein refolding
F	0042098	biological_process	T cell proliferation
F	0042542	biological_process	response to hydrogen peroxide
F	0044325	molecular_function	transmembrane transporter binding
F	0048680	biological_process	positive regulation of axon regeneration
F	0050849	biological_process	negative regulation of calcium-mediated signaling
F	0051209	biological_process	release of sequestered calcium ion into cytosol
F	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
F	0051284	biological_process	positive regulation of sequestering of calcium ion
F	0051775	biological_process	response to redox state
F	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
F	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
F	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
G	0002027	biological_process	regulation of heart rate
G	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
G	0005102	molecular_function	signaling receptor binding
G	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
G	0005515	molecular_function	protein binding
G	0005528	molecular_function	FK506 binding
G	0005737	cellular_component	cytoplasm
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006458	biological_process	'de novo' protein folding
G	0006939	biological_process	smooth muscle contraction
G	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
G	0009749	biological_process	response to glucose
G	0010459	biological_process	negative regulation of heart rate
G	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G	0016020	cellular_component	membrane
G	0016247	molecular_function	channel regulator activity
G	0016529	cellular_component	sarcoplasmic reticulum
G	0019227	biological_process	neuronal action potential propagation
G	0019722	biological_process	calcium-mediated signaling
G	0019855	molecular_function	calcium channel inhibitor activity
G	0022417	biological_process	protein maturation by protein folding
G	0030018	cellular_component	Z disc
G	0030073	biological_process	insulin secretion
G	0030551	molecular_function	cyclic nucleotide binding
G	0033017	cellular_component	sarcoplasmic reticulum membrane
G	0033197	biological_process	response to vitamin E
G	0034704	cellular_component	calcium channel complex
G	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
G	0042026	biological_process	protein refolding
G	0042098	biological_process	T cell proliferation
G	0042542	biological_process	response to hydrogen peroxide
G	0044325	molecular_function	transmembrane transporter binding
G	0048680	biological_process	positive regulation of axon regeneration
G	0050849	biological_process	negative regulation of calcium-mediated signaling
G	0051209	biological_process	release of sequestered calcium ion into cytosol
G	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
G	0051284	biological_process	positive regulation of sequestering of calcium ion
G	0051775	biological_process	response to redox state
G	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
G	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
G	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
H	0002027	biological_process	regulation of heart rate
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005102	molecular_function	signaling receptor binding
H	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
H	0005515	molecular_function	protein binding
H	0005528	molecular_function	FK506 binding
H	0005737	cellular_component	cytoplasm
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006458	biological_process	'de novo' protein folding
H	0006939	biological_process	smooth muscle contraction
H	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
H	0009749	biological_process	response to glucose
H	0010459	biological_process	negative regulation of heart rate
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016247	molecular_function	channel regulator activity
H	0016529	cellular_component	sarcoplasmic reticulum
H	0019227	biological_process	neuronal action potential propagation
H	0019722	biological_process	calcium-mediated signaling
H	0019855	molecular_function	calcium channel inhibitor activity
H	0022417	biological_process	protein maturation by protein folding
H	0030018	cellular_component	Z disc
H	0030073	biological_process	insulin secretion
H	0030551	molecular_function	cyclic nucleotide binding
H	0033017	cellular_component	sarcoplasmic reticulum membrane
H	0033197	biological_process	response to vitamin E
H	0034704	cellular_component	calcium channel complex
H	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
H	0042026	biological_process	protein refolding
H	0042098	biological_process	T cell proliferation
H	0042542	biological_process	response to hydrogen peroxide
H	0044325	molecular_function	transmembrane transporter binding
H	0048680	biological_process	positive regulation of axon regeneration
H	0050849	biological_process	negative regulation of calcium-mediated signaling
H	0051209	biological_process	release of sequestered calcium ion into cytosol
H	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
H	0051284	biological_process	positive regulation of sequestering of calcium ion
H	0051775	biological_process	response to redox state
H	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
H	0140839	molecular_function	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
H	0140840	molecular_function	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
I	0000086	biological_process	G2/M transition of mitotic cell cycle
I	0000922	cellular_component	spindle pole
I	0002027	biological_process	regulation of heart rate
I	0005509	molecular_function	calcium ion binding
I	0005513	biological_process	detection of calcium ion
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005813	cellular_component	centrosome
I	0005819	cellular_component	spindle
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005876	cellular_component	spindle microtubule
I	0005886	cellular_component	plasma membrane
I	0007186	biological_process	G protein-coupled receptor signaling pathway
I	0008076	cellular_component	voltage-gated potassium channel complex
I	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
I	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
I	0010856	molecular_function	adenylate cyclase activator activity
I	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I	0016020	cellular_component	membrane
I	0016240	biological_process	autophagosome membrane docking
I	0019855	molecular_function	calcium channel inhibitor activity
I	0019901	molecular_function	protein kinase binding
I	0021762	biological_process	substantia nigra development
I	0030017	cellular_component	sarcomere
I	0031432	molecular_function	titin binding
I	0031514	cellular_component	motile cilium
I	0031954	biological_process	positive regulation of protein autophosphorylation
I	0031982	cellular_component	vesicle
I	0032465	biological_process	regulation of cytokinesis
I	0032991	cellular_component	protein-containing complex
I	0034704	cellular_component	calcium channel complex
I	0035458	biological_process	cellular response to interferon-beta
I	0043209	cellular_component	myelin sheath
I	0043539	molecular_function	protein serine/threonine kinase activator activity
I	0044305	cellular_component	calyx of Held
I	0044325	molecular_function	transmembrane transporter binding
I	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
I	0046872	molecular_function	metal ion binding
I	0048306	molecular_function	calcium-dependent protein binding
I	0050848	biological_process	regulation of calcium-mediated signaling
I	0051592	biological_process	response to calcium ion
I	0055117	biological_process	regulation of cardiac muscle contraction
I	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
I	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
I	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
I	0071346	biological_process	cellular response to type II interferon
I	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
I	0072542	molecular_function	protein phosphatase activator activity
I	0097225	cellular_component	sperm midpiece
I	0097720	biological_process	calcineurin-mediated signaling
I	0098901	biological_process	regulation of cardiac muscle cell action potential
I	0099523	cellular_component	presynaptic cytosol
I	0140056	biological_process	organelle localization by membrane tethering
I	0140238	biological_process	presynaptic endocytosis
I	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
I	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
I	1902494	cellular_component	catalytic complex
I	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
I	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
J	0000086	biological_process	G2/M transition of mitotic cell cycle
J	0000922	cellular_component	spindle pole
J	0002027	biological_process	regulation of heart rate
J	0005509	molecular_function	calcium ion binding
J	0005513	biological_process	detection of calcium ion
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005819	cellular_component	spindle
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005876	cellular_component	spindle microtubule
J	0005886	cellular_component	plasma membrane
J	0007186	biological_process	G protein-coupled receptor signaling pathway
J	0008076	cellular_component	voltage-gated potassium channel complex
J	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
J	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
J	0010856	molecular_function	adenylate cyclase activator activity
J	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J	0016020	cellular_component	membrane
J	0016240	biological_process	autophagosome membrane docking
J	0019855	molecular_function	calcium channel inhibitor activity
J	0019901	molecular_function	protein kinase binding
J	0021762	biological_process	substantia nigra development
J	0030017	cellular_component	sarcomere
J	0031432	molecular_function	titin binding
J	0031514	cellular_component	motile cilium
J	0031954	biological_process	positive regulation of protein autophosphorylation
J	0031982	cellular_component	vesicle
J	0032465	biological_process	regulation of cytokinesis
J	0032991	cellular_component	protein-containing complex
J	0034704	cellular_component	calcium channel complex
J	0035458	biological_process	cellular response to interferon-beta
J	0043209	cellular_component	myelin sheath
J	0043539	molecular_function	protein serine/threonine kinase activator activity
J	0044305	cellular_component	calyx of Held
J	0044325	molecular_function	transmembrane transporter binding
J	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
J	0046872	molecular_function	metal ion binding
J	0048306	molecular_function	calcium-dependent protein binding
J	0050848	biological_process	regulation of calcium-mediated signaling
J	0051592	biological_process	response to calcium ion
J	0055117	biological_process	regulation of cardiac muscle contraction
J	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
J	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
J	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
J	0071346	biological_process	cellular response to type II interferon
J	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
J	0072542	molecular_function	protein phosphatase activator activity
J	0097225	cellular_component	sperm midpiece
J	0097720	biological_process	calcineurin-mediated signaling
J	0098901	biological_process	regulation of cardiac muscle cell action potential
J	0099523	cellular_component	presynaptic cytosol
J	0140056	biological_process	organelle localization by membrane tethering
J	0140238	biological_process	presynaptic endocytosis
J	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
J	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
J	1902494	cellular_component	catalytic complex
J	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
J	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
K	0000086	biological_process	G2/M transition of mitotic cell cycle
K	0000922	cellular_component	spindle pole
K	0002027	biological_process	regulation of heart rate
K	0005509	molecular_function	calcium ion binding
K	0005513	biological_process	detection of calcium ion
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005876	cellular_component	spindle microtubule
K	0005886	cellular_component	plasma membrane
K	0007186	biological_process	G protein-coupled receptor signaling pathway
K	0008076	cellular_component	voltage-gated potassium channel complex
K	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
K	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
K	0010856	molecular_function	adenylate cyclase activator activity
K	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K	0016020	cellular_component	membrane
K	0016240	biological_process	autophagosome membrane docking
K	0019855	molecular_function	calcium channel inhibitor activity
K	0019901	molecular_function	protein kinase binding
K	0021762	biological_process	substantia nigra development
K	0030017	cellular_component	sarcomere
K	0031432	molecular_function	titin binding
K	0031514	cellular_component	motile cilium
K	0031954	biological_process	positive regulation of protein autophosphorylation
K	0031982	cellular_component	vesicle
K	0032465	biological_process	regulation of cytokinesis
K	0032991	cellular_component	protein-containing complex
K	0034704	cellular_component	calcium channel complex
K	0035458	biological_process	cellular response to interferon-beta
K	0043209	cellular_component	myelin sheath
K	0043539	molecular_function	protein serine/threonine kinase activator activity
K	0044305	cellular_component	calyx of Held
K	0044325	molecular_function	transmembrane transporter binding
K	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
K	0046872	molecular_function	metal ion binding
K	0048306	molecular_function	calcium-dependent protein binding
K	0050848	biological_process	regulation of calcium-mediated signaling
K	0051592	biological_process	response to calcium ion
K	0055117	biological_process	regulation of cardiac muscle contraction
K	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
K	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
K	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
K	0071346	biological_process	cellular response to type II interferon
K	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
K	0072542	molecular_function	protein phosphatase activator activity
K	0097225	cellular_component	sperm midpiece
K	0097720	biological_process	calcineurin-mediated signaling
K	0098901	biological_process	regulation of cardiac muscle cell action potential
K	0099523	cellular_component	presynaptic cytosol
K	0140056	biological_process	organelle localization by membrane tethering
K	0140238	biological_process	presynaptic endocytosis
K	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
K	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
K	1902494	cellular_component	catalytic complex
K	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
K	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
L	0000086	biological_process	G2/M transition of mitotic cell cycle
L	0000922	cellular_component	spindle pole
L	0002027	biological_process	regulation of heart rate
L	0005509	molecular_function	calcium ion binding
L	0005513	biological_process	detection of calcium ion
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005813	cellular_component	centrosome
L	0005819	cellular_component	spindle
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005876	cellular_component	spindle microtubule
L	0005886	cellular_component	plasma membrane
L	0007186	biological_process	G protein-coupled receptor signaling pathway
L	0008076	cellular_component	voltage-gated potassium channel complex
L	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
L	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
L	0010856	molecular_function	adenylate cyclase activator activity
L	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L	0016020	cellular_component	membrane
L	0016240	biological_process	autophagosome membrane docking
L	0019855	molecular_function	calcium channel inhibitor activity
L	0019901	molecular_function	protein kinase binding
L	0021762	biological_process	substantia nigra development
L	0030017	cellular_component	sarcomere
L	0031432	molecular_function	titin binding
L	0031514	cellular_component	motile cilium
L	0031954	biological_process	positive regulation of protein autophosphorylation
L	0031982	cellular_component	vesicle
L	0032465	biological_process	regulation of cytokinesis
L	0032991	cellular_component	protein-containing complex
L	0034704	cellular_component	calcium channel complex
L	0035458	biological_process	cellular response to interferon-beta
L	0043209	cellular_component	myelin sheath
L	0043539	molecular_function	protein serine/threonine kinase activator activity
L	0044305	cellular_component	calyx of Held
L	0044325	molecular_function	transmembrane transporter binding
L	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
L	0046872	molecular_function	metal ion binding
L	0048306	molecular_function	calcium-dependent protein binding
L	0050848	biological_process	regulation of calcium-mediated signaling
L	0051592	biological_process	response to calcium ion
L	0055117	biological_process	regulation of cardiac muscle contraction
L	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
L	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
L	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
L	0071346	biological_process	cellular response to type II interferon
L	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
L	0072542	molecular_function	protein phosphatase activator activity
L	0097225	cellular_component	sperm midpiece
L	0097720	biological_process	calcineurin-mediated signaling
L	0098901	biological_process	regulation of cardiac muscle cell action potential
L	0099523	cellular_component	presynaptic cytosol
L	0140056	biological_process	organelle localization by membrane tethering
L	0140238	biological_process	presynaptic endocytosis
L	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
L	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
L	1902494	cellular_component	catalytic complex
L	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
L	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
I	ASP21-LEU33
I	ASP57-PHE69
I	ASP94-LEU106
I	ASP130-PHE142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03

Chain	Residue	Details
I	ASP21
I	GLU68
J	ASP21
J	ASP23
J	ASP25
J	THR27
J	GLU32
J	ASP57
J	ASP59
J	ASN61
J	THR63
I	ASP23
J	GLU68
K	ASP21
K	ASP23
K	ASP25
K	THR27
K	GLU32
K	ASP57
K	ASP59
K	ASN61
K	THR63
I	ASP25
K	GLU68
L	ASP21
L	ASP23
L	ASP25
L	THR27
L	GLU32
L	ASP57
L	ASP59
L	ASN61
L	THR63
I	THR27
L	GLU68
I	GLU32
I	ASP57
I	ASP59
I	ASN61
I	THR63

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0000269|PubMed:29724949, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03, ECO:0007744|PDB:6CNN, ECO:0007744|PDB:6CNO

Chain	Residue	Details
I	ASP94
J	GLU105
K	ASP94
K	ASP96
K	ASN98
K	TYR100
K	GLU105
L	ASP94
L	ASP96
L	ASN98
L	TYR100
I	ASP96
L	GLU105
C	THR4580-PHE4600
C	VAL4730-PHE4750
C	LEU4769-PHE4789
C	PHE4850-PHE4870
I	ASN98
I	TYR100
I	GLU105
J	ASP94
J	ASP96
J	ASN98
J	TYR100

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03

Chain	Residue	Details
I	ASP130
J	GLU141
K	ASP130
K	ASP132
K	ASP134
K	GLN136
K	GLU141
L	ASP130
L	ASP132
L	ASP134
L	GLN136
I	ASP132
L	GLU141
I	ASP134
I	GLN136
I	GLU141
J	ASP130
J	ASP132
J	ASP134
J	GLN136

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
I	ALA2
D	SER2947
B	SER1341
B	SER2369
B	SER2797
B	SER2811
B	SER2947
C	SER1341
C	SER2369
C	SER2797
C	SER2811
J	ALA2
C	SER2947
K	ALA2
L	ALA2
A	SER2947
D	SER1341
D	SER2369
D	SER2797
D	SER2811

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
I	LYS22
J	LYS22
K	LYS22
L	LYS22
B	SER1869
B	SER2697
C	SER1869
C	SER2697

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29

Chain	Residue	Details
I	THR45
J	THR45
K	THR45
L	THR45

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
I	SER82
J	SER82
K	SER82
L	SER82

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
I	LYS95
J	LYS95
K	LYS95
L	LYS95

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
I	TYR100
J	TYR100
K	TYR100
L	TYR100

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
I	SER102
J	SER102
K	SER102
L	SER102

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
I	THR111
J	THR111
K	THR111
L	THR111

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315

Chain	Residue	Details
I	LYS116
J	LYS116
K	LYS116
L	LYS116

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
I	TYR139
J	TYR139
K	TYR139
L	TYR139

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
I	LYS22
J	LYS22
K	LYS22
L	LYS22

---