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7U5I

Cryo-EM Structure of Mitochondrial Creatine Kinase

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004111molecular_functioncreatine kinase activity
A0005524molecular_functionATP binding
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0016301molecular_functionkinase activity
A0016772molecular_functiontransferase activity, transferring phosphorus-containing groups
A0043066biological_processnegative regulation of apoptotic process
A0046314biological_processphosphocreatine biosynthetic process
B0003824molecular_functioncatalytic activity
B0004111molecular_functioncreatine kinase activity
B0005524molecular_functionATP binding
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0016301molecular_functionkinase activity
B0016772molecular_functiontransferase activity, transferring phosphorus-containing groups
B0043066biological_processnegative regulation of apoptotic process
B0046314biological_processphosphocreatine biosynthetic process
C0003824molecular_functioncatalytic activity
C0004111molecular_functioncreatine kinase activity
C0005524molecular_functionATP binding
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0016301molecular_functionkinase activity
C0016772molecular_functiontransferase activity, transferring phosphorus-containing groups
C0043066biological_processnegative regulation of apoptotic process
C0046314biological_processphosphocreatine biosynthetic process
D0003824molecular_functioncatalytic activity
D0004111molecular_functioncreatine kinase activity
D0005524molecular_functionATP binding
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0016301molecular_functionkinase activity
D0016772molecular_functiontransferase activity, transferring phosphorus-containing groups
D0043066biological_processnegative regulation of apoptotic process
D0046314biological_processphosphocreatine biosynthetic process
E0003824molecular_functioncatalytic activity
E0004111molecular_functioncreatine kinase activity
E0005524molecular_functionATP binding
E0005739cellular_componentmitochondrion
E0005743cellular_componentmitochondrial inner membrane
E0016301molecular_functionkinase activity
E0016772molecular_functiontransferase activity, transferring phosphorus-containing groups
E0043066biological_processnegative regulation of apoptotic process
E0046314biological_processphosphocreatine biosynthetic process
F0003824molecular_functioncatalytic activity
F0004111molecular_functioncreatine kinase activity
F0005524molecular_functionATP binding
F0005739cellular_componentmitochondrion
F0005743cellular_componentmitochondrial inner membrane
F0016301molecular_functionkinase activity
F0016772molecular_functiontransferase activity, transferring phosphorus-containing groups
F0043066biological_processnegative regulation of apoptotic process
F0046314biological_processphosphocreatine biosynthetic process
G0003824molecular_functioncatalytic activity
G0004111molecular_functioncreatine kinase activity
G0005524molecular_functionATP binding
G0005739cellular_componentmitochondrion
G0005743cellular_componentmitochondrial inner membrane
G0016301molecular_functionkinase activity
G0016772molecular_functiontransferase activity, transferring phosphorus-containing groups
G0043066biological_processnegative regulation of apoptotic process
G0046314biological_processphosphocreatine biosynthetic process
H0003824molecular_functioncatalytic activity
H0004111molecular_functioncreatine kinase activity
H0005524molecular_functionATP binding
H0005739cellular_componentmitochondrion
H0005743cellular_componentmitochondrial inner membrane
H0016301molecular_functionkinase activity
H0016772molecular_functiontransferase activity, transferring phosphorus-containing groups
H0043066biological_processnegative regulation of apoptotic process
H0046314biological_processphosphocreatine biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00112
Number of Residues7
DetailsPHOSPHAGEN_KINASE Phosphagen kinase active site signature. CP.SNLGT
ChainResidueDetails
ACYS316-THR322

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues48
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00843
ChainResidueDetails
ASER161
BARG325
BARG353
BASP368
CSER161
CHIS224
CARG269
CARG325
CARG353
CASP368
DSER161
AHIS224
DHIS224
DARG269
DARG325
DARG353
DASP368
ESER161
EHIS224
EARG269
EARG325
EARG353
AARG269
EASP368
FSER161
FHIS224
FARG269
FARG325
FARG353
FASP368
GSER161
GHIS224
GARG269
AARG325
GARG325
GARG353
GASP368
HSER161
HHIS224
HARG269
HARG325
HARG353
HASP368
AARG353
AASP368
BSER161
BHIS224
BARG269

site_idSWS_FT_FI2
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P25809
ChainResidueDetails
ASER151
ESER196
FSER151
FSER196
GSER151
GSER196
HSER151
HSER196
ASER196
BSER151
BSER196
CSER151
CSER196
DSER151
DSER196
ESER151

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P00564
ChainResidueDetails
ATHR213
BTHR213
CTHR213
DTHR213
ETHR213
FTHR213
GTHR213
HTHR213

site_idSWS_FT_FI4
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P30275
ChainResidueDetails
ASER232
ESER365
FSER232
FSER365
GSER232
GSER365
HSER232
HSER365
ASER365
BSER232
BSER365
CSER232
CSER365
DSER232
DSER365
ESER232

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P07310
ChainResidueDetails
ATHR355
BTHR355
CTHR355
DTHR355
ETHR355
FTHR355
GTHR355
HTHR355

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PDB entries from 2024-07-17

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