7U5L

Cryo-EM Structure of Ferritin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006955	biological_process	immune response
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016491	molecular_function	oxidoreductase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0046872	molecular_function	metal ion binding
A	0110076	biological_process	negative regulation of ferroptosis
B	0004322	molecular_function	ferroxidase activity
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005776	cellular_component	autophagosome
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0008198	molecular_function	ferrous iron binding
B	0008199	molecular_function	ferric iron binding
B	0008285	biological_process	negative regulation of cell population proliferation
B	0016491	molecular_function	oxidoreductase activity
B	0031410	cellular_component	cytoplasmic vesicle
B	0046872	molecular_function	metal ion binding
B	0110076	biological_process	negative regulation of ferroptosis
C	0004322	molecular_function	ferroxidase activity
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005776	cellular_component	autophagosome
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006955	biological_process	immune response
C	0008198	molecular_function	ferrous iron binding
C	0008199	molecular_function	ferric iron binding
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016491	molecular_function	oxidoreductase activity
C	0031410	cellular_component	cytoplasmic vesicle
C	0046872	molecular_function	metal ion binding
C	0110076	biological_process	negative regulation of ferroptosis
D	0004322	molecular_function	ferroxidase activity
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005776	cellular_component	autophagosome
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0008198	molecular_function	ferrous iron binding
D	0008199	molecular_function	ferric iron binding
D	0008285	biological_process	negative regulation of cell population proliferation
D	0016491	molecular_function	oxidoreductase activity
D	0031410	cellular_component	cytoplasmic vesicle
D	0046872	molecular_function	metal ion binding
D	0110076	biological_process	negative regulation of ferroptosis
E	0004322	molecular_function	ferroxidase activity
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005776	cellular_component	autophagosome
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0008198	molecular_function	ferrous iron binding
E	0008199	molecular_function	ferric iron binding
E	0008285	biological_process	negative regulation of cell population proliferation
E	0016491	molecular_function	oxidoreductase activity
E	0031410	cellular_component	cytoplasmic vesicle
E	0046872	molecular_function	metal ion binding
E	0110076	biological_process	negative regulation of ferroptosis
F	0004322	molecular_function	ferroxidase activity
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005776	cellular_component	autophagosome
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0008198	molecular_function	ferrous iron binding
F	0008199	molecular_function	ferric iron binding
F	0008285	biological_process	negative regulation of cell population proliferation
F	0016491	molecular_function	oxidoreductase activity
F	0031410	cellular_component	cytoplasmic vesicle
F	0046872	molecular_function	metal ion binding
F	0110076	biological_process	negative regulation of ferroptosis
G	0004322	molecular_function	ferroxidase activity
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005776	cellular_component	autophagosome
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0008198	molecular_function	ferrous iron binding
G	0008199	molecular_function	ferric iron binding
G	0008285	biological_process	negative regulation of cell population proliferation
G	0016491	molecular_function	oxidoreductase activity
G	0031410	cellular_component	cytoplasmic vesicle
G	0046872	molecular_function	metal ion binding
G	0110076	biological_process	negative regulation of ferroptosis
H	0004322	molecular_function	ferroxidase activity
H	0005737	cellular_component	cytoplasm
H	0005764	cellular_component	lysosome
H	0005776	cellular_component	autophagosome
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0008198	molecular_function	ferrous iron binding
H	0008199	molecular_function	ferric iron binding
H	0008285	biological_process	negative regulation of cell population proliferation
H	0016491	molecular_function	oxidoreductase activity
H	0031410	cellular_component	cytoplasmic vesicle
H	0046872	molecular_function	metal ion binding
H	0110076	biological_process	negative regulation of ferroptosis
I	0004322	molecular_function	ferroxidase activity
I	0005737	cellular_component	cytoplasm
I	0005764	cellular_component	lysosome
I	0005776	cellular_component	autophagosome
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006955	biological_process	immune response
I	0008198	molecular_function	ferrous iron binding
I	0008199	molecular_function	ferric iron binding
I	0008285	biological_process	negative regulation of cell population proliferation
I	0016491	molecular_function	oxidoreductase activity
I	0031410	cellular_component	cytoplasmic vesicle
I	0046872	molecular_function	metal ion binding
I	0110076	biological_process	negative regulation of ferroptosis
J	0004322	molecular_function	ferroxidase activity
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005776	cellular_component	autophagosome
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006955	biological_process	immune response
J	0008198	molecular_function	ferrous iron binding
J	0008199	molecular_function	ferric iron binding
J	0008285	biological_process	negative regulation of cell population proliferation
J	0016491	molecular_function	oxidoreductase activity
J	0031410	cellular_component	cytoplasmic vesicle
J	0046872	molecular_function	metal ion binding
J	0110076	biological_process	negative regulation of ferroptosis
K	0004322	molecular_function	ferroxidase activity
K	0005737	cellular_component	cytoplasm
K	0005764	cellular_component	lysosome
K	0005776	cellular_component	autophagosome
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006955	biological_process	immune response
K	0008198	molecular_function	ferrous iron binding
K	0008199	molecular_function	ferric iron binding
K	0008285	biological_process	negative regulation of cell population proliferation
K	0016491	molecular_function	oxidoreductase activity
K	0031410	cellular_component	cytoplasmic vesicle
K	0046872	molecular_function	metal ion binding
K	0110076	biological_process	negative regulation of ferroptosis
L	0004322	molecular_function	ferroxidase activity
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005776	cellular_component	autophagosome
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0008198	molecular_function	ferrous iron binding
L	0008199	molecular_function	ferric iron binding
L	0008285	biological_process	negative regulation of cell population proliferation
L	0016491	molecular_function	oxidoreductase activity
L	0031410	cellular_component	cytoplasmic vesicle
L	0046872	molecular_function	metal ion binding
L	0110076	biological_process	negative regulation of ferroptosis
M	0004322	molecular_function	ferroxidase activity
M	0005737	cellular_component	cytoplasm
M	0005764	cellular_component	lysosome
M	0005776	cellular_component	autophagosome
M	0006826	biological_process	iron ion transport
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006955	biological_process	immune response
M	0008198	molecular_function	ferrous iron binding
M	0008199	molecular_function	ferric iron binding
M	0008285	biological_process	negative regulation of cell population proliferation
M	0016491	molecular_function	oxidoreductase activity
M	0031410	cellular_component	cytoplasmic vesicle
M	0046872	molecular_function	metal ion binding
M	0110076	biological_process	negative regulation of ferroptosis
N	0004322	molecular_function	ferroxidase activity
N	0005737	cellular_component	cytoplasm
N	0005764	cellular_component	lysosome
N	0005776	cellular_component	autophagosome
N	0006826	biological_process	iron ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006955	biological_process	immune response
N	0008198	molecular_function	ferrous iron binding
N	0008199	molecular_function	ferric iron binding
N	0008285	biological_process	negative regulation of cell population proliferation
N	0016491	molecular_function	oxidoreductase activity
N	0031410	cellular_component	cytoplasmic vesicle
N	0046872	molecular_function	metal ion binding
N	0110076	biological_process	negative regulation of ferroptosis
O	0004322	molecular_function	ferroxidase activity
O	0005737	cellular_component	cytoplasm
O	0005764	cellular_component	lysosome
O	0005776	cellular_component	autophagosome
O	0006826	biological_process	iron ion transport
O	0006879	biological_process	intracellular iron ion homeostasis
O	0006955	biological_process	immune response
O	0008198	molecular_function	ferrous iron binding
O	0008199	molecular_function	ferric iron binding
O	0008285	biological_process	negative regulation of cell population proliferation
O	0016491	molecular_function	oxidoreductase activity
O	0031410	cellular_component	cytoplasmic vesicle
O	0046872	molecular_function	metal ion binding
O	0110076	biological_process	negative regulation of ferroptosis
P	0004322	molecular_function	ferroxidase activity
P	0005737	cellular_component	cytoplasm
P	0005764	cellular_component	lysosome
P	0005776	cellular_component	autophagosome
P	0006826	biological_process	iron ion transport
P	0006879	biological_process	intracellular iron ion homeostasis
P	0006955	biological_process	immune response
P	0008198	molecular_function	ferrous iron binding
P	0008199	molecular_function	ferric iron binding
P	0008285	biological_process	negative regulation of cell population proliferation
P	0016491	molecular_function	oxidoreductase activity
P	0031410	cellular_component	cytoplasmic vesicle
P	0046872	molecular_function	metal ion binding
P	0110076	biological_process	negative regulation of ferroptosis
Q	0004322	molecular_function	ferroxidase activity
Q	0005737	cellular_component	cytoplasm
Q	0005764	cellular_component	lysosome
Q	0005776	cellular_component	autophagosome
Q	0006826	biological_process	iron ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0006955	biological_process	immune response
Q	0008198	molecular_function	ferrous iron binding
Q	0008199	molecular_function	ferric iron binding
Q	0008285	biological_process	negative regulation of cell population proliferation
Q	0016491	molecular_function	oxidoreductase activity
Q	0031410	cellular_component	cytoplasmic vesicle
Q	0046872	molecular_function	metal ion binding
Q	0110076	biological_process	negative regulation of ferroptosis
R	0004322	molecular_function	ferroxidase activity
R	0005737	cellular_component	cytoplasm
R	0005764	cellular_component	lysosome
R	0005776	cellular_component	autophagosome
R	0006826	biological_process	iron ion transport
R	0006879	biological_process	intracellular iron ion homeostasis
R	0006955	biological_process	immune response
R	0008198	molecular_function	ferrous iron binding
R	0008199	molecular_function	ferric iron binding
R	0008285	biological_process	negative regulation of cell population proliferation
R	0016491	molecular_function	oxidoreductase activity
R	0031410	cellular_component	cytoplasmic vesicle
R	0046872	molecular_function	metal ion binding
R	0110076	biological_process	negative regulation of ferroptosis
S	0004322	molecular_function	ferroxidase activity
S	0005737	cellular_component	cytoplasm
S	0005764	cellular_component	lysosome
S	0005776	cellular_component	autophagosome
S	0006826	biological_process	iron ion transport
S	0006879	biological_process	intracellular iron ion homeostasis
S	0006955	biological_process	immune response
S	0008198	molecular_function	ferrous iron binding
S	0008199	molecular_function	ferric iron binding
S	0008285	biological_process	negative regulation of cell population proliferation
S	0016491	molecular_function	oxidoreductase activity
S	0031410	cellular_component	cytoplasmic vesicle
S	0046872	molecular_function	metal ion binding
S	0110076	biological_process	negative regulation of ferroptosis
T	0004322	molecular_function	ferroxidase activity
T	0005737	cellular_component	cytoplasm
T	0005764	cellular_component	lysosome
T	0005776	cellular_component	autophagosome
T	0006826	biological_process	iron ion transport
T	0006879	biological_process	intracellular iron ion homeostasis
T	0006955	biological_process	immune response
T	0008198	molecular_function	ferrous iron binding
T	0008199	molecular_function	ferric iron binding
T	0008285	biological_process	negative regulation of cell population proliferation
T	0016491	molecular_function	oxidoreductase activity
T	0031410	cellular_component	cytoplasmic vesicle
T	0046872	molecular_function	metal ion binding
T	0110076	biological_process	negative regulation of ferroptosis
U	0004322	molecular_function	ferroxidase activity
U	0005737	cellular_component	cytoplasm
U	0005764	cellular_component	lysosome
U	0005776	cellular_component	autophagosome
U	0006826	biological_process	iron ion transport
U	0006879	biological_process	intracellular iron ion homeostasis
U	0006955	biological_process	immune response
U	0008198	molecular_function	ferrous iron binding
U	0008199	molecular_function	ferric iron binding
U	0008285	biological_process	negative regulation of cell population proliferation
U	0016491	molecular_function	oxidoreductase activity
U	0031410	cellular_component	cytoplasmic vesicle
U	0046872	molecular_function	metal ion binding
U	0110076	biological_process	negative regulation of ferroptosis
V	0004322	molecular_function	ferroxidase activity
V	0005737	cellular_component	cytoplasm
V	0005764	cellular_component	lysosome
V	0005776	cellular_component	autophagosome
V	0006826	biological_process	iron ion transport
V	0006879	biological_process	intracellular iron ion homeostasis
V	0006955	biological_process	immune response
V	0008198	molecular_function	ferrous iron binding
V	0008199	molecular_function	ferric iron binding
V	0008285	biological_process	negative regulation of cell population proliferation
V	0016491	molecular_function	oxidoreductase activity
V	0031410	cellular_component	cytoplasmic vesicle
V	0046872	molecular_function	metal ion binding
V	0110076	biological_process	negative regulation of ferroptosis
W	0004322	molecular_function	ferroxidase activity
W	0005737	cellular_component	cytoplasm
W	0005764	cellular_component	lysosome
W	0005776	cellular_component	autophagosome
W	0006826	biological_process	iron ion transport
W	0006879	biological_process	intracellular iron ion homeostasis
W	0006955	biological_process	immune response
W	0008198	molecular_function	ferrous iron binding
W	0008199	molecular_function	ferric iron binding
W	0008285	biological_process	negative regulation of cell population proliferation
W	0016491	molecular_function	oxidoreductase activity
W	0031410	cellular_component	cytoplasmic vesicle
W	0046872	molecular_function	metal ion binding
W	0110076	biological_process	negative regulation of ferroptosis
X	0004322	molecular_function	ferroxidase activity
X	0005737	cellular_component	cytoplasm
X	0005764	cellular_component	lysosome
X	0005776	cellular_component	autophagosome
X	0006826	biological_process	iron ion transport
X	0006879	biological_process	intracellular iron ion homeostasis
X	0006955	biological_process	immune response
X	0008198	molecular_function	ferrous iron binding
X	0008199	molecular_function	ferric iron binding
X	0008285	biological_process	negative regulation of cell population proliferation
X	0016491	molecular_function	oxidoreductase activity
X	0031410	cellular_component	cytoplasmic vesicle
X	0046872	molecular_function	metal ion binding
X	0110076	biological_process	negative regulation of ferroptosis

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFIEthYLneqveaIK

Chain	Residue	Details
A	ASP127-LYS147

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site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaERLMklQNqRgGR

Chain	Residue	Details
A	GLU62-ARG80

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3576
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	120
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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