7U7N
IL-27 quaternary receptor signaling complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0002376 | biological_process | immune system process |
| C | 0004896 | molecular_function | cytokine receptor activity |
| C | 0005125 | molecular_function | cytokine activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005788 | cellular_component | endoplasmic reticulum lumen |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006959 | biological_process | humoral immune response |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
| C | 0019221 | biological_process | cytokine-mediated signaling pathway |
| C | 0032729 | biological_process | positive regulation of type II interferon production |
| C | 0042088 | biological_process | T-helper 1 type immune response |
| C | 0042098 | biological_process | T cell proliferation |
| C | 0045523 | molecular_function | interleukin-27 receptor binding |
| C | 0046641 | biological_process | positive regulation of alpha-beta T cell proliferation |
| D | 0002230 | biological_process | positive regulation of defense response to virus by host |
| D | 0002376 | biological_process | immune system process |
| D | 0005102 | molecular_function | signaling receptor binding |
| D | 0005125 | molecular_function | cytokine activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005788 | cellular_component | endoplasmic reticulum lumen |
| D | 0005829 | cellular_component | cytosol |
| D | 0006954 | biological_process | inflammatory response |
| D | 0007165 | biological_process | signal transduction |
| D | 0009617 | biological_process | response to bacterium |
| D | 0009986 | cellular_component | cell surface |
| D | 0032729 | biological_process | positive regulation of type II interferon production |
| D | 0042129 | biological_process | regulation of T cell proliferation |
| D | 0045087 | biological_process | innate immune response |
| D | 0045523 | molecular_function | interleukin-27 receptor binding |
| D | 0045625 | biological_process | regulation of T-helper 1 cell differentiation |
| D | 0050688 | biological_process | regulation of defense response to virus |
| D | 0050863 | biological_process | regulation of T cell activation |
| D | 0140459 | biological_process | response to Gram-positive bacterium |
Functional Information from PROSITE/UniProt
| site_id | PS01354 |
| Number of Residues | 41 |
| Details | HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPegVrlsplaerq..LqvqWepPgSWpfpei.FsLkYwI |
| Chain | Residue | Details |
| C | ILE127-ILE167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 191 |
| Details | Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Motif: {"description":"WSXWS motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 94 |
| Details | Domain: {"description":"Ig-like C2-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 96 |
| Details | Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
