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7U2X

Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with Kir6.2-CTD in the down conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0001666biological_processresponse to hypoxia
A0001669cellular_componentacrosomal vesicle
A0002931biological_processresponse to ischemia
A0003229biological_processventricular cardiac muscle tissue development
A0005242molecular_functioninward rectifier potassium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005635cellular_componentnuclear envelope
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0006006biological_processglucose metabolic process
A0006813biological_processpotassium ion transport
A0006915biological_processapoptotic process
A0006950biological_processresponse to stress
A0008282cellular_componentinward rectifying potassium channel
A0008340biological_processdetermination of adult lifespan
A0009410biological_processresponse to xenobiotic stimulus
A0014704cellular_componentintercalated disc
A0015272molecular_functionATP-activated inward rectifier potassium channel activity
A0016020cellular_componentmembrane
A0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
A0030315cellular_componentT-tubule
A0030506molecular_functionankyrin binding
A0030673cellular_componentaxolemma
A0031072molecular_functionheat shock protein binding
A0031669biological_processcellular response to nutrient levels
A0032355biological_processresponse to estradiol
A0033198biological_processresponse to ATP
A0033574biological_processresponse to testosterone
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0034765biological_processregulation of monoatomic ion transmembrane transport
A0042383cellular_componentsarcolemma
A0042391biological_processregulation of membrane potential
A0042734cellular_componentpresynaptic membrane
A0043025cellular_componentneuronal cell body
A0044325molecular_functiontransmembrane transporter binding
A0046676biological_processnegative regulation of insulin secretion
A0050796biological_processregulation of insulin secretion
A0050877biological_processnervous system process
A0061762biological_processCAMKK-AMPK signaling cascade
A0070852cellular_componentcell body fiber
A0071316biological_processcellular response to nicotine
A0071333biological_processcellular response to glucose stimulus
A0071356biological_processcellular response to tumor necrosis factor
A0071805biological_processpotassium ion transmembrane transport
A0098662biological_processinorganic cation transmembrane transport
A0098978cellular_componentglutamatergic synapse
A0099505biological_processregulation of presynaptic membrane potential
A0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1904638biological_processresponse to resveratrol
A1990573biological_processpotassium ion import across plasma membrane
B0001508biological_processaction potential
B0001666biological_processresponse to hypoxia
B0001669cellular_componentacrosomal vesicle
B0002931biological_processresponse to ischemia
B0003229biological_processventricular cardiac muscle tissue development
B0005242molecular_functioninward rectifier potassium channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005635cellular_componentnuclear envelope
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005886cellular_componentplasma membrane
B0006006biological_processglucose metabolic process
B0006813biological_processpotassium ion transport
B0006915biological_processapoptotic process
B0006950biological_processresponse to stress
B0008282cellular_componentinward rectifying potassium channel
B0008340biological_processdetermination of adult lifespan
B0009410biological_processresponse to xenobiotic stimulus
B0014704cellular_componentintercalated disc
B0015272molecular_functionATP-activated inward rectifier potassium channel activity
B0016020cellular_componentmembrane
B0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
B0030315cellular_componentT-tubule
B0030506molecular_functionankyrin binding
B0030673cellular_componentaxolemma
B0031072molecular_functionheat shock protein binding
B0031669biological_processcellular response to nutrient levels
B0032355biological_processresponse to estradiol
B0033198biological_processresponse to ATP
B0033574biological_processresponse to testosterone
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0034765biological_processregulation of monoatomic ion transmembrane transport
B0042383cellular_componentsarcolemma
B0042391biological_processregulation of membrane potential
B0042734cellular_componentpresynaptic membrane
B0043025cellular_componentneuronal cell body
B0044325molecular_functiontransmembrane transporter binding
B0046676biological_processnegative regulation of insulin secretion
B0050796biological_processregulation of insulin secretion
B0050877biological_processnervous system process
B0061762biological_processCAMKK-AMPK signaling cascade
B0070852cellular_componentcell body fiber
B0071316biological_processcellular response to nicotine
B0071333biological_processcellular response to glucose stimulus
B0071356biological_processcellular response to tumor necrosis factor
B0071805biological_processpotassium ion transmembrane transport
B0098662biological_processinorganic cation transmembrane transport
B0098978cellular_componentglutamatergic synapse
B0099505biological_processregulation of presynaptic membrane potential
B0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1903078biological_processpositive regulation of protein localization to plasma membrane
B1904638biological_processresponse to resveratrol
B1990573biological_processpotassium ion import across plasma membrane
C0001508biological_processaction potential
C0001666biological_processresponse to hypoxia
C0001669cellular_componentacrosomal vesicle
C0002931biological_processresponse to ischemia
C0003229biological_processventricular cardiac muscle tissue development
C0005242molecular_functioninward rectifier potassium channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005635cellular_componentnuclear envelope
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005886cellular_componentplasma membrane
C0006006biological_processglucose metabolic process
C0006813biological_processpotassium ion transport
C0006915biological_processapoptotic process
C0006950biological_processresponse to stress
C0008282cellular_componentinward rectifying potassium channel
C0008340biological_processdetermination of adult lifespan
C0009410biological_processresponse to xenobiotic stimulus
C0014704cellular_componentintercalated disc
C0015272molecular_functionATP-activated inward rectifier potassium channel activity
C0016020cellular_componentmembrane
C0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
C0030315cellular_componentT-tubule
C0030506molecular_functionankyrin binding
C0030673cellular_componentaxolemma
C0031072molecular_functionheat shock protein binding
C0031669biological_processcellular response to nutrient levels
C0032355biological_processresponse to estradiol
C0033198biological_processresponse to ATP
C0033574biological_processresponse to testosterone
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0034765biological_processregulation of monoatomic ion transmembrane transport
C0042383cellular_componentsarcolemma
C0042391biological_processregulation of membrane potential
C0042734cellular_componentpresynaptic membrane
C0043025cellular_componentneuronal cell body
C0044325molecular_functiontransmembrane transporter binding
C0046676biological_processnegative regulation of insulin secretion
C0050796biological_processregulation of insulin secretion
C0050877biological_processnervous system process
C0061762biological_processCAMKK-AMPK signaling cascade
C0070852cellular_componentcell body fiber
C0071316biological_processcellular response to nicotine
C0071333biological_processcellular response to glucose stimulus
C0071356biological_processcellular response to tumor necrosis factor
C0071805biological_processpotassium ion transmembrane transport
C0098662biological_processinorganic cation transmembrane transport
C0098978cellular_componentglutamatergic synapse
C0099505biological_processregulation of presynaptic membrane potential
C0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1903078biological_processpositive regulation of protein localization to plasma membrane
C1904638biological_processresponse to resveratrol
C1990573biological_processpotassium ion import across plasma membrane
D0001508biological_processaction potential
D0001666biological_processresponse to hypoxia
D0001669cellular_componentacrosomal vesicle
D0002931biological_processresponse to ischemia
D0003229biological_processventricular cardiac muscle tissue development
D0005242molecular_functioninward rectifier potassium channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005635cellular_componentnuclear envelope
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005886cellular_componentplasma membrane
D0006006biological_processglucose metabolic process
D0006813biological_processpotassium ion transport
D0006915biological_processapoptotic process
D0006950biological_processresponse to stress
D0008282cellular_componentinward rectifying potassium channel
D0008340biological_processdetermination of adult lifespan
D0009410biological_processresponse to xenobiotic stimulus
D0014704cellular_componentintercalated disc
D0015272molecular_functionATP-activated inward rectifier potassium channel activity
D0016020cellular_componentmembrane
D0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
D0030315cellular_componentT-tubule
D0030506molecular_functionankyrin binding
D0030673cellular_componentaxolemma
D0031072molecular_functionheat shock protein binding
D0031669biological_processcellular response to nutrient levels
D0032355biological_processresponse to estradiol
D0033198biological_processresponse to ATP
D0033574biological_processresponse to testosterone
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0034765biological_processregulation of monoatomic ion transmembrane transport
D0042383cellular_componentsarcolemma
D0042391biological_processregulation of membrane potential
D0042734cellular_componentpresynaptic membrane
D0043025cellular_componentneuronal cell body
D0044325molecular_functiontransmembrane transporter binding
D0046676biological_processnegative regulation of insulin secretion
D0050796biological_processregulation of insulin secretion
D0050877biological_processnervous system process
D0061762biological_processCAMKK-AMPK signaling cascade
D0070852cellular_componentcell body fiber
D0071316biological_processcellular response to nicotine
D0071333biological_processcellular response to glucose stimulus
D0071356biological_processcellular response to tumor necrosis factor
D0071805biological_processpotassium ion transmembrane transport
D0098662biological_processinorganic cation transmembrane transport
D0098978cellular_componentglutamatergic synapse
D0099505biological_processregulation of presynaptic membrane potential
D0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1903078biological_processpositive regulation of protein localization to plasma membrane
D1904638biological_processresponse to resveratrol
D1990573biological_processpotassium ion import across plasma membrane
E0005267molecular_functionpotassium channel activity
E0005524molecular_functionATP binding
E0005886cellular_componentplasma membrane
E0006813biological_processpotassium ion transport
E0008281molecular_functionsulfonylurea receptor activity
E0016020cellular_componentmembrane
E0016887molecular_functionATP hydrolysis activity
E0032991cellular_componentprotein-containing complex
E0042626molecular_functionATPase-coupled transmembrane transporter activity
E0055085biological_processtransmembrane transport
E0071805biological_processpotassium ion transmembrane transport
E0140359molecular_functionABC-type transporter activity
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL
ChainResidueDetails
ELEU830-LEU844
EPHE1482-PHE1496

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues98
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:10506167
ChainResidueDetails
EMET1-VAL34
EGLY97-SER101
EVAL155-LEU167
ELEU1027-SER1073
EARG1274-SER1277
CILE167-SER390
DMET1-TRP68
DILE167-SER390

site_idSWS_FT_FI2
Number of Residues20
DetailsTRANSMEM: Helical; Name=1
ChainResidueDetails
EPRO35-SER55
BPRO69-ILE93
CPRO69-ILE93
DPRO69-ILE93

site_idSWS_FT_FI3
Number of Residues828
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:10506167
ChainResidueDetails
ESER56-TRP75
ETYR123-LYS134
ETYR195-LEU311
ESER606-LEU1005
EVAL1299-LYS1582
CARG136-LEU144
DALA94-SER116
DARG136-LEU144

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2
ChainResidueDetails
EILE76-ASP96
BPHE117-GLN128
CPHE117-GLN128
DPHE117-GLN128

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=3
ChainResidueDetails
EARG102-VAL122
BVAL129-GLY135
CVAL129-GLY135
DVAL129-GLY135

site_idSWS_FT_FI6
Number of Residues19
DetailsTRANSMEM: Helical; Name=4
ChainResidueDetails
ELEU135-PHE154
BALA145-CYS166
CALA145-CYS166
DALA145-CYS166

site_idSWS_FT_FI7
Number of Residues26
DetailsTRANSMEM: Helical; Name=5
ChainResidueDetails
EARG168-ARG194
BASN160
CASN160
DASN160

site_idSWS_FT_FI8
Number of Residues19
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ELEU312-ASN331
BTHR341
CTHR341
DTHR341

site_idSWS_FT_FI9
Number of Residues47
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
EHIS332-ALA355
ELEU456-VAL458
EVAL563-HIS584
EVAL1160

site_idSWS_FT_FI10
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ETYR356-SER376

site_idSWS_FT_FI11
Number of Residues231
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
ETYR377-LEU434
ELYS480-SER541
ELYS1095-SER1138
EPHE1182-MET1252

site_idSWS_FT_FI12
Number of Residues20
DetailsTRANSMEM: Helical; Name=8 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ECYS435-ILE455

site_idSWS_FT_FI13
Number of Residues20
DetailsTRANSMEM: Helical; Name=9 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ESER459-THR479

site_idSWS_FT_FI14
Number of Residues20
DetailsTRANSMEM: Helical; Name=10 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
EILE542-HIS562

site_idSWS_FT_FI15
Number of Residues20
DetailsTRANSMEM: Helical; Name=11 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
EILE585-VAL605

site_idSWS_FT_FI16
Number of Residues20
DetailsTRANSMEM: Helical; Name=12
ChainResidueDetails
ESER1006-VAL1026

site_idSWS_FT_FI17
Number of Residues20
DetailsTRANSMEM: Helical; Name=13 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ELEU1074-ALA1094

site_idSWS_FT_FI18
Number of Residues20
DetailsTRANSMEM: Helical; Name=14 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ETHR1139-TYR1159

site_idSWS_FT_FI19
Number of Residues20
DetailsTRANSMEM: Helical; Name=15 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ETHR1161-TYR1181

site_idSWS_FT_FI20
Number of Residues20
DetailsTRANSMEM: Helical; Name=16 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
EGLU1253-HIS1273

site_idSWS_FT_FI21
Number of Residues20
DetailsTRANSMEM: Helical; Name=17
ChainResidueDetails
EALA1278-MET1298

site_idSWS_FT_FI22
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
EGLY713
EGLY1379

site_idSWS_FT_FI23
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10506167, ECO:0000269|PubMed:8942641
ChainResidueDetails
EASN10

site_idSWS_FT_FI24
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
EASN1050

227111

PDB entries from 2024-11-06

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