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7U5U

Structure of the SK/DHQase/DHSD dimer from Candida albicans Aro1

Functional Information from GO Data
ChainGOidnamespacecontents
A0002181biological_processcytoplasmic translation
A0003824molecular_functioncatalytic activity
A0003855molecular_function3-dehydroquinate dehydratase activity
A0003856molecular_function3-dehydroquinate synthase activity
A0003866molecular_function3-phosphoshikimate 1-carboxyvinyltransferase activity
A0004764molecular_functionshikimate 3-dehydrogenase (NADP+) activity
A0004765molecular_functionshikimate kinase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0008652biological_processamino acid biosynthetic process
A0009073biological_processaromatic amino acid family biosynthetic process
A0009423biological_processchorismate biosynthetic process
A0016301molecular_functionkinase activity
A0016491molecular_functionoxidoreductase activity
A0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
A0016829molecular_functionlyase activity
A0046872molecular_functionmetal ion binding
B0002181biological_processcytoplasmic translation
B0003824molecular_functioncatalytic activity
B0003855molecular_function3-dehydroquinate dehydratase activity
B0003856molecular_function3-dehydroquinate synthase activity
B0003866molecular_function3-phosphoshikimate 1-carboxyvinyltransferase activity
B0004764molecular_functionshikimate 3-dehydrogenase (NADP+) activity
B0004765molecular_functionshikimate kinase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0008652biological_processamino acid biosynthetic process
B0009073biological_processaromatic amino acid family biosynthetic process
B0009423biological_processchorismate biosynthetic process
B0016301molecular_functionkinase activity
B0016491molecular_functionoxidoreductase activity
B0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
B0016829molecular_functionlyase activity
B0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00104
Number of Residues15
DetailsEPSP_SYNTHASE_1 EPSP synthase signature 1. LYlGNAGTASRfLtT
ChainResidueDetails
ALEU487-THR501

site_idPS00107
Number of Residues31
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGAGGTSRAAiYalhqmgcakiylvnr...TAAK
ChainResidueDetails
AVAL1403-LYS1433

site_idPS00885
Number of Residues19
DetailsEPSP_SYNTHASE_2 EPSP synthase signature 2. RvKECNRIeAMvteLakFG
ChainResidueDetails
AARG751-GLY769

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor; for 3-dehydroquinate synthase activity => ECO:0000255|HAMAP-Rule:MF_03143
ChainResidueDetails
AGLU262
AHIS277
BGLU253
BHIS268

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity => ECO:0000255|HAMAP-Rule:MF_03143
ChainResidueDetails
AARG1203
BARG1194

site_idSWS_FT_FI3
Number of Residues38
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03143
ChainResidueDetails
AASP51
AASN168
APHE185
AASN196
AGLU200
ALYS252
AARG266
AHIS273
AHIS289
ALYS360
AGLY874
AGLU89
BASP42
BGLU80
BGLY111
BASP116
BARG127
BTHR136
BASP143
BLYS149
BLYS158
BASN159
AGLY120
BPHE176
BASN187
BGLU191
BLYS243
BARG257
BHIS264
BHIS280
BLYS351
BGLY865
AASP125
AARG136
ATHR145
AASP152
ALYS158
ALYS167

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PDB entries from 2024-11-06

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