Loading
PDBj
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

7U8K

Magic Angle Spinning NMR Structure of Human Cofilin-2 Assembled on Actin Filaments

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001725cellular_componentstress fiber
A0003785molecular_functionactin monomer binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005523molecular_functiontropomyosin binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005865cellular_componentstriated muscle thin filament
A0005884cellular_componentactin filament
A0010628biological_processpositive regulation of gene expression
A0016887molecular_functionATP hydrolysis activity
A0019904molecular_functionprotein domain specific binding
A0030027cellular_componentlamellipodium
A0030041biological_processactin filament polymerization
A0030175cellular_componentfilopodium
A0030240biological_processskeletal muscle thin filament assembly
A0031013molecular_functiontroponin I binding
A0031432molecular_functiontitin binding
A0031941cellular_componentfilamentous actin
A0032036molecular_functionmyosin heavy chain binding
A0032432cellular_componentactin filament bundle
A0042802molecular_functionidentical protein binding
A0044297cellular_componentcell body
A0048306molecular_functioncalcium-dependent protein binding
A0048741biological_processskeletal muscle fiber development
A0051017biological_processactin filament bundle assembly
A0090131biological_processmesenchyme migration
A0098723cellular_componentskeletal muscle myofibril
A0140660molecular_functioncytoskeletal motor activator activity
B0000287molecular_functionmagnesium ion binding
B0001725cellular_componentstress fiber
B0003785molecular_functionactin monomer binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005523molecular_functiontropomyosin binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005865cellular_componentstriated muscle thin filament
B0005884cellular_componentactin filament
B0010628biological_processpositive regulation of gene expression
B0016887molecular_functionATP hydrolysis activity
B0019904molecular_functionprotein domain specific binding
B0030027cellular_componentlamellipodium
B0030041biological_processactin filament polymerization
B0030175cellular_componentfilopodium
B0030240biological_processskeletal muscle thin filament assembly
B0031013molecular_functiontroponin I binding
B0031432molecular_functiontitin binding
B0031941cellular_componentfilamentous actin
B0032036molecular_functionmyosin heavy chain binding
B0032432cellular_componentactin filament bundle
B0042802molecular_functionidentical protein binding
B0044297cellular_componentcell body
B0048306molecular_functioncalcium-dependent protein binding
B0048741biological_processskeletal muscle fiber development
B0051017biological_processactin filament bundle assembly
B0090131biological_processmesenchyme migration
B0098723cellular_componentskeletal muscle myofibril
B0140660molecular_functioncytoskeletal motor activator activity
C0000287molecular_functionmagnesium ion binding
C0001725cellular_componentstress fiber
C0003785molecular_functionactin monomer binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005523molecular_functiontropomyosin binding
C0005737cellular_componentcytoplasm
C0005856cellular_componentcytoskeleton
C0005865cellular_componentstriated muscle thin filament
C0005884cellular_componentactin filament
C0010628biological_processpositive regulation of gene expression
C0016887molecular_functionATP hydrolysis activity
C0019904molecular_functionprotein domain specific binding
C0030027cellular_componentlamellipodium
C0030041biological_processactin filament polymerization
C0030175cellular_componentfilopodium
C0030240biological_processskeletal muscle thin filament assembly
C0031013molecular_functiontroponin I binding
C0031432molecular_functiontitin binding
C0031941cellular_componentfilamentous actin
C0032036molecular_functionmyosin heavy chain binding
C0032432cellular_componentactin filament bundle
C0042802molecular_functionidentical protein binding
C0044297cellular_componentcell body
C0048306molecular_functioncalcium-dependent protein binding
C0048741biological_processskeletal muscle fiber development
C0051017biological_processactin filament bundle assembly
C0090131biological_processmesenchyme migration
C0098723cellular_componentskeletal muscle myofibril
C0140660molecular_functioncytoskeletal motor activator activity
D0000287molecular_functionmagnesium ion binding
D0001725cellular_componentstress fiber
D0003785molecular_functionactin monomer binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005523molecular_functiontropomyosin binding
D0005737cellular_componentcytoplasm
D0005856cellular_componentcytoskeleton
D0005865cellular_componentstriated muscle thin filament
D0005884cellular_componentactin filament
D0010628biological_processpositive regulation of gene expression
D0016887molecular_functionATP hydrolysis activity
D0019904molecular_functionprotein domain specific binding
D0030027cellular_componentlamellipodium
D0030041biological_processactin filament polymerization
D0030175cellular_componentfilopodium
D0030240biological_processskeletal muscle thin filament assembly
D0031013molecular_functiontroponin I binding
D0031432molecular_functiontitin binding
D0031941cellular_componentfilamentous actin
D0032036molecular_functionmyosin heavy chain binding
D0032432cellular_componentactin filament bundle
D0042802molecular_functionidentical protein binding
D0044297cellular_componentcell body
D0048306molecular_functioncalcium-dependent protein binding
D0048741biological_processskeletal muscle fiber development
D0051017biological_processactin filament bundle assembly
D0090131biological_processmesenchyme migration
D0098723cellular_componentskeletal muscle myofibril
D0140660molecular_functioncytoskeletal motor activator activity
E0000287molecular_functionmagnesium ion binding
E0001725cellular_componentstress fiber
E0003785molecular_functionactin monomer binding
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005523molecular_functiontropomyosin binding
E0005737cellular_componentcytoplasm
E0005856cellular_componentcytoskeleton
E0005865cellular_componentstriated muscle thin filament
E0005884cellular_componentactin filament
E0010628biological_processpositive regulation of gene expression
E0016887molecular_functionATP hydrolysis activity
E0019904molecular_functionprotein domain specific binding
E0030027cellular_componentlamellipodium
E0030041biological_processactin filament polymerization
E0030175cellular_componentfilopodium
E0030240biological_processskeletal muscle thin filament assembly
E0031013molecular_functiontroponin I binding
E0031432molecular_functiontitin binding
E0031941cellular_componentfilamentous actin
E0032036molecular_functionmyosin heavy chain binding
E0032432cellular_componentactin filament bundle
E0042802molecular_functionidentical protein binding
E0044297cellular_componentcell body
E0048306molecular_functioncalcium-dependent protein binding
E0048741biological_processskeletal muscle fiber development
E0051017biological_processactin filament bundle assembly
E0090131biological_processmesenchyme migration
E0098723cellular_componentskeletal muscle myofibril
E0140660molecular_functioncytoskeletal motor activator activity
F0000287molecular_functionmagnesium ion binding
F0001725cellular_componentstress fiber
F0003785molecular_functionactin monomer binding
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005523molecular_functiontropomyosin binding
F0005737cellular_componentcytoplasm
F0005856cellular_componentcytoskeleton
F0005865cellular_componentstriated muscle thin filament
F0005884cellular_componentactin filament
F0010628biological_processpositive regulation of gene expression
F0016887molecular_functionATP hydrolysis activity
F0019904molecular_functionprotein domain specific binding
F0030027cellular_componentlamellipodium
F0030041biological_processactin filament polymerization
F0030175cellular_componentfilopodium
F0030240biological_processskeletal muscle thin filament assembly
F0031013molecular_functiontroponin I binding
F0031432molecular_functiontitin binding
F0031941cellular_componentfilamentous actin
F0032036molecular_functionmyosin heavy chain binding
F0032432cellular_componentactin filament bundle
F0042802molecular_functionidentical protein binding
F0044297cellular_componentcell body
F0048306molecular_functioncalcium-dependent protein binding
F0048741biological_processskeletal muscle fiber development
F0051017biological_processactin filament bundle assembly
F0090131biological_processmesenchyme migration
F0098723cellular_componentskeletal muscle myofibril
F0140660molecular_functioncytoskeletal motor activator activity
G0000287molecular_functionmagnesium ion binding
G0001725cellular_componentstress fiber
G0003785molecular_functionactin monomer binding
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005523molecular_functiontropomyosin binding
G0005737cellular_componentcytoplasm
G0005856cellular_componentcytoskeleton
G0005865cellular_componentstriated muscle thin filament
G0005884cellular_componentactin filament
G0010628biological_processpositive regulation of gene expression
G0016887molecular_functionATP hydrolysis activity
G0019904molecular_functionprotein domain specific binding
G0030027cellular_componentlamellipodium
G0030041biological_processactin filament polymerization
G0030175cellular_componentfilopodium
G0030240biological_processskeletal muscle thin filament assembly
G0031013molecular_functiontroponin I binding
G0031432molecular_functiontitin binding
G0031941cellular_componentfilamentous actin
G0032036molecular_functionmyosin heavy chain binding
G0032432cellular_componentactin filament bundle
G0042802molecular_functionidentical protein binding
G0044297cellular_componentcell body
G0048306molecular_functioncalcium-dependent protein binding
G0048741biological_processskeletal muscle fiber development
G0051017biological_processactin filament bundle assembly
G0090131biological_processmesenchyme migration
G0098723cellular_componentskeletal muscle myofibril
G0140660molecular_functioncytoskeletal motor activator activity
H0000287molecular_functionmagnesium ion binding
H0001725cellular_componentstress fiber
H0003785molecular_functionactin monomer binding
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005523molecular_functiontropomyosin binding
H0005737cellular_componentcytoplasm
H0005856cellular_componentcytoskeleton
H0005865cellular_componentstriated muscle thin filament
H0005884cellular_componentactin filament
H0010628biological_processpositive regulation of gene expression
H0016887molecular_functionATP hydrolysis activity
H0019904molecular_functionprotein domain specific binding
H0030027cellular_componentlamellipodium
H0030041biological_processactin filament polymerization
H0030175cellular_componentfilopodium
H0030240biological_processskeletal muscle thin filament assembly
H0031013molecular_functiontroponin I binding
H0031432molecular_functiontitin binding
H0031941cellular_componentfilamentous actin
H0032036molecular_functionmyosin heavy chain binding
H0032432cellular_componentactin filament bundle
H0042802molecular_functionidentical protein binding
H0044297cellular_componentcell body
H0048306molecular_functioncalcium-dependent protein binding
H0048741biological_processskeletal muscle fiber development
H0051017biological_processactin filament bundle assembly
H0090131biological_processmesenchyme migration
H0098723cellular_componentskeletal muscle myofibril
H0140660molecular_functioncytoskeletal motor activator activity
I0000287molecular_functionmagnesium ion binding
I0001725cellular_componentstress fiber
I0003785molecular_functionactin monomer binding
I0005509molecular_functioncalcium ion binding
I0005515molecular_functionprotein binding
I0005523molecular_functiontropomyosin binding
I0005737cellular_componentcytoplasm
I0005856cellular_componentcytoskeleton
I0005865cellular_componentstriated muscle thin filament
I0005884cellular_componentactin filament
I0010628biological_processpositive regulation of gene expression
I0016887molecular_functionATP hydrolysis activity
I0019904molecular_functionprotein domain specific binding
I0030027cellular_componentlamellipodium
I0030041biological_processactin filament polymerization
I0030175cellular_componentfilopodium
I0030240biological_processskeletal muscle thin filament assembly
I0031013molecular_functiontroponin I binding
I0031432molecular_functiontitin binding
I0031941cellular_componentfilamentous actin
I0032036molecular_functionmyosin heavy chain binding
I0032432cellular_componentactin filament bundle
I0042802molecular_functionidentical protein binding
I0044297cellular_componentcell body
I0048306molecular_functioncalcium-dependent protein binding
I0048741biological_processskeletal muscle fiber development
I0051017biological_processactin filament bundle assembly
I0090131biological_processmesenchyme migration
I0098723cellular_componentskeletal muscle myofibril
I0140660molecular_functioncytoskeletal motor activator activity
J0000287molecular_functionmagnesium ion binding
J0001725cellular_componentstress fiber
J0003785molecular_functionactin monomer binding
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005523molecular_functiontropomyosin binding
J0005737cellular_componentcytoplasm
J0005856cellular_componentcytoskeleton
J0005865cellular_componentstriated muscle thin filament
J0005884cellular_componentactin filament
J0010628biological_processpositive regulation of gene expression
J0016887molecular_functionATP hydrolysis activity
J0019904molecular_functionprotein domain specific binding
J0030027cellular_componentlamellipodium
J0030041biological_processactin filament polymerization
J0030175cellular_componentfilopodium
J0030240biological_processskeletal muscle thin filament assembly
J0031013molecular_functiontroponin I binding
J0031432molecular_functiontitin binding
J0031941cellular_componentfilamentous actin
J0032036molecular_functionmyosin heavy chain binding
J0032432cellular_componentactin filament bundle
J0042802molecular_functionidentical protein binding
J0044297cellular_componentcell body
J0048306molecular_functioncalcium-dependent protein binding
J0048741biological_processskeletal muscle fiber development
J0051017biological_processactin filament bundle assembly
J0090131biological_processmesenchyme migration
J0098723cellular_componentskeletal muscle myofibril
J0140660molecular_functioncytoskeletal motor activator activity
K0003779molecular_functionactin binding
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005737cellular_componentcytoplasm
K0005856cellular_componentcytoskeleton
K0008154biological_processactin polymerization or depolymerization
K0015629cellular_componentactin cytoskeleton
K0016363cellular_componentnuclear matrix
K0030018cellular_componentZ disc
K0030042biological_processactin filament depolymerization
K0030836biological_processpositive regulation of actin filament depolymerization
K0031674cellular_componentI band
K0051014biological_processactin filament severing
K0051015molecular_functionactin filament binding
K0070062cellular_componentextracellular exosome
L0003779molecular_functionactin binding
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005737cellular_componentcytoplasm
L0005856cellular_componentcytoskeleton
L0008154biological_processactin polymerization or depolymerization
L0015629cellular_componentactin cytoskeleton
L0016363cellular_componentnuclear matrix
L0030018cellular_componentZ disc
L0030042biological_processactin filament depolymerization
L0030836biological_processpositive regulation of actin filament depolymerization
L0031674cellular_componentI band
L0051014biological_processactin filament severing
L0051015molecular_functionactin filament binding
L0070062cellular_componentextracellular exosome
M0003779molecular_functionactin binding
M0005515molecular_functionprotein binding
M0005576cellular_componentextracellular region
M0005737cellular_componentcytoplasm
M0005856cellular_componentcytoskeleton
M0008154biological_processactin polymerization or depolymerization
M0015629cellular_componentactin cytoskeleton
M0016363cellular_componentnuclear matrix
M0030018cellular_componentZ disc
M0030042biological_processactin filament depolymerization
M0030836biological_processpositive regulation of actin filament depolymerization
M0031674cellular_componentI band
M0051014biological_processactin filament severing
M0051015molecular_functionactin filament binding
M0070062cellular_componentextracellular exosome
N0003779molecular_functionactin binding
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005737cellular_componentcytoplasm
N0005856cellular_componentcytoskeleton
N0008154biological_processactin polymerization or depolymerization
N0015629cellular_componentactin cytoskeleton
N0016363cellular_componentnuclear matrix
N0030018cellular_componentZ disc
N0030042biological_processactin filament depolymerization
N0030836biological_processpositive regulation of actin filament depolymerization
N0031674cellular_componentI band
N0051014biological_processactin filament severing
N0051015molecular_functionactin filament binding
N0070062cellular_componentextracellular exosome
O0003779molecular_functionactin binding
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005737cellular_componentcytoplasm
O0005856cellular_componentcytoskeleton
O0008154biological_processactin polymerization or depolymerization
O0015629cellular_componentactin cytoskeleton
O0016363cellular_componentnuclear matrix
O0030018cellular_componentZ disc
O0030042biological_processactin filament depolymerization
O0030836biological_processpositive regulation of actin filament depolymerization
O0031674cellular_componentI band
O0051014biological_processactin filament severing
O0051015molecular_functionactin filament binding
O0070062cellular_componentextracellular exosome
P0003779molecular_functionactin binding
P0005515molecular_functionprotein binding
P0005576cellular_componentextracellular region
P0005737cellular_componentcytoplasm
P0005856cellular_componentcytoskeleton
P0008154biological_processactin polymerization or depolymerization
P0015629cellular_componentactin cytoskeleton
P0016363cellular_componentnuclear matrix
P0030018cellular_componentZ disc
P0030042biological_processactin filament depolymerization
P0030836biological_processpositive regulation of actin filament depolymerization
P0031674cellular_componentI band
P0051014biological_processactin filament severing
P0051015molecular_functionactin filament binding
P0070062cellular_componentextracellular exosome
Q0003779molecular_functionactin binding
Q0005515molecular_functionprotein binding
Q0005576cellular_componentextracellular region
Q0005737cellular_componentcytoplasm
Q0005856cellular_componentcytoskeleton
Q0008154biological_processactin polymerization or depolymerization
Q0015629cellular_componentactin cytoskeleton
Q0016363cellular_componentnuclear matrix
Q0030018cellular_componentZ disc
Q0030042biological_processactin filament depolymerization
Q0030836biological_processpositive regulation of actin filament depolymerization
Q0031674cellular_componentI band
Q0051014biological_processactin filament severing
Q0051015molecular_functionactin filament binding
Q0070062cellular_componentextracellular exosome
R0003779molecular_functionactin binding
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005737cellular_componentcytoplasm
R0005856cellular_componentcytoskeleton
R0008154biological_processactin polymerization or depolymerization
R0015629cellular_componentactin cytoskeleton
R0016363cellular_componentnuclear matrix
R0030018cellular_componentZ disc
R0030042biological_processactin filament depolymerization
R0030836biological_processpositive regulation of actin filament depolymerization
R0031674cellular_componentI band
R0051014biological_processactin filament severing
R0051015molecular_functionactin filament binding
R0070062cellular_componentextracellular exosome
Functional Information from PROSITE/UniProt
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
ATYR53-GLY63

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WITKqEYDE
ChainResidueDetails
ATRP356-GLU364

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
ALEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues250
DetailsRegion: {"description":"Interaction with alpha-actinin","evidences":[{"source":"PubMed","id":"8449927","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues10
DetailsModified residue: {"description":"N-acetylaspartate; in Actin, alpha skeletal muscle","evidences":[{"source":"PubMed","id":"1150665","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues20
DetailsModified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68134","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues10
DetailsModified residue: {"description":"N6-malonyllysine","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues10
DetailsModified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"1150665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"213279","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2395459","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"499690","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ATN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NWK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues10
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68133","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues10
DetailsModified residue: {"description":"ADP-ribosylarginine; by SpvB","evidences":[{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1192
DetailsDomain: {"description":"ADF-H","evidences":[{"source":"PROSITE-ProRule","id":"PRU00599","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues824
DetailsRegion: {"description":"Interaction with CSRP3","evidences":[{"source":"PubMed","id":"19752190","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues32
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues8
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"37316325","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues8
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P45591","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues8
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"37316325","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

259987

PDB entries from 2026-09-23

PDB statisticsPDBj update infoContact PDBjnumon